Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Nociceptin | Nociceptin, a 17 amino acid neuropeptide involved in a variety of biological systems, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic. Synonyms: Orphanin FQ; H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH; L-phenylalanyl-glycyl-glycyl-L-phenylalanyl-L-threonyl-glycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-asparagyl-L-glutamine; Nociceptin/orphanin FQ; Nociceptin (1-17); Orphanin FQ (rat, human, swine). Grade: ≥98% by HPLC. CAS No. 170713-75-4. Molecular formula: C79H129N27O22. Mole weight: 1809.04. |  |
| Nociceptin | Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic. Uses: Scientific research. Group: Peptides. Alternative Names: Orphanin FQ. CAS No. 170713-75-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0183. |  |
| Nociceptin (1-13), amide | Nociceptin (1-13), amide is an effective ORL1 (OP4) receptor agonist. Synonyms: Orphanin FQ (1-13) amide; N/OFQ-(1-13)-NH2; H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2; L-phenylalanyl-glycyl-glycyl-L-phenylalanyl-L-threonyl-glycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysinamide; Demethyl-AMPA; nociceptin/orphanin FQ-(1-13)-NH2. Grade: ≥95%. CAS No. 178064-02-3. Molecular formula: C61H100N22O15. Mole weight: 1381.59. | |
| Nociceptin (1-13) amide TFA | Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes. Synonyms: H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2.TFA; L-phenylalanyl-glycyl-glycyl-L-phenylalanyl-L-threonyl-glycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysinamide trifluoroacetic acid. Grade: 99%. Molecular formula: C63H101F3N22O17. Mole weight: 1495.61. | |
| Nociceptin (1-7) | Nociceptin (1-7), the N-terminal fragment of Nociceptin, antagonizes nociceptin-induced hyperalgesia, with no effect on nociceptin-induced analgesia. Synonyms: L-Phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanine; 1-7-Orphanin FQ (pig); (2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoic acid. CAS No. 178249-42-8. Molecular formula: C31H41N7O9. Mole weight: 655.7. | |
| Nociceptin (1-7) acetate | Nociceptin (1-7) acetate is a potent opioid receptor-like 1 (ORL1) receptor agonist, which in combination with nociceptin can reduce hyperalgesia and has antinociceptive activity. Synonyms: L-Alanine, N-[N-[N-[N-[N-(N-L-phenylalanylglycyl)glycyl]-L-phenylalanyl]-L-threonyl]glycyl]-, acetate; L-Phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanine acetate; 1-7-Orphanin FQ (pig) acetate; H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-OH.CH3CO2H. Grade: ≥95%. Molecular formula: C31H41N7O9. Mole weight: 655.70. | |
| Nociceptin - CAS 170713-75-4 | Endogenous ligand for the opioid-like G-protein coupled receptor, ORL1 (Opioid Receptor-Like 1). Group: Fluorescence/luminescence spectroscopy. |  |
| [Arg14, Lys15]Nociceptin | [Arg14, Lys15]Nociceptin. Group: Biochemicals. Grades: Purified. CAS No. 236098-40-1. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| [Arg14,Lys15]Nociceptin | [Arg14,Lys15]Nociceptin behaves as a highly potent agonist of the OP(4) receptor (EC50 = 1 nM) and is able to produce long-lasting effects in vivo, compared with the natural ligand NC. It exhibits > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Synonyms: H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Arg-Lys-Asn-Gln-OH; [Arg(14),Lys(15)]NC. CAS No. 236098-40-1. Molecular formula: C82H137N31O22. Mole weight: 1909.18. | |
| [Arg14,Lys15]Nociceptin TFA | [Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist with an EC50 of 1 nM. It displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively. Molecular formula: C84H138F3N31O24. Mole weight: 2023.18. | |
| [Nphe1]Nociceptin(1-13)NH2 | [Nphe1]Nociceptin(1-13)NH2 acts as the first truly selective and competitive nociceptin receptor antagonist and is devoid of any residual agonist activity. It binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo. Synonyms: (S,Z)-6-amino-N-((S,Z)-1-(((S,Z)-1-(((S,Z)-1-(((S)-6-amino-1-hydroxy-1-iminohexan-2-yl)imino)-5-guanidino-1-hydroxypentan-2-yl)imino)-1-hydroxypropan-2-yl)imino)-1,3-dihydroxypropan-2-yl)-2-((Z)-((4Z,7Z,10Z,12S,13Z,15S,16Z,19Z,21S,22Z,24S)-12-benzyl-24-(3. CAS No. 267234-08-2. Molecular formula: C61H100N22O15. Mole weight: 1381.6. | |
| [Nphe1]Nociceptin(1-13)NH2 | [Nphe1]Nociceptin(1-13)NH2. Group: Biochemicals. Grades: Purified. CAS No. 267234-08-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| [Nphe1]Nociceptin(1-13)NH2 TFA | [Nphe1]Nociceptin(1-13)NH2 is a novel nociceptin/orphanin FQ (NC) endogenous ligand. It is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2 binds selectively to recombinant nociceptin receptors (pKi = 8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2 = 6.0). Molecular formula: C63H101F3N22O17. Mole weight: 1495.61. | |
