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| Product | Description | |
|---|---|---|
| Neoaureothin | Neoaureothin is a metabolite produced by Streptomyces. It acts as an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Synonyms: 4H-Pyran-4-one, 2-methoxy-3,5-dimethyl-6-[(2R,4Z)-tetrahydro-4-[(2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)-2,4,6-heptatrien-1-ylidene]-2-furanyl]-; 2-Methoxy-3,5-dimethyl-6-[(2R,4Z)-tetrahydro-4-[(2E,4E,6E)-2,4,6-trimethyl-7-(4-nitrophenyl)-2,4,6-heptatrien-1-ylidene]-2-furanyl]-4H-pyran-4-one; 4H-Pyran-4-one, 2-methoxy-3,5-dimethyl-6-[tetrahydro-4-[2,4,6-trimethyl-7-(4-nitrophenyl)-2,4,6-heptatrienylidene]-2-furanyl]-, (Z,E,E,E)-(+)-; (+)-Spectinabilin; NSC 260179; Spectinabilin; Spectinabiline. Grades: ≥98%. CAS No. 59795-94-7. Molecular formula: C28H31NO6. Mole weight: 477.55. |  |
| Neoaureothin (Spectabilin) | Neoaureothin is an unusual chain-extended analogue of aureothin. It was first reported as a co-metabolite of neoantimycin in Streptomyces orinoci. It has been reported to have anti-HIV and antifungal activity. In-house bioassays have shown this metabolite to possess potent nematocidal and antitumor activity, with limited antifungal activity. Group: Biochemicals. Alternative Names: Spectabilin. Grades: Highly Purified. CAS No. 28900-27-8. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Luteoreticulin | Luteoreticulin is a rare nitrophenyl pyranone closely related to aureothin, neoaureothin and its unusual photoisomers Antibiotics SNF4435C and D. It is a potent antitumor agent produced by Streptomyces luteoreticuli with pronounced immunosuppressive. It also has nematocide activity. Synonyms: Griseulin; 6-[(1E,3E)-1,3-Dimethyl-4-(4-nitrophenyl)-1,3-butadien-1-yl]-4-methoxy-3-methyl-2H-pyran-2-one; (E,E)-6-[1,3-Dimethyl-4-(4-nitrophenyl)-1,3-butadienyl]-4-methoxy-3-methyl-2H-Pyran-2-one. Grades: >99% by HPLC. CAS No. 22388-89-2. Molecular formula: C19H19NO5. Mole weight: 341.36. | |
| Luteoreticulin (Griseulin) | Luteoreticulin is a rare nitrophenyl pyranone closely related to aureothin, neoaureothin and its unusual photoisomers Antibiotics SNF4435C and D. Metabolites within this class have been shown to be potent antitumor agents with pronounced immunosupressive activity and more recently, the ability to reverse multi-drug resistence. The lack of availability of luteoreliculin has hitherto restricted a more intensive investigation of this interesting metabolite with publications relating only to the metabolite's isolation and chemistry. Group: Biochemicals. Alternative Names: Griseulin. Grades: Highly Purified. CAS No. 22388-89-2. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
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