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| Product | Description | |
|---|---|---|
| MMP-13 Inhibitor | MMP-13 Inhibitor is a potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 value of 8 nM. Synonyms: Collagenase-3 Inhibitor; Matrix Metalloproteinase-13 Inhibitor; 4,6-Pyrimidinedicarboxamide; N4,N6-Bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-dicarboxamide. Grades: ≥98%. CAS No. 544678-85-5. Molecular formula: C22H20F2N4O2. Mole weight: 410.4. |  |
| MMP-13 Inhibitor - CAS 544678-85-5 | The MMP-13 Inhibitor, also referenced under CAS 544678-85-5, controls the biological activity of MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. |  |
| 3-(Chloromethyl)-2-methylpyridine | Used in the preparation of Oxytocin antagonists and inhibitors of aggrecanase and MMP-13. Group: Biochemicals. Alternative Names: 2-Methyl-3- (chloromethyl) pyridine. Grades: Highly Purified. CAS No. 120277-68-1. Pack Sizes: 100mg. US Biological Life Sciences. |  Worldwide |
| BI-4394 | BI-4394 (MMP13-IN-3) is a potent, selective, and orally active MMP-13 inhibitor ( IC 50=1 nM [1] ) for the potential treatment of osteoarthritis [2]. BI-4394 is >1000 selective over other MMPs [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MMP13-IN-3. CAS No. 1222173-37-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124029. |  |
| CL 82,198 | CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13). It doesn't have effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is also used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis. Synonyms: CL-82198; N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide. Grades: ≥95%. CAS No. 307002-71-7. Molecular formula: C17H22N2O3. Mole weight: 302.4. | |
| CL-82198 - CAS 1188890-36-9 | A selective inhibitor of MMP-13 (IC?? = 10 μM). Group: Fluorescence/luminescence spectroscopy. | |
| CL 82198 hydrochloride | The hydrochloride salt form of CL 82198, an inhibitor of MMP-13, has been found to restrain in vitro invasion by the human pituitary adenoma cell line HP75. Synonyms: CL 82198 hydrochloride; CL82198 hydrochloride; CL-82198 hydrochloride; N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1188890-36-9. Molecular formula: C17H23N2O3.HCl. Mole weight: 338.83. | |
| CP 471474 | CP 471474 a broad spectrum Matrix Metalloprotease inhibitor with sub-nanomolar affinity for MMP-2 and 13 among MMPs (IC50: 1170, 0.7, 16, 13, 0.9 for MMP-1, MMP-2, MMP-3, MMP-9, and MMP-13 respectively). Synonyms: CP-471474; CP 471474; CP471474; UNII-96U47H947L; 2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide; CP 471474; CP-471474; 210755-45-6; CHEMBL323612. Grades: >97 %. CAS No. 210755-45-6. Molecular formula: C16H17FN2O5S. Mole weight: 368.38. | |
| Matrix Metalloproteinase-13 (HisoTag) from Human, Recombinant | Matrix metalloproteinases are members of a unique family of proteolytic enzymes that have a zinc ion at their active sites and can degrade collagens, elastin and other components of the extracellular matrix (ECM). These enzymes are present in normal healthy individuals and have been shown to have an important role in processes such as wound healing, pregnancy, and bone resorption. However, overexpression and activation of MMPs have been linked with a range of pathological processes and disease states involved in the breakdown and remodeling of the ECM. Such diseases include tumor invasion and metastasis, rheumatoid arthritis, periodontal disease and vascular pr..., a ca2+- and zn2+- binding catalytic domain, a hinge region, and a c-terminal hemopexin domain. hydrolyzes collagen type ii 5-6 times faster than collagens type i and iii. exhibits high activity towards gelatin and degrades α1-antichymotrypsin and plasminogen activator inhibitor-2. Group: Enzymes. Synonyms: Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Purity: >90% by SDS-PAGE. Matrix Metalloproteinase. Mole weight: 60 kDa. Activity: >50 mU/mg protein. Storage: < -70°C; Avoid freeze/thaw. Form: Liquid. Source: S. frugiperda. Species: Human. Collagenase-3; Matrix metallopeptidase 13; MMP13; CLG3; MANDP1; MMP-13. Cat No: NATE-0859. |  |
