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| Product | Description | |
|---|---|---|
| Nitric Oxide Synthase, Inducible from mouse, Recombinant | Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free ...DPH); Inducible Nitric Oxide Synthase; NOS II; iNOS; macNOS; EC 1.14.13.39; NOSs. Enzyme Commission Number: EC 1.14.13.39. CAS No. 125978-95-2. NOSs. Mole weight: mol wt 130 kDa (homodimer); mol wt 130 kDa (subunit, homodimer). Storage: -70°C. Form: buffered aqueous solution; Solution in 50 mM HEPES, pH 7.4, with 10% glycerol, 8 μM tetrahydrobiopterin. Source: E. coli. Species: Mouse. nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase; nitric-oxide synthase (NADPH); Inducible Nitric Oxide Synthase; NOS II; iNOS; macNOS; EC 1.14.13.39; NOSs. Cat No: NATE-0489. |  |
| Inducible Nitric Oxide Synthase, Control Peptide (iNOS, iNOS 2, mNOS) | Sequence: Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 150nmole. US Biological Life Sciences. |  Worldwide |
| nitric-oxide synthase (NADPH) | Binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin. This eukaryotic enzyme, which is found in plants and animals, consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain. Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. May produce superoxide under certain conditions. cf. EC 1.14.13.165, nitric-oxide synthase [NAD(P)H dependent]. Group: Enzymes. Synonyms: nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase. Enzyme Commission Number: EC 1.14.13.39. CAS No. 125978-95-2. NOSs. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0846; nitric-oxide synthase (NADPH); EC 1.14.13.39; 125978-95-2; nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase. Cat No: EXWM-0846. | |
| nitric-oxide synthase [NAD(P)H] | Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. Most of the bacterial and archaeal enzymes consist of only an oxidase domain and function together with bacterial ferredoxins. The enzyme from the Δ-proteobacterium Sorangium cellulosum also includes a reductase domain that binds FAD, FMN and a [2Fe-2S] cluster. The similar enzymes from plants and animals use only NADPH as acceptor (cf. EC 1.14.13.39). Group: Enzymes. Synonyms: nitric oxide synthetase; NO synthase. Enzyme Commission Number: EC 1.14.13.165. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0764; nitric-oxide synthase [NAD(P)H]; EC 1.14.13.165; nitric oxide synthetase; NO synthase. Cat No: EXWM-0764. | |
| Synthase,nitric oxide | Synthase,nitric oxide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NCNOS;NCNOS, RAT;NCNOS (RAT RECOMBINANT);NITRIC OXIDE SYNTHASE (NEURONAL);NITRIC OXIDE SYNTHASE, NEURONAL RAT;NITRIC OXIDE SYNTHASE;NITRIC OXIDE SYNTHASE, CONSTITUTIVE, RAT BRAIN;NITRIC OXIDE SYNTHASE, CONSTITUTIVE, RAT NEURONAL. Product Category: Heterocyclic Organic Compound. CAS No. 125978-95-2. Product ID: ACM125978952. Alfa Chemistry ISO 9001:2015 Certified. |  |
| (11 β , ?16α ) ?-9-?Fluoro-?11-?hydroxy-?17, ?21-?[ (1-?methoxypentylidene) ?bis (oxy) ?]?-?16-?methyl-pregna-?1, ?4-?diene-?3, ?20-?dione | (11 β , ?16α ) ?-9-?Fluoro-?11-?hydroxy-?17, ?21-?[ (1-?methoxypentylidene) ?bis (oxy) ?]?-?16-?methyl-pregna-?1, ?4-?diene-?3, ?20-?dione is an intermediate in synthesizing Dexamethasone Valerate (D298870), an impurity of Dexamethasone (D298800), which is a glucocorticoid that is used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1062-64-2. Pack Sizes: 25mg, 50mg. Molecular Formula: C28H39FO6, Molecular Weight: 490.6. US Biological Life Sciences. | Worldwide |
| 1400W | 1400W is a selective inducible nitric oxide synthase (NOS) inhibitor (Ki = 7 nM, IC50=2.0 uM). By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury, acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor. Uses: A selective inducible nitric oxide synthase (inos) inhibitor. a long-acting human inos inhibitor possessing an ic50 value of 2.0um. Synonyms: N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL; N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE. Grades: >98%. CAS No. 180001-34-7. Molecular formula: C10H15N3. Mole weight: 177.251. |  |
