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| Product | Description | |
|---|---|---|
| (2Z,6E)-farnesyl diphosphate synthase | Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate. Group: Enzymes. Synonyms: (Z)-farnesyl diphosphate synthase; Z-farnesyl diphosphate synthase. Enzyme Commission Number: EC 2.5.1.68. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2805; (2Z,6E)-farnesyl diphosphate synthase; EC 2.5.1.68; (Z)-farnesyl diphosphate synthase; Z-farnesyl diphosphate synthase. Cat No: EXWM-2805. |  |
| 4-hydroxyphenylalkanoate adenylyltransferase | The mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to the phenolphthiocerol/phthiocerol polyketide synthase. Group: Enzymes. Synonyms: fadD29 (gene name); 4-hydroxyphenylalkanoate adenylase. Enzyme Commission Number: EC 2.7.7.94. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3308; 4-hydroxyphenylalkanoate adenylyltransferase; EC 2.7.7.94; fadD29 (gene name); 4-hydroxyphenylalkanoate adenylase. Cat No: EXWM-3308. | |
| decaprenylphospho-β-D-erythro-pentofuranosid-2-ulose 2-reductase | The reaction is catalysed in the reverse direction. The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.98.3, decaprenylphospho-β-D-ribofuranose 2-oxidase, in the epimerization of trans,octacis-decaprenylphospho-β-D-ribofuranose to trans,octacis-decaprenylphospho-β-D-arabinoofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers. Group: Enzymes. Synonyms: decaprenylphospho-β-D-ribofuranose 2'-epimerase; Rv3791; DprE2. Enzyme Commission Number: EC 1.1.1.333. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0247; decaprenylphospho-β-D-erythro-pentofuranosid-2-ulose 2-reductase; EC 1.1.1.333; decaprenylphospho-β-D-ribofuranose 2'-epimerase; Rv3791; DprE2. Cat No: EXWM-0247. | |
| decaprenylphospho-β-D-ribofuranose 2-dehydrogenase | The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.1.333, decaprenylphospho-D-erythro-pentofuranosid-2-ulose 2-reductase, in the epimerization of trans,octacis-decaprenylphospho-β-D-ribofuranose to trans,octacis-decaprenylphospho-β-D-arabinofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers. Group: Enzymes. Synonyms: decaprenylphosphoryl-β-D-ribofuranose 2'-epimerase; Rv3790; DprE1; decaprenylphospho-β-D-ribofuranose 2-oxidase. Enzyme Commission Number: EC 1.1.98.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0440; decaprenylphospho-β-D-ribofuranose 2-dehydrogenase; EC 1.1.98.3; decaprenylphosphoryl-β-D-ribofuranose 2'-epimerase; Rv3790; DprE1; decaprenylphospho-β-D-ribofuranose 2-oxidase. Cat No: EXWM-0440. | |
| mycocerosate synthase | This mycobacterial enzyme loads long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three or four methylmalonyl (but not malonyl) residues, to form tri- or tetramethyl-branched fatty-acids, respectively, such as 2,4,6,8-tetramethyloctacosanoate (C32-mycocerosate). Since the enzyme lacks a thioesterase domain, the products remain bound to the enzyme and require additional enzyme(s) for removal. Even though the enzyme can accept C6 to C20 substrates in vitro, it prefers to act on C14-C20 substrates in vivo. Group: Enzymes. Synonyms: mas (gene name); mycocerosic acid synthase; acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). Enzyme Commission Number: EC 2.3.1.111. CAS No. 95229-19-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2050; mycocerosate synthase; EC 2.3.1.111; 95229-19-9; mas (gene name); mycocerosic acid synthase; acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). Cat No: EXWM-2050. | |
| mycolipanoate synthase | This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyltetracosanoate (C27-mycolipanoate). Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal. Group: Enzymes. Synonyms: msl3 (gene name); Pks3/4; mycolipanoic acid synthase. Enzyme Commission Number: EC 2.3.1.252. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2202; mycolipanoate synthase; EC 2.3.1.252; msl3 (gene name); Pks3/4; mycolipanoic acid synthase. Cat No: EXWM-2202. | |
| N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase | Requires Mn2+ or Mg2+. Isolated from Mycobacterium smegmatis and Mycobacterium tuberculosis. The enzyme catalyses the addition of a rhamnosyl unit to N-acetyl-α-D-glucosaminyl-diphospho-trans,octacis-decaprenol, completing the synthesis of the linkage unit that attaches the arabinogalactan moiety to the peptidoglycan moiety in Mycobacterial cell wall. Group: Enzymes. Synonyms: WbbL. Enzyme Commission Number: EC 2.4.1.289. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2522; N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase; EC 2.4.1.289; WbbL. Cat No: EXWM-2522. | |
| Nebularine (High Purity) | Nucleoside analog. Cytotoxic. DNA, RNA and protein synthesis inhibitor. Shows anticancer activity. Anti-mycobacterial. Has tuberculostatic activity. Antifungal activity. Antiviral (anti-Herpes). Adenosine deaminase inhibitor. Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA. Group: Biochemicals. Alternative Names: Purine-9-ß-D-ribofuranoside; 9- β-D-Ribofuranosyl-9H-purine; Ribosyl-isopurine; Purinosine; NSC 65423. Grades: Highly Purified. CAS No. 550-33-4. Pack Sizes: 500ug, 1mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. |  Worldwide |
| trans,polycis-decaprenyl diphosphate synthase | The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan. Group: Enzymes. Synonyms: Rv2361c; (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase. Enzyme Commission Number: EC 2.5.1.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2824; trans,polycis-decaprenyl diphosphate synthase; EC 2.5.1.86; Rv2361c; (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase. Cat No: EXWM-2824. | |
