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| Product | Description | |
|---|---|---|
| 1-Pyrrolidinecarbodithio ic Acid Ammonium Salt | 1-Pyrrolidinecarbodithio ic Acid induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. It also prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA. Group: Biochemicals. Grades: Highly Purified. CAS No. 5108-96-3. Pack Sizes: 15g, 100g. Molecular Formula: C5H12N2S2. US Biological Life Sciences. |  Worldwide |
| 5-Methoxyindole-3-acetonitrile-d2 | 5-Methoxyindole-3-acetonitrile-d2 is a labelled analogue of 5-Methoxyindole-3-acetonitrile (M262818), which is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors. 5-Methoxyindole-3-acetonitrile-d2 is also an intermediate in synthesizing Melatonin-d4 (M215002), a hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation / metastasis of breast cancer cells by inhibiting estrogen receptor action. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C11H8D2N2O. US Biological Life Sciences. | Worldwide |
| 6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride | 6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride is a synthetic reduced pterin cofactor for nitric oxide synthetase, and for phenylalanine, tyrosine, and tryptophan hydroxylases; less active than the natural cofactor, tetrahydrobiopterin (BH4). Applications: A synthetic reduced pterin cofactor. Group: Coenzymes. Synonyms: DMPH4; 2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine. CAS No. 945-43-7. Purity: ≥95%. Mole weight: 231.68. Appearance: Powder. Form: Solid. DMPH4; 2-Amino-6,7-dimethyl-4-hydroxy-5,6,7,8-tetrahydropteridine; 6,7-Dimethyl-5,6,7,8-tetrahydropterine hydrochloride; 945-43-7. Cat No: COEC-094. |  |
| β-Nicotinamide adenine dinucleotide phosphate, reduced tetra(cyclohexylammonium) salt | β-Nicotinamide adenine dinucleotide 2'-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2'-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) that work together in a wide range of enzyme catalyzed oxidation reduction reactions. One of the pairs actions is that it facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is also used in a variety of antioxidation mechanisms where it protects against reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP). Applications: An electron donor and a cofactor for nitric oxide synthetase. Group: Coenzymes. Synonyms: β-NADPH; NADPH; TPNH. CAS No. 100929-71-3. Purity: ≥95%. Mole weight: 1142.12. Appearance: Powder. Form: Solid. β-NADPH; NADPH; TPNH; β-Nicotinamide adenine dinucleotide phosphate, reduced tetra(cyclohexylammonium) salt; 100929-71-3. Cat No: COEC-079. | |
| L-NAME HCl | L-NAME is a nonselective inhibitor of nitric oxide synthetases (NOS) for nNOS (bovine), eNOS (human), and iNOS (murine), with Ki of 15 nM, 39 nM and 4.4 μM, respectively. Synonyms: Nω-Nitro-L-arginine methyl ester hydrochloride. Grades: >98%. CAS No. 51298-62-5. Molecular formula: C7H15N5O4.HCl. Mole weight: 269.69. |  |
| Melatonin-d4 (N-Acetyl-5-methoxytryptamine-a,a-b,b-d4) | Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase. Group: Biochemicals. Alternative Names: N-Acetyl-5-methoxytryptamine-a,a-b,b-d4. Grades: Highly Purified. CAS No. 66521-38-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Melatonin Methoxy-d3 | Melatonin Methoxy-d3 is the isotope labelled analog of Melatonin (M215000). Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation / metastasis of breast cancer cells by inhibiting estrogen receptor action. Group: Biochemicals. Grades: Highly Purified. CAS No. 60418-64-6. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C13H13D3N2O2, Molecular Weight: 235.3. US Biological Life Sciences. | Worldwide |
| Nitric Oxide Synthase, Inducible from mouse, Recombinant | Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, is involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free ...DPH); Inducible Nitric Oxide Synthase; NOS II; iNOS; macNOS; EC 1.14.13.39; NOSs. Enzyme Commission Number: EC 1.14.13.39. CAS No. 125978-95-2. NOSs. Mole weight: mol wt 130 kDa (homodimer); mol wt 130 kDa (subunit, homodimer). Storage: -70°C. Form: buffered aqueous solution; Solution in 50 mM HEPES, pH 7.4, with 10% glycerol, 8 μM tetrahydrobiopterin. Source: E. coli. Species: Mouse. nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase; nitric-oxide synthase (NADPH); Inducible Nitric Oxide Synthase; NOS II; iNOS; macNOS; EC 1.14.13.39; NOSs. Cat No: NATE-0489. | |
| nitric-oxide synthase (NADPH) | Binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin. This eukaryotic enzyme, which is found in plants and animals, consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain. Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. May produce superoxide under certain conditions. cf. EC 1.14.13.165, nitric-oxide synthase [NAD(P)H dependent]. Group: Enzymes. Synonyms: nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase. Enzyme Commission Number: EC 1.14.13.39. CAS No. 125978-95-2. NOSs. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0846; nitric-oxide synthase (NADPH); EC 1.14.13.39; 125978-95-2; nitric oxide synthetase; endothelium-derived relaxation factor-forming enzyme; endothelium-derived relaxing factor synthase; NO synthase; NADPH-diaphorase. Cat No: EXWM-0846. | |
