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Nirmatrelvir (1R,2S,5S)-N-((1S)-1-Cyano-2-((3S)-2-oxopyrrolidin-3-yl)ethyl)-6,6-dimethyl-3-(3-methyl-N-(trifluoroacetyl)-L-valyl)-3-azabicyclo(3. 1.0)hexane-2-carboxamide is a synthetic antibiotic that is active against bacteria and some parasites. It has been shown to be effective in the treatment of AIDS patients infected with HIV and Mycobacterium tuberculosis. This drug also has antiviral and antifungal properties which may be due to its inhibition of viral DNA polymerase and fungal RNA polymerase. CAS No. 2628280-40-8. Product ID: API2628280408. SMILES: CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)[C@H](C(C)(C)C)NC(=O)C(F)(F)F)C(=O)N[C@@H](C[C@@H]3CCNC3=O)C#N)C. Category: Active Pharmaceutical Ingredients. Protheragen
Nirmatrelvir Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CL PRO ) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-07321332. CAS No. 2628280-40-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-138687. MedChemExpress MCE
Nirmatrelvir impurity 2 Nirmatrelvir impurity 2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (1R,2S,5S)-N-((R)-1-Cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide. Appearance: Solid. CAS No. 2755812-41-8. Molecular formula: C23H32F3N5O4. Mole weight: 499.53. Product ID: ACM2755812418. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry. 2
PF-07321332 Nirmatrelvir, also known as PF-07321332 (brand name: Paxlovid), is an orally bioavailable 3C-like protease (3CLPRO) inhibitor and SARS-CoV-2 Mpro inhibitor. This drug is being investigated for safety, tolerability, and pharmacokinetics before moving on to studies of efficacy in the treatment or prophylaxis of COVID-19. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. PF-07321332 is an oral COVID-19 antiviral clinical candidate. By inhibiting the main protease, PF-07321332 prevents the virus from cleaving long protein chains into the parts it needs to reproduce itself. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nirmatrelvir; PF-07321332; PF 07321332; PF07321332; brand name Paxlovid. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2628280-40-8. Molecular formula: C23H32F3N5O4. Mole weight: 499.54. Purity: >98%. IUPACName: (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide. Canonical SMILES: [H][C@]12CN([C@H](C(=O)N[C@@H](C[C@]3([H])CCNC3=O)C#N)[C@@]1([H])C2(C)C)C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C. Product ID: ACM2628280408. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.
Ritonavir Ritonavir is an HIV protease inhibitor. It is often used in a low dose with another protease inhibitor lopinavir. Ritonavir was approved for COVID-19 treatment in combination with Nirmatrelvir. Synonyms: Norvir; ABT-538; A-84538; 538, ABT; ABT 538; ABT-538; ABT538; Abbott 84538. Grade: ≥98%. CAS No. 155213-67-5. Molecular formula: C37H48N6O5S2. Mole weight: 720.95. BOC Sciences 2

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