| UDP-N-acetylglucosamine-decaprenyl-phosphate N-acetylglucosaminephosphotransferase | Isolated from Mycobacterium tuberculosis and Mycobacterium smegmatis. This enzyme catalyses the synthesis of monotrans,octacis-decaprenyl-N-acetyl-α-D-glucosaminyl diphosphate (mycobacterial lipid I), an essential lipid intermediate for the biosynthesis of various bacterial cell envelope components. cf. EC 2.7.8.33, UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase. Group: Enzymes. Synonyms: GlcNAc-1-phosphate transferase; UDP-GlcNAc:undecaprenyl phosphate GlcNAc-1-phosphate transferase; WecA; WecA transferase. Enzyme Commission Number: EC 2.7.8.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3334; UDP-N-acetylglucosamine-decaprenyl-phosphate N-acetylglucosaminephosphotransferase; EC 2.7.8.35; GlcNAc-1-phosphate transferase; UDP-GlcNAc:undecaprenyl phosphate GlcNAc-1-phosphate transferase; WecA; WecA transferase. Cat No: EXWM-3334. | |
| 16S rRNA (cytidine1409-2'-O)-methyltransferase | The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1409 in helix 44 of 16S rRNA and cytidine1920 in helix 69 of 23S rRNA (cf. EC 2.1.1.226, 23S rRNA (cytidine1920-2'-O)-methyltransferase). Group: Enzymes. Synonyms: TlyA (ambiguous). Enzyme Commission Number: EC 2.1.1.227. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1830; 16S rRNA (cytidine1409-2'-O)-methyltransferase; EC 2.1.1.227; TlyA (ambiguous). Cat No: EXWM-1830. | |
| 23S rRNA (cytidine1920-2'-O)-methyltransferase | The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1920 in helix 69 of 23S rRNA and cytidine1409 in helix 44 of 16S rRNA (cf. EC 2.1.1.227, 16S rRNA (cytidine1409-2'-O)-methyltransferase). These methylations result in increased susceptibility to the antibiotics capreomycin and viomycin. Group: Enzymes. Synonyms: TlyA (ambiguous). Enzyme Commission Number: EC 2.1.1.226. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1829; 23S rRNA (cytidine1920-2'-O)-methyltransferase; EC 2.1.1.226; TlyA (ambiguous). Cat No: EXWM-1829. | |
| 2-nitroimidazole nitrohydrolase | The enzyme catalyses the initial step in the biodegradation of 2-nitroimidazole by the soil bacterium Mycobacterium sp. JS330. Group: Enzymes. Synonyms: NnhA; 2NI nitrohydrolase; 2NI denitrase. Enzyme Commission Number: EC 3.5.99.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4592; 2-nitroimidazole nitrohydrolase; EC 3.5.99.9; NnhA; 2NI nitrohydrolase; 2NI denitrase. Cat No: EXWM-4592. | |
| 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-CoA ligase | The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol and cholate. The enzyme is very specific for its substrate, and requires that the side chain at C17 is completely removed. Group: Enzymes. Synonyms: fadD3 (gene name); HIP-CoA ligase. Enzyme Commission Number: EC 6.2.1.41. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5700; 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate-CoA ligase; EC 6.2.1.41; fadD3 (gene name); HIP-CoA ligase. Cat No: EXWM-5700. | |
| (3 β ) -24-Bromo-3-[ (tert-butyl) dimethylsilyloxy]-chol-5-ene | (3 β ) -24-Bromo-3-[ (tert-butyl) dimethylsilyloxy]-chol-5-ene is a reactant used in the preparation of series of cholesterol side-chain analogs used in studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P 450 enzymes CYP124A1, CYP125A1 and CYP142A1. Group: Biochemicals. Alternative Names: (3 β ) -24-Bromo-3-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]-chol-5-ene. Grades: Highly Purified. CAS No. 1384736-07-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (3 β)-24-Bromochol-5-en-3-ol | (3 β)-24-Bromochol-5-en-3-ol is used as an substrate in the study of ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes. Group: Biochemicals. Grades: Highly Purified. CAS No. 74041-57-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| (3 β)-3-O-tert-Butyldimethylsilyl-cholest-5-ene-3,24-diol | (3 β)-3-O-tert-Butyldimethylsilyl-cholest-5-ene-3,24-diol is a reactant used in the preparation of series of cholesterol side-chain analogs used in studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P 450 enzymes. It is used in the preparation of (25S)-Δ7-dafachronic acid, (25S)-Δ4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid. Group: Biochemicals. Alternative Names: (3 β ) -3-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]-chol-5-en-24-ol. Grades: Highly Purified. CAS No. 84529-86-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 3-ketosteroid 9α-monooxygenase | The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis. It is a two-component system consisting of a terminal oxygenase (KshA) and a ferredoxin reductase (KshB). The oxygenase contains a Rieske-type iron-sulfur center and non-heme iron. The reductase component is a flavoprotein containing an NAD-binding domain and a plant-type iron-sulfur cluster. The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione. Group: Enzymes. Synonyms: KshAB; 3-ketosteroid 9α-hydroxylase. Enzyme Commission Number: EC 1.14.13.142. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0742; 3-ketosteroid 9α-monooxygenase; EC 1.14.13.142; KshAB; 3-ketosteroid 9α-hydroxylase. Cat No: EXWM-0742. | |
| 3-oxocholest-4-en-26-oate-CoA ligase | The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol. It is responsible for the activation of the C8 side chain. 3β-hydroxycholest-5-en-26-oate can also be used as substrate. Group: Enzymes. Synonyms: fadD19 (gene name). Enzyme Commission Number: EC 6.2.1.42. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5701; 3-oxocholest-4-en-26-oate-CoA ligase; EC 6.2.1.42; fadD19 (gene name). Cat No: EXWM-5701. | |
