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Methylmalonic acid Methylmalonate, a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA), binds with coenzyme A to form methylmalonyl-CoA. It is a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models and induces apoptotic cell death in striatal neurons. Synonyms: 2-methylpropanedioic acid. Grades: > 98 %. CAS No. 516-05-2. Molecular formula: C4H6O4. Mole weight: 118.09. BOC Sciences 9
Methylmalonic acid Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer. Uses: Scientific research. Group: Natural products. Alternative Names: Methylpropanedioic acid; Methylmalonate. CAS No. 516-05-2. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-103395. MedChemExpress MCE
Methylmalonic Acid Binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status. Group: Biochemicals. Alternative Names: 2-Methylpropanedioic Acid; Methylpropanedioic Acid; 1,1-Ethanedicarboxylic Acid; Isosuccinic Acid; NSC 25201. Grades: Highly Purified. CAS No. 516-05-2. Pack Sizes: 1g. US Biological Life Sciences. USBiological 2
Worldwide
Methylmalonic acid-d3 Methylmalonic acid-d 3 is the deuterium labeled Methylmalonic acid. Methylmalonic acid (Methylmalonate) is an indicator of Vitamin B-12 deficiency in cancer[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Methylpropanedioic acid-d3; Methylmalonate-d3. CAS No. 42522-59-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-103395S. MedChemExpress MCE
Methylmalonic Acid-d3 An isotope labeled derivative of Methylmalonic Acid , binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status. Group: Biochemicals. Alternative Names: Methyl-d3-propanedioic Acid; 2-Methyl-d3-propanedioic Acid; 1,1-Ethanedicarboxylic Acid-d3; Isosuccinic Acid-d3; NSC 2520-d3. Grades: Highly Purified. CAS No. 42522-59-8. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 2
Worldwide
2-(5-fluoropentyl)-2-methylmalonic acid This molecular is a [18F] PET (positron emission tomography) radiotracer. It can accumulate in cells presenting apoptosis-specific membrane alterations. ML-10 allows for the detection of apoptotic cells located in atherosclerotic plaques. In Jun 2015, GlaxoSmithKline terminated a phase II trial in Solid tumours (Diagnosis) in United Kingdom. In Mar 2016, Phase-II for solid tumours, lung cancer and head Brain metastases and neck cancer (Diagnosis) in USA was suspended. Uses: Used as an cancer diagnostic reagents. Synonyms: ML 10;[18F]-ML-10; ApoSense-PET; F-18-ML-10. Grades: 98%. CAS No. 1216897-16-3. Molecular formula: C9H15FO4. Mole weight: 206.21. BOC Sciences 9
2-Allyl-2-methylmalonic Acid Eiethyl Ester Can be used in the preparation of Meprobamate and its metabolites. Group: Biochemicals. Alternative Names: Diethyl Allylmethylmalonate; 2-Methyl-2-(2-propen-1-yl)-propanedioic Acid 1,3-Diethyl Ester. Grades: Highly Purified. CAS No. 53651-72-2. Pack Sizes: 500mg. US Biological Life Sciences. USBiological 1
Worldwide
2-[4-(1,1-Dicarboethoxy)benzyl]-2-methyl malonic acid 2-[4-(1,1-Dicarboethoxy)benzyl]-2-methyl malonic acid. Group: Biochemicals. Alternative Names: 2-[4-(2,2-Dicarboxy-propyl)-phenyl]-2-methylmalonic acid; [[4- (1, 1-Dicarboxyethyl) phenyl]methyl]methyl-propanedioic acid. Grades: Highly Purified. CAS No. 189287-73-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C15H16O8. US Biological Life Sciences. USBiological 7
Worldwide
2-[4-(1,1-Dicarboethoxy)benzyl]-2-methyl Malonic Acid-d3 2-[4-(1,1-Dicarboethoxy)benzyl]-2-methyl Malonic Acid-d3. Group: Biochemicals. Alternative Names: 2-[4-(2,2-Dicarboxy-propyl)-phenyl]-2-methylmalonic Acid-d3; [[4- (1, 1-Dicarboxyethyl) phenyl]methyl]methyl-propanedioic Acid-d3. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. USBiological 2
Worldwide
2-Methylcitric acid 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Methylcitric acid. CAS No. 6061-96-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113371. MedChemExpress MCE