| [(pF)Phe4]Nociceptin(1-13)NH2 | [(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80), with 8000-fold selectivity over δ, κ, and μ opioid receptors. Synonyms: (S,Z)-6-amino-N-((S,Z)-1-(((S,Z)-1-(((S,Z)-1-(((S)-6-amino-1-hydroxy-1-iminohexan-2-yl)imino)-5-guanidino-1-hydroxypentan-2-yl)imino)-1-hydroxypropan-2-yl)imino)-1,3-dihydroxypropan-2-yl)-2-((Z)-((2S,3Z,5S,6Z,9Z,11S,12Z,14S,15Z,18Z,21Z,23S)-23-amino-2-(3-. CAS No. 380620-88-2. Molecular formula: C61H99FN22O15. Mole weight: 1399.6. | |
| [(pF)Phe4]Nociceptin(1-13)NH2 acetate | [(pF)Phe4]Nociceptin(1-13)NH2 acetate is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide. It has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo. Grade: 98%. Molecular formula: C63H103FN22O17. Mole weight: 1459.63. | |
| [(pF)Phe4]Nociceptin(1-13)NH2 TFA | [(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50=9.80). It displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo. Molecular formula: C63H100F4N22O17. Mole weight: 1513.60. | |
| [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 | [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 is the first selective antagonist to prevent the binding of the endogenous ligand orphanin FQ?/Nociceptin (OFQ?/N) at the orphan opioid-like receptor, demonstrated both in vitro and in vivo. It is selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively). Synonyms: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide; N-[(2S)-2-Amino-3-phenylpropyl]glycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysinamide; N-[(2S)-2-Amino-3-phenylpropyl]-13-L-lysinamide-2-13-orphanin FQ (swine). CAS No. 213130-17-7. Molecular formula: C61H102N22O14. Mole weight: 1367.6. | |
| Ac-RYYRIK-NH2 acetate | Ac-RYYRIK-NH2 acetate is a potent and partial agonist on ORL1 transfected in CHO cells (Kd = 1.5 nM). Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain. Synonyms: Ac-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2.CH3CO2H; N-acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-isoleucyl-L-lysinamide acetic acid. Grade: ≥95%. CAS No. 2863659-08-7. Molecular formula: C46H74N14O11. Mole weight: 999.17. | |
| Ac-RYYRIK-NH2 TFA | Ac-RYYRIK-NH2 TFA is a potent and partial agonist on ORL1 transfected in CHO cells (Kd = 1.5 nM). Ac-RYYRIK-NH2 is a specific antagonist for the activation of G protein and competitively antagonizes the stimulation of [35S]-GTPgS binding to G proteins by nociceptin/orphanin FQ (noc/OFQ) in membranes and sections of rat brain. Grade: 98%. Molecular formula: C46H71F3N14O11. Mole weight: 1053.13. | |
| Ac-RYYRWK-NH2 | Ac-RYYRWK-NH, a hexapeptide, is a partial agonist of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptorr (Ki = 0.71 nM), which exhibits selectivity over μ, δ and κ opioid receptors (IC50 > 4000 nM). Synonyms: L-Lysinamide, N2-acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-tryptophyl-; N2-Acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-tryptophyl-L-lysinamide; Ac-Arg-Tyr-Tyr-Arg-Trp-Lys-NH2; N-acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-tryptophyl-L-lysinamide. Grade: ≥95%. CAS No. 200959-47-3. Molecular formula: C49H69N15O9. Mole weight: 1012.17. | |
| Ac-RYYRWK-NH2 acetate | Ac-RYYRWK-NH2 acetate is a potent and selective partial agonist of the nociceptin receptor (NOP), which is the endogenous ORL1 receptor agonist. Synonyms: Ac-Arg-Tyr-Tyr-Arg-Trp-Lys-NH2.CH3CO2H; N-acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-tryptophyl-L-lysinamide acetic acid. Grade: ≥95%. CAS No. 2863657-54-7. Molecular formula: C51H73N15O11. Mole weight: 1072.22. | |
| Ac-RYYRWK-NH2 TFA | Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP). Synonyms: Ac-Arg-Tyr-Tyr-Arg-Trp-Lys-NH2.TFA; N-acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-tryptophyl-L-lysinamide trifluoroacetic acid; L-Lysinamide, N2-acetyl-L-arginyl-L-tyrosyl-L-tyrosyl-L-arginyl-L-tryptophyl-, mono(trifluoroacetate) (salt). Grade: ≥95%. CAS No. 408305-09-9. Molecular formula: C51H70F3N15O11. Mole weight: 1126.19. | |