| 5-Deoxy-2-O-methanesulfonyl-5-tridecyl-D-ribofuranose | 5-Deoxy-2-O-methanesulfonyl-5-tridecyl-D-ribofuranose is a novel and intriguing biomedical compound having applications in research of drug-resistant bacterial infections, including the formidable Mycobacterium tuberculosis. The intricate mechanism of this compound lies in its ability to impede pivotal enzymes crucial to bacterial cell wall bioenhancement, culminating in an irreversible cessation of cellular vitality. Molecular formula: C19H38O6S. Mole weight: 394.57. |  |
| 5-Isopropyl-3-methylphenol | 5-Isopropyl-3-methylphenol is a derivative of Carvacrol (C184600); a major phenolic component of oregano oil and a novel inhibitor of the Mycobacterium tuberculosis (MTB) chorismate mutase (CM) enzyme. Group: Biochemicals. Grades: Highly Purified. CAS No. 3228-3-3. Pack Sizes: 2.5g, 25g. Molecular Formula: C10H14O, Molecular Weight: 150.22. US Biological Life Sciences. | Worldwide |
| 7,8-dihydroneopterin epimerase | The enzyme, which has been characterized in bacteria and plants, also has the activity of EC 4.1.2.25, dihydroneopterin aldolase. The enzyme from the bacterium Mycobacterium tuberculosis has an additional oxygenase function (EC 1.13.11.81, 7,8-dihydroneopterin oxygenase). Group: Enzymes. Enzyme Commission Number: EC 5.1.99.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5440; 7,8-dihydroneopterin epimerase; EC 5.1.99.8. Cat No: EXWM-5440. | |
| 7,8-dihydroneopterin oxygenase | The enzyme from the bacterium Mycobacterium tuberculosis is multifunctional and also catalyses the epimerisation of the 2'-hydroxy group of 7,8-dihydroneopterin (EC 5.1.99.8, 7,8-dihydroneopterin epimerase) and the reaction of EC 4.1.2.25 (dihydroneopterin aldolase). Group: Enzymes. Enzyme Commission Number: EC 1.13.11.81. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0602; 7,8-dihydroneopterin oxygenase; EC 1.13.11.81. Cat No: EXWM-0602. | |
| [acyl-carrier-protein] S-malonyltransferase | This enzyme, along with EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis. The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis. In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7, holo-[acyl-carrier-protein] synthase) is the preferred substrate. This enzyme also forms part of the multienzyme complexes EC 4.1.1.88 (biotin-independent malonate decarboxylase) and EC 4.1.1.89 (biotin-dependent malonate decarboxylase). Malonylation of ACP is immediately followed by d... malonyl coenzyme A-acyl carrier protein transacylase; malonyl transacylase; malonyl transferase; malonyl-CoA-acyl carrier protein transacylase; malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase; malonyl-CoA:ACP transacylase; malonyl-CoA:ACP-SH transacylase; malonyl-CoA:AcpM transacylase; malonyl-CoA:acyl carrier protein transacylase; malonyl-CoA:acyl-carrier-protein transacylase; malonyl-CoA/dephospho-CoA acyltransferase; MAT; MCAT; MdcH. Enzyme Commission Number: EC 2.3.1.39. CAS No. 37257-17-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2217; [acyl-carrier-protein] S-malon | |
| α-lytic endopeptidase | From the myxobacterium Lysobacter enzymogenes. In peptidase family S1 (trypsin family). Group: Enzymes. Synonyms: myxobacter α-lytic proteinase; α-lytic proteinase; α-lytic protease; Mycobacterium sorangium α-lytic proteinase; Myxobacter 495 α-lytic proteinase; α-lytic proteinase; Myxobacter α-lytic proteinase; Mycobacterium sorangium α-lytic proteinase. Enzyme Commission Number: EC 3.4.21.12. CAS No. 37288-76-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4115; α-lytic endopeptidase; EC 3.4.21.12; 37288-76-9; myxobacter α-lytic proteinase; α-lytic proteinase; α-lytic protease; Mycobacterium sorangium α-lytic proteinase; Myxobacter 495 α-lytic proteinase; α-lytic proteinase; Myxobacter α-lytic proteinase; Mycobacterium sorangium α-lytic proteinase. Cat No: EXWM-4115. | |
| arabinofuranan 3-O-arabinosyltransferase | Isolated from Mycobacterium smegmatis. Involved in the formation of the cell wall in mycobacteria. Group: Enzymes. Synonyms: AftC. Enzyme Commission Number: EC 2.4.2.47. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2676; arabinofuranan 3-O-arabinosyltransferase; EC 2.4.2.47; AftC. Cat No: EXWM-2676. | |
| β-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase | Involved in the formation of mannooligosaccharides in the membrane of Mycobacterium smegmatis. Group: Enzymes. Synonyms: mannosylphospholipid-methylmannoside α-1,6-mannosyltransferase; β-D-mannosylphosphodecaprenol:1,6-α-D-mannosyloligosaccharide 1,6-α-D-mannosyltransferase. Enzyme Commission Number: EC 2.4.1.199. CAS No. 125008-27-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2426; β-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase; EC 2.4.1.199; 125008-27-7; mannosylphospholipid-methylmannoside α-1,6-mannosyltransferase; β-D-mannosylphosphodecaprenol:1,6-α-D-mannosyloligosaccharide 1,6-α-D-mannosyltransferase. Cat No: EXWM-2426. | |
| BTZ043 | The new antitubercular drug candidate 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (BTZ043) targets the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase. To monitor the potential development of benzothiazinone (BTZ) resistance, a total of 240 sensitive and multidrug-resistant Mycobacterium tuberculosis clinical isolates from four European hospitals were surveyed for the presence of mutations in the dprE1 gene and for BTZ susceptibility. All 240 strains were susceptible, thus establishing the baseline prior to the introduction of BTZ043 in clinical trials. Synonyms: BZT043; BZT 043; BZT-043; 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one. CAS No. 1161233-85-7. Molecular formula: C17H16F3N3O5S. Mole weight: 431.39. | |
