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Intermediate in the preparation of racemic analogs of Viloxazine. Group: Biochemicals. Alternative Names: 2-(Hydroxymethyl)-. Grades: Highly Purified. CAS No. 135065-69-9. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
(3R)-4-Methyl-3-morpholinecarboxylicAcid
(3R)-4-Methyl-3-morpholinecarboxylicAcid. Group: Biochemicals. Alternative Names: (3R)-N-Me-3-morpholine-3-carboxylicAcid. Grades: Highly Purified. Pack Sizes: 50mg. Molecular Formula: C6H11NO3, Molecular Weight: 145.16. US Biological Life Sciences.
Worldwide
(3S)-4-Methyl-3-morpholinecarboxylicAcid
(3S)-4-Methyl-3-morpholinecarboxylicAcid. Group: Biochemicals. Alternative Names: (3S)-N-Me-3-morpholine-3-carboxylicAcid. Grades: Highly Purified. CAS No. 1315051-74-1. Pack Sizes: 100mg. Molecular Formula: C6H11NO3, Molecular Weight: 145.16. US Biological Life Sciences.
Worldwide
Boc-(R,S)-2-carboxymorpholine
Boc-(R,S)-2-carboxymorpholine is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multiple myelomas. Synonyms: Boc-(R,S)-Cop-OH; 4-Boc-2-morpholinecarboxylicacid; 4-Boc-2-morpholinecarboxylicacid; N-Boc-Morpholine-2-carboxylicacid; 4-(tert-butoxycarbonyl)morpholine-2-carboxylicacid; 2,4-Morpholinedicarboxylicacid, 4-(1,1-dimethylethyl) ester; N-Boc-2-morpholinecarboxylicacid; (2S)-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-2-carboxylicacid. Grades: ≥ 98 % (NMR). CAS No. 189321-66-2. Molecular formula: C10H17NO5. Mole weight: 231.25.
RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 μl/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 μl/min per mg protein, respectively. The induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction. Group: Inhibitors. Alternative Names: RO6889678; RO-6889678; RO 6889678. CAS No. 1578153-27-1. Molecular formula: C21H20ClFN4O5S. Mole weight: 494.92. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-4-(((R)-6-(2-Chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylicacid. Canonical SMILES: O=C ([C@H]1N (CC2=C (C (OC)=O)[C@H] (C3=CC=C (F)C=C3Cl)N=C (C4=NC=CS4)N2)CCOC1)O. Catalog: ACM1578153271.
A-1210477
A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members. Synonyms: A 1210477; A1210477; Abbvie Mcl-1 Inhibitor; 7-(5-((4-(4-(N,N-Dimethylsulfamoyl)piperazin-1-yl)phenoxy)methyl)-1,3-dimethyl-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylicacid. Grades: 98%. CAS No. 1668553-26-1. Molecular formula: C46H55N7O7S. Mole weight: 850.04.
Vedroprevir
Vedroprevir is a selective hepatitis C virus (HCV) NS3 protease inhibitor. It is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1(GT1) infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion. It retained wild-type activity against multiple classes of NS5B and NS5A inhibitor resistance mutations. It showed good oral bioavailability in all three species tested. It was developed by Gilead Sciences and was terminated in clinic phase 2 trials. Uses: Vedroprevir is a pharmaceutical drug that is used in the treatment of hepatitis c virus in patients with hcv genotype 1(gt1) infection. Synonyms: GS9451; GS-9451; GS 9451; Vedroprevir; (1R,2R)-N-[[(1alpha,3beta,5alpha)-Bicyclo[3.1.0]hex-3-yloxy]carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-chloro-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-7-[2-(4-morpholinyl)ethoxy]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethyl-cyclopropanecarboxylicacid;GS9451;GS-9451;(1R,2R)-1-((2S,4R)-1-((2S)-2-(((((1R,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-2-(2-(isopropylamino)thiazol-4-yl)-7-(2-morpholinoethoxy)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropane-1-carboxylicacid. Grades: >98%. CAS No. 1098189-15-1. Molecular formula: C45H60ClN7O9S. Mole weight: 910.52.
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