| AT-121 | T-121 is a dual μ-opioid and nociceptin receptor partial agonist (Kis = 16.49 and 3.67 nM, respectively). AT-121 can decrease capsaicin-induced thermal allodynia without increasing scratching activity in rhesus monkeys in a dose-dependent manner. Synonyms: AT-121; 2099681-31-7; N-[2-[1,2-dihydro-1'-[cis-4-(1-methylethyl)cyclohexyl]-3-oxospiro[isoquinoline-4(3H),4'-piperidin]-2-yl]ethyl]-sulfamide; 3-oxo-1'-(4-propan-2-ylcyclohexyl)-2-[2-(sulfamoylamino)ethyl]spiro[1H-isoquinoline-4,4'-piperidine]; SCHEMBL18920959; SCHEMBL20230173; SCHEMBL21179793; DTXSID801336428; GLXC-25688; EX-A8003; AKOS040755934; HY-112692; CS-0062666; Q56448036; N-{2-[1'-(cis-4-Isopropylcyclohexyl)-3-oxo-1H-spiro[isoquinoline-4,4'-piperidin]-2(3H)-yl]ethyl}sulfuric diamide. Grade: ≥95%. CAS No. 2099681-31-7. Molecular formula: C24H38N4O3S. Mole weight: 462.65. | |
| BPR1M97 | BPR1M97 is a dual-acting mu-opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist (Kis: 1.8 and 4.2 nM) with blood-brain barrier penetration. It produces potent antinociceptive effects. Synonyms: 3,4-Dichloro-N-[(1,2,3,4-tetrahydro-2-methyl-1-isoquinolinyl)methyl]benzamide. Grade: 98%. CAS No. 2059904-66-2. Molecular formula: C18H18Cl2N2O. Mole weight: 349.25. | |
| (±)-J 113397 | (+/-)-J 113397 has been found to be a NOP receptor antagonist and could restrain nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test. Synonyms: (±)-J 113397; (±)-J113397; (±)-J-113397; (±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one. Grade: ≥98% by HPLC. CAS No. 217461-40-0. Molecular formula: C24H37N3O2. Mole weight: 399.57. | |
| (±)-J-113397 | (±)-J-113397 is a potent and selective non-peptidyl ORL1 receptor antagonist with a K i of 1.8 nM for cloned human ORL1. J-113397 inhibited nociceptin/orphanin FQ-stimulated GTPγS binding to CHO cells expressing ORL1 with an IC 50 value of 5.3 nM. J-113397 can be used for researching the physiological roles of nociceptin/orphanin FQ [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 217461-40-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107721. | |
| LY2940094 | LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BTRX-246040. CAS No. 1307245-86-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-114452. | |
| MCOPPB trihydrochloride | MCOPPB trihydrochloride is a nociceptin receptor agonist with pKi of 10. Uses: Scientific research. Group: Signaling pathways. CAS No. 1108147-88-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13101. | |
| MCOPPB Trihydrochloride | A potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. It is the most potent, non-peptide NOP full agonists in vitro and a potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis. Group: Biochemicals. Alternative Names: 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-(3R)-3-piperidinyl-1H-benzimidazole TriHydrochloride; PF-01678059. Grades: Highly Purified. CAS No. 1108147-88-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Orphanin FQ (1-11) | Orphanin FQ is a NOP agonist and it shows analgesic properties. Synonyms: H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-OH; L-phenylalanyl-glycyl-glycyl-L-phenylalanyl-L-threonyl-glycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanine; 1-11-Orphanin FQ (pig); 1-11-Orphanin FQ (swine); Nociceptin (1-11). Grade: ≥98% by HPLC. CAS No. 178249-41-7. Molecular formula: C49H75N15O14. Mole weight: 1098.20. | |
| Orphanin FQ (1-11) acetate | Orphanin FQ (1-11) acetate, the peptide fragment containing amino acids 1-11 of Nociceptin, is a potent agonist of the ORL1/KOR-3 receptor with a Ki of 55 nM. Orphanin FQ is a NOP agonist with analgesic effects. Synonyms: H-Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-OH.CH3CO2H; L-phenylalanyl-glycyl-glycyl-L-phenylalanyl-L-threonyl-glycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanine acetate; 1-11-Orphanin FQ (pig) acetate; 1-11-Orphanin FQ (swine) acetate. Grade: ≥95%. Molecular formula: C51H79N15O16. Mole weight: 1158.26. | |
| SB-612111 hydrochloride | SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 hydrochloride exhibits selectivity for ?-,??- and??-receptors with Ki values of?57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model[1].. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18618A. | |
| SCH 221510 | SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC 50 of 12 nM and K i of 0.3 nM. SCH 221510 shows an anxiolytic-like effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 322473-89-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107722. | |
| UFP-101 | UFP-101 is a potent, selective and competitive silent antagonist for the NOP opioid receptor, displaying > 3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 exhibits antinociceptive activity by opposing the action of nociceptin in vivo. Synonyms: UFP-101; UFP 101; UFP101. Grade: >98%. CAS No. 849024-68-6. Molecular formula: C82H138N32O21. Mole weight: 1908.19. | |
Our database is helping our users find suppliers everyday.
