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Montelukast sodium (MK0476) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT 1 ). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage. Montelukast sodium decreases eosinophil infiltration into the asthmatic airways. Montelukast sodium can also be used for COVID-19 research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK0476. CAS No. 151767-02-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-13315.
Montelukast is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: MK-0476; MK 0476; MK0476. Grades: >98%. CAS No. 151767-02-1. Molecular formula: C35H36ClNO3S.Na. Mole weight: 608.17.
2'-Des(1-hydroxy-1-methylethyl)-2'-carboxy Montelukast Bissodium Salt
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: Sodium (R, E) -2- (3- ( ( (1- (Carboxylatomethyl) cyclopropyl) methyl) thio) -3- (3- (2- (7-chloroquinolin-2-yl) vinyl) phenyl) propyl) benzoate; Montelukast Impurity 7; 2- ( (E) -3- ( (R, E) -1- ( ( (1- (carboxymethyl) cyclopropyl) methyl) sulfonyl) -3- (2-carboxyphenyl) allyl) styryl) -7-chloroquinoline 1-oxide Sodium. Grades: > 95%. Molecular formula: C33H28ClNNa2O4S. Mole weight: 616.08.
2-Des(1-hydroxy-1-methylethyl)-2-carboxy Montelukast Bissodium Salt
2-Des(1-hydroxy-1-methylethyl)-2-carboxy Montelukast Bissodium Salt is an impurity of Montelukast Sodium Salt (M568000), a selective leukotriene D4-receptor antagonist. Used as an antiasthmatic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 500mg. Molecular Formula: C33H28ClNNa2O4S, Molecular Weight: 616.08. US Biological Life Sciences.
Worldwide
Dihydro Montelukast Sodium Salt
A Montelukast impurity. A saturated hydroxyalkylquinoline acid as leukotriene antagonist and biosynthesis inhibitor. Group: Biochemicals. Alternative Names: (R) -1- [ [ [1- [3- [2- (7-Chloro-2-quinolinyl) ethyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic Acid Monosodium Salt. Grades: Highly Purified. CAS No. 142147-98-6. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences.
Worldwide
ent-Montelukast Sodium Salt
The S-enantiomer of Montelukast. Results indicate that there is no apparent bioinversion of Montelukast to its S-enantiomer in humans. Group: Biochemicals. Alternative Names: 1- [ [ [ (1S) -1- [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic Acid Sodium Salt; L 768232. Grades: Highly Purified. CAS No. 190078-45-6. Pack Sizes: 10mg. US Biological Life Sciences.
A selective leukotriene D4-receptor antagonist. Used as an antiasthmatic. Group: Biochemicals. Alternative Names: 1- [1- [ [ [ (1R) -1- [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl-d6) phenyl] propyl] thio] methyl] cyclopropaneacetic Acid Sodium Salt; MK-476-d6, Singulair. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Montelukast S-Enantiomer Sodium Salt
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1- [ [ [ (1S) -1- [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic Acid Sodium Salt; L 768232; Montelukast EP Impurity A. Grades: > 95%. CAS No. 190078-45-6. Molecular formula: C35H35ClNO3S.Na. Mole weight: 608.2.
Montelukast Sulfoxide Sodium
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: Cyclopropaneacetic acid, 1-[[[1-[3-[2- (7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2- (1-hydroxy-1-methylethyl) phenyl]propyl]sulfinyl]methyl]-, sodium salt (1:1); Cyclopropaneacetic acid, 1-[[[1-[3-[2- (7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2- (1-hydroxy-1-methylethyl) phenyl]propyl]sulfinyl]methyl]-, monosodium salt. Grades: >95%. CAS No. 909796-71-0. Molecular formula: C35H35ClNNaO4S. Mole weight: 624.19.
