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| Product | Description | |
|---|---|---|
| MMP-9 Inhibitor I | MMP-9 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinase-9 (MMP-9) with IC50 value of 5 nM, respectively. Synonyms: Matrix Metalloproteinase-9 Inhibitor I; 2-[Benzyl(4-methoxyphenylsulfonyl)amino]-3-methyl-5-(diethylaminomethyl)benzohydroximic acid. Grades: ≥95%. CAS No. 1177749-58-4. Molecular formula: C27H33N3O5S. Mole weight: 511.6. |  |
| MMP-9 Inhibitor I - CAS 1177749-58-4 | MMP-9 Inhibitor I, CAS 1177749-58-4, is a cell-permeable, potent, and reversible MMP-9 Inhibitor (IC?? = 5 nM). At high concentration inhibits MMP-1 (IC?? = 1.05 μM) & MMP-13 (IC?? = 113 nM). Group: Fluorescence/luminescence spectroscopy. |  |
| MMP-9 Inhibitor II | The MMP-9 Inhibitor II controls the biological activity of MMP-9. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. | |
| MMP-9 Inhibitor II (MMP-9 PEX Inhibitor) | This compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a =2.1uM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100uM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100M, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20mg/kg, 6 days/week, i.v. and i.t.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| MMP-9/MMP-13 Inhibitor I | MMP-9/MMP-13 inhibitor I is a selective and cell-permeable inhibitor of matrix metalloproteinases MMP-9/MMP-13 with IC50 values of 0.9 nM for both. It also less potently inhibits MMP-1, MMP-3, and MMP-7. Synonyms: Matrix Metalloproteinase-9/Matrix Metalloproteinase-13 Inhibitor I; N-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide. Grades: ≥98%. CAS No. 204140-01-2. Molecular formula: C25H25N3O6S. Mole weight: 495.6. | |
| MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 | The MMP-9/MMP-13 Inhibitor I, also referenced under CAS 204140-01-2, controls the biological activity of MMP-9/MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| 1-?Biphenyl-?4-?yl-?propan-?2-?one | 1-?Biphenyl-?4-?yl-?propan-?2-?one is a reactant used in the preparation of potent inhibitors of metalloproteinases 2 and 9 (MMP-2, MMP-9). This affects such processes such as homeostatic regulation, tumor progression, etc. Group: Biochemicals. Grades: Highly Purified. CAS No. 5333-1-7. Pack Sizes: 1g, 2.5g. Molecular Formula: C15H14O, Molecular Weight: 210.27. US Biological Life Sciences. | Worldwide |
| Actinonin | Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M , aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K i of 0.28 nM. Actinonin also inhibits MMP-1 , MMP-3 , MMP-8 , MMP-9 , and hmeprin α with K i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Actinonin. CAS No. 13434-13-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113952. |  |
| Aminopeptidase N Inhibitor | Membrane alanyl aminopeptidase is also known as alanyl aminopeptidase (AAP) or aminopeptidase N (AP-N), which is an enzyme that in humans is encoded by the ANPEP gene. Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM). It is selective for AP-N/CD13 over matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE), neutral endopeptidase (NEP), γ-glutamyl transpeptidase, and the serine proteases dipeptidyl peptidase 4 (DPP-4) and cathepsin G at a concentration of 1 mM. AP-N inhibitor is non-cytotoxic to U937 cells at a concentration of 100 μM. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. Synonyms: AP-N Inhibitor. Grades: ≥95%. CAS No. 596108-59-7. Molecular formula: C17H10N2O8. Mole weight: 370.27. | |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Synonyms: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. Grades: >98%. CAS No. 91037-65-9. Molecular formula: C15H27N7O8. Mole weight: 433.42. | |
| Batimastat | Batimastat is a potent broad spectrum MMP inhibitor with IC 50 of 3, 4, 4, 6, and 20 nM for MMP-1 , MMP-2 , MMP-9 , MMP-7 and MMP-3 , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BB94. CAS No. 130370-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13564. | |
| BPHA | BPHA is a potent and orally active MMP-2 , MMP-9 and MMP-14 inhibitor with IC 50 s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC 50 s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 193807-60-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114785. | |