| 1400W dihydrochloride | 1400W is a selective inducible nitric oxide synthase (NOS) inhibitor (Ki=7nM). By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury, acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor. Uses: A selective inducible nitric oxide synthase (inos) inhibitor which has the potential for treatment of ischemia reperfusion injury,acute hypobaric hypoxia and tumor. Synonyms: N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride; 1400W HCl; 1400W hydrochloride; 1400W (hydrochloride). Grades: >98%. CAS No. 214358-33-5. Molecular formula: C10H17Cl2N3. Mole weight: 250.167. | |
| 1400W Dihydrochloride | 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase ( iNOS ) inhibitor, with a K d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 214358-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18731. |  |
| 1400W Dihydrochloride | Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤7nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with K? values of 2 and 50uM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices. Group: Biochemicals. Alternative Names: N- (3- (Aminomethyl) benzyl) acetamidine 2HCl. Grades: Highly Purified. CAS No. 214358-33-5. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| 1400W dihydrochloride (N- (3- (Aminomethyl) benzyl) acetamidine. 2HCl) | A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd < 7 nM). Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki < 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki < 50 µM). Inhibits tumor growth. Increases vasoconstriction to noradrenaline. Improves contractile function. Improves stroke outcome and decreases glutamate release. Anti-inflammatory. Group: Biochemicals. Alternative Names: N- (3- (Aminomethyl) benzyl) acetamidine. 2HCl. Grades: Highly Purified. CAS No. 214358-33-5. Pack Sizes: 5mg, 25mg, 100mg. Molecular Formula: C10H15N3. 2HCl. US Biological Life Sciences. | Worldwide |
| 1,5-Isoquinolinediol | 1,5-Isoquinolinediol is a PARP1 inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent leading to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. 1,5-Isoquinolinediol is also an inducible nitric oxide synthase (NOS2) inhibitor. 1,5-Isoquinolinediol significantly inhibited mitochondrial membrane potential loss, AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: 1,5-Dihydroxyisoquinoline; Isoquinoline-1,5-diol; 5-Hydroxy-1(2H)-isoquinolinone; 5-Hydroxyisocarbostyril. Grades: 99%. CAS No. 5154-2-9. Molecular formula: C9H7NO2. Mole weight: 161.16. | |
| 1,5-Isoquinolinediol | PARP-1 inhibitor. Neuroprotectant. Blocks nitric oxide-induced neuronal toxicity. Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor. Stimulates homologous recombination. Group: Biochemicals. Alternative Names: 5-Hydroxy-1(2H)-isoquinolinone, 1,5-Dihydroxyisoquinoline. Grades: Highly Purified. CAS No. 5154-2-9. Pack Sizes: 5mg, 25mg, 100mg. Molecular Formula: C9H7NO2. US Biological Life Sciences. | Worldwide |
| 16α-Dexamethasone 9,11-Epoxide 21-Propionate | Dexamethasone 9,11-Epoxide 21-Propionate is an impurity of Dexamethasone (D298800) which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. Group: Biochemicals. Grades: Highly Purified. CAS No. 494870-08-5. Pack Sizes: 5mg, 50mg. Molecular Formula: C25H32O6. US Biological Life Sciences. | Worldwide |
| 21-Hydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione | 21-Hydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione is the impurity of Dexamethasone (D298800), which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation; it inhibits the induction of nitric oxide synthase. Group: Biochemicals. Grades: Highly Purified. CAS No. 56016-90-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C22H28O3, Molecular Weight: 340.46. US Biological Life Sciences. | Worldwide |
| 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one | A benzoxazolone analogue that may be used to inhibit the nitric oxide synthases (NOS). Group: Biochemicals. Alternative Names: 2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one; Oxazolo[4,5-b]pyridin-2(3H)-one; 3H-Oxazolo[4,5-b]pyridin-2-one; [1,3]Oxazolo[4,5-b]pyridin-2(3H)-one. Grades: Highly Purified. CAS No. 60832-72-6. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 2- (3-Fluorophenoxy) ethylamine | 2- (3-Fluorophenoxy) ethylamine acts as a reagent in the synthesis of neuronal nitric oxide synthase inhibitors with improved cellular permeability. Di methyl tetrahydropyrazino purinediones preparation as adenosine receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 120351-93-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H10FNO, Molecular Weight: 155.169999999999. US Biological Life Sciences. | Worldwide |
