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| Product | Description | |
|---|---|---|
| Neocarzinostatin | Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic produced by Str. carzinostatiuns var. neocarzinostaticus F41. It can resist gram-positive bacteria and is clinically used in acute myelogenous leukemia, acute lymphocytic leukemia, pancreatic cancer, etc. Synonyms: Holoneocarzinostatin; N 9162; Neocarcinostatin; NSC 157365; NSC 69856; Zinostatin. CAS No. 9014-2-2. |  |
| Neocarzinostatin chromophore | Neocarzinostatin chromophore is a macromolecular chromoprotein enediyne antitumor antibiotic produced by Streptomyces macromomyceticus. CAS No. 79633-18-4. Molecular formula: C35H33NO12. Mole weight: 659.6. | |
| Neocarzinostatin from Streptomyces carzinostaticus | ?90% (SDS-PAGE), ~0.5 mg/mL. Group: Fluorescence/luminescence spectroscopy. |  |
| neocarzinostatin naphthoate synthase | A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus. Group: Enzymes. Synonyms: naphthoic acid synthase; NNS; ncsB (gene name). Enzyme Commission Number: EC 2.3.1.237. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2185; neocarzinostatin naphthoate synthase; EC 2.3.1.237; naphthoic acid synthase; NNS; ncsB (gene name). Cat No: EXWM-2185. |  |
| 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | The enzyme from the bacterium Streptomyces carzinostaticus is involved in the biosynthesis of 2-hydroxy-7-methoxy-5-methyl-1-naphthoate. This compound is part of the enediyne chromophore of the antitumor antibiotic neocarzinostatin. In vivo the enzyme catalyses the regiospecific methylation at the 7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1-naphthoate. In vitro it also recognizes other dihydroxynaphthoic acids and catalyses their regiospecific O-methylation. Group: Enzymes. Synonyms: NcsB1; neocarzinostatin O-methyltransferase. Enzyme Commission Number: EC 2.1.1.303. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1911; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase; EC 2.1.1.303; NcsB1; neocarzinostatin O-methyltransferase. Cat No: EXWM-1911. | |
| 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase | A heme-thiolate protein (P-450) enzyme involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus. Group: Enzymes. Synonyms: NcsB3. Enzyme Commission Number: EC 1.14.99.49. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1059; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase; EC 1.14.99.49; NcsB3. Cat No: EXWM-1059. | |
| 2-hydroxy-7-methoxy-5-methyl-1-naphthoate-CoA ligase | The enzyme from the bacterium Streptomyces carzinostaticus is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1-naphthoate moiety of the antibiotic neocarzinostatin. In vitro the enzyme also catalyses the activation of other 1-naphthoic acid analogues, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate. Group: Enzymes. Synonyms: NcsB2. Enzyme Commission Number: EC 6.2.1.43. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5702; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate-CoA ligase; EC 6.2.1.43; NcsB2. Cat No: EXWM-5702. | |
| 6-Methylsalicylic acid | It is the core salicylic acid unit in the biosynthesis of many secondary metabolites in actinomycetes, fungi and lichens. This polyketone is a key structural part of many different antibiotics and anticancer drugs, such as chlorothricin, maduropeptin, neocarzinostatin and terreic acid. Synonyms: 6-Hydroxy-o-toluic acid; 2,6-Cresotic acid; 6-MSA; 6-Methyl-2-hydroxybenzenecarboxylate; 6-hydroxy-2-methylbenzoic acid; NSC 403256. Grades: > 95 % by HPLC. CAS No. 567-61-3. Molecular formula: C8H8O3. Mole weight: 152.15. | |
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