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Acts also on N-acetylglucosamine 4-sulfate. Group: Enzymes. Synonyms: chondroitinsulfatase; chondroitinase; arylsulfatase B; acetylgalactosamine 4-sulfatase; N-acetylgalactosamine 4-sulfate sulfohydrolase. Enzyme Commission Number: EC 3.1.6.12. CAS No. 55354-43-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3745; N-acetylgalactosamine-4-sulfatase; EC 3.1.6.12; 55354-43-3; chondroitinsulfatase; chondroitinase; arylsulfatase B; acetylgalactosamine 4-sulfatase; N-acetylgalactosamine 4-sulfate sulfohydrolase. Cat No: EXWM-3745.
The enzyme is activated by divalent cations and reduced glutathione. The enzyme from human transfers sulfate to position 6 of both internal residues and non-reducing terminal GalNAc 4-sulfate residues of chondroitin sulfate and dermatan sulfate. Oligosaccharides derived from chondroitin sulfate also serve as acceptors but chondroitin sulfate E, keratan sulfate and heparan sulfate do not. Differs from EC 2.8.2.17, chondroitin 6-sulfotransferase, in being able to use both chondroitin and dermatan as effective substrates. Group: Enzymes. Synonyms: GalNAc4S-6ST; CHST15 (gene name). Enzyme Commission Number: EC 2.8.2.33. CAS No. 242469-38-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3393; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase; EC 2.8.2.33; 242469-38-1; GalNAc4S-6ST; CHST15 (gene name). Cat No: EXWM-3393.
N-acetylgalactosamine-6-sulfatase
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. This enzyme participates in glycosaminoglycan degradation and degradation of glycan structures. Group: Enzymes. Synonyms: chondroitin sulfatase; chondroitinase; galactose-6-sulfate sulfatase; acetylgalactosamine 6-sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; N-acetylgalactosamine 6-sulfatase. Enzyme Commission Number: EC 3.1.6.4. CAS No. 9025-60-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3755; N-acetylgalactosamine-6-sulfatase; EC 3.1.6.4; 9025-60-9; chondroitin sulfatase; chondroitinase; galactose-6-sulfate sulfatase; acetylgalactosamine 6-sulfatase; N-acetylgalactosamine-6-sulfate sulfatase; N-acetylgalactosamine 6-sulfatase. Cat No: EXWM-3755.
N-acetylgalactosamine kinase
The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity. Group: Enzymes. Synonyms: GALK2; GK2; GalNAc kinase; N-acetylgalactosamine (GalNAc)-1-phosphate kinase; ATP:N-acetyl-D-galactosamine 1-phosphotransferase. Enzyme Commission Number: EC 2.7.1.157. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2986; N-acetylgalactosamine kinase; EC 2.7.1.157; GALK2; GK2; GalNAc kinase; N-acetylgalactosamine (GalNAc)-1-phosphate kinase; ATP:N-acetyl-D-galactosamine 1-phosphotransferase. Cat No: EXWM-2986.
Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway. Group: Enzymes. Synonyms: PglJ. Enzyme Commission Number: EC 2.4.1.291. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2525; N-acetylgalactosamine-N,N'-diacetylbacillosaminyl-diphospho-undecaprenol 4-α-N-acetylgalactosaminyltransferase; EC 2.4.1.291; PglJ. Cat No: EXWM-2525.
2-(5-Chloro-2-hydroxyphenyl)-6-chloro-4(3H)-quinazolinonyl a-D-N-acetylgalactosamine is a potent and selective compound within the biomedical industry. With an emphasis on targeting aberrant glycosylation, it showcases its efficacy in combatting various disorders linked to abnormal N-acetylgalactosamine-related mechanisms, including certain congenital disorders research of glycosylation (CDGs). Synonyms: ELF-a-D-GalNAc; 2-(5'-Chloro-2'-hydroxyphenyl)-6-chloro-4(3H)-quinazolinonyl a-D-N-acetylgalactosamine. Molecular formula: C22H21Cl2N3O7. Mole weight: 510.32.
The non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins can act as acceptors. Group: Enzymes. Synonyms: uridine diphosphogalactose-mucin β-(1?3)-galactosyltransferase; UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-β-D-galactosyltransferase. Enzyme Commission Number: EC 2.4.1.122. CAS No. 97089-61-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2348; glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase; EC 2.4.1.122; 97089-61-7; uridine diphosphogalactose-mucin β-(1?3)-galactosyltransferase; UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-β-D-galactosyltransferase. Cat No: EXWM-2348.
2-Acetamido-2-deoxy-3-O-(a-D-galactopyranosyl)-D-galactose is a carbohydrate compound within the biomedical sector, employed for the synthesis of glycoconjugates and glycoproteins. This compound exhibits immense potential in the realms of drug delivery and targeted therapies research. Synonyms: Gal-a-1,3-GalNAc; 2-(Acetylamino)-2-deoxy-3-O-α-D-galactopyranosyl-D-galactose; Galactose, 2-acetamido-2-deoxy-3-O-α-D-galactopyranosyl-; 2-Acetamido-2-deoxy-3-O-(α-d-galactopyranosyl)-d-galactose; α-Galactosyl-(1→3)-N-acetylgalactosamine. CAS No. 60283-31-0. Molecular formula: C14H25NO11. Mole weight: 383.35.
It is found in hydrolysates of blood group A,B,H, and the substances and forms an essential part of their antigenic determinants. It is also inherent in the structure of the brain gangliosides in which it constitutes the terminal part of the molecule. Uses: It is found in hydrolysates of blood group a,b,h, and le substances and forms an essential part of their antigenic determinants. it is also inherent in the structure of the brain gangliosides in which it constitutes the terminal part of the molecule. Synonyms: β-D-Galactosyl-(1-3)-N-acetylgalactosamine; Gal1-β-3GalNAc; O-β-D-Galactopyranosyl-(1-3)-N-acetylgalactosamine; 2-(Acetylamino)-2-deoxy-3-O-β-D-galactopyranosyl-D-galactose; D-Galactosyl-β1→3-D-N-acetylglucosamine; Gal-β(1-3)-GalNAc; β-D-Galactose-(1→3)-D-N-acetylgalactosamine; β-D-Galactosyl-(1→3)-N-acetyl-D-galactosamine; β-Galactosyl-(1→3)-N-acetylgalactosamine. Grade: 95%. CAS No. 3554-90-3. Molecular formula: C14H25NO11. Mole weight: 383.34.
2-Acetamido-2-deoxy-6-a-O-sialyl-D-galactopyranose, a compound utilized in the realm of biomedical research and pharmaceutical advancement, assumes a pivotal role in the exhaustive investigation of the intricate nature and performance of sialylated glycoproteins. Synonyms: 6-O-a-Sialyl-2-acetamido-2-deoxy-D-galactopyranose; 2-(Acetylamino)-6-O-(N-acetyl-α-neuraminosyl)-2-deoxy-D-galactose; Chondrosamine, N-acetyl-6-O-(N-acetyl-α-D-neuraminyl)-; Galactose, 2-acetamido-6-O-(N-acetyl-α-D-neuraminyl)-2-deoxy-, D-; Neu5Gc(α2,6)N-acetylgalactosamine. CAS No. 72506-87-7. Molecular formula: C19H32N2O14. Mole weight: 512.46.