| catalase-peroxidase | Differs from EC 1.11.1.7, peroxidase in having a relatively high catalase (EC 1.11.1.6) activity with H2O2 as donor, releasing O2; both activities use the same heme active site. In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid. Group: Enzymes. Synonyms: katG (gene name). Enzyme Commission Number: EC 1.11.1.21. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0503; catalase-peroxidase; EC 1.11.1.21; katG (gene name). Cat No: EXWM-0503. | |
| Ciprofloxacin Hydrochloride 10mg/ml | Ciprofloxacin Hydrochloride is a high activity fluoroquinolone antibiotic effective against a broad spectrum of gram positive and negative bacteria such as Pseudomonas, Salmonella, streptococcus and Staphylococcus. Effective against mycoplasma (12 days). Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. The bactericidal action of ciprofloxacin results from interference with the enzyme DNA gyrase which is needed for the synthesis of bacterial DNA. Ciprofloxacin has been shown to be active against most strains of the following organisms:Gram-Positive Ba...aris; Providencia rettgeri; Providencia stuartii; Pseudomonas aeruginosa; Salmonella enteritidis; Salmonella typhi; Serratia marcescens; Shigella flexneri; Shigella sonnei; Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus; Yersinia enterocolitica. Other Organisms:Chlamydia trachomatis (only moderately susceptible); Mycobacterium tuberculosis (only moderately susceptible).Also Available:C5074: Ciprofloxacin Hydrochloride. Group: Biochemicals. Alternative Names: Sterile-filtered aqueous solution. Grades: Molecular Biology Grade. CAS No. 86393-32-0. Pack Sizes: 10ml, 5x10ml. Molecular Formula: C17H18FN3O3 HCl H2O, Molecular Weight: 385.8. US Biological Life Sciences. | Worldwide |
| Ciprofloxacin Hydrochloride, Monohydrate | Ciprofloxacin Hydrochloride is a high activity fluoroquinolone antibiotic effective against a broad spectrum of gram positive and negative bacteria such as Pseudomonas, Salmonella, streptococcus and Staphylococcus. Effective against mycoplasma (12 days). Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position. The bactericidal action of ciprofloxacin results from interference with the enzyme DNA gyrase which is needed for the synthesis of bacterial DNA. Ciprofloxacin has been shown to be active against most strains of the following organisms:Gram-Positive ...a typhi; Serratia marcescens; Shigella flexneri; Shigella sonnei; Vibrio cholerae; Vibrio parahaemolyticus; Vibrio vulnificus; Yersinia enterocolitica. Other Organisms:Chlamydia trachomatis (only moderately susceptible); Mycobacterium tuberculosis (only moderately susceptible).Also Available:C5075: Ciprofloxacin Hydrochloride 10mg/ml. Group: Biochemicals. Alternative Names: 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid Hydrochloride; Bay Q3939 Hydrochloride. Grades: Molecular Biology Grade. CAS No. 86393-32-0. Pack Sizes: 1g, 10g, 25g, 50g. Molecular Formula: C17H18FN3O3 HCl H2O, Molecular Weight: 385.8. US Biological Life Sciences. | Worldwide |
| cyclo(L-tyrosyl-L-tyrosyl) synthase | The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-tyrosine residue. The protein, from the bacterium Mycobacterium tuberculosis, also forms small amounts of cyclo(L-tyrosyl-L-phenylalanyl). Group: Enzymes. Synonyms: Rv2275 (gene name); cYY synthase; cyclodityrosine synthase. Enzyme Commission Number: EC 2.3.2.21. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2295; cyclo(L-tyrosyl-L-tyrosyl) synthase; EC 2.3.2.21; Rv2275 (gene name); cYY synthase; cyclodityrosine synthase. Cat No: EXWM-2295. | |
| [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase | A pyridoxal-phosphate protein. The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor. The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O3-acetyl-L-serine (cf. EC 2.5.1.65, O-phosphoserine sulfhydrylase). Group: Enzymes. Synonyms: CysM. Enzyme Commission Number: EC 2.5.1.113. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2729; [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase; EC 2.5.1.113; CysM. Cat No: EXWM-2729. | |
| decaprenyl-phosphate phosphoribosyltransferase | Requires Mg2+. Isolated from Mycobacterium tuberculosis. Has some activity with other polyprenyl phosphates. Group: Enzymes. Synonyms: 5-phospho-α-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase; 5-phospho-α-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase; DPPR synthase; Rv3806. Enzyme Commission Number: EC 2.4.2.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2674; decaprenyl-phosphate phosphoribosyltransferase; EC 2.4.2.45; 5-phospho-α-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase; 5-phospho-α-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase; DPPR synthase; Rv3806. Cat No: EXWM-2674. | |
| D-erythrulose 4-kinase | The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of erythritol and D-threitol. Group: Enzymes. Synonyms: derK (gene name). Enzyme Commission Number: EC 2.7.1.210. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3046; D-erythrulose 4-kinase; EC 2.7.1.210; derK (gene name). Cat No: EXWM-3046. | |
| Dihydrofolate Reductase from human, Recombinant | Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11?q22 region of chromosome 5. Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. Human dhfr is an 186 amino acid protein with an apparent molecular weight of 25 kda. it is 30% homologous to the e. coli protein and up to 70% homologous to vertebrate protein... from mycobacterium smegmatis. human dihydrofolate reductase has been used in a study to investigate the stable expression of green fluorescent protein and the targeted disruption of thioredoxin peroxidase-1 gene in babesia bovis. human dihydrofolate reductase has also been used in a study to investigate the structural analysis of human dihydrofolate reductase as a binary complex. Group: Enzymes. Synonyms: DHFR; dihydrofolate reductase; DYR; DHFRP1; Tetrahydrofolate NADP+ oxidoreductase; EC 1.5.1.3; tetrahydrofolate dehydrogenase; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; f | |
