Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Mutant EGFR inhibitor | Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFR L858R , EGFR Exon 19 deletion and EGFR T790M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1421373-62-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13984. |  |
| 1-Methyl-4-(4-nitrophenyl)piperazine | 1-methyl-4-(4-nitrophenyl)piperazine was a reagent in the preparation of diaminopyrimidines as reversible and irreversible inhibitors of mutant EGFR tyrosine kinases for treatment of non-small-cell lung cancer. It was also used in the prepn. of disubstituted pyrimidine compds. as EGFR or/and ALK inhibitors useful in the treatment of diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 16155-03-6. Pack Sizes: 500mg, 1g. Molecular Formula: C11H15N3O2, Molecular Weight: 221.26. US Biological Life Sciences. |  Worldwide |
| ALW-II-41-27 | ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor. pharmacologic inhibition of EPHA2 by the small-molecule inhibitor ALW-II-41-27 decreased both survival and proliferation of erlotinib-resistant tumor cells and inhibited tumor growth in vivo. ALW-II-41-27 was also effective in decreasing viability of cells with acquired resistance to the third-generation EGFR TKI AZD9291. Collectively, these data define a role for EPHA2 in the maintenance of cell survival of TKI-resistant, EGFR-mutant lung cancer and indicate that EPHA2 may serve as a useful therapeutic target in TKI-resistant tumors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ALW-II-41-27; ALW II-41-27; ALWII-41-27; ALW-II-4127; ALW II-4127; ALWII-4127. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1186206-79-0. Molecular formula: C32H32F3N5O2S. Mole weight: 607.7. Purity: >98%. IUPACName: N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)-5-(thiophen-2-yl)nicotinamide. Canonical SMILES: O=C(NC1=CC(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)=CC=C1C)C4=CN=CC(C5=CC=CS5)=C4. Product ID: ACM1186206790. Alfa Chemistry ISO 9001:2015 Certified. |  |
| AP-26113 | AP26113 is an orally available inhibitor of receptor tyrosine kinases anaplastic lymphoma kinase (ALK) and the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. AP26113 appears to overcome mutation-based resistance. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. Synonyms: AP-26113; AP 26113; AP26113; (2-((5-chloro-2-((4-(4-(dimethylamino)piperidin-1-yl)-2-methoxyphenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide; AP26113-analog; AP-26113-analog; AP 26113-analog, Brigatinib-analog. Grade: 0.98. CAS No. 1197958-12-5. Molecular formula: C26H34ClN6O2P. Mole weight: 529.01. |  |
| AST-1306 | AST-1306 is a selective irreversible inhibitor of the epidermal growth factor receptor (EGFR) 1 and 2. Studies show that AST-1306 inhibited the enzymatic activities of wild-type EGF) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST-1306 was more effective in inhibiting tumors with ErbB2-overexpressing cells than EGFR-overexpressing tumor. Group: Biochemicals. Alternative Names: N- [4- [ [3-Chloro-4- [ (3-fluorobenzyl) oxy] phenyl] amino] quinazolin-6-yl] acrylamide; N-[4-[[3-Chloro-4-[ (3-fluorophenyl) methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide; ALS1306; AST 1306; AST 6. Grades: Highly Purified. CAS No. 897383-62-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Avitinib | Avitinib (AC0010) is a third generation inhibitor of the EGFR (epidermal growth factor receptor) that was permitted parallel phase I clinical trials in the US. It is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR. Uses: Tyrosine kinase inhibitors. Synonyms: AC0010. Grade: ≥98%. CAS No. 1557267-42-1. Molecular formula: C26H26FN7O2. Mole weight: 487.5. | |
| Avitinib maleate | Avitinib maleate, the maleate salt form of avitinib, is a pyrrolopyrimidine-based, irreversible epidermal growth factor receptor (EGFR) mutant-selective inhibitor (IC50 = 7.68 nM), with potential antineoplastic activity. Uses: Tyrosine kinase inhibitors. Synonyms: Avitinib maleate; AC0010MA; AC-0010MA; AC 0010MA; AC0010; AC-0010; AC 0010. CAS No. 1557268-88-8. Molecular formula: C30H30FN7O6. Mole weight: 603.6. | |
| AZD3759 | AZD3759 is a n orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. Synonyms: AZD3759; AZD-3759; AZD 3759. Grade: 98%. CAS No. 1626387-80-1. Molecular formula: C22H23ClFN5O3. Mole weight: 459.91. | |
| BLU-945 | BLU-945 is a potent, reversible, wild-type-sparing inhibitor of EGFR+/T790M and EGFR+/T790M/C797S resistance mutants that maintains activity against the sensitizing mutations, especially L858R. Synonyms: BLU 945; BLU945; Tigozertinib. Grade: 99% by HPLC. CAS No. 2660250-10-0. Molecular formula: C28H37FN6O3S. Mole weight: 556.7. | |
