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| Product | Description | |
|---|---|---|
| Nilotinib | Nilotinib. CAS No. 641571-10-0. Product ID: 2-08247. Molecular formula: C28H22F3N7O. Mole weight: 529.52. |  |
| Nilotinib | Nilotinib. CAS No. 641571-10-0. Product ID: 8-04315. Molecular formula: C28H22F3N7O. Mole weight: 529.52. Purity: 0.99. | |
| Nilotinib | Nilotinib is a Bcr-Abl inhibitor with IC50 less than 30 nM. It is under investigation as a possible treatment for chronic myelogenous leukemia (CML). Synonyms: Tasigna; AMN107; AMN 107; AMN-107; BW 33A, 51W89. Grades: ≥98%. CAS No. 641571-10-0. Molecular formula: C28H22F3N7O. Mole weight: 529.52. |  |
| Nilotinib | Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMN107. CAS No. 641571-10-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-10159. |  |
| Nilotinib 3-Imidazolyl N-Difluoroboryloxide | Nilotinib 3-Imidazolyl N-Difluoroboryloxide. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS002584. Format: Neat. |  |
| Nilotinib 3-Imidazolyl N-oxide | Nilotinib 3-Imidazolyl N-oxide. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2139382-75-3. IUPAC Name: 4-methyl-N-[3-(4-methyl-3-oxo-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridyl)pyrimidin-2-yl]amino]benzamide. Molecular Formula: C28H22F3N7O2. Mole Weight: 545.52. Catalog: APS2139382753. SMILES: Cc1ccc (cc1Nc2nccc (n2)c3cccnc3)C (=O)Nc4cc (cc (c4)C (F) (F)F)n5cc (C)n (=O)c5. Format: Neat. | |
| Nilotinib-d3 | Labeled analog of Nilotinib (AMN1O7), which might be useful in treatment of chronic myelogenous leukemia. Group: Biochemicals. Alternative Names: 4-Methyl-N- [3- (4- (methyl-d3) -1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl] -3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] benzamide; AMN 107-d3; Tasigna-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Nilotinib EP Impurity A | Nilotinib EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 641571-11-1. Molecular Formula: C11H10F3N3. Mole Weight: 241.22. Catalog: APB641571111. | |
| Nilotinib EP Impurity B | Nilotinib EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 18595-18-1. Molecular Formula: C9H11NO2. Mole Weight: 165.19. Catalog: APB18595181. | |
| Nilotinib EP Impurity C | Nilotinib EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2458-12-0. Molecular Formula: C8H9NO2. Mole Weight: 151.17. Catalog: APB2458120. | |
| Nilotinib EP Impurity D | Nilotinib EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 641569-94-0. Molecular Formula: C17H14N4O2. Mole Weight: 306.33. Catalog: APB641569940. | |
| Nilotinib EP Impurity E | Nilotinib EP Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2119583-26-3. Molecular Formula: C27H20F3N7O. Mole Weight: 515.5. Catalog: APB2119583263. | |
| Nilotinib EP Impurity F | Nilotinib EP Impurity F. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2119583-24-1. Molecular Formula: C29H24F3N7O. Mole Weight: 543.55. Catalog: APB2119583241. | |
| Nilotinib EP Impurity G | Nilotinib EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. CAS No. 917392-54-2. Molecular Formula: C18H16N4O2. Mole Weight: 320.35. Catalog: APB917392542. | |
| Nilotinib EP Impurity H | Nilotinib EP Impurity H. Uses: For analytical and research use. Group: Impurity standards. CAS No. 641571-15-5. Molecular Formula: C28H22F3N7O. Mole Weight: 529.53. Catalog: APB641571155. | |
| Nilotinib, Free Base (AMN107) | Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants. Group: Biochemicals. Alternative Names: 4-Methyl-N- [3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl] -3- [ [4- (3-pyridinyl) -2-pyrimidinyl] amino] benzamide; AMN107; Tasigna. Grades: Highly Purified. CAS No. 641571-10-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Nilotinib hydrochloride | Nilotinib is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor displaying antineoplastic activity. It is promisingly used for the treatment of chronic myelogenous leukemia (CML). Uses: Tyrosine kinase inhibitors. Synonyms: AMN-107 HCl; 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide hydrochloride. CAS No. 923288-95-3. Molecular formula: C28H22F3N7O·HCl. Mole weight: 565.98. | |
| Nilotinib Hydrochloride | Nilotinib Hydrochloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 923288-95-3. Molecular Formula: C28H23ClF3N7O. Mole Weight: 565.99. Catalog: APB923288953. | |
| Nilotinib Hydrochloride Hydrate | Nilotinib Hydrochloride Hydrate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 923288-90-8. Molecular Formula: C28H25ClF3N7O2. Mole Weight: 584. Catalog: APB923288908. | |
| Nilotinib Impurity 10 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 41 nM. Synonyms: tert-butyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate. Grades: > 95%. Molecular formula: C21H22N4O2. Mole weight: 362.44. | |
| Nilotinib Impurity 11 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 42 nM. Synonyms: 4-Desmethyl-4-ethylimidazolyl Nilotinib; N-(3-(4-ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide. Grades: > 95%. Molecular formula: C29H24F3N7O. Mole weight: 543.56. | |