It is a monovalent GalNAc (N-acetylgalactosamine) phosphoramidite designed for the synthesis of liver-targeting oligonucleotides. It features a GalNAc moiety linked to a trans-4-hydroxyprolinol (tHP) scaffold via a flexible linker, with a phosphoramidite group attached for incorporation into oligonucleotides using solid-phase synthesis. This building block enables the efficient conjugation of GalNAc epitopes to oligonucleotides, facilitating targeted delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, (3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]-3-pyrrolidinyl 2-cyanoethyl ester. CAS No. 1843261-46-0. Molecular formula: C54H73N4O15P. Mole weight: 1049.15.
4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (4-MU-Gal-6S) is a fluorogenic substrate for N-acetylgalactosamine-6-sulphatase (GALNS). 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence intensity increases as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient. Synonyms: 4-MU β-D-galactopyranoside-6-sulfate; 4-Methylumbelliferyl Gal-6S; 4-MU-Gal-6S; 4-methyl-7-[(6-O-sulfo-β-D-galactopyranosyl)oxy]-2H-1-benzopyran-2-one. Grade: ≥98%. CAS No. 126938-14-5. Molecular formula: C16H18O11S. Mole weight: 418.37.
4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate sodium salt
4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (4-MU-Gal-6S) is a fluorogenic substrate for N-acetylgalactosamine-6-sulphatase (GALNS). 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence intensity increases as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient. Synonyms: 4-MU β-D-galactopyranoside-6-sulfate; 4-Methylumbelliferyl Gal-6S; 4-MU-Gal-6S; 4-methyl-7-[(6-O-sulfo-β-D-galactopyranosyl)oxy]-2H-1-benzopyran-2-one monosodium salt. Grade: ≥98%. CAS No. 206443-06-3. Molecular formula: C16H17NaO11S. Mole weight: 440.35.
5'-GalNAc C3 Phosphoramidite
5'-GalNAc C3 Phosphoramidite is a specialized reagent used in oligonucleotide synthesis to introduce N-acetylgalactosamine (GalNAc) at the 5'-end of the oligonucleotide sequence. GalNAc is a carbohydrate moiety commonly found in glycoproteins and glycolipids and is involved in various biological processes, including cell signaling and immune response modulation. By attaching GalNAc to oligonucleotides, researchers can develop molecular probes and therapeutics targeting specific carbohydrate-binding proteins, such as lectins and receptors. This modification enables the study of carbohydrate-protein interactions and the development of oligonucleotide-based drugs for therapeutic applications, including gene regulation, RNA interference, and targeted delivery. Synonyms: Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl [1-[1-oxo-6-[[1-oxo-4-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]butyl]amino]hexyl]-4-[[tris(4-methoxyphenyl)methoxy]methyl]-4-piperidinyl]methyl ester; (2R,3R,4R,5R,6R)-5-Acetamido-2-(acetoxymethyl)-6-(4-((6-(4-((((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)methyl)-4-((tris(4-methoxyphenyl)methoxy)methyl)p. Grade: >98%. CAS No. 2437303-51-8. Molecular formula: C62H88N5O17P. Mole weight: 1206.36.
It is a DMT-protected GalNAc (N-acetylgalactosamine) derivative featuring a 6-carbon linker and a threoninol scaffold. It is designed as a monomeric building block for the synthesis of multivalent GalNAc clusters. The structure includes a tri-O-acetylated GalNAc moiety attached to a threoninol backbone via a hexyl linker, with the primary hydroxyl group protected by a dimethoxytrityl (DMT) group. This design allows for efficient incorporation into oligonucleotides during solid-phase synthesis while maintaining stability and reactivity. The acetyl groups on GalNAc can be selectively removed to reveal the active sugar for receptor binding, making it a versatile intermediate for constructing targeted siRNA or antisense oligonucleotide conjugates. Synonyms: N-[(1R,2R)-1-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-hydroxypropyl]-6-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexanamide. CAS No. 2241043-51-4. Molecular formula: C45H58N2O14. Mole weight: 850.95.
It is a GalNAc (N-acetylgalactosamine) monomer phosphoramidite designed for the solid-phase synthesis of oligonucleotide conjugates. It features a GalNAc moiety attached to a threoninol scaffold via a hexyl linker, with the primary hydroxyl group protected by a dimethoxytrityl (DMT) group. The presence of a phosphoramidite group at the terminal end enables efficient incorporation into oligonucleotides during automated synthesis. This structure is designed to facilitate the creation of multivalent GalNAc clusters on oligonucleotides, enhancing their targeting efficiency to hepatocytes via the asialoglycoprotein receptor (ASGPR). It is a phosphoramidite for developing targeted nucleic acid therapeutics. CAS No. 2241043-52-5. Molecular formula: C54H75N4O15P. Mole weight: 1051.17.
AB-729
AB-729 is a nucleoside analogue that acts as an RNA interference (RNAi) and can inhibit viral replication, reducing HBV antigens. AB-729 binds to a trimer of N-acetylgalactosamine (GalNAc) ligand that promotes entry into hepatocytes through asialoglycoprotein receptor (ASGR). Synonyms: AB-729|HY-132603. Grade: ≥98% (HPLC). CAS No. 2634739-74-3.
AdemA-GalNAc Phosphoramidite
AdemA-GalNAc Phosphoramidite is a specialized phosphoramidite reagent used for the synthesis of oligonucleotides with liver-targeting capabilities. It combines adenine and GalNAc (N-Acetylgalactosamine) moieties to facilitate targeted delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). This reagent enhances the efficiency of oligonucleotide uptake in liver cells. Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[2-[2-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]ethoxy]ethoxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; (2R,3R,4R,5R,6R)-5-Acetamido-2-(acetoxymethyl)-6-((5-((2-(2-((((2R,3R,4R,5R)-2-(6-benzamido-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)tetrahydrofuran-3-yl)oxy)methoxy)ethoxy)ethyl)amino)-5-oxopentyl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate; GalNAc Similar. Grade: ≥95%. CAS No. 1953147-02-8. Molecular formula: C71H90N9O20P. Mole weight: 1420.50.
AdemC-GalNAc Phosphoramidite
AdemC-GalNAc Phosphoramidite is a specialized phosphoramidite reagent designed for the synthesis of oligonucleotide conjugates with enhanced liver-targeting capabilities. It combines a cytosine derivative (AdemC) with N-acetylgalactosamine (GalNAc) to facilitate the attachment of GalNAc moieties to oligonucleotides, enabling efficient delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). This reagent is typically used in the synthesis of siRNA or antisense oligonucleotides to improve their cellular uptake and therapeutic efficacy. Synonyms: Cytosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[2-[2-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]ethoxy]ethoxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]. Grade: ≥95%. Molecular formula: C65H88N7O21P. Mole weight: 1334.42.
α-N-acetylgalactosaminide α-2,6-sialyltransferase
α-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position. Group: Enzymes. Enzyme Commission Number: EC 2.4.99.3. CAS No. 71124-50-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2707; α-N-acetylgalactosaminide α-2,6-sialyltransferase; EC 2.4.99.3; 71124-50-0. Cat No: EXWM-2707.
