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| Product | Description | |
|---|---|---|
| Momelotinib | Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC 50 a of 11 nM and 18 nM,respectively. CYT387 shows much less activity against JAK3. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CYT387. CAS No. 1056634-68-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10961. |  |
| Momelotinib sulfate | Momelotinib sulfate (CYT387 sulfate salt) is an ATP-competitive inhibitor of JAK1/JAK2 with IC 50 of 11 nM/18 nM, 10-fold selectivity versus JAK3 (IC 50 =155 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CYT387 sulfate salt. CAS No. 1056636-06-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10962. | |
| AZD-8931 | Sapitinib, also known as AZD-8931, is an erbB receptor tyrosine kinase inhibitor with potential antineoplastic activity. AZD8931 binds to and inhibits erbB tyrosine receptor kinases, which may result in the inhibition of cellular proliferation and angiogenesis in tumors expressing erbB. Synonyms: AZD8931; AZD 8931; Momelotinib; Sapitinib. Grades: 0.98. CAS No. 848942-61-0. Molecular formula: C23H25ClFN5O3. Mole weight: 473.933. |  |
| Cyt387 | Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 (IC50 = 11 nM and 18 nM respectively). It has been shown to decrease cancer stem cell associated tumor burden in a mouse model of human ovarian cancer. It is commonly used as a therapy for myelofibrosis. Uses: An orally bioavailable small-molecule inhibitor of janus kinases 1 and 2 (jak1/2) with potential antineoplastic activity (ic50s = 11 and 18 nm, respectively). Synonyms: Momelotinib; N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide; CYT 11387; CYT 387; CYT-387; CYT387; CYT-0387; GS 0387. Grades: >98%. CAS No. 1056634-68-4. Molecular formula: C23H22N6O2. Mole weight: 414.46. | |
| CYT387 Mesylate | CYT387 Mesylate is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Synonyms: Momelotinib Mesylate; CYT387 Mesylate; CYT 387 Mesylate; CYT-387 Mesylate. Grades: >98%. CAS No. 1056636-07-7. Molecular formula: C24H26N6O5S. Mole weight: 510.57. | |
| CYT387 sulfate salt | CYT387 sulfate is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Synonyms: momelotinib;CYT 387 sulfate salt; CYT387 sulfate salt; CYT-387 sulfate salt. Grades: >98%. CAS No. 1056636-06-6. Molecular formula: C23H26N6O10S2. Mole weight: 610.62. | |
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