1- (Mercapto methyl ) cyclopropane acetonitrile
1- (Mercapto methyl ) cyclopropane acetonitrile is used as a reagent in the synthesis of Montelukast Sodium Salt (M568000); a selective leukotriene D4-receptor antagonist. Also used as an antiasthmatic. Group: Biochemicals. Grades: Highly Purified. CAS No. 866923-64-0. Pack Sizes: 100mg, 1g. Molecular Formula: C6H9NS, Molecular Weight: 127.21. US Biological Life Sciences.
Worldwide
Alpha-Hydroxy Montelukast
Alpha-Hydroxy Montelukast. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Montelukast Sodium Imp. I (EP), Cyclopropaneacetic acid, 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-?-hydroxy-. CAS No. 2045402-27-3. IUPAC Name: 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]-2-hydroxyacetic acid. Molecular formula: C35H36ClNO4S. Mole weight: 602.18. Catalog: APS2045402273. SMILES: CC(C)(O)c1ccccc1CC[C@@H](SCC2(CC2)C(O)C(=O)O)c3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3. Format: Neat.
Dihydro montelukast
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast sodium salt is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Synonyms: ZINC58649359; 1-[[[ (1R) -1-[3-[2- (7-chloro-2-quinolinyl) ethyl]phenyl]-3-[2- (1-hydroxy-1-methylethyl) phenyl]propyl]thio]methyl]-cyclopropaneacetic acid. Grades: ≥98%. CAS No. 142147-67-9. Molecular formula: C35H38ClNO3S. Mole weight: 588.2.
Montelukast
Montelukast is a leukotriene receptor antagonist indicated for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Uses: Anti-asthmatic agents; leukotriene antagonists. Synonyms: Singulair; sodium 1- ( ( (1- (3- (2- (7-chloro-2-quinolinyl) ethenyl) phenyl) -3- (2- (1-hydroxy-1-methylethyl) phenyl) propyl) thio) methyl) cyclopropylacetate. Grades: >98%. CAS No. 158966-92-8. Molecular formula: C35H36ClNO3S. Mole weight: 586.18.
Montelukast 1, 2-Diol
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1- [1- [ [ [ (1R) -1- [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1, 2-diol-2-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic. Grades: > 95%. CAS No. 186352-97-6. Molecular formula: C35H36ClNO4S. Mole weight: 602.2.
Montelukast-Acyl-Glucuronide
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1-O-[2-[1-[[ (R) -1-[3-[ (E) -2- (7-Chloroquinolin-2-yl) ethenyl]phenyl]-3-[2- (1-methyl-1-hydroxyethyl) phenyl]propylthio]methyl]cyclopropan-1-yl]acetyl]-beta-D-glucopyranuronic acid. Grades: >95%. CAS No. 188717-17-1. Molecular formula: C41H44ClNO9S. Mole weight: 762.31.
Montelukast Bisolefin Impurity
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 2- ( (E) -3- ( (R, E) -1- ( ( (1- (carboxymethyl) cyclopropyl) methyl) sulfonyl) -3- (2- (2-hydroxypropan-2-yl) phenyl) allyl) styryl) -7-chloroquinoline 1-oxide. Grades: > 95%. Molecular formula: C35H34ClNO3S. Mole weight: 584.18.
Montelukast Bis-sulfide (mixture of diastereomers)
Montelukast Bis-sulfide (mixture of diastereomers). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-[[[(1R)-1-[3-[(1RS)-1-[[[1-(Carboxymethyl)cyclopropyl]methyl]sulfanyl]-2-(7-chloroquinolin-2-yl)ethyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic Acid, Montekulast Sodium Imp. D+E (Mixture of Stereoisomers) (EP), 1-[[[(1R)-1-[3-[1-[[[1-(Carboxymethyl)cyclopropyl]methyl]thio]-2-(7-chloro-2-quinolinyl)ethyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic Acid. CAS No. 1242260-05-4. Pack Sizes: 10MG. IUPAC Name: 2-[1-[[(1R)-1-[3-[1-[[1-(carboxymethyl)cyclopropyl]methylsulfanyl]-2-(7-chloroquinolin-2-yl)ethyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid. Molecular formula: C41H46ClNO5S2. Mole weight: 732.39. Catalog: APS1242260054. SMILES: CC(C)(O)c1ccccc1CC[C@@H](SCC2(CC(=O)O)CC2)c3cccc(c3)C(Cc4ccc5ccc(Cl)cc5n4)SCC6(CC(=O)O)CC6. Format: Neat. Shipping: Room Temperature.
