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| Product | Description | |
|---|---|---|
| Nebivolol hydrochloride | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.23 nM. Synonyms: 2H-1-Benzopyran-2-methanol, α,?α'-[iminobis(methylene)?]?bis[6-fluoro-3,?4-dihydro-, hydrochloride (1:1). Grade: > 95%. CAS No. 169293-50-9. Molecular formula: C22H25F2NO4. HCl. Mole weight: 441.91. |  |
| Nebivolol hydrochloride | Nebivolol hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 152520-56-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Nebivolol hydrochloride | Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R 065824 hydrochloride. CAS No. 152520-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0203A. |  |
| Nebivolol Hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardspharmaceutical toxicology. Alternative Names: [2R*[R*[R*(S*)]]]-(+/-)-alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride, Nebivolol hydrochloride, (alphaR,alpha'R,2R,2'S)-rel-alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride (1:1),Nebicard, Nebilet, (alphaR,alpha'R,2R,2'S)-rel-alpha,alpha'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol hydrochloride, Nodon, R 067555. |  |
| Nebivolol Hydrochloride (rel- (aR, aR, 2R, 2S)-a, a-[iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol] Hydrochloride, b1-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824, Narbivolol) | A competitive, highly selective beta-1-adrenoceptor antagonist (more than 40-fold selective for beta-1 than beta-2; Ki1 and beta-2, respectively). The most beta-1-selective chemical of the beta-blockers tested so far. Used for treatment of essential hypertension and highly cardioselective. Induces mild vasodialation via a nitric oxide- and cGMP-depedent pathways (EC50 = 11.36uM in renal arteries). Group: Biochemicals. Grades: Highly Purified. CAS No. 152520-56-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-Hydroxy Nebivolol, Hydrochloride Hydrate (Mixture of Diastereomers) | A metabolite of Nebivolol. Group: Biochemicals. Alternative Names: 6-Fluoro-α - [ [ [2- (6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-yl) -2-hydroxyethyl] amino] methyl] -3, 4-dihydro-4-hydroxy-2H-1-benzopyran-2-methanol Hydrochloride Hydrate. Grades: Highly Purified. CAS No. 178383-76-1. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| (±)-Nebivolol-d4 hydrochloride | (±)-Nebivolol-d4 is intended for use as an internal standard for the quantification of nebivolol by GC- or LC-MS. Nebivolol is a potent and selective β1-adrenergic receptor (β1-AR) antagonist (IC50s = 7.41 and 251 nM for β1- and β2-ARs, respectively, in a radioligand binding assay using rabbit lung membrane preparations). It is also selective for β1-ARs over serotonin 5-HT1A and 5-HT2, α1- and α2-adrenergic, histamine H1, and dopamine D2 receptors (IC50s = 27.5 and 2,239, 3,162 and >10,000, 5,623, and 10,000 nM, respectively). Nebivolol inhibits cAMP accumulation induced by norepinephrine in primary rat cardiac cells (IC50 = 22 nM) and induces vasodilation in mouse renal arteries via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 μM). It decreases contraction of isolated human left ventricular trabeculae induced by isoproterenol (IC50 = 7.0 μM) but does not exert intrinsic sympathomimetic activity (ISA). Nebivolol inhibits proliferation of human coronary artery smooth muscle cells (HCASMCs) in the presence and absence of growth factors (IC50s = 6.1, 6.8, 6.4, and 7.7 μM for HCASMCs grown in media containing no growth factor, PDGFBB, basic FGF, and TGF-β1, respectively). Formulations containing nebivolol have been used to treat hypertension. Synonyms: (S,R,R,R)-Nebivolol-d4 Hydrochloride; (1R)-2,2-dideuterio-2-[[(2R)-1,1-dideuterio-2-[(2S)-6-fluo | |
| (-)-Nebivolol-d4 Hydrochloride | Labeled (-)-Nebivolol. A β1-Adrenergic blocker. Used as an antihypertensive. Group: Biochemicals. Alternative Names: (α S, α S, 2R, 2S)-α , α -[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol]-d4 Hydrochloride; [2S-[2R*[R*[R* (S*)]]]]-α , α '-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol-d4 Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| (+)-Nebivolol-d4 Hydrochloride | Labeled (+)-Nebivolol. A β1-Adrenergic blocker. Used as an antihypertensive. Group: Biochemicals. Alternative Names: (α R, α R, 2R, 2S)-α , α -[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol]-d4; [2R-[2R*[R*[R* (S*)]]]]-α , α '-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol-d4 Hydrochloride; (S,R,R,R)-Nebivolol-d4 Hydrochloride; Dexnebivolol-d4 Hydrochloride; R 67138-d4; d-Nebivolol-d4 Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| rac nebivolol hydrochloride | rac nebivolol hydrochloride. Group: Biochemicals. Alternative Names: a, a'-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol]; a, a'- (Iminodimethylene) bis[6-fluoro-2-chromanmethanol] hydrochloride; Lobivon. Grades: Highly Purified. CAS No. 169293-50-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C22H26ClF2NO4. US Biological Life Sciences. | Worldwide |
| rac Nebivolol, Hydrochloride ( (aR, aR, 2R, 2S)-rel-a, a-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol], a, a- (Iminodimethylene) bis[6-fluoro-2-chromanmethanol] Hydrochloride , Lobivon, Nebilet, Nebilox, R-67555, ) | A b1-Adrenergic blocker. Used as an antihypertensive. Group: Biochemicals. Alternative Names: (aR, aR, 2R, 2S)-rel-a, a-[Iminobis (methylene)]bis[6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-methanol]; a, a- (Iminodimethylene) bis[6-fluoro-2-chromanmethanol] Hydrochloride; Lobivon; Nebilet;Nebilox; R-67555. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 4-Hydroxy Nebivolol | An impurity of Nebivolol, which selectively inhibits β1-adrenoceptor with IC50 of 0.11 nM. Synonyms: 4-Hydroxy nebivolol hydrochloride; 6-fluoro-2-[2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]-1-hydroxyethyl]-3,4-dihydro-2H-chromen-4-ol; hydrate; hydrochloride. Grade: > 95%. CAS No. 178383-76-1. Molecular formula: C22H25F2NO5. Mole weight: 421.45. | |
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