| MK-2 Inhibitor IV, MK-25 (MAPKAP-K2 Inhibitor IV, MK-25, 5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide, HCl) | A cell-permeable furanylcarboxamide compound that acts as a potent, reversible and non-ATP-competitive inhibitor of MK-2/MAPKAP-K2 activity (IC50=110nM; EC50=350nM for pHSP27 in IL-1b-stimulated SW1353 cells) with excellent selectivity over 150 kinases (% activity inhibition at 10uM against human CK2, Haspin, Arg and CK1y3=40, 40, 42 and >70, respectively). Shown to efficiently suppress the secretions of TNFa, IL6 (IC50=4.4 and 5.2uM in LPS-stimulated THP1 cell, respectively) and MMP-13 (IC50=5.7 and 2.2uM in IL1b-stimulated SW1353 and in primary osteoarthritis-derived chondrocytes, respectively). Exhibits desirable bioavailability and weakly inhibits a panel of cytochrome P450 isozymes (IC50>20uM for 3A4, 2D6 and 2C9). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MMP-9-IN-9 | MMP-9-IN-9 (compound 4f) is a slective MMP-9 inhibitor with an IC 50 of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 206549-55-5. Pack Sizes: 500 μg. Product ID: HY-116302. | |
| MMP-9 Inhibitor I - CAS 1177749-58-4 | MMP-9 Inhibitor I, CAS 1177749-58-4, is a cell-permeable, potent, and reversible MMP-9 Inhibitor (IC?? = 5 nM). At high concentration inhibits MMP-1 (IC?? = 1.05 μM) & MMP-13 (IC?? = 113 nM). Group: Fluorescence/luminescence spectroscopy. | |
| PF-00356231 hydrochloride | PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 ( IC 50 =1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC 50 s of 0.00065, 1.7, 0.98, 0.39 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 820223-77-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114091. | |
| T-26c | T-26c is a selective matrix metalloproteinase-13 (MMP-13) inhibitor with IC50 value of 0.0069 nM. It inhibits IL-1β- and oncostatin M-induced collagen degradation in bovine nasal septum cartilage explants by 87.4% when used at a concentration of 0.1 μM. T-26c is used for the treatment of osteroarthritis and rhuematoid arthritis. Synonyms: 4-[[2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-thieno[2,3-d]pyrimidin-5-yl]methoxymethyl]benzoic acid. Grades: ≥98%. CAS No. 869296-13-9. Molecular formula: C24H21N3O6S. Mole weight: 479.5. | |
| T-5224 | T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 530141-72-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12270. | |
| TMI 1 | TMI 1 is a dual inhibitor of Adam 17 (TACE) and MMP inhibitor (IC50 = 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). TMI 1 suppresses TNF-α production in an acute LPS-mouse model. TMI 1 exhibits selective cytotoxicity to tumor cells and cancer stem cells in vitro, and induces apoptosis in a breast cancer in vivo model. Synonyms: TMI-1; TMI-1; TMI-1; (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide. Grades: ≥98% by HPLC. CAS No. 287403-39-8. Molecular formula: C17H22N2O5S2. Mole weight: 398.49. | |
| UK 356618 | UK 356618 is a potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM) with selectivity over a range of MMPs (IC50 = 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1, respectively). Synonyms: UK-356618, UK356618, UK356618; N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine. Grades: ≥95% by HPLC. CAS No. 230961-08-7. Molecular formula: C34H43N3O4. Mole weight: 557.72. | |
| UK-356618 | Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively). Group: Biochemicals. Alternative Names: (2R) -N1- [ (1S) -2, 2-Dimethyl-1- [ [ [ (1R) -1-phenylethyl] amino] carbonyl] propyl] -N4-hydroxy-2- [3- (2-methyl [1, 1'-biphenyl] -4-yl) propyl] butanediamide; UK 356618;PF-03890101. Grades: Highly Purified. CAS No. 230961-08-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| WAY 170523 | WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 = 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively). Synonyms: WAY-170523; WAY 170523; WAY170523; N-[2-[4-[[[2-[ (Hydroxyamino) carbonyl]-4, 6-dimethylphenyl] (phenylmethyl) amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide. Grades: ≥99% by HPLC. CAS No. 307002-73-9. Molecular formula: C33H31N3O7S. Mole weight: 613.68. | |
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