Montelukast Chloro Alcohol Impurity
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 2-[2-[(3S)-3-[3-[(1E)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-chloropropyl]phenyl]-2-propanol. Grades: > 95%. CAS No. 880769-28-8. Molecular formula: C29H27Cl2NO. Mole weight: 476.45.
Montelukast CN Impurity
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: Montelukast Cyclopropaneacetonitrile; 1- [ [ [ (1R) -1- [3- [ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetonitrile. Grades: > 95%. CAS No. 866923-62-8. Molecular formula: C35H35ClN2OS. Mole weight: 567.2.
Montelukast Cyclopropacetaneamide Impurity
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1-[[[ (1R) -1-[3-[ (1E) -2- (7-Chloro-2-quinolinyl) ethenyl]phenyl]-3-[2- (1-hydroxy-1-methylethyl) phenyl]propyl]thio]methyl]-cyclopropaneacetamide. Grades: > 95%. CAS No. 866923-63-9. Molecular formula: C35H37ClN2O2S. Mole weight: 585.21.
Montelukast Dihydro Impurity
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: (R) -1- [ [ [1- [3- [2- (7-Chloro-2-quinolinyl) ethyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropaneacetic Acid Monosodium Salt. Grades: > 95%. CAS No. 142147-98-6. Molecular formula: C35H38ClNO3S. Mole weight: 588.22.
Montelukast Impurity 8
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: m-Xylene, α,α,α'-trichloro- (6CI,8CI)1-(Chloromethyl)-3-(dichloromethyl)benzene. Grades: > 95%. CAS No. 30220-25-8. Molecular formula: C8H7Cl3. Mole weight: 209.5.
Montelukast Impurity 9
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: m-Xylene, α,α,α',α'-tetrachloro- (8CI)1,3-Bis(dichloromethyl)benzene3-Dichloromethylbenzal chloride. Grades: > 95%. CAS No. 30430-40-1. Molecular formula: C8H6Cl4. Mole weight: 243.95.
Montelukast Keto Carbinol Impurity
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: Montelukast Hydroxymethylcarbonyl Analog; (R, E) -2- (1- ( ( (1- (3- (2- (7-chloroquinolin-2-yl) vinyl) phenyl) -3- (2- (2-hydroxyacetyl) phenyl) propyl) thio) methyl) cyclopropyl) acetic acid. Grades: > 95%. Molecular formula: C34H32ClNO4S. Mole weight: 586.14.
Montelukast Methyl Ketone
Montelukast Methyl Ketone. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Montekulast Sodium Imp. F (EP), Mok-3 Keto,1-[[[(1R)-3-(2-Acetylphenyl)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl]thio]methyl]-cyclopropaneacetic Acid, Montelukast Methyl Ketone. CAS No. 937275-23-5. Pack Sizes: 10MG. IUPAC Name: 2-[1-[[(1R)-3-(2-acetylphenyl)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid. Molecular formula: C34H32ClNO3S. Mole weight: 570.14. Catalog: APS937275235. SMILES: CC(=O)c1ccccc1CC[C@@H](SCC2(CC(=O)O)CC2)c3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3. Format: Neat. Shipping: Room Temperature.
Montelukast Related Impurity 1
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]-1-propanone. Grades: > 95%. CAS No. 1258428-71-5. Molecular formula: C29H26ClNO2. Mole weight: 455.99.
Montelukast Related Impurity 2
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 2-[3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoic Acid Methyl Ester; Methyl (E)-2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoate. Grades: > 95%. CAS No. 149968-11-6. Molecular formula: C28H22ClNO3. Mole weight: 455.95.
