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| Product | Description | |
|---|---|---|
| Mitoxantrone | 50mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C22H28N4O6. CAS No. 65271-80-9. Prepack ID 28035650-50mg. Molecular Weight 444.48. See USA prepack pricing. |  |
| Mitoxantrone | Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent. Group: Biochemicals. Alternative Names: 1, 4-Dihydroxy-5, 8-bis[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione; 1, 4-Bis [ (2- (2- hydroxyethylamino) ethyl) amino] -5, 8-di hydroxyanthraquinone. Grades: Highly Purified. CAS No. 65271-80-9. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| Mitoxantrone | Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity [1] [2] [3] [4]. Mitoxantrone also has anti- orthopoxvirus activity with EC 50 s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Mitozantrone; NSC 301739. CAS No. 65271-80-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13502. |  |
| Mitoxantrone | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. It is used in the treatment of certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma. Uses: Analgesics. Synonyms: mitoxantrone; 65271-80-9; Mitoxanthrone; Mitozantrone; DHAQ. Grades: >98%. CAS No. 65271-80-9. Molecular formula: C22H28N4O6. Mole weight: 444.48. |  |
| Mitoxantrone (1, 4-Dihydroxy-5, 8-bis[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione) | An anti-tumor antibiotic and type II topoisomerase inhibitor. It disrupts DNA synthesis and DNA repair in both healthy and cancer cells. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 65271-80-9. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| Mitoxantrone (2-hydroxyethyl) piperazine impurity(mitoxantrone impurity D) | Mitoxantrone (2-hydroxyethyl) piperazine impurity(mitoxantrone impurity D). Group: Biochemicals. Alternative Names: 1, 2, 3, 4-Tetrahydro-8, 11-dihydroxy-4- (2-hydroxyethyl) -6- [ [2- [ (2-hydroxyethyl) amino] ethyl] amino] naphtho [2, 3-f] quinoxaline-7, 12-dione; Mitoxantrone impurity D. Grades: Highly Purified. CAS No. 137132-70-8. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C22H26N4O6. US Biological Life Sciences. | Worldwide |
| Mitoxantrone (2-Hydroxyethyl) piperazine Impurity (Mitoxantrone Impurity D) | A metabolite of the anticancer agent Mitoxantrone. Group: Biochemicals. Alternative Names: 1, 2, 3, 4-Tetrahydro-8, 11-dihydroxy-4- (2-hydroxyethyl) -6- [ [2- [ (2-hydroxyethyl) amino] ethyl] amino] naphtho [2, 3-f] quinoxaline-7, 12-dione; Mitoxantrone Impurity D. Grades: Highly Purified. CAS No. 137132-70-8. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Mitoxantrone-d8 (1, 4-Dihydroxy-5, 8-bis[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione-d8) | A DNA intercalating drug. Inhibits DNA synthesis. Used as an anti-cancer agent. Group: Biochemicals. Alternative Names: 1, 4-Dihydroxy-5, 8-bis[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione-d8. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Mitoxantrone dihydrochloride | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C22H28N4O6 ยท 2HCl. CAS No. 70476-82-3. Prepack ID 24343907-1g. Molecular Weight 517.4. See USA prepack pricing. | |
| Mitoxantrone dihydrochloride | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Mitoxantrone dihydrochloride | It is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively. Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating and antineoplastic anthraquinone derivative. Synonyms: 1, 4-dihydroxy-5, 8-bis ( (2- ( (2-hydroxyethyl) amino) ethyl) amino) anthracene-9, 10-dione dihydrochloride; DHAQ; CL-232325; CL 232325; CL232325; Novantrone; Mitroxone; Neotalem; Onkotrone; Pralifan; Mitoxantrone 2HCl; Immunex. Grades: >98%. CAS No. 70476-82-3. Molecular formula: C22H28N4O6.2HCl. Mole weight: 517.40. | |