| Nilotinib Impurity 12 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 43 nM. Synonyms: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzonitrile; 3-(4-Methyl-imidazol-1-yl)-5-trifluoromethyl-benzonitrile. Grades: > 95%. CAS No. 641571-12-2. Molecular formula: C12H8F3N3. Mole weight: 251.21. | |
| Nilotinib Impurity 13 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 44 nM. Synonyms: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide. Grades: > 95%. CAS No. 917391-28-7. Molecular formula: C12H10F3N3O. Mole weight: 269.23. | |
| Nilotinib Impurity 1 HCl | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 32 nM. Synonyms: 3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline HCl. Grades: > 95%. Molecular formula: C12H12F3N3. HCl. Mole weight: 255.24 36.46. | |
| Nilotinib Impurity 2 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 33 nM. Synonyms: 3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline. Grades: > 95%. CAS No. 641571-06-4. Molecular formula: C11H10F3N3. Mole weight: 241.22. | |
| Nilotinib Impurity ((2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one) | an Intermediate of Imatinib. Synonyms: (2E)-3-(Dimethylamino)-1-(3-pyridyl)prop-2-en-1-one. Grades: > 95%. CAS No. 123367-26-0. Molecular formula: C10H12N2O. Mole weight: 176.22. | |
| Nilotinib Impurity 3 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 34 nM. Synonyms: 3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)-aniline. Grades: > 95%. CAS No. 943320-48-7. Molecular formula: C10H8F3N3. Mole weight: 227.19. | |
| Nilotinib Impurity 4 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 35 nM. Synonyms: 3-(2,4-Dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline. Grades: > 95%. Molecular formula: C12H12F3N3. Mole weight: 255.24. | |
| Nilotinib Impurity 6 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 37 nM. Synonyms: 4-methyl-N-(3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide. Grades: > 95%. Molecular formula: C28H22F3N7O. Mole weight: 529.53. | |
| Nilotinib Impurity 7 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 38 nM. Synonyms: N-(3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide. Grades: > 95%. Molecular formula: C27H20F3N7O. Mole weight: 515.5. | |
| Nilotinib Impurity 8 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 39 nM. Synonyms: N-(3-(2,4-dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide. Grades: > 95%. Molecular formula: C29H24F3N7O. Mole weight: 543.56. | |
| Nilotinib Impurity 8 | Nilotinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2119583-27-4. Molecular Formula: C12H12F3N3. Mole Weight: 255.24. Catalog: APB2119583274. | |
| Nilotinib Impurity 9 | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 40 nM. Synonyms: 4-Methyl-N-(3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)phenyl)-3-((4-(pyridin-3-yl)pyriMidin-2-yl)aMino)benzaMide. Grades: > 95%. CAS No. 641571-15-5. Molecular formula: C28H22F3N7O. Mole weight: 529.53. | |
| Nilotinib Impurity 9 | Nilotinib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C37H29ClF3N11O. Mole Weight: 736.16. Catalog: APB10655. | |
| Nilotinib monohydrochloride monohydrate | Nilotinib monohydrochloride monohydrate is an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. It binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. It also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). Uses: Tyrosine kinase inhibitors. Synonyms: AMN-107; AMN 107; AMN107; Tasigna. Grades: >98%. CAS No. 923288-90-8. Molecular formula: C28H25ClF3N7O2. Mole weight: 583.99. | |
| Nilotinib N-Oxide | A metabolite of Nilotinib. Group: Biochemicals. Alternative Names: 4-Methyl-N- [3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl] -3- [ [4- (3-pyridinyl-N-oxide) -2-pyrimidinyl] amino] benzamide. Grades: Highly Purified. CAS No. 1246817-85-5. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Nilotinib N-Oxide | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 30 nM. Synonyms: 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl-N-oxide)-2-pyrimidinyl]amino]benzamide. Grades: > 95%. CAS No. 1246817-85-5. Molecular formula: C28H22F3N7O2. Mole weight: 545.53. | |
| 3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)-aniline | 3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)-aniline is a reactant used in the synthesis of novel Bcr/Abl inhibitors as anti-cancer drugs. Nilotinib (N465300) impurity, which might be useful in treatment of chronic myelogenous leukemia. Group: Biochemicals. Grades: Highly Purified. CAS No. 943320-48-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H8F3N3, Molecular Weight: 227.19. US Biological Life Sciences. | Worldwide |
| 3- (2, 4-Dimethyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline | 3- (2, 4-Dimethyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline is a reactant used in various organic and pharmaceutical syntheses. Nilotinib (N465300) impurity, which might be useful in treatment of chronic myelogenous leukemia. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 500mg. Molecular Formula: C12H12F3N3, Molecular Weight: 255.24. US Biological Life Sciences. | Worldwide |
