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| Product | Description | |
|---|---|---|
| Navitoclax | Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x L , Bcl-2 and Bcl-w, with a K i of less than 1 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-263. CAS No. 923564-51-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10087. |  |
| Navitoclax | Navitoclax Inhibitor. Uses: Scientific use. Product Category: T2101. CAS No. 923564-51-6. |  |
| Navitoclax | Navitoclax is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Uses: Antineoplastic agents. Synonyms: ABT-263; ABT 263; ABT263; 4-[4-[[2- (4-chlorophenyl) -5, 5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[ (2R) -4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3- (trifluoromethylsulfonyl) phenyl]sulfonylbenzamide. Grades: 98%. CAS No. 923564-51-6. Molecular formula: C47H55ClF3N5O6S3. Mole weight: 974.611. |  |
| Navitoclax (ABT 263) | A novel inhibitor of antiapoptotic BCL-2 proteins; a new. Group: Biochemicals. Alternative Names: 4- [4- [ [2- (4-Chlorophenyl) -5, 5-dimethyl-1-cyclohexen-1-yl] methyl] -1-piperazinyl] -N- [ [4- [ [ (1R) -3- (4-morpholinyl) -1- [ (phenylthio) methyl] propyl] amino] -3- [ (trifluoromethyl) sulfonyl] phenyl] sulfonyl] benzamide; Navitoclax. Grades: Highly Purified. CAS No. 923564-51-6. Pack Sizes: 5mg, 10mg, 50mg, 100mg. Molecular Formula: C??H??ClF?N?O?S?, Molecular Weight: 974.61. US Biological Life Sciences. |  Worldwide |
| DT2216 | DT2216 is a potent and selective BCL-XL ( Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax (HY-10087), a linker, and a VHL E3 ubiquitin ligase (Red: Navitoclax; Blue: VHL ligand; Black: linker) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2365172-42-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130604. | |
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