| nitric-oxide synthase [NAD(P)H] | Binds heme (iron protoporphyrin IX) and tetrahydrobiopterin. Most of the bacterial and archaeal enzymes consist of only an oxidase domain and function together with bacterial ferredoxins. The enzyme from the Δ-proteobacterium Sorangium cellulosum also includes a reductase domain that binds FAD, FMN and a [2Fe-2S] cluster. The similar enzymes from plants and animals use only NADPH as acceptor (cf. EC 1.14.13.39). Group: Enzymes. Synonyms: nitric oxide synthetase; NO synthase. Enzyme Commission Number: EC 1.14.13.165. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0764; nitric-oxide synthase [NAD(P)H]; EC 1.14.13.165; nitric oxide synthetase; NO synthase. Cat No: EXWM-0764. | |
| N,N-Diethylaminoethyl 2,2-diphenylvalerate hydrochloride (SKF-525A HCl) | Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis. Group: Biochemicals. Alternative Names: α-Phenyl-α-Propylbenzeneacetic Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2,2-Diphenylvaleric Acid 2-(Diethylamino)ethyl Ester Hydrochloride; 2-(Diethylamino)ethyl 2,2-Diphenylvalerate Hydrochloride; Proadifen Hydrochloride; RP 5171; SKF 525; U 5446. Grades: Highly Purified. CAS No. 62-68-0. Pack Sizes: 250mg, 500mg, 1g, 5g. Molecular Formula: C??H??ClNO?, Molecular Weight: 389.96. US Biological Life Sciences. | Worldwide |
| S-Ethyl N-Phenylisothiourea | A potent inhibitor of the human neuronal constitutive and inducible isoforms of nitric oxide synthetase. It also binds competitively with L-Arginine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| SKF-525A, Hydrochloride (Proadifen, HCl, a-Phenyl-a-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl) | Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis. Group: Biochemicals. Alternative Names: Proadifen, HCl, a-Phenyl-a-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl. Grades: Highly Purified. Pack Sizes: 2g. US Biological Life Sciences. | Worldwide |
| S-Methylisothiourea hemisulfate salt | (S)-Methylisothiourea sulfate is a more potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS). The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively. Synonyms: methyl carbamimidothioate;sulfuric acid. Grades: ≥98% (HPLC). CAS No. 867-44-7. Molecular formula: C4H14N4O4S3. Mole weight: 139.19. | |
| Spermidine Free Base | Biogenic polyamine formed from putrescine, a precursor of spermine; essential for normal and neoplastic tissue growth, promoting T4 polynucleotide kinase. Acts as a neuronal nitric oxide synthetase inhibitor. Used in cancer research and cell culture media. Group: Biochemicals. Alternative Names: N1-(3-Aminopropyl)-1,4-butanediamine; N-(3-Aminopropyl)-1,4-butanediamine; 1,5,10-Triazadecane; 1,8-Diamino-4-azaoctane; 4-Azaoctane-1,8-diamine; N-(3-Aminopropyl)-1,4-diaminobutane; N-(3-Aminopropyl)-4-aminobutylamine; N-(4-Aminobutyl)-1,3-diaminopropane; Spermidin. Grades: Molecular Biology Grade. CAS No. 124-20-9. Pack Sizes: 1g, 5g, 25g. Molecular Formula: C?H??N?, Molecular Weight: 145.25. US Biological Life Sciences. | Worldwide |
| ZM323881 | ZM323881 inhibits VEGF-A, EGF and bFEF induced HUVEC cell proliferation with IC50 of 8 nM, 1.9 μM and 1.6 μM, respectively. ZM323881 (10 nM) abolishes VEGF-A-mediated increases in vascular permeability in perfused mesenteric microvessels in male leopard. ZM323881 (10 nM) blocks the increase in intensity of the VEGF-R2 band in the lung of male leopard frogs. M323881 (1 μM) blocks activation of extracellular regulated-kinase, p38, Akt, and endothelial nitric oxide synthetase (eNOS) by VEGF, but did not inhibit p38 activation by the VEGFR-1-specific ligand, placental growth factor (PIGF) in human aortic endothelial cells (HAECs). ZM323881 (1 μM) also perturbes VEGF-induced membrane extension, cell migration, and tube formation by HAECs. ZM323881 (1 μM) reverses VEGF-stimulated phosphorylation of CrkII and its Src homology 2 (SH2)-binding protein p130Cas, which are known to play a pivotal role in regulating endothelial cell migration. ZM323881 (10 nM) completely blocks VEGF-induced VEGF promoter activity in SCC-9 cells. ZM323881 (10 nM) blocks VEGF stimulated Hif-1α protein accumulation in SCC-9 cells. ZM323881 (10 nM) blocks VEGF-induced Rac1 activation at 30 min in HUVECs. ZM323881 (10 nM) prevents Vav2 tyrosine phosphorylation in response to VEGF in HUVECs. Synonyms: ZM 323881; ZM-323881. Grades: >98%. CAS No. 193001-14-8. Molecular formula: C22H18FN3O2. Mole weight: 375.4. | |
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