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| Product | Description | |
|---|---|---|
| Nintedanib Impurity 12 | Nintedanib Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1139458-48-2. Molecular formula: C26H23N3O4. Mole weight: 441.49. Catalog: APB1139458482. |  |
| Nintedanib Impurity 1 (Intedanib Impurity 1) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/74 nM. Synonyms: Dimethyl 2-oxoindoline-3,6-dicarboxylate; 3,6-dimethyl 2-oxo-2,3-dihydro-1H-indole-3,6-dicarboxylate. Grades: > 95%. Molecular formula: C12H11NO5. Mole weight: 249.23. |  |
| Nintedanib Impurity 2 (Intedanib Impurity 2) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/75 nM. Synonyms: methyl (3E)-1-(2-chloroacetyl)-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate. Grades: > 95%. CAS No. 1174335-83-1. Molecular formula: C20H16ClNO5. Mole weight: 385.81. | |
| Nintedanib Impurity 3 (Intedanib Impurity 3) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/76 nM. Synonyms: Methyl (3E)-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate. Grades: > 95%. Molecular formula: C18H15NO4. Mole weight: 309.32. | |
| Nintedanib Impurity 4 (Intedanib Impurity 4) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/77 nM. Synonyms: Methyl (3Z)-3- ({[4- (methylamino)phenyl]amino} (phenyl)methylidene)-2-oxo-2, 3-dihydro-1H-indole-6-carboxylate. Grades: > 95%. Molecular formula: C24H21N3O3. Mole weight: 399.45. | |
| Nintedanib Impurity 6 | Nintedanib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1038972-16-5. Molecular formula: C13H18N4O3. Mole weight: 278.31. Catalog: APB1038972165. | |
| Nintedanib Impurity 6 (Intedanib Impurity 6) | BIBF 1202 is the major in-vivo metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. It is a related compound of Intedanib, which is an indolinone derivative that inhibits angiokinase and an antitumor agent. It is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (VEGF) signaling pathway thus inhibition of tumor angiogenesis. Uses: Bibf 1202 is a novel treatment modality in oncology through blockade of the vascular endothelial growth factor (vegf) signaling pathway thus inhibition of tumor angiogenesis. Synonyms: BIBF-1202; BIBF 1202; BIBF1202. (3Z) -2, 3-Dihydro-3- [ [ [4- [methyl [ (4-methyl-1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-1H-indole-6-carboxylic acid;(Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1 -yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylic acid;Nintedanib Impurity 5. Grades: >98%. CAS No. 894783-71-2. Molecular formula: C30H31N5O4. Mole weight: 525.60. | |
| Nintedanib Impurity 7 (Intedanib Impurity 7) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/80 nM. Synonyms: Methyl (3Z)-1-(2-chloroacetyl)-3-[hydroxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate. Grades: > 95%. Molecular formula: C19H14ClNO5. Mole weight: 371.78. | |
| Nintedanib Impurity 8 (Intedanib Impurity 8) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/81 nM. Synonyms: methyl (3Z)-3-[hydroxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate. Grades: > 95%. Molecular formula: C17H13NO4. Mole weight: 295.3. | |
| Nintedanib Impurity 9 | Nintedanib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1860012-61-8. Molecular formula: C9H10N2O4. Mole weight: 210.19. Catalog: APB1860012618. | |
| Nintedanib Impurity 9 (Intedanib Impurity 9) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/86 nM. Synonyms: (Z)-methyl 3- ( ( (4- (N-methyl-2- (4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-7-carboxylate. Grades: > 95%. Molecular formula: C32H37N5O4. Mole weight: 555.68. | |
| Nintedanib Impurity A (Intedanib Impurity A) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/66 nM. Synonyms: (Z)-3- ( ( (4- (2- (4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylic acid. Grades: > 95%. Molecular formula: C29H29N5O4. Mole weight: 511.59. | |
| Nintedanib Impurity B (Intedanib Impurity B) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/67 nM. Synonyms: Methyl (3Z)-3-[ ({4-[2- (4-methylpiperazin-1-yl)acetamido]phenyl}amino) (phenyl)methylidene]-2-oxo-2, 3-dihydro-1H-indole-6-carboxylate. Grades: > 95%. Molecular formula: C30H31N5O4. Mole weight: 525.61. | |