| dihydroneopterin aldolase | The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyse the epimerisation of the 2' hydroxy-group (EC 5.1.99.8, 7,8-dihydroneopterin epimerase). The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyses EC 5.1.99.8 and EC 1.13.11.81, 7,8-dihydroneopterin oxygenase. The enzyme from the yeast Saccharomyces cerevisiae also catalyses the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3, 2-amino-4-hydroxy-6-(hydroxymethyl)dihydropteridine diphosphokinase, and EC 2.5.1.15, dihydropteroate synthase. Group: Enzymes. Synonyms: 7,8-dihydroneopterin aldolase; 2-amino-. Enzyme Commission Number: EC 4.1.2.25. CAS No. 37290-59-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4864; dihydroneopterin aldolase; EC 4.1.2.25; 37290-59-8; 7,8-dihydroneopterin aldolase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming); DHNA; mptD (gene name); folB (gene name). Cat No: EXWM-4864. | |
| D-threitol dehydrogenase (NAD+) | The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of D-threitol. Group: Enzymes. Synonyms: dthD (gene name). Enzyme Commission Number: EC 1.1.1.403. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0325; D-threitol dehydrogenase (NAD+); EC 1.1.1.403; dthD (gene name). Cat No: EXWM-0325. | |
| enoyl-[acyl-carrier-protein] reductase (NADH) | The enzyme catalyses an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier-protein] derivatives of the elongating fatty acid moiety. The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18. The enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons. Group: Enzymes. Synonyms: enoyl-[acyl carrier protein] reductase; enoyl-ACP reductase; NADH-enoyl acyl carrier protein reductase; NADH-specific enoyl-ACP reductase; acyl-[acyl-carrier-protein]:NAD+ oxidoreductase; fabI (gene name); inhA (gene name). Enzyme Commission Number: EC 1.3.1.9. CAS No. 37251-08-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1359; enoyl-[acyl-carrier-protein] reductase (NADH); EC 1.3.1.9; 37251-08-4; enoyl-[acyl carrier protein] reductase; enoyl-ACP reductase; NADH-enoyl acyl carrier protein reductase; NADH-specific enoyl-ACP reductase; acyl-[acyl-carrier-protein]:NAD+ oxidoreductase; fabI (gene name); inhA (gene name). Cat No: EXWM-1359. | |
| formaldehyde dismutase | The enzyme contains a tightly but noncovalently bound NADP(H) cofactor, as well as Zn2+ and Mg2+. Enzyme-bound NADPH formed by oxidation of formaldehyde to formate is oxidized back to NADP+ by reaction with a second formaldehyde, yielding methanol. The enzyme from the bacterium Mycobacterium sp. DSM 3803 also catalyses the reactions of EC 1.1.99.36, alcohol dehydrogenase (nicotinoprotein) and EC 1.1.99.37, methanol dehydrogenase (nicotinoprotein). Formaldehyde and acetaldehyde can act as donors; formaldehyde, acetaldehyde and propanal can act as acceptors. Group: Enzymes. Synonyms: aldehyde dismutase; cannizzanase; nicotinoprotein aldehyde dismutase. Enzyme Commission Number: EC 1.2.98.1. CAS No. 85204-94-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1232; formaldehyde dismutase; EC 1.2.98.1; 85204-94-0; aldehyde dismutase; cannizzanase; nicotinoprotein aldehyde dismutase. Cat No: EXWM-1232. | |
| galactan 5-O-arabinofuranosyltransferase | Isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum. These arabinofuranosyl groups form the start of an arabinofuranan chain as part of the of the cell wall in mycobacteria. Group: Enzymes. Synonyms: AftA; Rv3792. Enzyme Commission Number: EC 2.4.2.46. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2675; galactan 5-O-arabinofuranosyltransferase; EC 2.4.2.46; AftA; Rv3792. Cat No: EXWM-2675. | |
| galactofuranosyl galactofuranosyl rhamnosyl -N-acetyl glucosaminyl -diphospho-decaprenol β-1,5/1,6-galactofuranosyltransferase | Isolated from Mycobacterium tuberculosis. The enzyme adds approximately twenty-eight galactofuranosyl residues with alternating 1?5 and 1?6 links forming a galactan domain with approximately thirty galactofuranosyl residues. Involved in the formation of the cell wall in mycobacteria. Group: Enzymes. Synonyms: GlfT2. Enzyme Commission Number: EC 2.4.1.288. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2521; galactofuranosyl galactofuranosyl rhamnosyl -N-acetyl glucosaminyl -diphospho-decaprenol β-1,5/1,6-galactofuranosyltransferase; EC 2.4.1.288; GlfT2. Cat No: EXWM-2521. | |
| γ-glutamyl hercynylcysteine S-oxide hydrolase | The enzyme is part of the biosynthesis pathway of ergothioneine in mycobacteria. Group: Enzymes. Synonyms: EgtC. Enzyme Commission Number: EC 3.5.1.118. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4398; γ-glutamyl hercynylcysteine S-oxide hydrolase; EC 3.5.1.118; EgtC. Cat No: EXWM-4398. | |