| 2-Amino-3,4-dimethylpyridine | 2-Amino-3,4-dimethylpyridine is a dimethyl-substituted 2-aminopyridine that can be used as an inhibitor of human nitric oxide synthase. Group: Biochemicals. Grades: Highly Purified. CAS No. 823-39-2. Pack Sizes: 100mg, 1g. Molecular Formula: C7H10N2, Molecular Weight: 122.17. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-methoxypyridine | 2-Amino-4-methoxypyridine is a highly selective inducible nitric oxide synthase inhibitors. Group: Biochemicals. Alternative Names: (4-Methoxypyridin-2-yl)amine; 4-(Methyloxy)-2-pyridinamine; 4-Methoxy-2-aminopyridine; 4-Methoxypyridin-2-amine. Grades: Highly Purified. CAS No. 10201-73-7. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| 2-Amino-5,6,7,8-tetrahydro-6-methyl-4(1H)-pteridinone Dihydrochloride | 2-Amino-5,6,7,8-tetrahydro-6-methyl-4(1H)-pteridinone is an analog of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases. It is also used to study mechanisms of nitric oxide (NO) synthase and free radical induced L-DOPA release from striatal tissue. Group: Biochemicals. Grades: Highly Purified. CAS No. 69113-63-9. Pack Sizes: 100mg, 1g. Molecular Formula: C7H13Cl2N5O, Molecular Weight: 254.12. US Biological Life Sciences. | Worldwide |
| 2-Iminobiotin | 2-Iminobiotin (Guanidinobiotin) is a biotin (vitamin H or B7) analog. 2-Iminobiotin is a reversible nitric oxide synthases inhibitor with K i s of 21.8 and 37.5μM for murine iNOS and rat n-cNOS , respectively [1]. 2-Iminobiotin superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Guanidinobiotin. CAS No. 13395-35-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-118700. | |
| 2-Iminobiotin | 2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Kis = 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively). Synonyms: Guanidinobiotin; 1H-Thieno[3,4-d]imidazole-6-pentanoicacid, 2-amino-3a,4,6,6a-tetrahydro-, (3aR,6S,6aS)-. Grades: ≥98%. CAS No. 13395-35-2. Molecular formula: C10H17N3O2S. Mole weight: 243.3. | |
| 2-Iminobiotin hydrobromide | 2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with K i s of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS , respectively [1]. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Guanidinobiotin hydrobromide. CAS No. 76985-52-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg. Product ID: HY-118700A. | |
| 2-Iminopiperidine hydrochloride | 2-Iminopiperidine hydrochloride is the hydrochloride salt of 2-Iminopiperidine, which is a potent inhibitor of human nitric oxide synthase isoform (iNOS). It is selective for iNOS and is more potent than NG-methyl-L-arginine. Synonyms: 2-Pyridinamine, 3,4,5,6-tetrahydro-, hydrochloride (1:1); 2-Pyridinamine, 3,4,5,6-tetrahydro-, monohydrochloride; Piperidine, 2-imino-, monohydrochloride; (3,4,5,6-Tetrahydropyridin-2-yl)amine monohydrochloride; 3,4,5,6-Tetrahydro-2-pyridinamine Hydrochloride. Grades: ≥95%. CAS No. 16011-96-4. Molecular formula: C5H11N2Cl. Mole weight: 134.61. | |
| 2-Methylthio Uracil | A competitive inhibitor of Nitric Oxide Synthase (NOS). Group: Biochemicals. Alternative Names: 2-(Methylthio)-4(1H)-pyrimidinone; 2-(Methylthio)-4-pyrimidinol; 2-(Methylthio)-4(1H)-pyrimidinone; 2-(Methylthio)-4(3H)-pyrimidinone; 2-(Methylthio)-4-pyrimidinol; 2-(Methylthio)-4-pyrimidinone; 2-(Methylthio)-4-pyrimidone; 2-(Methylthio)pyrimidine-4(3H)-one; 2-Methylsulfanyl-3H-pyrimidin-4-one; 2- methyl sulfanylpyrimidin-4-ol; 2-Methylthio-3H-pyrimidin-4-one; 2-Methylthio-4-hydroxypyrimidine; 2-Methylthiouracil; 4-Hydroxy-2- (methylthio) pyrimidine; NSC 125339; NSC 165518. Grades: Highly Purified. CAS No. 5751-20-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2-Naphthalene methanethiol | 2-Naphthalene methanethiol is a widely used reactant and an impurity in the synthesis of N- [3- (1, 2, 3, 6-Tetrahydro-1- methyl -d3-4-pyridinyl) -1H-indol-5-yl] -2-thiophene carboximidamide (T293452), the labeled analogue of N- [3- (1, 2, 3, 6-Tetrahydro-1- methyl -4-pyridinyl) -1H-indol-5-yl] -2-thiophene carboximidamide, a neuronal nitric oxide synthase(nNOS) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1076-67-1. Pack Sizes: 500mg, 5g. Molecular Formula: C11H10S, Molecular Weight: 174.26. US Biological Life Sciences. | Worldwide |