| Brigatinib | Brigatinib, also known as AP-26113, is an orally active, potent and selective dual ALK/EGFR inhibitor. AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK; IC50 < 100 nM in Ba/F3 cells). AP26113 binds to and inhibits ALK kinase and ALK fusion proteins as well as EGFR and mutant forms. It blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants. Synonyms: AP26113. Grade: ≥98%. CAS No. 1197953-54-0. Molecular formula: C29H39ClN7O2P. Mole weight: 584.10. | |
| CHMFL-EGFR-202 | CHMFL-EGFR-202 is a potent and irreversible EGFR mutant kinase inhibitor with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. It adopts the covalent ''DFG-in-C-helix-out'' inactive binding conformation with EGFR and has strong anti-proliferative effect on EGFR-mutation-driven non-small cell lung cancer (NSCLC) cell lines. Synonyms: 2-Propen-1-one, 1-[(3R)-3-[4-amino-3-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-; 1-[(3R)-3-{4-Amino-3-[3-chloro-4-(2-pyridinylmethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-1-piperidinyl]-2-propen-1-one. Grade: ≥95%. CAS No. 2089381-40-6. Molecular formula: C25H24ClN7O2. Mole weight: 489.96. | |
| CNX-2006 | CNX-2006 is a potent and mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the prototype for CO-1686, which is currently in a Phase I clinical trial for the treatment of EGFR-mutant lung cancer. Synonyms: CNX2006; CNX 2006; N-[3-[[2-[4-[[1-(2-fluoroethyl)azetidin-3-yl]amino]-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide. Grade: 98%. CAS No. 1375465-09-0. Molecular formula: C26H27F4N7O2. Mole weight: 545.543. | |
| Depatuxizumab | Depatuxizumab is a brain-penetrant and humanized tumor-specific anti EGFR monoclonal antibody. Depatuxizumab inhibits the growth of xenograft models of mutant EGFRvIII and wild-type EGFR. Depatuxizumab can be used for research on cancer [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ABT-806. CAS No. 1471999-69-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99849. | |
| EAI045 | EAI045 is an allosteric, non-ATP competitive inhibitor of mutant EGFR. In vitro studies proved that EAI045 is active and selective for T790M- harboring EGFR mutants that are in a monomer state. In vivo the combination of EAI045 and cetuximab caused a marked tumor shrinkage in a mouse model carrying the EGFR mutant with L858R/T790M/C797S. Therefore, EAI045 is the first allosteric inhibitor that targets T790M and C797S EGFR mutants but it is effective only in combination with cetuximab. Synonyms: 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide; 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide; EAI045; EAI 045; EAI-045. CAS No. 1942114-09-1. Molecular formula: C19H14FN3O3S. Mole weight: 383.397. | |
| EGF816 | EGF816, also called as Nazartinib, a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M resistance mutation while sparing wild-type EGFR. in vivo: demonstrated strong tumor regressions in several EGFR activating and resistant tumor m. Synonyms: EGF816; EGF-816; EGF 816; NVS-816; NVS 816; NVS816; Nazartinib; N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamideEGF816UNII-KE7K32EME8KE7K32EME8EGF-8161508250-71-2GTPL9204SCHEMBL16767232SCHEMBL16767240EGF 816compound 47 [PMID: 27433829]. CAS No. 1508250-71-2. Molecular formula: C26H31ClN6O2. Mole weight: 495.02. | |
| EGF816 mesylate | EGF816 mesylate is the mesylate salt of EGF816 which is a covalent mutant-selective EGFR inhibitor and potently inhibits the T790M. Synonyms: N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide; methanesulfonic acid. CAS No. 1508250-72-3. Molecular formula: C27H35ClN6O5S. Mole weight: 591.12. | |
| EGFR-IN-1 | EGFR-IN-1 is an orally active and irreversible mutant selective EGFR inhibitor of L858R/T790M that effectively inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. It shows strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. It has antitumor activity. Synonyms: N-{3-[2-({4-[2-(Dimethylamino)ethoxy]-2-methoxyphenyl}amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl}acrylamide; 2-Propenamide, N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl]-. Grade: ≥95%. CAS No. 1625677-63-5. Molecular formula: C28H30N6O4. Mole weight: 514.58. | |