β-N-Acetylglucosaminidase from Streptococcus pneumoniae, Recombinant
Hexosaminidase, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Appli...Commission Number: 3.2.1.52. CAS No. 9012-33-3. β-N-Acetylhexosaminidase. Activity: > 80 units/mg protein. Storage: 2-8°C. Form: buffered aqueous solution, Solution in 20 mM Tris-HCl, pH 7.5, 25 mM NaCl. Source: E. coli. Species: Streptococcus pneumoniae. EC 3.2.1.52; 9012-33-3; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase. Pack: vial of > 1.0 unit. Cat No: NATE-0782.
β-N-Acetylhexosaminidase (EC 3.2.1.52) is an exoglycosidase that catalyzes the hydrolysis of terminal non-reducing β-N-acetylgalactosamine and glucosamine residues in oligosaccharides for epigenetic applications [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9012-33-3. Pack Sizes: 5 U; 10 U. Product ID: HY-P2866.
chondroitin 6-sulfotransferase
The sulfation is at the 6-position of N-acetylgalactosamine residues of chondroitin. Not identical with EC 2.8.2.5 chondroitin 4-sulfotransferase. Group: Enzymes. Synonyms: chondroitin 6-O-sulfotransferase; 3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase; terminal 6-sulfotransferase. Enzyme Commission Number: EC 2.8.2.17. CAS No. 37292-93-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3375; chondroitin 6-sulfotransferase; EC 2.8.2.17; 37292-93-6; chondroitin 6-O-sulfotransferase; 3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase; terminal 6-sulfotransferase. Cat No: EXWM-3375.
chondroitin AC lyase
Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(β1-3)GalNAc(β1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(α1-3)GalNAc(β1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source. Group: Enzymes. Synonyms: chondroitinase (ambiguous); chondroitin sulfate lyase; chondroitin AC eliminase; chondroitinase AC; ChnAC. Enzyme Commission Number: EC 4.2.2.5. CAS No. 9047-57-8. ChnAC. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5104; chondroitin AC lyase; EC 4.2.2.5; 9047-57-8; chondroitinase (ambiguous); chondroitin sulfate lyase; chondroitin AC eliminase; chondroitinase AC; ChnAC. Cat No: EXWM-5104.
chondroitin B lyase
This is the only lyase that is known to be specific for dermatan sulfate as substrate. The minimum substrate length required for catalysis is a tetrasaccharide. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(β1-3)GalNAc(β1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(α1-3)GalNAc(β1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycansource. Group: Enzymes. Synonyms: chondroitinase B; ChonB; ChnB. Enzyme Commission Number: EC 4.2.2.19. CAS No. 52227-83-5. ChonB. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5094; chondroitin B lyase; EC 4.2.2.19; 52227-83-5; chondroitinase B; ChonB; ChnB. Cat No: EXWM-5094.
chondroitin-sulfate-ABC endolyase
This enzyme degrades a variety of glycosaminoglycans of the chondroitin-sulfate- and dermatan-sulfate type. Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan sulfate are the best substrates but the enzyme can also act on hyaluronan at a much lower rate. Keratan sulfate, heparan sulfate and heparin are not substrates. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(β1-3)GalNAc(β1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of...ous); chondroitin ABC lyase (ambiguous);chondroitin sulfate ABC lyase (ambiguous); ChS ABC lyase (ambiguous); chondroitin sulfate ABC endoeliminase; chondroitin sulfate ABC endolyase; ChS ABC lyase I. Enzyme Commission Number: EC 4.2.2.20. CAS No. 9024-13-9. Chondroitinase ABC. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5096; chondroitin-sulfate-ABC endolyase; EC 4.2.2.20; 9024-13-9; chondroitinase (ambiguous); chondroitin ABC eliminase (ambiguous); chondroitinase ABC (ambiguous); chondroitin ABC lyase (ambiguous);chondroitin sulfate ABC lyase (ambiguous); ChS ABC lyase (ambiguous); cho
dermatan 4-sulfotransferase
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAα(1,3)GalNAcβ(1,4) that is flanked by GlcUAβ(1,3)GalNAcβ(1,4) as compared with IdoUAα(1,3)GalNAcβ(1,4) flanked by IdoUAα(1,3)GalNAcβ(1,4). Group: Enzymes. Synonyms: dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase; dermatan-4-sulfotransferase-1; dermatan-4-sulfotransferase 1; D4ST-1; dermatan N-acetylgalactosamine 4-O-sulfotransferase; CHST14 protein; CHST14. Enzyme Commission Number: EC 2.8.2.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3395; dermatan 4-sulfotransferase; EC 2.8.2.35; dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase; dermatan-4-sulfotransferase-1; dermatan-4-sulfotransferase 1; D4ST-1; dermatan N-acetylgalactosamine 4-O-sulfotransferase; CHST14 protein; CHST14. Cat No: EXWM-3395.
DSPE-PEG2000-Tri-b-GalNAc
DSPE-PEG2000-Tri-b-GalNAc is a multifunctional lipid material designed for targeted drug delivery. It combines DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) with a PEG2000 spacer and three N-acetylgalactosamine (GalNAc) moieties. This structure allows it to selectively bind to the asialoglycoprotein receptor (ASGPR) on hepatocytes, enabling efficient delivery of therapeutic agents to the liver. It is commonly used to construct liposomes or lipid nanoparticles for applications in RNA-based therapies, small molecule drug delivery, and gene delivery, enhancing the therapeutic efficacy while minimizing off-target effects. Synonyms: Tris-β-GalNAc-GABA-PEG-Phospholipid; Triantennary β-D-GalNAc-GABA-PEG-phospholipid; Tri-GalNAc-PEG2000-DSPE; (β-D-GalNAc-sp)3-NHC(O)-GABA-PEG2k-phospholipid; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[tris-GalNAc-GABA-(polyethylene glycol)-2000. Molecular formula: (C2H4O)nC115H210N13O40P.
DSPE-PEG2000-triGalNAc ammonium salt
DSPE-PEG2000-triGalNAc ammonium salt is a polar lipid designed for targeted drug delivery to hepatocytes. It combines DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) with a PEG2000 spacer and three N-acetylgalactosamine (triGalNAc) moieties, which enable specific binding to the asialoglycoprotein receptor (ASGPR) on liver cells. This material is widely used in the construction of liposomes or lipid nanoparticles for applications in RNA interference, gene therapy, and small molecule drug delivery. Synonyms: DSPE-PEG2000-triGalNAc ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000]-N-tri(N-acetylgalactosamine), ammonium salt. CAS No. 2936651-86-2. Molecular formula: (C2H4O)nC97H180N9O38P.H3N.