| cis-ACCP | cis-ACCP is a reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9. Synonyms: [(1R,2S)-2-aminocyclohexyl]carbamoylphosphonic acid; P-[[[(1R,2S)-2-aminocyclohexyl]amino]carbonyl]-phosphonic acid. Grades: ≥95%. CAS No. 777075-44-2. Molecular formula: C7H15N2O4P. Mole weight: 222.2. | |
| CL 82,198 | CL 82,198 is a selective inhibitor of human collagenase-3, also known as matrix metalloproteinase-13 (MMP-13). It doesn't have effect against MMP-1, MMP-9 or TNF-α converting enzyme. CL 82,198 is also used to evaluate the role of MMP-13 in diverse processes, including cancer cell migration, acute lung injury, and joint degeneration associated with osteoarthritis. Synonyms: CL-82198; N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide. Grades: ≥95%. CAS No. 307002-71-7. Molecular formula: C17H22N2O3. Mole weight: 302.4. | |
| CP 471474 | CP 471474 a broad spectrum Matrix Metalloprotease inhibitor with sub-nanomolar affinity for MMP-2 and 13 among MMPs (IC50: 1170, 0.7, 16, 13, 0.9 for MMP-1, MMP-2, MMP-3, MMP-9, and MMP-13 respectively). Synonyms: CP-471474; CP 471474; CP471474; UNII-96U47H947L; 2-[[4-(4-fluorophenoxy)phenyl]sulfonylamino]-N-hydroxy-2-methylpropanamide; CP 471474; CP-471474; 210755-45-6; CHEMBL323612. Grades: >97 %. CAS No. 210755-45-6. Molecular formula: C16H17FN2O5S. Mole weight: 368.38. | |
| CTTHWGFTLC, CYCLIC acetate | CTTHWGFTLC, CYCLIC acetate is a cyclic peptide inhibitor for matrix metalloproteinases (MMP-2) and MMP-9. Synonyms: L-Cysteine, L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophylglycyl-L-phenylalanyl-L-threonyl-L-leucyl-, cyclic (1?10)-disulfide acetate; CTT 1 acetate; H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH.CH3CO2H (Disulfide Bridge: Cys1-Cys10); L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophyl-glycyl-L-phenylalanyl-L-threonyl-L-leucyl-L-cysteine (1->10)-disulfide acetic acid acetate. Grades: ≥95%. Molecular formula: C54H75N13O16S2. Mole weight: 1226.39. | |
| Flocoumafen | Flocoumafen (WL 108366) is an orally active vitamin K epoxide reductase inhibitor and a multi-target ligand, which includes prostaglandin F synthase, serum albumin, glucocorticoid receptor 2 , and MMP-9. Flocoumafen is a second-generation anticoagulant rodenticide (ARs) with a half-life of 177.4 hours and has deadly anticoagulant effects [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WL 108366. CAS No. 90035-08-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-111186. | |
| Glaucine | Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 ( PDE4 ), with a K i of 3.4 μM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB , leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. Alternative Names: O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396. CAS No. 475-81-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N3945. | |
| GM 1489 | GM 1489 is a potent broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. Synonyms: Hexanoic acid, 3- [ [ [ (1S) -1- (1H-indol-3-ylmethyl) -2-oxo-2- [ [ (1S) -1-phenylethyl] amino] ethyl] amino] carbonyl] -5-methyl-, (3R)-; (3R) -3- [ [ [ (1S) -1- (1H-Indol-3-ylmethyl) -2-oxo-2- [ [ (1S) -1-phenylethyl] amino] ethyl] amino] carbonyl] -5-methylhexanoic acid; Hexanoic acid, 3-[[[1- (1H-indol-3-ylmethyl) -2-oxo-2-[ (1-phenylethyl) amino]ethyl]amino]carbonyl]-5-methyl-, [3R-[3R*[S*(S*)]]]-; GM-1489; GM1489. Grades: ≥98%. CAS No. 171347-75-4. Molecular formula: C27H33N3O4. Mole weight: 463.57. | |
| H-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH (Disulfide bond) | It is a cyclic peptide inhibitor for matrix metalloproteinases (MMP-2) and MMP-9. Synonyms: CTTHWGFTLC, CYCLIC; L-cysteinyl-L-threonyl-L-threonyl-L-histidyl-L-tryptophyl-glycyl-L-phenylalanyl-L-threonyl-L-leucyl-L-cysteine (1->10)-disulfide; MMP-2/MMP-9 Inhibitor III; Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III. Grades: ≥90%. CAS No. 244082-19-7. Molecular formula: C52H71N13O14S2. Mole weight: 1166.33. | |
| Imidapril | Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-6366 free base. CAS No. 89371-37-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B1451A. | |
| Imidapril hydrochloride | Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-6366. CAS No. 89396-94-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1451. | |
| Inotilone | Inotilone is a potent and selective COX-2 inhibitor with IC50 value of 0.03 μM. Study indicated that inotilone exhibited anti-inflammatory effects via inhibition of MMP-9, NF-κB, and MAPK. Synonyms: 2-[(3,4-dihydroxyphenyl)methylidene]-5-methyl-3-furanone. Grades: ≥98%. CAS No. 906366-79-8. Molecular formula: C12H10O4. Mole weight: 218.2. | |