| (2S, 4R) -4-Azido-1, 2-pyrrolidinedicarboxyl ic Acid 1-(1,1-Dimethylethyl) 2-Methyl Ester | Used in the preparation of neuronal nitric oxide synthase inhibitors. Group: Biochemicals. Alternative Names: (2S, 4R) -4-Azido-1- (tert-butoxycarbonyl) pyrrolidine-2-carboxylic Acid Methyl Ester; (2S-trans) -4-Azido-1, 2-pyrrolidinedicarboxyl ic Acid 1-(1,1-Dimethylethyl) 2-Methyl Ester. Grades: Highly Purified. CAS No. 121147-97-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2-Thiouracil | 2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a K i value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Thiouracil. CAS No. 141-90-2. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B0503. | |
| 3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-amine | 3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-amine is the unlabeled intermediate in the synthesis of N- [3- (1, 2, 3, 6-Tetrahydro-1- methyl -d3-4-pyridinyl) -1H-indol-5-yl] -2-thiophene carboximidamide (T293450), a labeled neuronal nitric oxide synthase(nNOS) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 116480-62-7. Pack Sizes: 500mg, 5g. Molecular Formula: C14H17N3, Molecular Weight: 227.3. US Biological Life Sciences. | Worldwide |
| 3-(1-Methyl-d3-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-amine | 3-(1-Methyl-d3-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-amine is an intermediate in the synthesis of N- [3- (1, 2, 3, 6-Tetrahydro-1- methyl -d3-4-pyridinyl) -1H-indol-5-yl] -2-thiophene carboximidamide (T293452), a labeled neuronal nitric oxide synthase(nNOS) inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C14H14D3N3, Molecular Weight: 230.32. US Biological Life Sciences. | Worldwide |
| 3- (4-Chlorophenyl) -4, 5-dihydro-N'- (1-iminoethyl) -4-phenyl-N-[[4- (trifluoromethyl) phenyl]sulfonyl]-1H-pyrazole-1-carboximidamide | 3- (4-Chlorophenyl) -4, 5-dihydro-N'- (1-iminoethyl) -4-phenyl-N-[[4- (trifluoromethyl) phenyl]sulfonyl]-1H-pyrazole-1-carboximidamide, can be used in synthesis of novel dual-target compounds with antagonist/inverse agonist activity at cannabinoid receptor type 1 (CB1R) and inhibitory effect on inducible nitric oxide synthase (iNOS). Group: Biochemicals. Grades: Highly Purified. CAS No. 1610420-28-4. Pack Sizes: 10mg, 25mg. Molecular Formula: C25H21ClF3N5O2S, Molecular Weight: 547.98. US Biological Life Sciences. | Worldwide |
| 3-Aminobenzamidine Dihydrochloride | 3-Aminobenzamidine Dihydrochloride is a reactant that has been used in the synthesis of N-phenylamidines as selective inhibitors of human neuronal nitric oxide synthase. Group: Biochemicals. Grades: Highly Purified. CAS No. 37132-68-6. Pack Sizes: 500mg, 1g. Molecular Formula: C7H11Cl2N3, Molecular Weight: 208.09. US Biological Life Sciences. | Worldwide |
| 3-Bromo-7-nitroindazole | A more potent inhibitor of rat cerebellar nitric oxide synthase than 7-nitroindazole. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| (6R)-5,6,7,8-Tetrahydro-L-biopterin 2HCl | Tetrahydrobiopterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin, melatonin, dopamine, norepinephrine , epinephrine, and is a cofactor for the production of nitric oxide by the nitric oxide synthases. Chemically, its structure is that of a reduced pteridine derivative. Group: Biochemicals. Alternative Names: (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; 6R-BH4; Sapropterin; Sapropterin dihydrochloride; BioMarin T 1401, Biopten, Kuvan, SUN 0588; Shiratori SN 0588. Grades: Highly Purified. CAS No. 69056-38-8,17528-72-2. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C?H??N?O?; 2(HCl), Molecular Weight: 314.17. US Biological Life Sciences. | Worldwide |
| (6R)-Tetrahydro-L-biopterin-d3 Sulfate(Mixture of Diastereomers) | (6R)-Tetrahydro-L-biopterin-d3 Sulfate(Mixture of Diastereomers) is the labeled R-enantiomer of Tetrahydro-L-biopterin. It is a natural cofactor for phenylalanine hydroxylase, tryptophan hydroxylase, tyrosine hydroxylase, and nitric oxide synthase. An essential cofactor for the production of neurotransmitters such as catecholamines, serotonin, and nitric oxide. Increasing BH4 levels boosts sensitivity to pain. Applications: A natural cofactor for phenylalanine hydroxylase. Group: Coenzymes. CAS No. 103130-44-5 (unlabeled). Mole weight: 342.34. (6R)-Tetrahydro-L-biopterin-d3 Sulfate(Mixture of Diastereomers); 103130-44-5 (unlabeled). Cat No: COEC-090. | |