| Nintedanib Impurity C (Intedanib Impurity C) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/68 nM. Synonyms: Methyl (3E)-3-[ ({4-[2- (4-methylpiperazin-1-yl)acetamido]phenyl}amino) (phenyl)methylidene]-2-oxo-2, 3-dihydro-1H-indole-7-carboxylate. Grades: > 95%. Molecular formula: C30H31N5O4. Mole weight: 525.61. | |
| Nintedanib Impurity D | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: (3Z) ?-2, ?3-Dihydro-3-[[[4- (methylamino) ?phenyl]?amino]?phenylmethylene]?-2-oxo-1H-Indole-6-carboxylic Acid Methyl Ester. Grades: >95%. CAS No. 1987887-92-2. Molecular formula: C24H21N3O3. Mole weight: 399.45. | |
| Nintedanib Impurity Dimer | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. CAS No. 2410649-56-6. Molecular formula: C56H52N8O8. Mole weight: 965.06. | |
| Nintedanib Impurity E (Intedanib Impurity E) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/70 nM. Synonyms: N-methyl-2- (4-methylpiperazin-1-yl) -N-[4- ({[ (3E) -2-oxo-2, 3-dihydro-1H-indol-3-ylidene] (phenyl) methyl}amino) phenyl]acetamide. Grades: > 95%. Molecular formula: C29H31N5O2. Mole weight: 481.6. | |
| Nintedanib Impurity F (Intedanib Impurity F) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/71 nM. Synonyms: (3Z)-N-{4-[N-methyl-2- (4-methylpiperazin-1-yl)acetamido]phenyl}-3-[ ({4-[N-methyl-2- (4-methylpiperazin-1-yl)acetamido]phenyl}amino) (phenyl)methylidene]-2-oxo-2, 3-dihydro-1H-indole-6-carboxamide. Grades: > 95%. Molecular formula: C44H51N9O4. Mole weight: 769.95. | |
| Nintedanib Impurity G (Intedanib Impurity G) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/72 nM. Synonyms: Methyl (3E)-3-[ ({4-[2- (4-methylpiperazin-1-yl)acetamido]phenyl}amino) (phenyl)methylidene]-2-oxo-2, 3-dihydro-1H-indole-6-carboxylate. Grades: > 95%. Molecular formula: C30H31N5O4. Mole weight: 525.61. | |
| Nintedanib Impurity H (Intedanib Impurity H) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/73 nM. Synonyms: (E)-1- (2- ( (4- ( ( (6- (methoxycarbonyl)-2-oxoindolin-3-ylidene) (phenyl)methyl)amino)phenyl) (methyl)amino)-2-oxoethyl)-4-methylpiperazine 1,4-dioxide. Grades: > 95%. Molecular formula: C31H33N5O6. Mole weight: 571.64. | |
| Nintedanib Impurity I | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: (Z)-Methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate; NINTEDANIB IMPURITY I; 3TK2E45UHG; BIBF1053; Nintedanib metabolite M3 (m/Z 526); (Z)-Methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate ( Nintedanib Impurity); 1H-Indole-6-carboxylic acid, 2, 3-dihydro-3- ( ( (4- (methyl (2- (1-piperazinyl) acetyl) amino) phenyl) amino) phenylmethylene) -2-oxo-, methyl ester, (3Z)-; methyl 2-hydroxy-3-[N-[4-[methyl-(2-piperazin-1-ylacetyl)amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate. Grades: ≥95%. Molecular formula: C14H22N4O2. Mole weight: 278.36. | |
| Nintedanib Impurity J | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. Molecular formula: C28H42N8O2. Mole weight: 522.70. | |
| Nintedanib Impurity K | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. Molecular formula: C28H40N8O2. Mole weight: 520.68. | |
| Nintedanib Impurity L | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. Molecular formula: C28H40N8O3. Mole weight: 536.68. | |
| Nintedanib Impurity N'-oxide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Grades: ≥95%. Molecular formula: C31H33N5O5. Mole weight: 555.64. | |
| Nintedanib Acetyl Impurity | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: (3Z)-1H-Indole-6-carboxylic acid, 3-[[[4- (acetylmethylamino) phenyl]amino]phenylmethylene]-2, 3-dihydro-2-oxo-, methyl ester. Grades: ≥95%. CAS No. 1139458-48-2. Molecular formula: C26H23N3O4. Mole weight: 441.48. | |
| 1,2-bis(4-methylpiperazin-1-yl)ethanone | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Piperazine, 1-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-(5CI); Nintedanib Impurity E. Grades: ≥95%. CAS No. 856843-88-4. Molecular formula: C12H24N4O. Mole weight: 240.35. | |
| 2,2'-(piperazine-1,4-diyl)bis(N-methyl-N-(4-nitrophenyl)acetamide) | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib Impurity G. Grades: ≥95%. CAS No. 2410649-54-4. Molecular formula: C22H26N6O6. Mole weight: 470.48. | |
| 2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: 4-Methyl-N-(4-nitrophenyl)-1-piperazineacetamide; Nintedanib Impurity F. Grades: ≥95%. CAS No. 708279-23-6. Molecular formula: C13H18N4O3. Mole weight: 278.31. | |