| EGFR-IN-11 | EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18 nM against the triple mutant EGFRL858R/T790M/C797S. It significantly inhibits EGFR phosphorylation, induces apoptosis and arrests cell cycle at G0/G1. Synonyms: 9H-Purine-2,8-diamine, 9-[(3R)-1-(cyclopropylsulfonyl)-3-pyrrolidinyl]-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-phenyl-; 9-[(3R)-1-(Cyclopropylsulfonyl)-3-pyrrolidinyl]-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-phenyl-9H-purine-2,8-diamine. Grade: ≥95%. CAS No. 2463200-44-2. Molecular formula: C29H35N9O2S. Mole weight: 573.71. | |
| EGFR-IN-11 | EGFR-IN-11 is a fourth-generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) with an IC50 of 18 nM for triple mutant EGFRL858R/T790M/C797S. EGFR-IN-11 significantly suppresses the EGFR phosphorylation, induce the apoptosis, and arrest cell cycle at G0/G1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2463200-44-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130616. | |
| EGFR-IN-1 hydrochloride | EGFR-IN-1 hydrochloride is an orally active and irreversible mutant selective EGFR inhibitor of L858R/T790M that effectively inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. It shows strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. It has antitumor activity. Synonyms: N-{3-[2-({4-[2-(Dimethylamino)ethoxy]-2-methoxyphenyl}amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl}acrylamide hydrochloride (1:1); 2-Propenamide, N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl]-, hydrochloride (1:1). Grade: ≥95%. CAS No. 2227455-78-7. Molecular formula: C28H31ClN6O4. Mole weight: 551.04. | |
| EGFR-IN-1 TFA | EGFR-IN-1 TFA is an orally active and irreversible mutant selective EGFR inhibitor of L858R/T790M that effectively inhibits Gefitinib-resistant EGFR L858R, T790M with 100-fold selectivity over wild-type EGFR. It shows strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. It has antitumor activity. Synonyms: N-{3-[2-({4-[2-(Dimethylamino)ethoxy]-2-methoxyphenyl}amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl}acrylamide trifluoroacetate (1:1); Acetic acid, 2,2,2-trifluoro-, compd. with N-[3-[2-[[4-[2-(dimethylamino)ethoxy]-2-methoxyphenyl]amino]-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl]phenyl]-2-propenamide (1:1). Grade: ≥99%. Molecular formula: C30H31F3N6O6. Mole weight: 628.60. | |
| EGFR-IN-2 | EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor. It showed excellent cellular activity against both the single and double mutants of EGFR, demonstrating target engagement in vivo and ADME-PK properties that are suitable for further evaluation. CAS No. 1643497-70-4. Molecular formula: C26H33N9O3S. Mole weight: 551.66. | |
| EGFR-IN-5 | EGFR-IN-5 is an inhibitor of EGFR with IC50s of 10.4, 1.1, 34 and 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M and EGFRL858R/T790M/C797S, respectively. Synonyms: mutant EGFR inhibitor B30; (1-(6-((5-(4-(Dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-2-((4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol; 4-Piperidinemethanol, 1-[6-[[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]amino]-2-[(4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-4-yl]-. Grade: ≥95%. CAS No. 2225887-26-1. Molecular formula: C31H38FN9O. Mole weight: 571.69. | |
| EGFR-IN-9 | EGFR-IN-9 is a potent inhibitor of EGFR kinase with IC50s of 7 and 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). It has antitumor activity. Synonyms: (S)-N-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)acrylamide; 2-Propenamide, N-[3-[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-6-phenylfuro[2,3-d]pyrimidin-5-yl]phenyl]-. Grade: ≥95%. CAS No. 1226549-39-8. Molecular formula: C29H24N4O3. Mole weight: 476.53. | |
| EGFR mutant-IN-1 | EGFR mutant-IN-1 is a potent and selective EGFRL858R/T790M/C797S mutant inhibitor (IC50 = 27.5 nM), and a significantly less potent for EGFRWT (IC50 >1.0 μM). Synonyms: 6-(2-Chloro-3-fluorophenyl)-5-methyl-2-{[3-methyl-4-(4-methyl-1-piperazinyl)phenyl]amino}-8-[(3R)-1-propionyl-3-piperidinyl]pyrido[2,3-d]pyrimidin-7(8H)-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2-chloro-3-fluorophenyl)-5-methyl-2-[[3-methyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-8-[(3R)-1-(1-oxopropyl)-3-piperidinyl]-. Molecular formula: C34H39ClFN7O2. Mole weight: 632.17. | |
| EGFR mutant-IN-2 | EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFR L858R/T790M/C797S mutant with an IC 50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFR del19/T790M/C797S mutant with an IC 50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2770009-06-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155005. | |
