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Product | Description | |
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Netupitant Quick inquiry Where to buy Suppliers range | Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy. Synonyms: AGE94200; AGE-94200; AGE 94200;Ro 67-3189; Ro-67-3189; Ro67-3189; CHEBI441603; CID6451149; D05152; UNII-7732P08TIR, CHEMBL206253, AG-E-94200, Netupitant. Grades: >98%. CAS No. 290297-26-6. Molecular formula: C30H32F6N4O. Mole weight: 578.603. | |
Netupitant Quick inquiry Where to buy Suppliers range | Netupitant. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 290297-26-6. IUPAC Name: 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide. Molecular formula: C30H32F6N4O. Mole weight: 578.59. Catalog: APS290297266. SMILES: CN (C (=O)C (C) (C)c1cc (cc (c1)C (F) (F)F)C (F) (F)F)c2cnc (cc2c3ccccc3C)N4CCN (C)CC4. Format: Neat. | |
Netupitant Quick inquiry Where to buy Suppliers range | Netupitant. CAS No. 290297-26-6. | |
Netupitant Impurity 1 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 6-(piperazin-1-yl)-4-(o-tolyl)nicotinamide. Grades: > 95%. Molecular formula: C17H20N4O. Mole weight: 296.38. | |
Netupitant Impurity 10 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-N-methyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)acetamide. Grades: > 95%. Molecular formula: C28H28F6N4O. Mole weight: 550.55. | |
Netupitant Impurity 11 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-N-methyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide. Grades: > 95%. Molecular formula: C29H30F6N4O. Mole weight: 564.58. | |
Netupitant Impurity 12 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: N-methyl-6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-amine. Grades: > 95%. Molecular formula: C17H22N4. Mole weight: 282.39. | |
Netupitant Impurity 13 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: (2-(5-(methylamino)-2-(4-methylpiperazin-1-yl)pyridin-4-yl)phenyl)methanol. Grades: > 95%. Molecular formula: C18H24N4O. Mole weight: 312.42. | |
Netupitant Impurity 14 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 4-(5-carbamoyl-4-(o-tolyl)pyridin-2-yl)-1-methylpiperazine 1-oxide. Grades: > 95%. Molecular formula: C18H22N4O2. Mole weight: 326.4. | |
Netupitant Impurity 2 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: (6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)methanamine. Grades: > 95%. Molecular formula: C18H24N4. Mole weight: 296.42. | |
Netupitant Impurity 3 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 4-(2-(hydroxymethyl)phenyl)-6-(piperazin-1-yl)nicotinamide. Grades: > 95%. Molecular formula: C18H22N4O2. Mole weight: 326.4. | |
Netupitant Impurity 4 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 1-methyl-4-(5-(methylamino)-4-(o-tolyl)pyridin-2-yl)piperazine 1-oxide. Grades: > 95%. Molecular formula: C18H24N4O. Mole weight: 312.42. | |
Netupitant Impurity 5 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: (6-(piperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)methanamine. Grades: > 95%. Molecular formula: C17H22N4. Mole weight: 282.39. | |
Netupitant Impurity 6 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl-N-((6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)methyl)propanamide. Grades: > 95%. Molecular formula: C29H30F6N4O. Mole weight: 564.58. | |
Netupitant Impurity 7 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine. Grades: > 95%. Molecular formula: C18H24N4. Mole weight: 296.42. | |
Netupitant Impurity 8 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 4-(2-methylphenyl)?-6-(4-methyl-1-piperazinyl)?- 3-Pyridinamine. Grades: > 95%. CAS No. 290297-24-4. Molecular formula: C17H22N4. Mole weight: 282.39. | |
Netupitant Impurity 9 Quick inquiry Where to buy Suppliers range | An impurity of Netupitant, which is a selective neurokinin 1 receptor antagonist with potential antiemetic activity. Synonyms: 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide. Grades: > 95%. Molecular formula: C29H30F6N4O. Mole weight: 564.58. | |
Netupitant N-Oxide Quick inquiry Where to buy Suppliers range | Netupitant N-Oxide is a derivative of Netupitant which is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active. Synonyms: Netupitant metabolite Netupitant N-oxide;2-[3,5-bis(trifluoromethyl)phenyl]-3,3,3-trideuterio-N-methyl-N-[6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-4-(2-methylphenyl)pyridin-3-yl]-2-(trideuteriomethyl)propanamide. Grades: >98%. CAS No. 910808-11-6. Molecular formula: C30H32F6N4O2. Mole weight: 594.59. | |
Monohydroxy Netupitant Quick inquiry Where to buy Suppliers range | Monohydroxy Netupitant is the metabolite of Netupitant which is a potent and selective neurokinin-1 receptor (NK1) receptor antagonist. It is achiral and orally active. Synonyms: 2-[3, 5-bis(trifluoromethyl)phenyl]-3, 3, 3-trideuterio-N-[4-[2-(hydroxymethyl)phenyl]-6-(4-methylpiperazin-1-yl)pyridin-3-yl]-N-methyl-2-(trideuteriomethyl)propanamide; Netupitant metabolite. Grades: >98%. CAS No. 910808-12-7. Molecular formula: C30H32F6N4O2. Mole weight: 594.59. | |
N-Desmethyl Netupitant Quick inquiry Where to buy Suppliers range | N-desmethyl Netupitant is a metabolite of an antiemitic drug called Netupitant. Synonyms: 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-piperazin-1-ylpyridin-3-yl]propanamide Netupitant metabolite N-desmethyl Netupitant SCHEMBL1399508 SRVSDBHUBFLSFE-UHFFFAOYSA-N. Grades: > 95%. CAS No. 290296-72-9. Molecular formula: C29H30F6N4O. Mole weight: 564.576. |