| (6R)-Tetrahydro-L-biopterin Sulfate | (6R)-Tetrahydro-L-biopterin Sulfate is a natural cofactor for tyrosine hydroxylase, phenylalanine hydroxylase, tryptophan hydroxylase, and nitric oxide synthase. It is also an essential cofactor in the the production of neurotransmitters such as catecholamines, serotonin, and nitric oxide. Applications: An essential cofactor in the the production of neurotransmitters. Group: Coenzymes. CAS No. 103130-44-5. Mole weight: 339.33. Form: Solid. (6R)-Tetrahydro-L-biopterin Sulfate; 103130-44-5. Cat No: COEC-074. | |
| 7,3',4'-Tri-O-Methylluteolin | 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 29080-58-8. Molecular formula: C18H16O6. Mole weight: 328.32. Purity: 0.99. Product ID: ACM29080588. Alfa Chemistry ISO 9001:2015 Certified. | |
| 7,8-Dihydroneopterin | 7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase ( iNOS ) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases [1]. Uses: Scientific research. Group: Natural products. CAS No. 1218-98-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-136341. | |
| 7-Nitroindazole | 7-Nitroindazole is a nitric oxide synthase inhibitor. Synonyms: 7-Nitroindazole (7-NI);1H-Indazole, 7-nitro-; NSC 72843. Grades: ≥98% by HPLC. CAS No. 2942-42-9. Molecular formula: C7H5N3O2. Mole weight: 163.14. | |
| 7-Nitroindazole | 7-Nitroindazole is a selective and BBB-penatrable inhibitor of nitric oxide synthase ( NOS ). 7-Nitroindazole can inhibit the activity of central NOS with an IC 50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole has anti-injurious and neuroprotective properties [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2942-42-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-69019. | |
| 7-Nitroindazole (7-NI) | A potent, selective brain inhibitor of mouse cerebellar Nitric Oxide Synthase. Group: Biochemicals. Alternative Names: 7-NI. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| (9β,11β,16α)-9,11-Epoxy-1,21-dihydroxy-4,16-dimethyl-19-norpregna-1,3,5(10)-trien-20-one | (9β,11β,16α)-9,11-Epoxy-1,21-dihydroxy-4,16-dimethyl-19-norpregna-1,3,5(10)-trien-20-one is the impurity of Dexamethasone, which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation, it inhibits the induction of nitric oxide synthase. Synonyms: 2-Hydroxy-1-((4bS, 5aS, 6aS, 7S, 8R, 9aS, 9bS)-4-hydroxy-1, 6a, 8-trimethyl-5a, 6, 6a, 7, 8, 9, 9a, 9b, 10, 11-decahydrocyclopenta[1, 2]phenanthro[4, 4a-b]oxiren-7-yl)ethanone; Dexamethasone Impurity; Dexamethasone Impurity S. CAS No. 916347-23-4. Molecular formula: C22H28O4. Mole weight: 356.45. | |
| Agmatine sulfate | Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Uses: Scientific research. Group: Natural products. CAS No. 2482-00-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-101238. | |
| Aminoguanidine hydrochloride | Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride. CAS No. 1937-19-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1041. | |
| Anthrarufin | An anthraquinone derivative with suppressive effects against nitric oxide (NO) synthase. Potential antimalarial agent. Used in studies as a potential competitive non-peptidic inhibitor of HIV-1 proteinase. Group: Biochemicals. Alternative Names: 1, 5-Di hydroxyanthraquinone; 1,5-Dihydroxy-9,10-anthraquinone; NSC 646570; NSC 7211. Grades: Highly Purified. CAS No. 117-12-4. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| Antibiotic A 7884 | It is an inducible nitric oxide synthase (iNOS) inhibitor produced by the strain of Streptomyces sp. AM1699. It inhibits iNOS with IC50 of 43.5 X 10-6 mol/L. Synonyms: A 7884. CAS No. 127902-60-7. Molecular formula: C37H42O14. Mole weight: 710.72. | |
| ARL 17477 dihydrochloride | The hydrochloride salt form of ARL 17477, which has been found to be a nitric oxide synthase (NOS) inhibitor and could induce apoptosis/cell death in leukemia cells. Synonyms: 2-Thiophenecarboximidamide, N-[4-[2-[[ (3-chlorophenyl) methyl]amino]ethyl]phenyl]-, hydrochloride (1:2); 2-Thiophenecarboximidamide, N-[4-[2-[[ (3-chlorophenyl) methyl]amino]ethyl]phenyl]-, dihydrochloride; ARL17477 dihydrochloride; ARL-17477 dihydrochloride; N-[4-[2-[[ (3-Chlorophenyl) methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 866914-87-6. Molecular formula: C20H20ClN3S.2HCl. Mole weight: 442.83. | |