GalNAc-Cluster-COOH
GalNAc-Cluster-COOH is a functionalized ligand designed for targeted delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). It features a trivalent GalNAc (N-acetylgalactosamine) cluster linked to a PEG spacer and terminated with a carboxylic acid group, which facilitates conjugation to other molecules. This compound is widely used in the development of lysosome-targeting chimeras (LYTACs) and for delivering nucleic acids or protein complexes to liver cells in a cell-specific manner. Its structure and valency enhance binding affinity to ASGPR, enabling efficient internalization and delivery of therapeutic agents. Synonyms: N2,N6-Bis[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]acetyl]-L-lysyl-N6-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]acetyl]-L-lysine; (17S,20S)-1-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-20-(1-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-11-oxo-3,6,9-trioxa-12-azahexadecan-16-yl)-17-(2-(2-(2-(2-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)acetamido)-11,18-dioxo-3,6,9-trioxa-12,19-diazahenicosan-21-oic acid. Grade: >98%. CAS No. 1332358-22-1. Molecular formula: C60H107N7O33. Mole weight: 1454.52.
GalNAc-hexyl-threoninol-CPG
GalNAc-hexyl-threoninol-CPG is a solid-supported GalNAc (N-acetylgalactosamine) monomer designed for the efficient synthesis of GalNAc-conjugated oligonucleotides. It features a GalNAc moiety attached to a threoninol scaffold via a hexyl linker, with the primary hydroxyl group protected by a dimethoxytrityl (DMT) group. The compound is immobilized on a solid support (controlled-pore glass, CPG) through a succinylated linker, facilitating its use in solid-phase synthesis. This configuration allows for the convenient and scalable incorporation of GalNAc units into oligonucleotides, enhancing their targeting efficiency to hepatocytes via the asialoglycoprotein receptor (ASGPR). GalNAc-hexyl-threoninol-CPG serves as a versatile building block for developing targeted nucleic acid therapeutics with improved cellular uptake and specificity.
GalNAc-L96-Amide
GalNAc-L96-Amide is a specialized compound within the GalNAc series, designed for targeted delivery of nucleic acid drugs to hepatocytes. This molecule features a triantennary GalNAc (N-acetylgalactosamine) core linked to a longer PEG-based linker and terminated with an amide group. The GalNAc core serves as a high-affinity ligand for the asialoglycoprotein receptor (ASGPR), which is highly expressed on hepatocytes, enabling efficient liver-targeted delivery. The compound is used primarily for the synthesis of GalNAc-siRNA conjugates, which leverage the ASGPR pathway to enhance the uptake and efficacy of siRNA molecules in the liver. This targeted delivery system avoids the immunogenicity associated with lipid-based delivery methods and improves the safety and specificity of nucleic acid therapies. GalNAc-L96-Amide is also a key intermediate in the development of advanced drug delivery systems, particularly for RNA interference (RNAi) therapies. Grade: >98%.
GalNac-L96 analog
GalNAc-L96 analog is an intermediate used in the synthesis of ligands targeting the asialoglycoprotein receptor (ASGPR), a receptor highly expressed on hepatocytes and involved in the internalization and degradation of desialylated glycoproteins. It features a triantennary GalNAc (N-acetylgalactosamine) structure designed to enhance the targeting and delivery of nucleic acid drugs to liver cells. It is commonly used in the development of GalNAc-siRNA conjugates, which leverage the high affinity of GalNAc for ASGPR to facilitate efficient cellular uptake and endosomal release of siRNA molecules, thereby improving the efficacy of RNA-based therapies. Synonyms: N-Acetylgalactosamine-L96 analog; GalNAc-L96; N-acetyl-D-Galactosamine-L96 analog; (2S,4R)-2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-N-[2-[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]-1,1-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]ethyl]-1-pyrrolidinedodecanamide. Grade: ≥95%. CAS No. 1159408-72-6. Molecular formula: C117H175N11O42. Mole weight: 2407.69.
GalNAc-L96 Linker-Acid
GalNAc-L96 Linker-Acid is a specialized chemical compound designed for the synthesis of targeted nucleic acid delivery systems. It features a triantennary GalNAc (N-acetylgalactosamine) cluster linked to a longer PEG-based linker, terminating with a carboxylic acid group. This structure allows for efficient conjugation to oligonucleotides, such as siRNA, enabling targeted delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). The compound is widely used in the development of RNA interference (RNAi) therapies, particularly for liver-related diseases. This linker is a key intermediate in the synthesis of GalNAc-siRNA conjugates, which have demonstrated superior stability and gene silencing efficiency compared to traditional lipid nanoparticle delivery systems. Synonyms: 12,19,25-Trioxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacosanoic acid; 1-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-16,16-bis((3-((3-(5-(((2R,3R,4. Grade: ≥97%. CAS No. 1426159-34-3. Molecular formula: C91H148N10O39. Mole weight: 2006.22.
GalNAc-L96 Linker-Azide
GalNAc-L96 Linker-Azide is a specialized chemical compound designed for the development of targeted nucleic acid delivery systems. It features a triantennary GalNAc (N-acetylgalactosamine) cluster linked to a PEG-based linker, terminating with an azide group. This structure allows for efficient conjugation to oligonucleotides or other therapeutic agents through click chemistry, enabling targeted delivery to hepatocytes via the asialoglycoprotein receptor (ASGPR). GalNAc-L96 Linker-Azide is particularly useful in the synthesis of GalNAc-siRNA conjugates, which have demonstrated high efficiency in liver-targeted gene silencing. The azide group provides a convenient handle for conjugation, making it suitable for the development of advanced drug delivery systems, especially for RNA interference (RNAi) therapies. Grade: ≥97%. CAS No. 2135330-72-0. Molecular formula: C90H147N13O37. Mole weight: 2003.22.
GalNAc-Lipid GL6
GalNAc-Lipid GL6 is a potent and scalable ligand designed for targeted liver delivery of therapeutic agents, particularly in the context of CRISPR base editing therapies. It features a multi-valent N-acetylgalactosamine (GalNAc) structure that binds specifically to the asialoglycoprotein receptor (ASGPR), enabling efficient uptake by hepatocytes. This ligand is part of the second-generation GalNAc design, which incorporates a lysine-based scaffold and a longer PEG spacer (34-38 units) compared to earlier designs. The combination of a 1,2-O-dioctadecyl-sn-glyceryl (DSG) lipid anchor and the optimized PEG spacer enhances the stability and delivery efficiency of lipid nanoparticles (LNPs) in vivo. In preclinical studies, GalNAc-Lipid GL6 demonstrated superior performance in liver-targeted gene editing compared to other GalNAc ligands, achieving high editing rates in both wild-type and LDLR-deficient mice and non-human primates. This ligand has shown significant potential for non-LDLR-dependent delivery of CRISPR therapies, making it a valuable tool for treating genetic disorders and metabolic diseases. Grade: 98%.
GalNAc-NAG-25 Phosphoramidite
GalNAc-NAG-25 Phosphoramidite is a modified phosphoramidite that incorporates a N-acetylgalactosamine (GalNAc) moiety linked to the NAG component, specifically designed for the synthesis of oligonucleotides. This compound enhances the stability and bioactivity of nucleic acids, particularly in applications involving targeted delivery and therapeutic interventions. Its unique structural features allow for improved interactions with cellular receptors, making GalNAc-NAG-25 Phosphoramidite valuable in the development of glyco-engineered therapeutics and in the field of glycobiology, where carbohydrate-based modifications play a crucial role in biological processes. Synonyms: NAG-25; NAG 25; NAG25; GalNAc NAG-25 Phosphoramidite; N2-[23-[Bis(1-methylethyl)amino]-26-cyano-1-oxo-4,7,10,13,16,19,22,24-octaoxa-23-phosphahexacos-1-yl]-N-[2-[2-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]-L-γ-glutamyl-N,N2-bis[2-[2-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]-L-glutamamide. Grade: ≥95%. CAS No. 2130036-52-9. Molecular formula: C88H145N10O43P. Mole weight: 2062.13.