| EGFR T790M/L858R-IN-8 | EGFR T790M/L858R-IN-8 (compound 9) is a potent inhibitor of EGFR , targeting mutant EGFR T790M/L858R with IC 50 of 56.8 μM. The anti-proliferative effect of EGFR T790M/L858R-IN-8 on cancer cell lines A549, A431, and NHI-H1975 is not significant [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 333419-97-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164056. | |
| EMI1 | EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 35773-42-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138072. | |
| Firmonertinib | Firmonertinib (Alflutinib; Furmonertinib) is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Alflutinib; Furmonertinib; AST2818. CAS No. 1869057-83-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112870. | |
| Firmonertinib mesylate | Firmonertinib (Alflutinib; Furmonertinib) mesylate is is an orally active, mutant-selective, and highly brain penetrant EGFR inhibitor. Firmonertinib mesylate inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib mesylate has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Alflutinib mesylate; Furmonertinib mesylate; AST2818 mesylate. CAS No. 2130958-55-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112870A. | |
| Flumatinib | Flumatinib is a multi-kinase inhibitor of c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2 nM, 307.6 nM and 2662 nM respectively. It can predominantly inhibit the autophosphorylation of Bcr-Abl in K562 cell in vitro. It can inhibit the phosphorylation of c-Kit in Mo7e cell and the phosphorylation of PDGFR in Swiss3T3 cell in higher concentration. It has no or little effect on other tyrosine kinase including EGFR, KDR, c-Src andHER2. It can reduce the expression of C-MYC, HIF-1 α and VEGF in U266 cell line in a time- and dose-dependent manners. It effectively overcame the drug resistance of certain KIT mutants with activation loop mutations. It was developed by Jiangsu Hansoh Pharmaceutical Co., Ltd. and is currently in Phase III clinical trials in China for the treatment of chronic myelogenous leukemia (CML). Uses: Flumatinib is used for the treatment of chronic myelogenous leukemia (cml). Synonyms: 4-[(4-methylpiperazin-1-yl)methyl]-N-(6-methyl-5-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}pyridin-3-yl)-3-(trifluoromethyl)benzamide; HH-GV678; HHGV678; HH GV678; 4-[(4-Methyl-1-piperazinyl)methyl]-N-(6-methyl-5-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}-3-pyridinyl)-3-(trifluoromethyl)benzamide. Grade: >98%. CAS No. 895519-90-1. Molecular formula: C29H29F3N8O. Mole weight: 562.59. | |
| Icotinib | Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with an IC 50 of 5 nM; also inhibits mutant EGFR L858R , EGFR L858R/T790M , EGFR T790M and EGFR L861Q. Icotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPI-2009. CAS No. 610798-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15164A. | |
| Icotinib Hydrochloride | Icotinib Hydrochloride (BPI-2009) is a potent and specific EGFR inhibitor with an IC 50 of 5 nM; also inhibits mutant EGFR L858R , EGFR L858R/T790M , EGFR T790M and EGFR L861Q. Icotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPI-2009H. CAS No. 1204313-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15164. | |
| IK-930 | IK930, a novel TEAD inhibitor, sensitizes KRAS and EGFR mutant tumors to oncogene targeted therapy. CAS No. 2563892-44-2. Molecular formula: C19H19F3N4O2S. Mole weight: 424.44. | |
| Iruplinalkib | Iruplinalkib (WX-0593) is an orally active and selective ALK/ROS1 inhibitor. Iruplinalkib can effectively inhibit tyrosine autophosphorylation of ALK and mutant ALK , EGFR , with the IC 50 between 5.38 and 16.74 nM. Iruplinalkib is also a suppressive agent of the transporter MATE1 , MATE2K , P-gp and BCRP. Iruplinalkib can be used in the study of non-small cell lung cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WX-0593. CAS No. 1854943-32-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145574. | |
| Lazertinib | Lazertinib (YH25448) is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YH25448; GNS-1480. CAS No. 1903008-80-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109061. | |
| Mavelertinib | Mavelertinib is a selective, orally available and irreversible EGFR tyrosine kinase inhibitor (EGFR TKI), with IC50s of 5, 4, 12 and 3 nM for Del, L858R, and double mutants T790M/L858R and T790M/Del, respectively. Mavelertinib can be used for the research of non-small-cell lung cancer (NSCLC)[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06747775. CAS No. 1776112-90-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12972. | |