| Mitoxantrone dihydrochloride | Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity [1] [2] [3] [4]. Mitoxantrone dihydrochloride also has anti- orthopoxvirus activity with EC 50 s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Mitozantrone dihydrochloride; NSC 301739 dihydrochloride. CAS No. 70476-82-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13502A. | |
| Mitoxantrone Dihydrochloride | Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent. Group: Biochemicals. Alternative Names: 1, 4-Dihydroxy-5, 8-bis[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione Hydrochloride; Bisantrone; CL 232315; DHAD; Immunex; Mitoxantrone Hydrochloride; NCI 301739; NSC 301739; Novantron; Novantrone; Novatrone. Grades: Highly Purified. CAS No. 70476-82-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Mitoxantrone hydrochloride | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardsapi standardseuropean pharmacopoeia (ph. eur.)pharmaceutical toxicologypharmacopoeial standards. Alternative Names: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthracene-9,10-dione dihydrochloride,Mitoxantrone hydrochloride. | |
| Mitoxantrone Impurity4 | Mitoxantrone Impurity4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 100204-25-9. Molecular formula: C24H28ClF3N4O7. Mole weight: 576.95. Catalog: APB100204259. | |
| Mitoxantrone Impurity A | An impurity of Mitoxantrone, which is a DNA intercalating drug. Synonyms: Des[2-[(2-Hydroxyethyl)amino]ethyl] Mitoxantrone; 1-Amino-5,8-dihydroxy-4-[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione. Grades: > 95%. CAS No. 89991-52-6. Molecular formula: C18H19N3O5. Mole weight: 357.37. | |
| Mitoxantrone Impurity B | An impurity of Mitoxantrone, which is a DNA intercalating drug. Synonyms: 1-Deshydroxy Mitoxantrone; 4-Hydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione; 1-Deshydroxy DHAQ; Dihydroxyanthraquinone 1-Deshydroxy; Mitox 1-Deshydroxy; Mitoxanthrone 1-Deshydroxy; Mitozantrone 1-Deshydroxy; Nimitoxantron 1-Deshydroxy. Grades: > 95%. CAS No. 80189-44-2. Molecular formula: C22H28N4O5. Mole weight: 428.49. | |
| Mitoxantrone Impurity C | An impurity of Mitoxantrone, which is a DNA intercalating drug. Synonyms: 2-Choloride-1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione; 2-Choloride-1,4-Bis[(2-(2-hydroxyethylamino)ethyl)amino]-5,8-dihydroxyanthraquinone. Grades: > 95%. Molecular formula: C22H27ClN4O6. Mole weight: 478.94. | |
| Mitoxantrone Impurity D | An impurity of Mitoxantrone, which is a DNA intercalating drug. Synonyms: Mitoxantrone (2-Hydroxyethyl)piperazine Impurity; 1, 2, 3, 4-Tetrahydro-8, 11-dihydroxy-4- (2-hydroxyethyl) -6-[[2-[ (2-hydroxyethyl) amino]ethyl]amino]naphtho[2, 3-f]quinoxaline-7, 12-dione. Grades: > 95%. CAS No. 137132-70-8. Molecular formula: C22H26N4O6. Mole weight: 442.48. | |
| Mitoxantrone Liposome | Mitoxantrone is an anthracycline that enters the nucleus of the cell and binds to DNA, thereby inhibiting nucleic acid synthesis and mitosis, leading to cell death. This product is a pre-formulated liposome with mitoxantrone. It is only for research purposes and for the injection to laboratory animals. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes. |  |
| Mitoxantrone System Suitability Mixture | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| 1-Deshydroxy Mitoxantrone | 1-Deshydroxy Mitoxantrone. Group: Biochemicals. Alternative Names: 4-Hydroxy-5, 8-bis[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione; 1-Deshydroxy DHAQ; Dihydroxyanthraquinone 1-Deshydroxy; Mitox 1-Deshydroxy; Mitoxanthrone 1-Deshydroxy; Mitozantrone 1-Deshydroxy; Nimitoxantron 1-Deshydroxy; Novantron 1-Deshydroxy; Novantrone 1-Deshydroxy; Ralenova 1-Deshydroxy; NSC 279836 1-Deshydroxy; Mitoxantrone Impurity B. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C22H28N4O5, Molecular Weight: 428.48. US Biological Life Sciences. | Worldwide |