| 2-chloro-N-methyl-N-(4-nitrophenyl)acetamide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Acetamide, 2-chloro-N-methyl-N-(4-nitrophenyl)-; α-Chloro-N-methyl-p-nitroacetanilide; Nintedanib Impurity B. Grades: ≥95%. CAS No. 2653-16-9. Molecular formula: C9H9ClN2O3. Mole weight: 228.63. | |
| (3Z)-2,3-Dihydro-2-oxo-3-(phenyl-1-piperidinylmethylene)-1H-indole-6-carboxylic acid methyl ester | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib Impurity U. Grades: ≥95%. CAS No. 2102162-79-6. Molecular formula: C22H22N2O3. Mole weight: 362.42. | |
| Desmethyl Nintedanib | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/73 nM. Synonyms: Nintedanib Impurity G; 2, 3-Dihydro-3- [ [ [4- [ [ (4-methyl-1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-methyl Ester-1H-indole-6-carboxylic Acid; (Z)-Methyl 3- ( ( (4- (2- (4-methylpiperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate. CAS No. 894783-61-0. Molecular formula: C30H31N5O4. Mole weight: 525.60. | |
| Dimethyl 3, 3'- ( ( ( ( (2, 2'- (piperazine-1, 4-diyl)bis (acetyl))bis (methylazanediyl))bis (4, 1-phenylene))bis (azanediyl))bis (phenylmethanylylidene)) (3Z, 3'E)-bis (2-oxoindoline-6-carboxylate) | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib Impurity 50. Grades: ≥95%. CAS No. 2410284-90-9. Molecular formula: C56H52N8O8. Mole weight: 965.08. | |
| methyl 1-(2-chloroacetyl)-2-oxo-3H-indole-6-carboxylate | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/66 nM. Synonyms: 1160293-25-3; methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl estermethyl 1-(2-chloroacetyl)-2-oxo-3H-indole-6-carboxylate1H-Indole-6-carboxylic acid, 1-(2-chloroacetyl)-2,3-dihydro-2-oxo-, methyl ester. Grades: 95%. CAS No. 1160293-25-3. Molecular formula: C12H10ClNO4. Mole weight: 267.66. | |
| Methyl 1-Acetyl-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: 1-acetyl-2-oxo-3H-indole-6-carboxylic acid methyl ester; methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate. CAS No. 676326-36-6. Molecular formula: C12H11NO4. Mole weight: 233.22. | |
| methyl (Z)-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/73 nM. Synonyms: methyl 3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate; Nintedanib Impurity 06. CAS No. 2093243-16-2. Molecular formula: C17H13NO4. Mole weight: 295.29. | |
| Nintedanib dimer | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/73 nM. Synonyms: 2,2'-(Piperazine-1,4-diyl)bis(N-(4-aminophenyl)-N-methylacetamide). Grades: 95% by HPLC. CAS No. 2410284-89-6. Molecular formula: C22H30N6O2. Mole weight: 410.51. | |
| Nintedanib E-isomer (Intedanib E-isomer) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/82 nM. Synonyms: Nintedanib E-isomer. Grades: > 95%. Molecular formula: C31H33N5O4. Mole weight: 539.64. | |
| Nintedanib N-Glucuronide (Intedanib N-Glucuronide) | An impurity of Nintedanib, which is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/85 nM. Synonyms: Intedanib N-β-D-Glucuronide; (3Z) -2, 3-Dihydro-3- [ [ [4- [methyl [2- (4-methyl-1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-H-Indole-6-carboxylic Acid Methyl Ester N-β-D-Glucuronide. Grades: > 95%. Molecular formula: C37H41N5O10. Mole weight: 715.77. | |
| N-Methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: N-methyl-2-(4-methyl-1-piperazinyl)-N-(4-nitrophenyl)acetamide; N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide. CAS No. 1139453-98-7. Molecular formula: C14H20N4O3. Mole weight: 292.33. | |
| N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide; 1038972-16-5; CS-0011633; N-Methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide (Nintedanib Impurity). CAS No. 1038972-16-5. Molecular formula: C13H18N4O3. Mole weight: 278.31. | |
| N-methyl-N-(4-nitrophenyl)-2-(piperazin-1-yl)acetamide hydrochloride | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. CAS No. 2037385-84-3. Molecular formula: C13H19ClN4O3. Mole weight: 314.77. | |
| (Z)-Methyl 3- ( ( (4- (N-methyl-2- (piperazin-1-yl)acetamido)phenyl)amino) (phenyl)methylene)-2-oxoindoline-6-carboxylate | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib metabolite M3; Nintedanib impurity I; 1H-Indole-6-carboxylic acid, 2, 3-dihydro-3- [ [ [4- [methyl [2- (1-piperazinyl) acetyl] amino] phenyl] amino] phenylmethylene] -2-oxo-, methyl ester, (3Z)-. Grades: ≥95%. CAS No. 334951-61-0. Molecular formula: C30H31N5O4. Mole weight: 525.60. | |
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