| Asiaticoside | Antibacterial. Human collagen I synthesis inducer. Anti-wrinkle activity. Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth. Suppresses collagen expression and TGF-beta/Smad signaling by inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII. Anti-inflammatory. Anti-gastric ulcer. Mitogen-activated protein kinases (MAPKs), nuclear factor-kappaB (NF-kappaB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-alpha) and interleukin-6 (IL-6) inhibitor. Apoptosis inducer in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy. Anxiolytic. Antidepressant-like activity. Hepatoprotective effects. CYP2C19 and CYP3A4 inhibitor. Neuroprotective. Antileishmanial activity. cPLA2 and sPLA2 inhibitor. Group: Biochemicals. Alternative Names: Blastostimulina, Centelase, Emdecassol, Madecassol, Marticassol, FK1080, BRN 0078195, NSC 166062. Grades: Highly Purified. CAS No. 16830-15-2. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H78O19. US Biological Life Sciences. | Worldwide |
| Asperuloside | Asperuloside is an iridoid isolated from Hedyotis diffusa , with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase ( iNOS ), suppresses NF-κB and MAPK signaling pathways [1]. Uses: Scientific research. Group: Natural products. CAS No. 14259-45-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N1382. | |
| Asymmetric dimethylarginine | Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS) , and functions as a marker of endothelial dysfunction in a number of pathological states. Uses: Scientific research. Group: Natural products. Alternative Names: NG,NG-Dimethylarginine. CAS No. 30315-93-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-113216. | |
| BBS 4 | BBS4, inhibits the dimerization of iNOS monomers, is a potent, orally active and selective inducible nitric oxide synthase dimerization inhibitor. Uses: Inos dimmerization inbibitor. Synonyms: BBS4; BBS-4; (R)-1-(2-(1H-imidazol-1-yl)-6-methylpyrimidin-4-yl)-N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)pyrrolidine-2-carboxamide. Grades: ≥98%. CAS No. 402934-09-2. Molecular formula: C22H24N6O3. Mole weight: 420.47. | |
| BBS-4 | BBS-4 is a potent and selective inducible nitric oxide synthase (NOS2) dimerization inhibitor, with an IC 50 of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 402934-09-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12124. | |
| Benidipine hydrochloride | Benidipine hydrochloride is an orally active calcium channel antagonist. Benidipine hydrochloride can inhibit cell proliferation and apoptosis. Benidipine hydrochloride has antioxidant activity and can increase nitric oxide synthase activity and improve coronary circulation in hypertensive rats [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KW-3049. CAS No. 91599-74-5. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1448. | |
| Boc-DL-Prolinol | Boc-DL-Prolinol (CAS# 170491-63-1) is used to prepare 1,3-thiazolidin-2-imines derivatives as inhibitors of nitric oxide synthase. Synonyms: tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate; 1-Boc-(2-hydroxymethyl)pyrrolidine; N-Boc-2-pyrrolidinemethanol. CAS No. 170491-63-1. Molecular formula: C10H19NO3. Mole weight: 201.3. | |
| Boc-L-thiocitrulline tert-Butyl Ester | Boc-L-thiocitrulline tert-Butyl Ester is an analogue of L-thiocitrulline as inhibitor of the isoforms of nitric oxide synthase (NOS). Group: Biochemicals. Alternative Names: N5- (Aminothioxomethyl) -N2-[ (1, 1-dimethylethoxy) carbonyl]-L-ornithine 1,1-Dimethylethyl Ester; N2-tert-Butyloxycarbonyl-L-thiocitrulline tert-Butyl Ester. Grades: Highly Purified. CAS No. 133565-49-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BYK 191023 dihydrochloride | BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC50 = 86, 17000, 162000 nM for iNOS, nNOS and eNOS, respectively) acting in a NADPH- and time-dependent manner. BYK 191023 decreases the nitrite levels in rats, and reverses pathological hypotension in the rodent endotoxin model. Synonyms: BYK191023 Dihydrochloride; BYK-191023 Dihydrochloride; BYK 191023 Dihydrochloride; BYK191023 2HCl; BYK-191023 2HCl; BYK 191023 2HCl;; 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1216722-25-6. Molecular formula: C14H14N4O.2HCl. Mole weight: 327.21. | |
| BYK 191023 dihydrochloride | BYK 191023 is a highly selective inducible nitric-oxide synthase (iNOS) inhibitor. BYK 191023 interacts with the catalytic center of the enzyme. BYK 191023 can be used to study the in vivo and in vitro effects mediated by iNOS [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216722-25-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107584. | |