| glucosyl-3-phosphoglycerate synthase | The enzyme is involved in biosynthesis of 2-O-(α-D-glucopyranosyl)-D-glycerate via the two-step pathway in which glucosyl-3-phosphoglycerate synthase catalyses the conversion of GDP-glucose and 3-phospho-D-glycerate into 2-O-(α-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(α-D-glucopyranosyl)-D-glycerate by EC 3.1.3.85 glucosyl-3-phosphoglycerate phosphatase. The activity is dependent on divalent cations (Mn2+, Co2+, or Mg2+). The enzyme from Persephonella marina shows moderate flexibility on the sugar donor concerning the nucleotide moiety (UDP-glucose, ADP-glucose, GDP-glucose) but is strictly specific for glucose. The enzyme is also strictly specific for 3-phospho-D-glycerate as acceptor. The enzyme from Methanococcoides burtonii is strictly specific for GDP-glucose and 3-phospho-D-glycerate. This enzyme catalyses the first glucosylation step in methylglucose lipopolysaccharide biosynthesis in mycobacteria. Group: Enzymes. Synonyms: GpgS protein; GPG synthase; glucosylphosphoglycerate s. Enzyme Commission Number: EC 2.4.1.266. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2497; glucosyl-3-phosphoglycerate synthase; EC 2.4.1.266; GpgS protein; GPG synthase; glucosylphosphoglycerate synthase. Cat No: EXWM-2497. | |
| halimadienyl-diphosphate synthase | Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol). Group: Enzymes. Synonyms: Rv3377c; halimadienyl diphosphate synthase; tuberculosinol diphosphate synthase; halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing); halima-5,13-dien-15-yl-diphosphate lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.16. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5617; halimadienyl-diphosphate synthase; EC 5.5.1.16; Rv3377c; halimadienyl diphosphate synthase; tuberculosinol diphosphate synthase; halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing); halima-5,13-dien-15-yl-diphosphate lyase (decyclizing). Cat No: EXWM-5617. | |
| Isoniazid | Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide. CAS No. 54-85-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0329. |  |
| Isoniazid-d4 | Isoniazid-d 4 is the deuterium labeled Isoniazid. Isoniazid (INH) is a proagent and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4. CAS No. 774596-24-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B0329S. | |
| isotuberculosinol synthase | Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives tuberculosinol in 1:1 mixture, cf. EC 3.1.7.8, tuberculosinol synthase. The isotuberculosinol form was a 3:1 mixture of the 13S and 13R forms, respectively. Group: Enzymes. Synonyms: Rv3378c. Enzyme Commission Number: EC 3.1.7.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3769; isotuberculosinol synthase; EC 3.1.7.9; Rv3378c. Cat No: EXWM-3769. | |
| L-Cycloserine | L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase ( GABA-t ) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone. CAS No. 339-72-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1122. | |
| L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase | This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes. Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics. The enzyme may represent a novel target for new classes of antituberculars. Group: Enzymes. Synonyms: MshC; MshC ligase; Cys:GlcN-Ins ligase; mycothiol ligase. Enzyme Commission Number: EC 6.3.1.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5716; L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase; EC 6.3.1.13; MshC; MshC ligase; Cys:GlcN-Ins ligase; mycothiol ligase. Cat No: EXWM-5716. | |
| L-erythrulose 4-kinase | The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol. Group: Enzymes. Synonyms: lerK (gene name). Enzyme Commission Number: EC 2.7.1.209. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3044; L-erythrulose 4-kinase; EC 2.7.1.209; lerK (gene name). Cat No: EXWM-3044. | |
| L-erythrulose 4-phosphate epimerase | The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of L-threitol. Group: Enzymes. Synonyms: lerI (gene name). Enzyme Commission Number: EC 5.1.3.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5426; L-erythrulose 4-phosphate epimerase; EC 5.1.3.39; lerI (gene name). Cat No: EXWM-5426. | |
| Methanol-d | Isotope labelled Methanol (M276585), which is a common chemical reagent in organic synthesis participating in a variety of reactions. Used to prepare novel triazole-polyphenol hybrid compounds as FabG4 (Rv0242c) enzyme inhibitors for the treatment of Mycobacterium Tuberculosis (1). Also used in the synthesis of prodelphinidin B1/B2/B4 which display antitumor activities against prostate cancer cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1455-13-6. Pack Sizes: 10g, 25 g. Molecular Formula: CH3DO, Molecular Weight: 33.0499999999999. US Biological Life Sciences. | Worldwide |
| Methyl Alcohol, 99+% | Methyl Alcohol is a common chemical reagent in organic synthesis participating in a variety of reactions. Used to prepare novel triazole-polyphenol hybrid compounds as FabG4 (Rv0242c) enzyme inhibitors for the treatment of Mycobacterium Tuberculosis (1). Also used in the synthesis of prodelphinidin B1/B2/B4 which display antitumor activities against prostate cancer cells.Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Group: Biochemicals. Alternative Names: Methanol; Bieleski's Solution; Carbinol; Methanol Cluster; Methyl Hydroxide; Methylol; Monohydroxymethane; NSC 85232; Wood Alcohol; MeOH, Hydroxymethane. Grades: Reagent Grade. CAS No. 67-56-1. Pack Sizes: 1L, 4L, 16L, 64L, 180L. Molecular Formula: CH3OH, Molecular Weight: 32.04. US Biological Life Sciences. | Worldwide |
| methyl-branched lipid ω-hydroxylase | The enzyme, found in pathogenic and nonpathogenic mycobacteria species, actinomycetes, and some proteobacteria, hydroxylates the ω-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. It is a P-450 heme-thiolate enzyme. Group: Enzymes. Synonyms: CYP124. Enzyme Commission Number: EC 1.14.15.14. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0939; methyl-branched lipid ω-hydroxylase; EC 1.14.15.14; CYP124. Cat No: EXWM-0939. | |