GalNAc-PEG-Cluster-1-CPG
GalNAc-PEG-Cluster-1-CPG is a specialized reagent used for the synthesis of oligonucleotide conjugates, particularly for liver-targeted drug delivery. It combines N-acetylgalactosamine (GalNAc) with a polyethylene glycol (PEG) linker and a controlled pore glass (CPG) support to facilitate the attachment of GalNAc clusters to oligonucleotides. This structure enhances the targeting of siRNA or other nucleic acid drugs to hepatocytes via the asialoglycoprotein receptor (ASGPR), improving cellular uptake and therapeutic efficacy. Grade: ≥98%.
Gangliotriose
Gangliotriose is a crucial component utilized in the biomedical industry for researching various neurodegenerative diseases. Its structural similarities to gangliosides make it an ideal tool for studying drug targets associated with Alzheimer's disease, Parkinson's disease and other neurological disorders. Synonyms: Asialo-GM2-trisaccharide; N-Acetylgalactosamine b1-4 Lactose; Asialo GM2 oligosaccharide; GalNAc(b1-4)Gal(b1-4)Glc. CAS No. 1355005-58-1. Molecular formula: C20H35NO16. Mole weight: 545.49.
Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates. For explanation of the superscripted '3' in the systematic name, see GL-5.3.4. Group: Enzymes. Synonyms: uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase; globoside synthetase; UDP-N-acetylgalactosamine: globotriaosylceramide β-3-N-acetylgalactosaminyltransferase; galactosylgalactosylglucosylceramide β-D-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine: globotriaosylceramide β1,3-N-acetylgalactosaminyltrans. Enzyme Commission Number: EC 2.4.1.79. CAS No. 62213-46-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2619; globotriaosylceramide 3-β-N-acetylgalactosaminyltransferase; EC 2.4.1.79; 62213-46-1; uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase; globoside synthetase; UDP-N-acetylgala
Hexosaminidase 3A from Thermotoga neapolitana, Recombinant
Hexosaminidase, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Group: Enzyme...weight: 40.6 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Thermotoga neapolitana. EC 3.2.1.52; 9012-33-3; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase; Hexosaminidase 3A. Cat No: NATE-1453.
Hexosaminidase 3C from Saccharophagus degradans, Recombinant
Hexosaminidase, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Group: Enzym...ght: 39.5 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Saccharophagus degradans. EC 3.2.1.52; 9012-33-3; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase; Hexosaminidase 3C. Cat No: NATE-1454.
hyaluronoglucosaminidase
Also hydrolyses 1,4-β-D-glycosidic linkages between N-acetyl-galactosamine or N-acetylgalactosamine sulfate and glucuronic acid in chondroitin, chondroitin 4- and 6-sulfates, and dermatan. Group: Enzymes. Synonyms: hyaluronidase; hyaluronoglucosidase; chondroitinase; chondroitinase I. Enzyme Commission Number: EC 3.2.1.35. CAS No. 37326-33-3. Hyaluronidase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3897; hyaluronoglucosaminidase; EC 3.2.1.35; 37326-33-3; hyaluronidase; hyaluronoglucosidase; chondroitinase; chondroitinase I. Cat No: EXWM-3897.
N-acetylhexosamine 1-dehydrogenase
Also acts on N-acetylgalactosamine and, more slowly, on N-acetylmannosamine. Anomeric specificity was tested with N-acetyl-D-glucosamine, and it was shown that the enzyme is specific for the α anomer. Group: Enzymes. Synonyms: N-acetylhexosamine dehydrogenase; N-acetyl-D-hexosamine dehydrogenase. Enzyme Commission Number: EC 1.1.1.240. CAS No. 122785-18-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0148; N-acetylhexosamine 1-dehydrogenase; EC 1.1.1.240; 122785-18-6; N-acetylhexosamine dehydrogenase; N-acetyl-D-hexosamine dehydrogenase. Cat No: EXWM-0148.
N-acetylhexosamine 1-kinase
This enzyme is involved in the lacto-N-biose I/galacto-N-biosedegradation pathway in the probiotic bacterium Bifidobacterium longum. Differs from EC 2.7.1.157, N-acetylgalactosamine kinase, as it can phosphorylate both N-acetylgalactosamine and N-acetylglucosamine at similar rates. Also has some activity with N-acetyl-D-mannosamine, D-talose and D-mannose as substrate. ATP can be replaced by GTP or ITP but with decreased enzyme activity. Requires a divalent cation, with Mg2+ resulting in by far the greatest stimulation of enzyme activity. Group: Enzymes. Synonyms: NahK; LnpB; N-acetylgalactosamine/N-acetylglucosamine 1-kinase. Enzyme Commission Number: EC 2.7.1.162. N-Acetylhexosamine 1-Kinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2992; N-acetylhexosamine 1-kinase; EC 2.7.1.162; NahK; LnpB; N-acetylgalactosamine/N-acetylglucosamine 1-kinase. Cat No: EXWM-2992.
N-acetylhexosamine 1-kinase from Bifidobacterium longum, Recombinant
N-acetylhexosamine 1-kinase (EC 2.7.1.162, NahK, LnpB, N-acetylgalactosamine/N-acetylglucosamine 1-kinase) is an enzyme with systematic name ATP:N-acetyl-D-hexosamine 1-phosphotransferase. This enzyme catalyses the following chemical reaction: ATP + N-acetyl-D-hexosamine ? ADP + N-acetyl-alpha-D-hexosamine 1-phosphate. This enzyme is involved in the lacto-N-biose I/galacto-N-biose degradation pathway in the probiotic bacterium Bifidobacterium longum. Group: Enzymes. Synonyms: EC 2.7.1.162; NahK; LnpB; N-acetylgalactosamine/N-acetylglucosamine 1-kinase; ATP:N-acetyl-D-hexosamine 1-phosphotransferase. Enzyme Commission Number: EC 2.7.1.162. Purity: min 95% by SDS-PAGE. N-Acetylhexosamine 1-Kinase. Mole weight: 40 kDa. Source: E. coli. Species: Bifidobacterium longum. N-acetylhexosamine 1-kinase; EC 2.7.1.162; NahK; LnpB; N-acetylgalactosamine/N-acetylglucosamine 1-kinase; ATP:N-acetyl-D-hexosamine 1-phosphotransferase. Cat No: NATE-1481.