| Calpain Inhibitor II | Calpain inhibitor II is a cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). It inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Calpain inhibitor II can block nitric oxide production by interfering with transcription of the inducible nitric oxide synthase gene, which is a weak inhibitor of proteasome. It has been used to demonstrate the involvement of ubiquitin-proteasome protein degradation in various biological systems. Uses: Cysteine proteinase inhibitors. Synonyms: L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-; L-Leucinamide, N-acetyl-L-leucyl-N-[1-formyl-3-(methylthio)propyl]-, (S)-; N-Acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]-L-leucinamide; ALLM; Calp II; CI 2; SUAM 312; N-acetylleucyl-leucyl-methioninal; Ac-Leu-Leu-Met-al; N-acetyl-L-leucyl-L-leucyl-L-methioninal. Grades: ≥98%. CAS No. 110115-07-6. Molecular formula: C19H35N3O4S. Mole weight: 401.57. | |
| Cindunistat | Cindunistat is a potent and oral selective iNOS inhibitor, potentially useful in patients with symptomatic osteoarthritis of the knee. Uses: Nitric oxide synthase type ii inhibitor. Synonyms: SC-84250; SC 84250; SC84250; SD-6010; SD 6010; SD6010; S-(2-(Acetimidoylamino)ethyl)-2-methyl-L-cysteine. Grades: ≥98%. CAS No. 364067-22-1. Molecular formula: C8H17N3O2S. Mole weight: 219.30. | |
| Cindunistat hydrochloride maleate | Cindunistat is a selective Nitric oxide synthase (iNOS) type II inhibitor. It is potentially useful in patients with symptomatic osteoarthritis of the knee. But in Feb 2012, Phase-II/III for Osteoarthritis was discontinued. Uses: Osteoarthritis. Synonyms: PHA-728669F; PHA 728669F; PHA728669F; SD-6010; SD 6010; SD6010 PF-00572986; PF00572986; PF 00572986; PF-572986; PF572986; PF 572986; PHA-84250; PHA84250; PHA 84250; SC-084250; SC 084250; SC084250; Cindunistat. cindunistat hydrochloride maleate;(R,Z)-2-amino-3-((2-((1-aminoethylidene)amino)ethyl)thio)-2-methylpropanoic acid compound with maleic acid (2:1) hydrochloride. Grades: 98%. CAS No. 753491-31-5. Molecular formula: C20H39ClN6O8S2. Mole weight: 591.15. | |
| Citropin-1.1 | Citropin-1.1 is isolated from Litoria citropa. It has bacteriostatic action for Gram-positive bacteria. Citropin-1.1 strongly inhibits the formation of NO by neuronal nitric oxide synthase (nNOS) at micromolar concentrations. It acts by a non-competitive mechanism, probably by binding to calcium/calmodulin and as a consequence blocking calmodulin attachment to nNOS. Molecular formula: C76H131N19O19. Mole weight: 1614.96. | |
| Coenzyme Q10 | Coenzyme Q10 is an electron transport chain component of the mitochondria, which assists proton and electron transfer across the inner mitochondrial membrane. Studies indicate that Coenzyme Q10 can protect human endothelial cells from oxidative damage by modulating the nitric oxide pathway. In addition, Coenzyme Q10 inhibits LDL oxidation, a major process in the development of atherosclerosis. Coenzyme Q10 is known to suppress the down regulation of NOS3 (endothelial nitric oxide synthase, eNOS) and up-regulation of NOS2 (inducible nitric oxide synthase, iNOS). As a result of its ability to bind Ca2+, Coenzyme Q10 can transport this cation across artificial biomimetic membranes. Applications: A mitochondrial transporter chain component. Group: Coenzymes. Synonyms: CoQ10; Ubidecarenone; Ubiquinone-10; Q-10. CAS No. 303-98-0. Purity: ≥98%. Mole weight: 863.34. Appearance: Powder. Form: Solid. CoQ10; Ubidecarenone; Ubiquinone-10; Q-10; Coenzyme Q10; 303-98-0. Cat No: COEC-013. | |
| C-Peptide 1 (rat) | C-Peptide 1 (rat) specifically binds to G-protein-coupled membrane receptors in the nanomolar concentration range, and subsequently activates Ca2+-dependent intracellular signaling pathways. This leads to a stimulation of the activity of both Na+-K+-ATPase, and endothelial nitric oxide synthase. Administration of C-peptide to streptozotocin induced diabetic rats elicited a substantial increase in whole-body glucose turnover. Synonyms: Insulin 1 Precursor (57-87) (rat); H-Glu-Val-Glu-Asp-Pro-Gln-Val-Pro-Gln-Leu-Glu-Leu-Gly-Gly-Gly-Pro-Glu-Ala-Gly-Asp-Leu-Gln-Thr-Leu-Ala-Leu-Glu-Val-Ala-Arg-Gln-OH; L-alpha-glutamyl-L-valyl-L-alpha-glutamyl-L-alpha-aspartyl-L-prolyl-L-glutaminyl-L-valyl-L-prolyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-leucyl-glycyl-glycyl-glycyl-L-prolyl-L-alpha-glutamyl-L-alanyl-glycyl-L-alpha-aspartyl-L-leucyl-L-glutaminyl-L-threonyl-L-leucyl-L-alanyl-L-leucyl-L-alpha-glutamyl-L-valyl-L-alanyl-L-arginyl-L-glutamine. Grades: ≥95%. CAS No. 41475-27-8. Molecular formula: C140H228N38O51. Mole weight: 3259.53. | |