| JNJ 0966 | JNJ 0966 is a selective inhibitor of MMP-9 (IC50 = 440 nM) with no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity. JNJ 0966 was indicated to alleviate the pain of experimental autoimmune encephalomyelitis in a mouse model. Synonyms: JNJ-0966; JNJ0966; N-[2-[(2-Methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]acetamide. Grades: ≥98% by HPLC. CAS No. 315705-75-0. Molecular formula: C16H16N4O2S2. Mole weight: 360.45. | |
| Marimastat | Marimastat (BB2516) is a broad spectrum and orally bioavailable inhibitor of MMPs , with potent activity against MMP-9 ( IC 50 =3 nM), MMP-1 ( IC 50 =5 nM), MMP-2 ( IC 50 =6 nM), MMP-14 ( IC 50 =9 nM) and MMP-7 ( IC 50 =13 nM), used in the treatment of cancer. Marimastat (BB2516) is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels. As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BB2516; TA2516. CAS No. 154039-60-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-12169. | |
| Marimastat | Marimastat is an orally-active synthetic broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Synonyms: BB-2516; BB2516; BB 2516; TA-2516; TA2516; TA 2516; Marimastat; N-[2,2-dimethyl-1- (methylcarbamoyl)propyl]-2- [hydroxy-(hydroxycarbamoyl)methyl]- 4- methyl-pentanamide; (2S,3R)-3-(((1S)-2,2-dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid; (2S,3R)-3-{(S)-[2,2-dimethyl-1-(methylcarbamoyl) propyl]carbamoyl}-2-hydroxy-5-methylhexanohydroxamic acid. CAS No. 154039-60-8. Molecular formula: C15H29N3O5. Mole weight: 331.413. | |
| Marimastat ( (2S, 3R) -N4-[ (1S) -2, 2-Dimethyl-1-[ (-[ (methylamino) carbonyl]propyl]-N1, 2-dihydroxy-3- (2-methylpropyl) butanediamide, BB-2516, TA-2516) | A broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to the zinc(II) ion in the active site of MMPs, thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| MMP2-IN-3 | MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC 50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8 , with IC 50 values of 26.6, and 32 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 897799-81-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147746. | |
| MMP-2/MMP-9-IN-1 | MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase ( MMP-9 and MMP-2 ) inhibitor with IC 50 s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 193807-58-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116399. | |
| MMP-9-IN-9 | MMP-9-IN-9 (compound 4f) is a slective MMP-9 inhibitor with an IC 50 of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 206549-55-5. Pack Sizes: 500 μg. Product ID: HY-116302. | |
| MMP Inhibitor II | MMP Inhibitor II (compound 4e) is a potent, reversible pan- MMP inhibitor with IC 50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 203915-59-7. Pack Sizes: 1 mg. Product ID: HY-119423. | |
| ND-336 | ND-336 is a selective inhibitor of the gelatinases matrix metalloproteinase MMP-2, MMP-9, and MMP-14 (Ki = 85, 150, and 120 nM, respectively). It has the potential to treat diabetes that accelerates healing of diabetic wounds. Synonyms: 4-[4-[(2-thiiranylmethyl)sulfonyl]phenoxy]-benzenemethanamine hydrochloride. Grades: ≥95%. CAS No. 1807453-83-3. Molecular formula: C16H17NO3S2·HCl. Mole weight: 371.9. | |
| NF-κB Activation Inhibitor III | NF-κB activation inhibitor III inhibits TNF-α-induced MMP-9 protein expression via blocking NF-κB activity. It has been used to suppress invasion and metastasis of tumor cells. Uses: Matrix metalloproteinase inhibitors. Synonyms: SM-7368; SM 7368; SM7368; 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide. Grades: ≥99%. CAS No. 380623-76-7. Molecular formula: C10H5ClN4O5S. Mole weight: 328.7. | |
| Pamidronate disodium | Pamidronate disodium, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin , and is applicable for research on osteoporosis and osteosarcoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGP 23339A. CAS No. 57248-88-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0012A. | |
| Pamidronic acid | Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin , and is applicable for research on osteoporosis and osteosarcoma [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 40391-99-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B0012. | |