| mycocyclosin synthase | A heme-thiolate (P-450) enzyme from the bacterium Mycobacterium tuberculosis catalysing an oxidative reaction that does not incorporate oxygen into the product. Group: Enzymes. Synonyms: CYP121; rv2276 (gene name). Enzyme Commission Number: EC 1.14.21.9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1030; mycocyclosin synthase; EC 1.14.21.9; CYP121; rv2276 (gene name). Cat No: EXWM-1030. | |
| mycothiol synthase | This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs). The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate. Group: Enzymes. Synonyms: MshD. Enzyme Commission Number: EC 2.3.1.189. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2131; mycothiol synthase; EC 2.3.1.189; MshD. Cat No: EXWM-2131. | |
| Native α-lytic protease | Alpha-lytic protease (aLP) is an alternative specificity protease for proteomics applications. This protease cleaves after T, A, S, and V residues. It geneRates peptides of similar average length as trypsin. aLP was first isolated from the myxobacterium Lysobacter enzymogenes. The pro-form of aLP is 397 amino acids long. In its mature form, aLP is 198 amino acids long. Its tertiary structural core resembles those of pancreatic serine proteases. Group: Enzymes. Synonyms: Alpha-lytic protease; myxobacter α-lytic proteinase; α-lytic proteinase; α-lytic protease; Mycobacterium sorangium α-lytic proteinase; Myxobacter 495 α-lytic proteinase; Alp. α-LP. Storage: -70°C. Form: Supplied as a solution in 10 mM sodium acetate buffer, pH 5.0. Alpha-lytic protease; myxobacter α-lytic proteinase; α-lytic proteinase; α-lytic protease; Mycobacterium sorangium α-lytic proteinase; Myxobacter 495 α-lytic proteinase; Alp. Cat No: NATE-0052. | |
| prokaryotic ubiquitin-like protein ligase | The enzyme has been characterized from the bacteria Mycobacterium tuberculosis and Corynebacterium glutamicum. It catalyses the ligation of the prokaryotic ubiquitin-like protein (Pup) to a target protein by forming a bond between an ε-amino group of a lysine residue of the target protein and the γ-carboxylate of the C-terminal glutamate of the ubiquitin-like protein (Pup). The attachment of Pup, also known as Pupylation, marks proteins for proteasomal degradation. Group: Enzymes. Synonyms: PafA (ambiguous); Pup ligase; proteasome accessory factor A. Enzyme Commission Number: EC 6.3.1.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5721; prokaryotic ubiquitin-like protein ligase; EC 6.3.1.19; PafA (ambiguous); Pup ligase; proteasome accessory factor A. Cat No: EXWM-5721. | |
| Pup amidohydrolase | The enzyme has been characterized from the bacterium Mycobacterium tuberculosis. It catalyses the hydrolysis of the amido group of the C-terminal glutamine of prokaryotic ubiquitin-like protein (Pup), thus activating it for ligation to target proteins, a process catalysed by EC 6.3.1.19, prokaryotic ubiquitin-like protein ligase. The reaction requires ATP as cofactor but not its hydrolysis. The enzyme also catalyses the hydrolytic cleavage of the bond formed by the ligase, between an ε-amino group of a lysine residue of the target protein and the γ-carboxylate of the C-terminal glutamate of the prokaryotic ubiquitin-like protein. Group: Enzymes. Synonyms: dop (gene name); Pup deamidase; depupylase/deamidase; DPUP; depupylase. Enzyme Commission Number: EC 3.5.1.119. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4399; Pup amidohydrolase; EC 3.5.1.119; dop (gene name); Pup deamidase; depupylase/deamidase; DPUP; depupylase. Cat No: EXWM-4399. | |
| Pyrazinamide | Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent. It is a prodrug that stops the growth of Mycobacterium tuberculosis. It is thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide; 2-Pyrazinecarboxamide; Zinamide; Aldinamide; Tebrazid; Pirazinamid; Unipyranamide; Farmizina; Eprazin; Novamid. Grades: >98%. CAS No. 98-96-4. Molecular formula: C5H5N3O. Mole weight: 123.11. | |
| Recombinant acid phosphatase from M. tuberculosis | Acid phosphotase is one of the main enzymes of Mycobacterium tuberculosis metabolism. Acid phosphotase is a probable target for antituberculosis drugs. Group: Enzymes. Synonyms: EC 3.1.3.2; acid phosphomonoesterase; phosphomonoesterase; glycerophosphatase; acid monophosphatase; acid phosphohydrolase; acid phosphomonoester hydrolase; uteroferrin; acid nucleoside diphosphate phosphatase; orthophosphoric-monoester phosphohydrolase (acid optimum). Enzyme Commission Number: EC 3.1.3.2. CAS No. 9001-77-8. Purity: > 95 %. Apase. Mole weight: 32 kDa. Activity: 48.33 micromole/min/mg. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: M. tuberculosis. EC 3.1.3.2; acid phosphomonoesterase; phosphomonoesterase; glycerophosphatase; acid monophosphatase; acid phosphohydrolase; acid phosphomonoester hydrolase; uteroferrin; acid nucleoside diphosphate phosphatase; orthophosphoric-monoester phosphohydrolase (acid optimum). Cat No: NATE-1012. | |
| Recombinant Aspartate transaminase from Mycobacterium tuberculosis | Aspartate transaminase catalyzes the reversible transfer of an α-amino group between aspartate and glutamate and, as such, is an important enzyme in amino acid metabolism. Group: Enzymes. Synonyms: EC 2.6.1.1; AAT; AspT; AST; GOT (enzyme); oxaloacetate transferase; aspartate:2-oxoglutaRate aminotransferase; glutamate oxaloacetate transaminase; 9000-97-9. Enzyme Commission Number: EC 2.6.1.1. CAS No. 9000-97-9. Purity: > 80 %. AST. Mole weight: 47 kDa. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: Mycobacterium tuberculosis. EC 2.6.1.1; AAT; AspT; AST; GOT (enzyme); oxaloacetate transferase; aspartate:2-oxoglutaRate aminotransferase; glutamate oxaloacetate transaminase; 9000-97-9. Cat No: NATE-1017. | |