N-acylhexosamine oxidase
Also acts on N-glycolylglucosamine, N-acetylgalactosamine and, more slowly, on N-acetylmannosamine. Group: Enzymes. Synonyms: N-acyl-D-hexosamine oxidase; N-acyl-β-D-hexosamine:oxygen 1-oxidoreductase. Enzyme Commission Number: EC 1.1.3.29. CAS No. 121479-58-1. N-Acylhexosamine Oxidase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0407; N-acylhexosamine oxidase; EC 1.1.3.29; 121479-58-1; N-acyl-D-hexosamine oxidase; N-acyl-β-D-hexosamine:oxygen 1-oxidoreductase. Cat No: EXWM-0407.
Native Bovine β-N-Acetylglucosaminidase
This enzyme, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Applications: Bovine ki...idase A; N-acetylhexosaminidase; β-D-hexosaminidase; 9012-33-3; EC 3.2.1.52. Enzyme Commission Number: EC 3.2.1.52. CAS No. 9012-33-3. β-N-Acetylhexosaminidase. Activity: 10-50 units/mg protein. Storage: 2-8°C. Form: ammonium sulfate suspension. Suspension in 3.2 M (NH4)2SO4, pH approx. 6.0. Source: Bovine kidney. Species: Bovine. hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase;
This enzyme, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. At ph 4.0, p-nit...ta;-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase; EC 3.2.1.52; 9012-33-3. Enzyme Commission Number: EC 3.2.1.52. CAS No. 9012-33-3. β-N-Acetylhexosaminidase. Activity: > 15 units/mg protein. Storage: 2-8°C. Form: ammonium sulfate suspension. Suspension in 2.5 M (NH4)2SO4, pH 7.0. Source: Canavalia ensiformis. hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-ac
Native Human β-N-Acetylglucosaminidase
This enzyme, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Applications: Β-n-...etylhexosaminidase; β-D-hexosaminidase; 9012-33-3; EC 3.2.1.52. Enzyme Commission Number: EC 3.2.1.52. CAS No. 9012-33-3. β-N-Acetylhexosaminidase. Activity: 6-20 units/mg protein. Storage: 2-8°C. Form: ammonium sulfate suspension. Suspension in 2.4 M (NH4)2SO4 containing 0.15 M NaCl and 0.1 M sodium phosphate, pH 6.0. Source: Human placenta. Species: Human. hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase
Native Jack Bean β-(1-2,3,4,6) Hexosaminidase, Sequencing-grade
Hexosaminidase, sometimes called β-N-acetylhexosaminidase, is reported to liberate terminal β-linked N-acetylglucosamine and N-acetylgalactosamine from a variety of substrates. The activity of β-N-actylglucosaminidase may be determined with the chromogenic substrate p-nitrophenyl-N-acetyl-β-D-glucosaminide. β-N-actylglucosaminidase hydrolyzes the terminal nonreducing N-acetyl-D-hexosamine residues. This enzyme contains two predominant isozymes, Hex A, a heterodimer, and Hex B, a homodimer. N-acetylglucosamine, acetamide, N-2-acetamido-2-deoyglucosylamine, N-acetylnojirimycin, and N-acetyldeoxynojirmycin are known inhibitors. Group: Enzymes. Synonyms: β-(1-2,3,4,6) Hexosaminidase; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhe. Hexosaminidase. Source: Jack Bean. β-(1-2,3,4,6) Hexosaminidase; hexosaminidase; β-acetylaminodeoxyhexosidase; N-acetyl-β-D-hexosaminidase; N-acetyl-beta-hexosaminidase; β-hexosaminidase; β-acetylhexosaminidinase; β-D-N-acetylhexosaminidase; β-N-acetyl-D-hexosaminidase; β-N-acetylglucosaminidase; hexosaminidase A; N-acetylhexosaminidase; β-D-hexosaminidase. Cat No: NATE-0343.
Native Jack bean β-N-Acetylhexosaminidase
The enzyme exhibits a broad specificity, cleaving non-reducing terminal β (1-2,3,4,6)-linked N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) residues. This enzyme is very useful in the study of isolated glycans, glycolipids and glycoproteins, especially in combination with β-N-acetylhexosaminidase from S. pneumoniae. Group: Enzymes. Synonyms: β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. β-N-Acetylhexosaminidase. Source: Jack bean. β-N-Acetylhexosaminidase; N-Acetyl-β-D-glucosaminidase, β-N-Acetylglucosaminidase. Cat No: NATE-0783.
polypeptide N-acetylgalactosaminyltransferase
Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, κ-casein, apofetuin and some other acceptors of high molecular mass. Group: Enzymes. Synonyms: protein-UDP acetylgalactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase; UDP-N-acetylgalactosamine:κ-casein polypeptide N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; glycoprotein acet. Enzyme Commission Number: EC 2.4.1.41. CAS No. 9075-15-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2588; polypeptide N-acetylgalactosaminyltransferase; EC 2.4.1.41; 9075-15-4; protein-UDP acetylgalactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase; UDP-N-acetylgalactosamine:κ-casein polypeptide N-acetylgalactosaminyltransferase; uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; glycoprotein acetylgalactosaminyltransferase; polypeptide-N-acetylgalactosamine transferase; UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase; UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase; UDP-GalNAc:polypeptide N-acetylgalactosami
Tn antigen
Tn antigen. Uses: Designed for use in research and industrial production. Additional or Alternative Names: GALNAC-ALPHA1-O-SER;SERINYL 2-ACETAMIDO-2-DEOXY-A-GALACTOPYRANOSIDE;N-ACETYLGALACTOSAMINE, ALPHA1-O-SERINE;N-ACETYL-ALPHA-D-GALACTOSAMINYL-1-O-SERINE;TN EPITOPE;TN ANTIGEN;Serinyl 2-acetamido-2-deoxy-a-galactopyranoside, N-acetyl-a-D-galactosaminyl-1-O-s. Product Category: Heterocyclic Organic Compound. Appearance: Yellow Solid. CAS No. 67262-86-6. Molecular formula: C11H20N2O8. Mole weight: 308.29. Purity: 0.96. IUPACName: (2S)-3-[(2S,3S,4R,5R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-aminopropanoic acid. Density: 1.517g/cm³. Product ID: ACM67262866. Alfa Chemistry ISO 9001:2015 Certified.
UDP-N-acetyl-D-galactosamine disodium salt
UDP-N-acetyl-D-galactosamine disodium salt is a donor substrate for N-acetylgalactosaminyltransferases. The compound is a major terminal sugar of the cyst wall of Giardia lamblia. UDP-N-acetyl-D-galactosamine is useful in the synthesis of aryl azide derivatives that can be employed in affinity labeling of glycosyltransferases and UDP-HexNAc pyrophosphorylase. Applications: A donor substrate for n-acetylgalactosaminyltransferases. Group: Coenzymes. Synonyms: UDP-N-acetylgalactosamine. CAS No. 108320-87-2. Purity: ≥95%. Mole weight: 651.32. Appearance: Crystalline powder. Form: Solid. UDP-N-acetylgalactosamine; UDP-N-acetyl-D-galactosamine disodium salt; 108320-87-2. Cat No: COEC-016.