| 1-Fluoro-1-des[2-[ (2-Hydroxyethyl) amino]ethylamino] Mitoxantrone | Mitoxantrone derivative, used in the preparation of Mitoxantrone analogues useful as stem-loop structure stabilizing ligand. Group: Biochemicals. Alternative Names: 1-Fluoro-5, 8-dihydroxy-4-[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione. Grades: Highly Purified. CAS No. 1195810-93-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-Chloro Mitoxantrone | 3-Chloro Mitoxantrone. Group: Biochemicals. Alternative Names: 1, 4-Dihydroxy-3-chloro-5, 8-bis[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione; 3-Chloro DHAQ; 3-Chloro Di hydroxyanthraquinone; 3-Chloro Mitox; 3-Chloro Mitoxanthrone; 3-Chloro Mitozantrone; 3-Chloro Nimitoxantron; 3-Chloro Novantron; 3-Chloro Novantrone; 3-Chloro Ralenova; NSC 279836; Mitoxantrone Impurity C. Grades: Highly Purified. Pack Sizes: 2.5mg. Molecular Formula: C22H27ClN4O6, Molecular Weight: 478.93. US Biological Life Sciences. | Worldwide |
| Des[2-[ (2-hydroxyethyl) amino]ethyl] mitoxantrone (mitoxantrone impurity A) | Des[2-[ (2-hydroxyethyl) amino]ethyl] mitoxantrone (mitoxantrone impurity A). Group: Biochemicals. Alternative Names: 1-Amino-5, 8-dihydroxy-4-[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione; Mitoxantrone impurity A. Grades: Highly Purified. CAS No. 89991-52-6. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C18H19N3O5. US Biological Life Sciences. | Worldwide |
| Des[2-[ (2-Hydroxyethyl) amino]ethyl] Mitoxantrone (Mitoxantrone Impurity A) | An impurity of the anticancer agent Mitoxantrone used in immunosuppresion studies. Group: Biochemicals. Alternative Names: 1-Amino-5, 8-dihydroxy-4-[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione; Mitoxantrone Impurity A. Grades: Highly Purified. CAS No. 89991-52-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 1, 4-Dihydroxy-5, 8-bis[2- (2-hydroxyethylamino) ethylamino]-anthracene-9, 10-dione | 1, 4-Dihydroxy-5, 8-bis[2- (2-hydroxyethylamino) ethylamino]-anthracene-9, 10-dione. Group: Biochemicals. Alternative Names: 1, 4-Dihydroxy-5, 8-bis[[2-[ (2-hydroxyethyl) amino]ethyl]amino]-9, 10-anthracenedione; DHAQ; NSC-279836; Mitoxantrone. Grades: Highly Purified. CAS No. 65271-80-9. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C22H28N4O6. US Biological Life Sciences. | Worldwide |
| 2- (2-Aminoethylamino) ethanol-d4 | Intermediate in the production of labeled Mitoxantrone. Group: Biochemicals. Alternative Names: (2-Hydroxyethyl) ethylenediamine-d4; ( β -Hydroxyethyl) ethylenediamine-d4; 1-(2-Hydroxyethylamino)-2-aminoethane-d4; 1-Aminooxyethylamine-d4; Amino Alcohol EA-d4; Aminoethylethanolamine-d4; N-(2-Hydroxyethyl)-1,2-diaminoethane-d4; N-(2-Hydroxyethyl)-1,2-ethanediamine-d4; NSC 461-d4. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-(4-Methoxy-3-methylbenzoyl)benzoic Acid | 2-(4-Methoxy-3-methylbenzoyl)benzoic Acid is an intermediate in synthesizing 2-Hydroxy-3-methylanthraquinone (H946680), a derivative of anthraquinone (A679245) which is an important precursor for many drugs, including Emodin (E523000), Aloe-emodin (A575400), Antimalarials such as Rufgallol, and also Antineoplastics used in the treatment of cancer, such as mitoxantrone (M373425), pixantrone (P552500), and the anthracyclines. Group: Biochemicals. Grades: Highly Purified. CAS No. 51671-71-7. Pack Sizes: 100mg, 250mg. Molecular Formula: C16H14O4. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-1-methyl-9,10-anthracenedione | 2-Hydroxy-1-methyl-9,10-anthracenedione is an intermediate in synthesizing 2-Hydroxy-3-methylanthraquinone (H946680), a derivative of anthraquinone (A679245) which is an important precursor for many drugs, including Emodin (E523000), Aloe-emodin (A575400), Antimalarials such as Rufgallol, and also Antineoplastics used in the treatment of cancer, such as mitoxantrone (M373425), pixantrone (P552500), and the anthracyclines. Group: Biochemicals. Grades: Highly Purified. CAS No. 5025-12-7. Pack Sizes: 25mg, 50mg. Molecular Formula: C15H10O3. US Biological Life Sciences. | Worldwide |