| Curcumin-d6 | Labeled Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Group: Biochemicals. Alternative Names: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione-d6; C Yellow 15-d6; C.I. 75300-d6; Curcuma-d6; Curcumine-d6; Diferuloylmethane-d6; Haidr-d6; Halad-d6; Haldar-d6; Ukon-d6. Grades: Highly Purified. CAS No. 1246833-26-0. Pack Sizes: 5mg. Molecular Formula: C21H14D6O6, Molecular Weight: 374.42. US Biological Life Sciences. | Worldwide |
| Cysteine, S-Nitrosylated (SNO-Cys) (BSA) | Nitric oxide (NO), generated by cell type-specific NO- synthase (NOS) isoforms, is a freely diffusible intercellular messenger that functions in target cells in NOS-dependent signaling. S-nitrosylation of cysteine thiols in proteins by the highly labile NO radical has been identified as an important effector of NO-related bioactivity both in NOS- containing cells and intercellular signaling. Most cells contain low levels of nitrosylated proteins that are thought to be regulated by S-nitrosylation and denitrosylation. S-nitrosylation of proteins serves as a ubiquitous post- translational modification that dynamically regulates a broad functional spectrum of proteins. The majority of these proteins are regulated by S-nitrosylation on a single critical cysteine residue within an acidic/basic or hydrophobic structural motif that may also be subject to oxygen- or glutathione-dependent modification. NO- sensitive ion channels including the cardiac and skeletal muscle ryanodine receptor (RyR1 Group: Biochemicals. Grades: Purified. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Dexamethasone-d5 | A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase. Group: Biochemicals. Alternative Names: (11 β,16α)-9-Fluoro-11,17,21-trihydroxy-16-pregna-1,4-diene-3,20-dione-d5; 16α-Methyl-9α-fluoroprednisolone-d5; Aeroseb-Dex-d5; Corson-d5; Cortisumman-d5; Decacort-d5; Decaderm-d5; Decadron-d5; Decalix-d5; Decasone-d5; Dekacort-d5. Grades: Highly Purified. CAS No. 358731-91-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Dexamethasone Hemisuccinate | Dexamethasone Hemisuccinate is a derivative of Dexamethasone (D298800); a glucocorticoid used as an anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Dexamethasone also inhibits the induction of nitric oxide synthase. Group: Biochemicals. Grades: Highly Purified. CAS No. 3800-86-0. Pack Sizes: 100mg, 1g. Molecular Formula: C26H33FO8, Molecular Weight: 492.53. US Biological Life Sciences. | Worldwide |
| Dexamethasone Sodium Phosphate Bisulfate Adduct | Dexamethasone Sodium Phosphate Bisulfate Adduct is a product of additions of sodium phosphate and sodium bisulfate to Dexamethasone. Dexamethasone is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase. Group: Biochemicals. Alternative Names: (11beta,16alpha)-9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxo-21-(phosphonooxy)-pregn-4-ene-1-sulfonic Acid Disodium Salt,9-Fluoro-11beta,17,21-trihydroxy-16alpha-methyl-3,20-dioxo-pregn-4-ene-1-sulfonic Acid 21-(dihydrogen phosphate) Disodium Salt. Grades: Highly Purified. CAS No. 39005-10-2. Pack Sizes: 5mg. Molecular Formula: C22H30FNa2O11PS. US Biological Life Sciences. | Worldwide |
| Di-(tert-Butyl-dimethylsilyl) Curcumin | Protected Curcumin. A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. Group: Biochemicals. Alternative Names: (1E, 4Z, 6E) -1, 7-Bis[4-[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]-3-methoxyphenyl]-5-hydroxy-1, 4, 6-heptatrien-3-one. Grades: Highly Purified. CAS No. 1134639-23-8. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| D-NAME hydrochloride | N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME). D-NAME was initially thought to be inactive and was often used as a negative control for L-NAME. Synonyms: D-NG-Nitroarginine methyl ester; N(G)-Nitro-D-Arginine methyl ester; D-NAME, NG-Nitro-D-arginine methyl ester hydrochloride. Grades: ≥95%. CAS No. 50912-92-0. Molecular formula: C7H15N5O4·HCl. Mole weight: 269.7. | |
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