Montelukast Related Impurity 3
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 2-[3-(R)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic Acid Methyl Ester. Grades: > 95%. CAS No. 150026-72-5. Molecular formula: C28H24ClNO3. Mole weight: 457.96.
Montelukast Related Impurity 4
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]benzoic Acid Methyl Ester. Grades: > 95%. CAS No. 142569-69-5. Molecular formula: C28H24ClNO3. Mole weight: 457.96.
Montelukast Related Impurity 6
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: Benzenemethanol, 2-[(2E)?-3-[3-[(1E)?-2-(7-chloro-2-quinolinyl)?ethenyl]?phenyl]?-2-propen-1-yl]?-α,?α-dimethyl-. Grades: > 95%. CAS No. 1187586-63-5. Molecular formula: C29H26ClNO. Mole weight: 439.99.
Montelukast R, R-Isomer
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 2- (1- ( ( ( (R) -1- (3- ( (R) -1- ( ( (1- (carboxymethyl) cyclopropyl) methyl) thio) -2- (7-chloroquinolin-2-yl) ethyl) phenyl) -3- (2- (2-hydroxypropan-2-yl) phenyl) propyl) thio) methyl) cyclopropyl) acetic acid. Grades: > 95%. Molecular formula: C41H46ClNO5S2. Mole weight: 732.41.
Montelukast Styrene
Montelukast Styrene. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Montekulast Sodium Imp. B (EP), 1-[[[(1R)-1-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-methylethenyl)phenyl]propyl]thio]methyl]-cyclopropaneacetic Acid,Montelukast Sodium Imp. B (EP), Montelukast Imp. B (EP), Montelukast Styrene. CAS No. 918972-54-0. IUPAC Name: 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-(2-prop-1-en-2-ylphenyl)propyl]sulfanylmethyl]cyclopropyl]acetic acid. Molecular formula: C35H34ClNO2S. Mole weight: 568.17. Catalog: APS918972540. SMILES: CC(=C)c1ccccc1CC[C@@H](SCC2(CC(=O)O)CC2)c3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3. Format: Neat.
Montelukast Sulfone
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1- [ [ [1- [3- [2- (7-Chloro-2-quinolinyl) ethenyl] phenyl] -3- [2- (1-hydroxy-1-methylethyl) phenyl] propyl] sulfonyl] methyl] cyclopropaneacetic Acid. Grades: > 95%. CAS No. 1266620-74-9. Molecular formula: C35H36ClNO5S. Mole weight: 618.18.
Montelukast Sulfone N-Oxide
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: (R, E) -2- (3- (1- ( ( (1- (carboxymethyl) cyclopropyl) methyl) sulfonyl) -3- (2- (2-hydroxypropan-2-yl) phenyl) propyl) styryl) -7-chloroquinoline 1-oxide. Grades: > 95%. Molecular formula: C35H35ClNO6S. Mole weight: 633.19.
Montelukast sulfoxide
Montelukast sulfoxide is an impurity of Montelukast, which is a leukotriene D4-receptor antagonist used in the treatment of allergies and asthma. Synonyms: 1-[[[ (1R) -1-[3-[ (1E) -2- (7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2- (1-hydroxy-1-methylethyl) phenyl]propyl]sulfinyl]methyl]-cyclopropaneacetic acid; Montelukast sodium specified impurity C [EP]; Montelukast sodium, sulfoxide impurity-[USP]. Grades: >98%. CAS No. 1152185-58-4. Molecular formula: C35H36ClNO4S. Mole weight: 602.18.
Montelukust Diol Impurity
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: (S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol. Grades: > 95%. Molecular formula: C29H28ClNO2. Mole weight: 457.99.
Montelukust Keto Impurity
An impurity of Montelukast Sodium, which is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Synonyms: 1-[2-[(3S)-3-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl]phenyl]acetate; [S-(E)]-1-[2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl]phenyl]ethanone. Grades: > 95%. CAS No. 184764-13-4. Molecular formula: C28H24ClNO2. Mole weight: 441.96.
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