| Nazartinib | Nazartinib (EGF816) is a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min?1 on EGFR(L858R/790M) mutant, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EGF816. CAS No. 1508250-71-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-12872. | |
| Osimertinib | Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-9291; Mereletinib. CAS No. 1421373-65-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15772. | |
| Osimertinib mesylate | Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-9291 mesylate; Mereletinib mesylate. CAS No. 1421373-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15772A. | |
| Osimertinib (Standard) | Osimertinib (Standard) is the analytical standard of Osimertinib. This product is intended for research and analytical applications. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1421373-65-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15772R. | |
| Pruvonertinib | YK-029A is an orally active inhibitor of mutant EGFR , targeting to both the T790M mutations (EGFR T790M ) and exon 20 insertion of EGFR (EGFRex20ins). YK-029A exhibits significant antitumor activity, and results tumor regression in EGFRex20ins-driven PDX models [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YK-029A. CAS No. 2064269-82-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-155537. | |
| (Rac)-JBJ-04-125-02 | (Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2140807-05-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135805A. | |
| Rociletinib | Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CO-1686; AVL-301; CNX-419. CAS No. 1374640-70-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15729. | |
| Rociletinib hydrobromide | Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CO-1686 hydrobromide; AVL-301 hydrobromide; CNX-419 hydrobromide. CAS No. 1446700-26-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15729A. | |
| Sorafenib, p-Toluenesulfonate Salt | Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-b and their associated signaling cascades. Although sorafenib was initially developed as a Raf kinase inhibitor (IC50=6nM), it has since been shown to have activity against many receptor tyrosine kinases involved in tumorigenesis and angiogenesis including FGFR-1, wt BRAF and V599E mutant BRAF, as well as members of the so-called "split kinase" family: VEGFR-2, VEGFR-3, PDGFR-b, c-KIT, and Flt3. However, sorafenib is not active against erbB1, erbB2, ERK-1, MEK-1, EGFR, HER-2, IGFR-1, c-MET, c-yes, PKB, PKA, cdk1/cyclinB, PKC, and pim-1. In cellular mechanistic assays, sorafenib decreased basal phosphorylation of the ERK pathway in melanoma, breast, colon, and pancreatic tumor cell lines. Group: Biochemicals. Grades: Highly Purified. CAS No. 475207-59-1. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C21H16ClF3N4O3 C7H8O3S, Molecular Weight: 637.03. US Biological Life Sciences. | Worldwide |
| SPH5030 | SPH5030 is a selective and irreversible HER2 inhibitor. SPH5030 inhibits HER2 WT and EGFR WT with IC 50 s of 3.51 and 8.13 nM, respectively. SPH5030 shows excellent activities against HER2 mutants. SPH5030 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2364326-23-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-143319. | |
| STX-721 | STX-721 is a mutant-selective inhibitor of EGFR and HER2 Exon 20 insertion (ex20ins) mutants [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765525-82-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157229. | |
| Sunvozertinib | Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC 50 s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DZD9008. CAS No. 2370013-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132842. | |
| Tamnorzatinib | Tamnorzatinib (ONO-7475) is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. Tamnorzatinib sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. Tamnorzatinib combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC). Uses: Scientific research. Group: Signaling pathways. Alternative Names: ONO-7475. CAS No. 1646839-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114358. | |
| Vociprotafib | Vociprotafib (RMC-4630) is an orally active, selective and potent phosphatase SHP2 inhibitor, which blocks activation of the RAS-RAF-MEK-ERK signaling pathway with antitumor activity. Vociprotafib accelerates the time to, and increases the magnitude of, tumor regressions in Osimertinib (HY-15772)-sensitive EGFR-mutant tumors of mice[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RMC-4630; SHP2-IN-7. CAS No. 2172652-48-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141523. | |
Our database is helping our users find suppliers everyday.