| Recombinant Imidazoleglycerol-phosphate dehydratase from Mycobacterium tuberculosis | Imidazole glycerol-phosphate dehydratase (IGPD) catalyzes the sixth step of histidine biosynthesis. The enzyme is of fundamental biochemical interest, because it catalyzes removal of a non-acidic hydrogen atom in the dehydration reaction. Group: Enzymes. Synonyms: IGPD; EC 4.2.1.19; 9024-35-5; IGP dehydratase; D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase. Enzyme Commission Number: EC 4.2.1.19. CAS No. 9024-35-5. Purity: > 80 %. IGPD. Mole weight: 25 kDa. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: Mycobacterium tuberculosis. IGPD; EC 4.2.1.19; 9024-35-5; IGP dehydratase; D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase. Cat No: NATE-1015. | |
| Recombinant Ketol-acid reductoisomerase from Mycobacterium tuberculosis | Ketol-acid reductoisomerase catalyzes two steps in the biosynthesis of branched-chain amino acids. Group: Enzymes. Synonyms: dihydroxyisovalerate dehydrogenase (isomerizing); acetohydroxy acid isomeroreductase; ketol acid reductoisomerase; alpha-keto-beta-hydroxylacyl reductoisomerase; 2-hydroxy-3-keto acid reductoisomerase; acetohydroxy acid reductoisomerase; acetolactate reductoisomerase; dihydroxyisovalerate (isomerizing) dehydrogenase; isomeroreductase; reductoisomerase; EC 1.1.1.86. Enzyme Commission Number: EC 1.1.1.86. CAS No. 9075-2-9. Purity: > 80 %. Ketol-acid reductoisomerase. Mole weight: 38 kDa. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: Mycobacterium tuberculosis. dihydroxyisovalerate dehydrogenase (isomerizing); acetohydroxy acid isomeroreductase; ketol acid reductoisomerase; alpha-keto-beta-hydroxylacyl reductoisomerase; 2-hydroxy-3-keto acid reductoisomerase; acetohydroxy acid reductoisomerase; acetolactate reductoisomerase; dihydroxyisovalerate (isomerizing) dehydrogenase; isomeroreductase; reductoisomerase; EC 1.1.1.86. Cat No: NATE-1016. | |
| Recombinant phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis | Coenzyme A is involved in a great number of metabolic pathways, in particular it participates in the synthesis of the cell wall components of mycobacteria. Therefore PPAT is a very promising target in the search for antituberculosis drugs. PPAT catalyzes the fourth stage of coenzyme A biosynthesis. Group: Enzymes. Synonyms: 3'-dephospho-CoA pyrophosphorylase; Dephospho-CoA diphosphorylase; Dephospho-CoA pyrophosphorylase; Dephospho-coenzyme A pyrophosphorylase; Phosphopantetheine adenylyltransferase; PPAT; EC 2.7.7.3. Enzyme Commission Number: EC 2.7.7.3. CAS No. 9026-99-7. Purity: > 80 %. PPAT. Mole weight: 17.6 kDa. Activity: 42 U/mg. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: Mycobacterium tuberculosis. 3'-dephospho-CoA pyrophosphorylase; Dephospho-CoA diphosphorylase; Dephospho-CoA pyrophosphorylase; Dephospho-coenzyme A pyrophosphorylase; Phosphopantetheine adenylyltransferase; PPAT; EC 2.7.7.3. Cat No: NATE-1011. | |
| Recombinant Ser/Thr protein kinase from Mycobacterium tuberculosis) | A serine/threonine protein kinase (EC 2.7.11.1) is a kinase enzyme that phosphorylates the OH group of serine or threonine (which have similar sidechains). At least 125 of the 500+ human protein kinases are serine/threonine kinases (STK). Group: Enzymes. Synonyms: Protein phosphokinase; Protein serine kinase; Protein serine-threonine kinase; Protein-serine kinase; Serine kinase; Serine protein kinase; Serine(threonine) protein kinase; Serine-specific protein kinase; Serine/threonine protein kinase; Threonine-specific protein kinase; EC 2.7.11.1; STK. Enzyme Commission Number: EC 2.7.11.1. CAS No. 9026-43-1. Purity: > 95 %. STK. Mole weight: 51 kDa. Activity: 13 U/mg. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: Mycobacterium tuberculosis. Protein phosphokinase; Protein serine kinase; Protein serine-threonine kinase; Protein-serine kinase; Serine kinase; Serine protein kinase; Serine(threonine) protein kinase; Serine-specific protein kinase; Serine/threonine protein kinase; Threonine-specific protein kinase; EC 2.7.11.1; STK. Cat No: NATE-1013. | |
| rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol β-1,3/1,4-galactofuranosyltransferase | Isolated from Mycobacterium tuberculosis and M. smegmatis, the enzyme has dual β-(1?4) and β-(1?5) transferase action. Involved in the formation of the cell wall in mycobacteria. Group: Enzymes. Synonyms: arabinogalactan galactofuranosyl transferase 1; GlfT1. Enzyme Commission Number: EC 2.4.1.287. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2520; rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol β-1,3/1,4-galactofuranosyltransferase; EC 2.4.1.287; arabinogalactan galactofuranosyl transferase 1; GlfT1. Cat No: EXWM-2520. | |
| starch synthase (maltosyl-transferring) | The enzyme from the bacterium Mycobacterium smegmatis is specific for maltose. It has no activity with α-D-glucose. Group: Enzymes. Synonyms: α1,4-glucan:maltose-1-P maltosyltransferase; GMPMT. Enzyme Commission Number: EC 2.4.99.16. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2700; starch synthase (maltosyl-transferring); EC 2.4.99.16; α1,4-glucan:maltose-1-P maltosyltransferase; GMPMT. Cat No: EXWM-2700. | |
| trehalose 2-sulfotransferase | The sulfation of trehalose in the bacterium Mycobacterium tuberculosis is required for the biosynthesis of sulfolipid-1. Group: Enzymes. Synonyms: Stf0 sulfotransferase. Enzyme Commission Number: EC 2.8.2.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3397; trehalose 2-sulfotransferase; EC 2.8.2.37; Stf0 sulfotransferase. Cat No: EXWM-3397. | |
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