2-Methylcitric Acid 2-Methylcitric Acid is a metabolite of Citric Acid. It is formed from the condensation of propionoyl-CoA and oxaloacetic acid catalyzed by a citrate synthase enzyme. 2-Methylcitric acid is an endogenous tricarboxylic acid formed by the condensation of propionyl-CoA with oxaloacetic acid by citrate synthase under conditions of propionyl-CoA accumulation. Accumulation of 2-methylcitric acid is associated with cobalamin deficiencies, propionic acidemia, and methylmalonic acidurias. Group: Biochemicals. Alternative Names: 2-Hydroxy-1,2,3-butanetricarboxylic Acid. Grades: Highly Purified. CAS No. 6061-96-7. Pack Sizes: 50mg, 250mg. Molecular Formula: C?H??O?, Molecular Weight: 206.15. US Biological Life Sciences. USBiological 10
Worldwide
Vatiquinone This active molecular has a para-benzoquinone structure and was developed for inherited mitochondrial diseases base on vitamin E. The mechanism of action of Vatiquinone involves increasing the synthesis of glutathione, optimizing metabolic control and so on. Now it is in Phase I for Gilles de la Tourette's syndrome, in Phase II for Friedreich's ataxia; Methylmalonic acidaemia; Mitochondrial disorders; Noise-induced hearing loss; Parkinson's disease; Rett syndrome Friedreich's ataxia; Methylmalonic acidaemia; Mitochondrial disorders; Noise-induced hearing loss; Parkinson's disease and Rett syndrome, in Phase III for Leigh disease. Uses: Inherited mitochondrial diseases. Synonyms: EPI743; EPI-743; EPI 743; alpha-Tocotrienol quinone;2-[(3R,6E,10E)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trienyl]-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione. Grades: 98%. CAS No. 1213269-98-7. Molecular formula: C29H44O3. Mole weight: 440.67. BOC Sciences 9
methylmalonyl-CoA epimerase It is an enzyme involved in fatty acid catabolism that is encoded in human by the "MCEE" gene located on chromosome 2. Group: Enzymes. Synonyms: methylmalonyl-CoA racemase; methylmalonyl coenzyme A racemase; DL-methylmalonyl-CoA racemase; 2-methyl-3-oxopropanoyl-CoA 2-epimerase [incorrect]. Enzyme Commission Number: EC 5.1.99.1. CAS No. 9024-3-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5433; methylmalonyl-CoA epimerase; EC 5.1.99.1; 9024-03-7; methylmalonyl-CoA racemase; methylmalonyl coenzyme A racemase; DL-methylmalonyl-CoA racemase; 2-methyl-3-oxopropanoyl-CoA 2-epimerase [incorrect]. Cat No: EXWM-5433. Creative Enzymes
mycocerosate synthase This mycobacterial enzyme loads long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8-tetramethyloctacosanoate (C32-mycocerosate). Since the enzyme lacks a thioesterase domain, the products remain bound to the enzyme and require additional enzyme(s) for removal. Even though the enzyme can accept C6 to C20 substrates in vitro, it prefers to act on C14-C20 substrates in vivo. Group: Enzymes. Synonyms: mas (gene name); mycocerosic acid synthase; acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). Enzyme Commission Number: EC 2.3.1.111. CAS No. 95229-19-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2050; mycocerosate synthase; EC 2.3.1.111; 95229-19-9; mas (gene name); mycocerosic acid synthase; acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). Cat No: EXWM-2050. Creative Enzymes
mycolipanoate synthase This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyltetracosanoate (C27-mycolipanoate). Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal. Group: Enzymes. Synonyms: msl3 (gene name); Pks3/4; mycolipanoic acid synthase. Enzyme Commission Number: EC 2.3.1.252. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2202; mycolipanoate synthase; EC 2.3.1.252; msl3 (gene name); Pks3/4; mycolipanoic acid synthase. Cat No: EXWM-2202. Creative Enzymes
oxaloacetate decarboxylase The enzyme from Klebsiella aerogenes is a biotinyl protein and also decarboxylates glutaconyl-CoA and methylmalonyl-CoA. The process is accompanied by the extrusion of two sodium ions from cells. Some animal enzymes require Mn2+. Group: Enzymes. Synonyms: oxaloacetate β-decarboxylase; oxalacetic acid decarboxylase; oxalate β-decarboxylase; oxaloacetate carboxy-lyase. Enzyme Commission Number: EC 4.1.1.3. CAS No. 9024-98-0. Oxaloacetate decarboxylase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4773; oxaloacetate decarboxylase; EC 4.1.1.3; 9024-98-0; oxaloacetate β-decarboxylase; oxalacetic acid decarboxylase; oxalate β-decarboxylase; oxaloacetate carboxy-lyase. Cat No: EXWM-4773. Creative Enzymes

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