| 3- (2-Methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline | 3- (2-Methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline is used in the preparation of cinnamaldehyde derivatives as inhibitors of bacterial cell division. Nilotinib (N465300) impurity, which might be useful in treatment of chronic myelogenous leukemia. Group: Biochemicals. Grades: Highly Purified. CAS No. 641571-06-4. Pack Sizes: 100mg, 500mg. Molecular Formula: C11H10F3N3, Molecular Weight: 241.21. US Biological Life Sciences. | Worldwide |
| 3- (4-Ethyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline | 3- (4-Ethyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline is an impurity of Nilotinib (N465300), a tyrosine kinase inhibitor and an anticancer agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H12F3N3, Molecular Weight: 255.24. US Biological Life Sciences. | Worldwide |
| 3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline | Intermediate in the preparation of Nilotinib. Group: Biochemicals. Alternative Names: 3- (4-Methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) benzenamine; 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole. Grades: Highly Purified. CAS No. 641571-11-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 3-(4-Methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline-d3 | Intermediate in the preparation of labeled Nilotinib. Group: Biochemicals. Alternative Names: 3- (4-Methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) benzenamine-d3; 1-(3-Amino-5-trifluoromethylphenyl)-4-methylimidazole-d3. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzenamine | An impurity of Nilotinib, which is a Bcr-Abl inhibitor with IC50 less than 36 nM. Synonyms: 641571-16-6; 3- (5-Methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) benzenamine3- (5-methylimidazol-1-yl) -5- (trifluoromethyl) aniline3- (5-Methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) anilinestarbld0029650. CAS No. 641571-16-6. Molecular formula: C11H10F3N3. Mole weight: 241.217. | |
| 3-Acetylpyridine N-Oxide | 3-Acetylpyridine N-Oxide is an intermediate in synthesizing Nilotinib N-Oxide (N465310), which is a metabolite of Nilotinib (N465300). Group: Biochemicals. Grades: Highly Purified. CAS No. 14188-94-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C7H7NO2. US Biological Life Sciences. | Worldwide |
| 3-Bromo-5-nitrobenzotrifluoride | 3-Bromo-5-nitrobenzotrifluoride is an efficient D-glucosamine-based copper catalyst for C-X couplings and its application in synthesis of nilotinib intermediate. 3-Bromo-5-nitrobenzotrifluoride is also an intermediate for Nilotinib (N465300). Group: Biochemicals. Grades: Highly Purified. CAS No. 630125-49-4. Pack Sizes: 1g, 5g. Molecular Formula: C7H3BrF3NO2, Molecular Weight: 270. US Biological Life Sciences. | Worldwide |
| 3-Iodo-4-methyl-N-[3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl]benzamide | Intermediate in the preparation of Nilotinib. Group: Biochemicals. Grades: Highly Purified. CAS No. 926922-18-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| 3-Iodo-4-methyl-N-[3- (4-methyl-1H-imidazol-1-yl) -5- (trifluoromethyl) phenyl]benzamide-d3 | Intermediate in the preparation of labeled Nilotinib. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 4-(2-Pyridinyl)-2-pyrimidinamine | Intermediate in the preparation of Nilotinib. Group: Biochemicals. Grades: Highly Purified. CAS No. 66521-65-1. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 4-(3-Pyridinyl)-2-pyrimidinamine | Intermediate in the preparation of Nilotinib. Group: Biochemicals. Alternative Names: 2-Amino-4-(3-pyridinyl)pyrimidine; 4-(3-Pyridyl)-2-pyrimidinamine; 4-(Pyridin-3-yl)pyrimidin-2-amine. Grades: Highly Purified. CAS No. 66521-66-2. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid (CAS# 641569-94-0) is used in the preparation of (pyridinyl)-N-[(triazolyl)phenyl]pyrimidinamine derivatives and (pyridinyl)-N-[oxadiazolyl)phenyl]pyrimidinamine derivatives, and can be used in the detection of their activity as antileukemia agents (neoplastic stem cell leukemia). 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid is also a Nilotinib (N465300) intermediate, which might be useful in treatment of chronic myelogenous leukemia. Synonyms: 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid; 4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzoic acid. Grades: 98 %. CAS No. 641569-94-0. Molecular formula: C17H14N4O2. Mole weight: 306.32. | |
| 4-Methyl-3- ( (4- (3-pyridinyl) -2-pyrimidinyl) amino) -N- (5- (4-methyl-1H-imidazol-1-yl) -3- (trifluoromethyl) phenyl) benzamide | 4-Methyl-3- ( (4- (3-pyridinyl) -2-pyrimidinyl) amino) -N- (5- (4-methyl-1H-imidazol-1-yl) -3- (trifluoromethyl) phenyl) benzamide. Group: Biochemicals. Alternative Names: Nilotinib. Grades: Highly Purified. CAS No. 641571-10-0. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C28H22F3N7O. US Biological Life Sciences. | Worldwide |
| Radotinib | Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Check for active clinical trials or closed clinical trials using this agent. Synonyms: IY-5511; IY 5511; IY5511; 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyrazin-2-ylpyrimidin-2-yl)amino]benzamide. Grades: >98%. CAS No. 926037-48-1. Molecular formula: C27H21F3N8O. Mole weight: 530.515. | |
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