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| Product | Description | |
|---|---|---|
| Niflumic acid | Niflumic acid is a calcium-activated chloride channel blocker and COX -2 inhibitor with the IC 50 value of 100 nM. Niflumic acid induces apoptosis through caspase-8 / Bid / Bax pathway in lung cancer cells. Niflumic acide exhibits anti-tumor activity by affecting the expression of ERK1/2 and the activity of MMP2 and MMP9. Niflumic acid has orally bioactivity. Niflumic acid acts on rheumatoid arthritis [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4394-00-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0493. |  |
| Niflumic Acid | Cyclooxygenase-2 (COX-2) inhibitor; GPR35 agonist. Nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35. Group: Biochemicals. Alternative Names: 2-[[3- (Trifluoromethyl) phenyl]amino]-3-pyridinecarboxylic Acid; 2-[3- (Trifluoromethyl) anilino]nicotinic Acid; Actol; Actol (analgesic); Donalgin; Flogovital; Forenol; Landruma; Nifluminic Acid; Nifluril; UP 83. Grades: Highly Purified. CAS No. 4394-00-7. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C13H9F3N2O2, Molecular Weight: 282.22. US Biological Life Sciences. |  Worldwide |
| Niflumic Acid | Niflumic Acid is a selective COX-2 inhibitor and GPR35 activator. Cox-2: IC50 = 918 nM (human); Cox-1: IC50 = 1.06 μM (human); GPR35: IC50 = 1.28 μM (human). Uses: Anti-inflammatory agents, non-steroidal. Synonyms: 2-[[3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid; Actol; Donalgin; Nifluril; UP83. CAS No. 4394-00-7. Molecular formula: C13H9F3N2O2. Mole weight: 282.2. |  |
| Niflumic Acid-d5 (Major) | Anti-inflammatory. Selective cyclooxygenase-2 (COX-2) inhibitor. Group: Biochemicals. Alternative Names: 2-[[3- (Trifluoromethyl) phenyl]amino]-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Niflumic acid-(phenyl-13C6) | analytical standard. Group: Opiates / synthetic analgesic drug standards. |  |
| Talniflumate | Talniflumate (BA 7602-06) is the proagent of Niflumic acid (HY-B0493), exerting its activity in the body through conversion to niflumic acid by esterase [1]. Talniflumate is an orally active Ca 2+ -activated Cl - channel (CaCC) blocker. Talniflumate can be used as an analgesic and anti-inflammatory agent in cystic fibrosis mouse model of distal intestinal obstructive syndrome [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BA 7602-06. CAS No. 66898-62-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103370. | |
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