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| Product | Description | |
|---|---|---|
| Netupitant | Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK 1 ) receptor antagonist with a K i of 0.95 nM for hNK 1 in CHO cells. Netupitant has antiemetic affect [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID 6451149. CAS No. 290297-26-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16346. |  |
| Netupitant | Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy. Synonyms: AGE94200; AGE-94200; AGE 94200;Ro 67-3189; Ro-67-3189; Ro67-3189; CHEBI441603; CID6451149; D05152; UNII-7732P08TIR, CHEMBL206253, AG-E-94200, Netupitant. Grades: >98%. CAS No. 290297-26-6. Molecular formula: C30H32F6N4O. Mole weight: 578.603. |  |
| Netupitant impurities 10 | Netupitant impurities 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2347562-52-9. Molecular Formula: C18H21N3O2. Mole Weight: 311.39. Catalog: APB2347562529. |  |
| Netupitant impurities 11 | Netupitant impurities 11. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H22N4O2. Mole Weight: 326.4. Catalog: APB12204. | |
| Netupitant impurities 12 | Netupitant impurities 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 290297-24-4. Molecular Formula: C17H22N4. Mole Weight: 282.39. Catalog: APB290297244. | |
| Netupitant impurities 13 | Netupitant impurities 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 910808-11-6. Molecular Formula: C30H32F6N4O2. Mole Weight: 594.6. Catalog: APB910808116. | |
| Netupitant impurities 3 | Netupitant impurities 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 873443-66-4. Molecular Formula: C13H8Cl2N2. Mole Weight: 263.12. Catalog: APB873443664. | |
| Netupitant impurities 4 | Netupitant impurities 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 873443-69-7. Molecular Formula: C18H19ClN4. Mole Weight: 326.83. Catalog: APB873443697. | |
| Netupitant impurities 5 | Netupitant impurities 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 825638-02-6. Molecular Formula: C18H20N4. Mole Weight: 292.39. Catalog: APB825638026. | |
| Netupitant impurities 6 | Netupitant impurities 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 85068-33-3. Molecular Formula: C10H6F6O2. Mole Weight: 272.15. Catalog: APB85068333. | |
| Netupitant impurities 7 | Netupitant impurities 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 144632-97-3. Molecular Formula: C12H10F6O2. Mole Weight: 300.2. Catalog: APB144632973. | |
| Netupitant impurities 8 | Netupitant impurities 8. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H14F6O2. Mole Weight: 328.25. Catalog: APB12203. | |
| Netupitant impurities 9 | Netupitant impurities 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 289686-73-3. Molecular Formula: C11H8F6O2. Mole Weight: 286.17. Catalog: APB289686733. | |
| Netupitant impurity 1 | Netupitant impurity 1. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C31H34F6N4O2. Mole Weight: 608.63. Catalog: APB12201. | |
| Netupitant Impurity 1 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 6-(piperazin-1-yl)-4-(o-tolyl)nicotinamide. Grades: > 95%. Molecular formula: C17H20N4O. Mole weight: 296.38. | |
| Netupitant Impurity 10 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-N-methyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)acetamide. Grades: > 95%. Molecular formula: C28H28F6N4O. Mole weight: 550.55. | |
| Netupitant Impurity 11 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-N-methyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide. Grades: > 95%. Molecular formula: C29H30F6N4O. Mole weight: 564.58. | |
| Netupitant Impurity 12 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: N-methyl-6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-amine. Grades: > 95%. Molecular formula: C17H22N4. Mole weight: 282.39. | |
| Netupitant Impurity 13 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: (2-(5-(methylamino)-2-(4-methylpiperazin-1-yl)pyridin-4-yl)phenyl)methanol. Grades: > 95%. Molecular formula: C18H24N4O. Mole weight: 312.42. | |
| Netupitant Impurity 14 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 4-(5-carbamoyl-4-(o-tolyl)pyridin-2-yl)-1-methylpiperazine 1-oxide. Grades: > 95%. Molecular formula: C18H22N4O2. Mole weight: 326.4. | |
| Netupitant impurity 2 | Netupitant impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 910808-12-7. Molecular Formula: C30H32F6N4O2. Mole Weight: 594.6. Catalog: APB910808127. | |
| Netupitant Impurity 2 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: (6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)methanamine. Grades: > 95%. Molecular formula: C18H24N4. Mole weight: 296.42. | |
| Netupitant Impurity 3 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 4-(2-(hydroxymethyl)phenyl)-6-(piperazin-1-yl)nicotinamide. Grades: > 95%. Molecular formula: C18H22N4O2. Mole weight: 326.4. | |
| Netupitant Impurity 4 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 1-methyl-4-(5-(methylamino)-4-(o-tolyl)pyridin-2-yl)piperazine 1-oxide. Grades: > 95%. Molecular formula: C18H24N4O. Mole weight: 312.42. | |
| Netupitant Impurity 5 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: (6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)methanamine. Grades: > 95%. Molecular formula: C17H22N4. Mole weight: 282.39. | |
| Netupitant Impurity 6 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl-N-((6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)methyl)propanamide. Grades: > 95%. Molecular formula: C29H30F6N4O. Mole weight: 564.58. | |
| Netupitant Impurity 7 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine. Grades: > 95%. Molecular formula: C18H24N4. Mole weight: 296.42. | |
| Netupitant Impurity 8 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 4-(2-methylphenyl)?-6-(4-methyl-1-piperazinyl)?- 3-Pyridinamine. Grades: > 95%. CAS No. 290297-24-4. Molecular formula: C17H22N4. Mole weight: 282.39. | |
| Netupitant Impurity 9 | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide. Grades: > 95%. Molecular formula: C29H30F6N4O. Mole weight: 564.58. | |
| Netupitant N-Oxide | Netupitant N-Oxide is a derivative of Netupitant which is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active. Synonyms: Netupitant metabolite Netupitant N-oxide;2-[3,5-bis(trifluoromethyl)phenyl]-3,3,3-trideuterio-N-methyl-N-[6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-4-(2-methylphenyl)pyridin-3-yl]-2-(trideuteriomethyl)propanamide. Grades: >98%. CAS No. 910808-11-6. Molecular formula: C30H32F6N4O2. Mole weight: 594.59. | |
| Fosnetupitant | Fosnetupitant (Pronetupitant) a methylene phosphate proagent of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pK i of 9.5 for human NK 1 receptor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pronetupitant. CAS No. 1703748-89-3. Pack Sizes: 5 mg. Product ID: HY-17615. | |
| Monohydroxy Netupitant | Monohydroxy Netupitant is the metabolite of Netupitant which is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active. Synonyms: 2-[3, 5-bis(trifluoromethyl)phenyl]-3, 3, 3-trideuterio-N-[4-[2-(hydroxymethyl)phenyl]-6-(4-methylpiperazin-1-yl)pyridin-3-yl]-N-methyl-2-(trideuteriomethyl)propanamide; Netupitant metabolite. Grades: >98%. CAS No. 910808-12-7. Molecular formula: C30H32F6N4O2. Mole weight: 594.59. | |
| N-Desmethyl Netupitant | N-desmethyl Netupitant is a metabolite of an antiemitic drug called Netupitant. Synonyms: 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-piperazin-1-ylpyridin-3-yl]propanamide Netupitant metabolite N-desmethyl Netupitant SCHEMBL1399508 SRVSDBHUBFLSFE-UHFFFAOYSA-N. Grades: > 95%. CAS No. 290296-72-9. Molecular formula: C29H30F6N4O. Mole weight: 564.576. | |
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