| PD 166793 | PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively). It displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure. Synonyms: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine; PD-166793; PD 166793; PD166793; PD-166793-0000. Grades: ≥99% by HPLC. CAS No. 199850-67-4. Molecular formula: C17H18BrNO4S. Mole weight: 412.3. | |
| PF-00356231 hydrochloride | PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 ( IC 50 =1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC 50 s of 0.00065, 1.7, 0.98, 0.39 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 820223-77-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114091. | |
| S 3304 | S 3304 is a novel matrix metalloproteinases ( MMP ) inhibitor specific for MMP-2 and MMP-9. S 3304 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 203640-27-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106992. | |
| SB-3CT | SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition, by a thiirane-opening mechanism, of the MMP2 and MMP9 zinc metalloproteases. SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. Besides, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. Synonyms: MMP-2/MMP-9 Inhibitor IV; 2- ( (4-phenoxyphenylsulfonyl) methyl) thiirane; SB-3CT; SB3CT; SB3-CT; IN1250; IN 1250; IN-1250. Grades: 98%. CAS No. 292605-14-2. Molecular formula: C15H14O3S2. Mole weight: 306.394. | |
| Tanomastat | Tanomastat is a biphenyl matrix metalloproteinase (MMP) inhibitor (MMPI) with potential antineoplastic activity. Tanomastat inhibits MMP-2, MMP-3, and MMP-9, inhibiting extracellular matrix degradation and potentially inhibiting angiogenesis, tumor growth and invasion, and metastasis. MMPs consist of at least 18 zinc-containing endo-proteinases that are capable of degrading collagen and proteoglycan. Uses: Antineoplastic agents. Synonyms: BAY 12-9566, BAY12-9566, BAY-12-9566, BAY 129566, BAY129566, BAY-129566, Tanomastat; (S)-4'-Chloro-g-oxo-a-[(phenylthio)methyl][1,1'-biphenyl]-4-butanoic Acid. Grades: >98%. CAS No. 179545-77-8. Molecular formula: C23H19ClO3S. Mole weight: 410.91. | |
| TMI 1 | TMI 1 is a dual inhibitor of Adam 17 (TACE) and MMP inhibitor (IC50 = 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). TMI 1 suppresses TNF-α production in an acute LPS-mouse model. TMI 1 exhibits selective cytotoxicity to tumor cells and cancer stem cells in vitro, and induces apoptosis in a breast cancer in vivo model. Synonyms: TMI-1; TMI-1; TMI-1; (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide. Grades: ≥98% by HPLC. CAS No. 287403-39-8. Molecular formula: C17H22N2O5S2. Mole weight: 398.49. | |
| UK 356618 | UK 356618 is a potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM) with selectivity over a range of MMPs (IC50 = 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1, respectively). Synonyms: UK-356618, UK356618, UK356618; N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine. Grades: ≥95% by HPLC. CAS No. 230961-08-7. Molecular formula: C34H43N3O4. Mole weight: 557.72. | |
| UK-356618 | Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively). Group: Biochemicals. Alternative Names: (2R) -N1- [ (1S) -2, 2-Dimethyl-1- [ [ [ (1R) -1-phenylethyl] amino] carbonyl] propyl] -N4-hydroxy-2- [3- (2-methyl [1, 1'-biphenyl] -4-yl) propyl] butanediamide; UK 356618;PF-03890101. Grades: Highly Purified. CAS No. 230961-08-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| WAY 170523 | WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 = 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively). Synonyms: WAY-170523; WAY 170523; WAY170523; N-[2-[4-[[[2-[ (Hydroxyamino) carbonyl]-4, 6-dimethylphenyl] (phenylmethyl) amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide. Grades: ≥99% by HPLC. CAS No. 307002-73-9. Molecular formula: C33H31N3O7S. Mole weight: 613.68. | |
| MMP-2 Inhibitor IV (Bone Resorption Inhibitor, (4'-chlorobiphenyl-4ylsulfonamido) methylenediphosphonic Acid) | A cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50=37nM), with good selectivity over MMP-8 (320nM), MMP-9 (>1uM), and MMP-14 (> 1uM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50=1.7uM), which is more potent compared with other bisphosphonates such as Alendronate, (IC50=30uM), and Zolendronate (7.8uM), without observable cytotoxicity in HepG2 cells. At 25uM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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