| 2-Hydroxy-3-methylanthraquinone | 2-Hydroxy-3-methylanthraquinone is a derivative of anthraquinone (A679245) which is an important precursor for many drugs, including Emodin (E523000), Aloe-emodin (A575400), Antimalarials such as Rufgallol, and also Antineoplastics used in the treatment of cancer, such as mitoxantrone (M373425), pixantrone (P552500), and the anthracyclines. Group: Biochemicals. Grades: Highly Purified. CAS No. 17241-40-6. Pack Sizes: 25mg, 250mg. Molecular Formula: C15H10O3. US Biological Life Sciences. | Worldwide |
| Cholesteryl sulfate sodium | Cholesteryl sulfate sodium is an orally available, NPC2 -targeted cholesterol biosynthesis agonist. Cholesteryl sulfate sodium activates SREBP2 by competitively binding to NPC2, promoting cholesterol synthesis ( EC 50 =50 μM). Cholesteryl sulfate sodium enhances the self-assembly ability of Mitoxantrone hydrochloride (HY-13502A), while repairing the intestinal mucosal barrier and inhibiting inflammation by regulating serine protease activity and PKCη signaling pathway. Cholesteryl sulfate sodium is a component of the platelet cell membrane and supports platelet adhesion. Cholesteryl sulfate sodium also regulates the activity of selective protein kinase C isoforms and modulates the specificity of PI3K, playing a role in keratinocyte differentiation [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 2864-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111355B. | |
| Ethonafide | Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerated and more effective at inhibiting tumor growth compared with mitoxantrone in a human xenograft tumor regression mouse model. Mechanistically, we found that ethonafide inhibited topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIalpha and -beta. In addition, ethonafide induced a potent G(2) cell cycle arrest in the DU 145 human prostate cancer cell line. By creating stable cell lines with decreased expression of topoisomerase IIalpha or -beta, we found that a decrease in topoisomerase IIalpha protein expression renders the cell line resistant to ethonafide. The decrease in sensitivity to ethonafide was associated with a decrease in DNA damage and an increase in DNA repair as measured by the neutral comet assay. These data demonstrate that ethonafide is a topoisomerase II poison and that it is topoisomerase IIalpha-specific in the DU 145 human prostate cancer cell line. Uses: Topoisomerase ii inhibitors. Synonyms: AMP-53; AMP 53; AMP53; 2-(2'-(Dimethylamino)ethyl)-1,2-dihydro-7-ethoxydibenz(de, H)isoquinoline-1,3-dione; 2-[2-(Dimethylamino)ethyl]-7-ethoxy-1H-dibenz[de,h]isoquinoline-1,3(2H)-dione. CAS No. 175293-23-9. Molecular formula: C22H22N2O3. Mole weight: 362.43. | |
| Ko 143 | Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines. It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice. Synonyms: Ko-143; Ko-143; Ko-143. Grades: >98%. CAS No. 461054-93-3. Molecular formula: C26H35N3O5. Mole weight: 469.57. | |
| Pirenoxine | 1-hydroxy-5-oxo-5H-pyrido-[3,2a]-phenoxazin-3-carboxylic acid, pirfenossone. immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic. CAS No. 1043-21-6. Product ID: 8-04347. Molecular formula: C16H8N2O5. Mole weight: 308.25. |  |
| YHO-13351 free base | YHO-13351 free base is a potent and specific inhibitor of BCRP, which is the water-soluble prodrug of YHO-13177. It potentiates the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 cells and SN-38-resistant human lung cancer A549 cells, but had little effect in the parental cells in vitro. It also potentiates the cytotoxicity of SN-38 in human lung cancer NCI-H23 and NCI-H460, myeloma RPMI-8226 and pancreatic cancer AsPC-1 cell. It increases the intracellular accumulation of Hoechst 33342. It is rapidly converted into YHO-13177 after its oral or intravenous administration in mice. Uses: Yho-13351 free base could potentiate the cytotoxicity of sn-38, mitoxantrone and topotecan. Synonyms: YHO13351 free base; YHO 13351 free base; YHO-13351 free base. Grades: >98%. CAS No. 912288-64-3. Molecular formula: C26H33N3O4S. Mole weight: 483.62. | |
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