4-Nitrophenyl 2-acetamido-2-deoxy-b-D-galactopyranoside is an extensively utilized compound serving as a quintessential substrate in activity detection of β-galactosidase enzyme. This pivotal enzymatic reaction is harnessed for the research of sundry ailments like lysosomal storage disorders and cancer. Synonyms: GalNAc-b-PNP; 4-Nitrophenyl N-acetyl-b-D-galactosaminide; 4-Nitrophenyl b-GalNAc; 4-Nitrophenyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside; Galactopyranoside, p-nitrophenyl 2-acetamido-2-deoxy-, β-D-; p-Nitrophenyl 2-acetamido-2-deoxy-β-D-galactopyranoside; p-Nitrophenyl β-D-N-acetylgalactosaminide; p-Nitrophenyl β-N-acetyl-D-galactosaminide; p-Nitrophenyl-N-acetyl-β-D-galactosaminide; p-Nitrophenyl-β-N-acetyl-D-galactoseaminide; p-Nitrophenyl-β-N-acetylgalactosaminide. CAS No. 14948-96-0. Molecular formula: C14H18N2O8. Mole weight: 342.30.
An analogue of p-nitrophenyl T-antigen as potential substrate for elucidation of the substrate specificity of endo-α-N-acetylgalactosaminidase. Synonyms: 4-Nitrophenyl 2-(Acetylamino)-3-O-[2-(acetylamino)-2-deoxy-α-D-glucopyranosyl]-2-deoxy-α-D-galactopyranoside; GlcNAc1-α-3GalNAc-α-PNP; GlcNAc(a1-3)GalNAc(a)-O-Ph(4-NO2). Molecular formula: C22H31N3O13. Mole weight: 545.49.
An analogue of p-nitrophenyl T-antigen as a potential substrate for elucidation of the substrate specificity of endo-α-N-acetylgalactosaminidase. Synonyms: 4-Nitrophenyl 2-Acetamido-2-deoxy-(6-O-2-acetamido-2-deoxy-α-D-gluco-pyranosyl)-α-D-galactopyranoside; GlcNAc1-α-6GalNAc-α-PNP; N-((2S,3R,4R,5S,6R)-2-(((2R,3R,4R,5R,6R)-5-Acetamido-3,4-dihydroxy-6-(4-nitrophenoxy)tetrahydro-2H-pyran-2-yl)methoxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide. Molecular formula: C22H31N3O13. Mole weight: 545.49.
4-O-[3-O-(2-Acetamido-2-deoxy-b-D-galactopyranosyl)-b-D-galactopyranosyl]-D-glucose is an intricately designed compound, serving as a potent compound research of ailments associated with disrupted glycosylation patterns. With its distinct ability to target key enzymes involved in glycosylation processes, this compound exhibits promising potential in the research of abnormalities stemming from impaired glycosylation. Synonyms: GalNAc-b-1,3-Gal-b-1,4-Glc; b-3-GalNAc-lactose; b-3-N-Acetylgalactosaminyllactose. CAS No. 97604-31-4. Molecular formula: C20H35NO16. Mole weight: 545.49.
α-1,3-N-acetyl-galactosaminyltransferase from Helicobacter mustelae, Recombinant
In enzymology, a glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC 2.4.1.40) is an enzyme that catalyzes the chemical reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose ? UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl- (1,2)]-D-galactose. Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose, whereas its 3 products are UDP, [[glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-]], and [[(1,2)]-D-galactose]]. Group: Enzymes. Synonyms: UDP-N-ace. Enzyme Commission Number: EC 2.4.1.40. CAS No. 9067-69-0. Purity: min 95% by SDS-PAGE. α-1,3-N-acetyl-galactosaminyltransferase. Mole weight: 37 kDa. Source: E. coli. Species: Helicobacter mustelae. UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-ga lactose 3-N-acetyl-D-galactosaminyltransferase; A-transferase; histo-blood group A glycosyltransferase; (Fucalpha1?2Galalpha1?3-N-acetylgalactosaminyltransferase); UDP-GalNAc:Fucalpha1?2Galalpha1?3-N-acetylgalactosaminyltransferase; alpha-3-N-acetylgalactosaminyltransferase; blood-group substance alpha-acetyltransferase; blood-group substance A-dependent acetylgalactosaminyltransferase; fucosylgalactose acetylga
α-N-acetylgalactosaminidase
The human lysosomal enzyme is involved in the degradation of blood type A epitope. Group: Enzymes. Synonyms: α-acetylgalactosaminidase; N-acetyl-α-D-galactosaminidase; N-acetyl-α-galactosaminidase; α-NAGAL; α-NAGA; α-GalNAcase. Enzyme Commission Number: EC 3.2.1.49. CAS No. 9075-63-2. α-NAGA. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3912; α-N-acetylgalactosaminidase; EC 3.2.1.49; 9075-63-2; α-acetylgalactosaminidase; N-acetyl-α-D-galactosaminidase; N-acetyl-α-galactosaminidase; α-NAGAL; α-NAGA; α-GalNAcase. Cat No: EXWM-3912.
α-N-Acetylgalactosaminidase from Chryseobacterium meningosepticum, Recombinant
α-N-acetylgalactosaminidase (EC 3.2.1.49) is a glycoside hydrolase from bacteria and animals, also known as nagalase. The human gene that codes for this enzyme is NAGA. Mutations in this gene and the deficiency in alpha-N-acetylgalactosaminidase activity have been identified as the cause of Schindler disease. Group: Enzymes. Synonyms: EC 3.2.1.49; α-N-acetylgalactosaminidase; Alpha-N-acetylgalactosaminidase; α-acetylgalactosaminidase; N-acetyl-α-D-galactosaminidase; N-acetyl-α-galactosaminidase; α-NAGAL; α-NAGA; α-GalNAcase. α-NAGA. Mole weight: 47 kDa. Storage: at -20°C. Source: E. coli. Species: Chryseobacterium meningosepticum. EC 3.2.1.49; α-N-acetylgalactosaminidase; Alpha-N-acetylgalactosaminidase; α-acetylgalactosaminidase; N-acetyl-α-D-galactosaminidase; N-acetyl-α-galactosaminidase; α-NAGAL; α-NAGA; α-GalNAcase. Cat No: NATE-1259.
Attaches N-acetylneuraminic acid in α-2,6-linkage to N-acetyl-galactosamine only when present in the structure of α-N-acetyl-neuraminyl-(2?3)-β-galactosyl-(1?3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 α-N-acetylgalactosaminide α-2,6-sialyltransferase. Group: Enzymes. Synonyms: sialyltransferase; cytid. Enzyme Commission Number: EC 2.4.99.7. CAS No. 129924-24-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2711; α-N-acetylneuraminyl-2,3-β-galactosyl-1,3-N-acetylgalactosaminide 6-α-sialyltransferase; EC 2.4.99.7; 129924-24-9; sialyltransferase; cytidine monophosphoacetylneuraminate-(α-N-acetylneuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide-α-2,6-sialyltransferase; α-N-acetylneuraminyl-2,3-β-galactosyl-1,3-N-acetyl-galactosaminide α-2,6-sialyltransferase; SIAT7; ST6GALNAC; (α-N-acetylneuraminyl-2,3-β-galactosyl-1,3)-N-acetyl-galactosaminide 6-α-sialyltransferase; CMP-N-acetylneuraminate:(α-N-acetylneuraminyl-2,3-β-D-galactosyl-1,3)-N-acetyl-D-galactosaminide α-2,6-N-acetylneuraminyl-transferase. Cat No: EXWM-2711.
