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| Product | Description | |
|---|---|---|
| Nav1.7 inhibitor | Nav1.7 inhibitor (compound II), a sulfonamide, is a potent Nav1.7 inhibitor. Nav1.7 inhibitor has the potential for a wide range of disorders, particularly pain [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1355631-24-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13985. |  |
| 3'-Methoxydaidzein | 3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC 50 of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels [1]. Uses: Scientific research. Group: Natural products. CAS No. 21913-98-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N1847. | |
| AM-0466 | AM-0466 is a potent and selective Nav1.7 inhibitor (IC50 = 0.020 nM). It exhibited an effective activity in a NaV1.7-dependent model of histamine-induced pruritus (itch) and also in a capsaicin-induced nociception model of pain. Synonyms: AM 0466; AM0466. CAS No. 1642113-59-4. Molecular formula: C27H19F3N4O4S. Mole weight: 552.52. |  |
| AM-2099 | AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 (IC50 = 0.16 μM) with excellent selectivity against hNav1.5 (IC50 > 30 uM). Synonyms: 4-[2-methoxy-4-(trifluoromethyl)phenyl]-N-(1,3-thiazol-2-yl)quinazoline-7-sulfonamide; AM-2099; AM2099; AM 2099. CAS No. 1443373-17-8. Molecular formula: C19H13F3N4O3S2. Mole weight: 466.46. | |
| DS-1971a | DS-1971a is a potent and selective NaV1.7 inhibitor. DS-1971a is expected to exert potent efficacy in patients with peripheral neuropathic pain, with a favorable safety profile. Synonyms: DS-1971. Grade: 98% by HPLC. CAS No. 1450595-86-4. Molecular formula: C20H21ClFN5O3S. Mole weight: 465.9. | |
| Funapide | Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is applicated for the treatment of a variety of chronic painconditions, including osteoarthritis, neuropathic pain, postherpetic, neuralgia, erythromelalgia and dental pain. In July 2014, Funapide has reached phase IIb clinical trials. Uses: Chronic painconditions. Synonyms: UNII-A5595LHJ2L; A5595LHJ2L; XEN-401-S; TV-45070; TV 45070; TV45070; XEN402; XEN-402; XEN 402; Funapide.(7S)-1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3'-indole]-2'-one. Grade: 98%. CAS No. 1259933-16-8. Molecular formula: C22H14F3NO5. Mole weight: 429.35. | |
| Funapide | Funapide (TV 45070; XEN402) is a potent inhibitor of the sodium channel Nav1.7 , Nav1.8 and other Nav channels expressed in the peripheral nervous system. Fornabil is an orally effective analgesic agent [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TV 45070; XEN402. CAS No. 1259933-16-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16723. | |
| GDC-0276 | GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1494581-70-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114237. | |
| GDC-0310 | Nav1.7 is an extensively investigated target for pain. GDC-0310 is a selective Nav1.7 inhibitor. Synonyms: UNII-72GO7NL642; GDC 0310. CAS No. 1788063-52-4. Molecular formula: C25H29Cl2FN2O4S. Mole weight: 543.48. | |
| GNE-616 | GNE-616 is a potent selective inhibitor of Nav1.7, with potential for the treatment of chronic pain. Synonyms: GNE616. Grade: 98%. CAS No. 2349371-81-7. Molecular formula: C24H23F4N5O3S. Mole weight: 537.53. | |
| HUN51998 | HUN51998, also known as CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor. HUN51998 was first reported in patent WO 2018144900, which functioned as a antagonist of small ubiquitin like modifier (SUMO) related modification (SUMOylation) of collapsin response mediator protein 2 (CRMP2)? with potential application for the treatment of voltage gated sodium channel 1.7 (Nav1.7) related itch, anosmia, migraine event, and?/or pain (e.g., neuropathic pain). Uses: Designed for use in research and industrial production. Additional or Alternative Names: CRMP2-Ubc9-NaV1.7 inhibitor; HUN51998; HUN-51998; HUN 51998. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2241651-99-8. Molecular formula: C34H31F2N3O3. Mole weight: 567.64. Purity: >98%. IUPACName: (4-(1-(3-Fluorobenzyl)-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-(3-fluorobenzyloxy)-3-methoxyphenyl)methanone. Canonical SMILES: O=C(N1CCC(C2=NC3=CC=CC=C3N2CC4=CC=CC(F)=C4)CC1)C5=CC=C(OCC6=CC=CC(F)=C6)C(OC)=C5. Product ID: ACM2241651998. Alfa Chemistry ISO 9001:2015 Certified. |  |
| ICA-121431 | ICA-121431 is a potent and selective inhibitor of human NaV1.3 (IC50=13 nM) and NaV1.1 channels (IC50=23 nM) with 1,000 fold selectivity against other resistant sodium channels like human Nav1.5 or Nav1.7 channels. Synonyms: ICA-121431; ICA 121431; ICA121431. 2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl)acetamideICA-121431; ICA 121431; ICA121431. CAS No. 313254-51-2. Molecular formula: C23H19N3O3S2. Mole weight: 449.54. | |
| PF-06456384 trihydrochloride | PF-06456384 trihydrochloride is a highly potent and selective NaV1.7 inhibitor with an IC50 of 0.01 nM. PF-06456384 trihydrochloride has the potential for formalin pain model research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1834610-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118952A. | |
| TC-N 1752 | TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 ?M, 0.3 ?M, 0.4 ?M, 1.1 ?M and 2.2 ?M at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1211866-85-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107405. | |
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