β-N-acetylgalactosaminidase
This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. Group: Enzymes. Synonyms: N-acetyl-β-galactosaminidase; N-acetyl-β-D-galactosaminidase; β-acetylgalactosaminidase; β-D-N-acetylgalactosaminidase; N-acetylgalactosaminidase. Enzyme Commission Number: EC 3.2.1.53. CAS No. 9054-43-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3916; β-N-acetylgalactosaminidase; EC 3.2.1.53; 9054-43-7; N-acetyl-β-galactosaminidase; N-acetyl-β-D-galactosaminidase; β-acetylgalactosaminidase; β-D-N-acetylgalactosaminidase; N-acetylgalactosaminidase. Cat No: EXWM-3916.
Blood-group endo-β-galactosidase 98A from Streptococcus pneumoniae, Recombinant
Blood-group-substance endo-1,4-beta-galactosidase (EC 3.2.1.102, endo-beta-galactosidase, blood-group-substance 1,4-beta-D-galactanohydrolase) is an enzyme with systematic name blood-group-substance 4-beta-D-galactanohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction: Endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances. Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to a 1,3-alpha-D-galactosyl or N-acetylgalactosaminyl residues and a 1,2-alpha-D-fucosyl residue. Group: Enzymes. Synonyms: Blood-group-substance endo-1,4-beta-galactosidase; EC 3.2.1.102; endo-beta-galactosidase; blood-group-substance 1,4-beta-D-galactanohydrolase. Enzyme Commission Number: EC 3.2.1.102. CAS No. 52720-51-1. Purity: >90% by SDS-PAGE. Endo-β-galactosidase. Mole weight: 69.7 kDa. Storage: This enzyme is shipped at room temperature but should be stored at -20 °C. Form: 35 mM NaHepes buffer, pH 7.5, 750 mM NaCl, 200 mM imidazol, 3.5 mM CaCl2, 0.02% sodium azide and 25% (v/v) glycerol. Source: E. coli. Species: Streptococcus pneumoniae. Blood-group-substance endo-1,4-beta-galactosidase; EC 3.2.1.102; endo-beta-galactosidase; blood-group-substance 1,4-beta-D-galactanohydrolase; Blood-group endo-β-galactosidase 98A. Cat No: NATE-1411.
blood-group-substance endo-1,4-β-galactosidase
Hydrolyses the 1,4-β-D-galactosyl linkages adjacent to a 1,3-α-D-galactosyl or N-acetylgalactosaminyl residues and a 1,2-α-D-fucosyl residue. Group: Enzymes. Synonyms: endo-β-galactosidase (ambiguous); blood-group-substance 1,4-β-D-galactanohydrolase. Enzyme Commission Number: EC 3.2.1.102. CAS No. 52720-51-1. Endo-β-galactosidase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3785; blood-group-substance endo-1,4-β-galactosidase; EC 3.2.1.102; 52720-51-1; endo-β-galactosidase (ambiguous); blood-group-substance 1,4-β-D-galactanohydrolase. Cat No: EXWM-3785.
Chondroitin synthase from Pasteurella multocida, Recombinant
In enzymology, a N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase (EC 2.4.1.226) is an enzyme that catalyzes the chemical reaction: UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl- proteoglycan ? UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)- beta-D-glucuronosyl-proteoglycan. The 3 substrates of this enzyme are UDP-alpha-D-glucuronate, [[N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-]], and proteoglycan, whereas its 3 products are UDP, [[beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-]], and beta-D-glucuronosyl-proteoglycan. Group: Enzymes. Synonyms: alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glu curonosyl-proteoglycan 3-beta-glucuronosyltransferase; chondroitin glucuronyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferas. Enzyme Commission Number: EC 2.4.1.226. CAS No. 269077-98-7. Purity: min 95% by SDS-PAGE. Chondroitin synthase. Source: E. coli. Species: Pasteurella multocida. alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glu curonosyl-proteoglycan 3-beta-glucuronosyltransferase; chondroitin glucuronyltransferase II; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase; EC 2.4.1.226; Chondroitin synthase. Cat No: NATE-1486.
EA2
EA2 is a biological active peptide. (This is a peptide substrate for polypeptide N-acetylgalactosaminyltransferase (polypeptide GalNAc-T).). Uses: Scientific research. Group: Peptides. CAS No. 562082-63-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5473.
endo-α-N-acetylgalactosaminidase
The enzyme catalyses the liberation of Gal-(1?3)-β-GalNAc α-linked to serine or threonine residues of mucin-type glycoproteins. EngBF from the bacterium Bifidobacterium longum specifically acts on core 1-type O-glycan to release the disaccharide Gal-(1?3)-β-GalNAc. The enzymes from the bacteria Clostridium perfringens, Enterococcus faecalis, Propionibacterium acnes and Alcaligenes faecalis show broader specificity (e.g. they can also release the core 2 trisaccharide Gal-(1?3)-β-(GlcNAc-(1?6)-β)-GalNAc or the core 3 disaccharide GlcNAc-(1?3)-β-GalNAc). The enzyme may play an important role in the degradation and utilization of mucins having co...alactosaminohydrolase. Enzyme Commission Number: EC 3.2.1.97. CAS No. 59793-96-3. O-Glycosidase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3960; endo-α-N-acetylgalactosaminidase; EC 3.2.1.97; 59793-96-3; endo-α-acetylgalactosaminidase; endo-α-N-acetyl-D-galactosaminidase; mucinaminylserine mucinaminidase; D-galactosyl-3-(N-acetyl-α-D-galactosaminyl)-L-serine mucinaminohydrolase; endo-α-GalNAc-ase; glycopeptide α-N-acetylgalactosaminidase; D-galactosyl-N-acetyl-α-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase. Cat No: EXWM-3960.
ganglioside galactosyltransferase
The substrate is also known as gangloside GM2, the product as gangloside GM1a. Group: Enzymes. Synonyms: UDP-galactose-ceramide galactosyltransferase; uridine diphosphogalactose-ceramide galactosyltransferase; UDP galactose-LAC Tet-ceramide α-galactosyltransferase;. Enzyme Commission Number: EC 2.4.1.62. CAS No. 37217-28-0. Galactosyltransferase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2605; ganglioside galactosyltransferase; EC 2.4.1.62; 37217-28-0; UDP-galactose-ceramide galactosyltransferase; uridine diphosphogalactose-ceramide galactosyltransferase; UDP galactose-LAC Tet-ceramide α-galactosyltransferase; UDP-galactose-GM2 galactosyltransferase; uridine diphosphogalactose-GM2 galactosyltransferase; uridine diphosphate D-galactose:glycolipid galactosyltransferase; UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase; UDP-galactose-GM2 ganglioside galactosyltransferase; GM1-synthase; UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine β-1,3-D-galactosyltransferase; UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1?4)-β-D-glucosyl-N-acylsphingosine 3-β-D-galactosyltransferase. Cat No: EXWM-2605.
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