Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
2,3-DCPE hydrochloride is a compound that selectively induces apoptosis and downregulates Bcl-XL protein expression in multiple human cancer cells versus normal cells in vitro. It also specifically cleaves caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase in cancer cells. Uses: Antitumor agent. Synonyms: 2,3-DCPE HCl; 2-((3-(2,3-Dichlorophenoxy)propyl)amino)ethan-1-ol hydrochloride. Grades: ≥99% by HPLC. CAS No. 1009555-55-8. Molecular formula: C11H16Cl3NO2. Mole weight: 300.61.
25-Hydroxy Vitamin D3 3, 3- (4-Maleimidopropanamide) propyl Ether is an analog of Vitamin D3 (V676045), a vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. Occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C37H56N2O5, Molecular Weight: 608.85. US Biological Life Sciences.
3- (4-Maleimidoacetamido) propyl-25-Hydroxy-Vitamin D3 is a derivative of Vitamin D3, the vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity. It occurs in and is isolated from fish liver oils. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. It modulates the proliferation and differentiation of both normal and cancer cells. It also has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C36H54N2O5, Molecular Weight: 594.82. US Biological Life Sciences.
Worldwide
CEP-7055
CEP-18770 is An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB. Synonyms: CEP 7055; CEP7055; 3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5H-indeno[2,1-a]pyrrolo[4,3-c]carbazol-12-yl)propyl 2-dimethylaminoacetate. CAS No. 402857-58-3. Molecular formula: C32H35N3O4. Mole weight: 525.65.
CTA056
CTA056 is a potent and selective ITK inhibitor (interleukin-2-inducible T-cell kinase inhibitor). ITK is a member of the Btk (Bruton's tyrosine kinase) family of tyrosine kinases, plays an important role in normal T-cell functions and in the pathophysiology of both autoimmune diseases and T-cell malignancies. CTA056 exhibits the highest inhibitory effects toward Itk, followed by Btk and endothelial and epithelial tyrosine kinase. Among the 41 cancer cell lines analyzed, CTA056 selectively targets acute lymphoblastic T-cell leukemia and cutaneous T-cell lymphoma. CTA056 may be potential therapeutic agent for the treatment of T-cell leukemia and lymphoma. Synonyms: CTA-056; CTA 056; 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one. Grades: 98%. CAS No. 1265822-30-7. Molecular formula: C35H34N6O. Mole weight: 554.69.
Glycerol for Injection. Synonyms: Glycerin(USP); Concentrated Glycerin(JP); glycerolum(PhEur). CAS No. 56-81-5. Product ID: PE-0636. Molecular formula: C3H8O3. Mole weight: 92.09. Category: Solvent; Suspending Agents. Product Keywords: Excipients for Liquid Dosage Form; Suspending Agents; PE-0636; Glycerol for Injection; Solvent; Suspending Agents; C3H8O3; 56-81-5. UNII: PDC6A3C0OX. Chemical Name: 1, 2, 3-Propanetriol; Propane-1, 2, 3-triol. Grade: Pharmceutical Excipients. Administration route: Absorbent; Injection; Nasal and ocular; Oral; Ear, rectum, local, transdermal, vaginal. Dosage Form: Absorbent; Injection; Nasal and ocular preparations; Oral capsules; A solution; Suspension agent; Tablets; Ear, rectum, local, transdermal, vaginal administration preparations. Stability and Storage Conditions: Glycerin is hygroscopic. Under normal storage conditions, pure glycerol is not easily oxidized by air, but when heated, it degrades and generates toxic acrolein. Glycerol is chemically stable with the mixture of water, ethanol and propylene glycol. Glycerol may crystallize if stored at low temperature, and the crystals will not melt until above 20°C. Glycerin should be stored in a cool, dry place in an airtight container. Source and Preparation: Glycerol is mainly produced from oils and fats as a by-product in the production of soap and fatty acids, or from natural products such as beetroot molasses fermented in
HDAC3 Inhibitor
HDAC3 inhibitor is an allosteric inhibitor of histone deacetylase 3 (HDAC3; Ki = 0.16 nM, IC50s = 0.95 nM). HDAC3 inhibitors increase histone acetylation and restore normal transcriptional patterns. Treatment with inhibitors primarily targeting HDAC3, including some with additional activity on HDAC1, led to improvement in motor function and working memory in N-terminal transgenic HD mice. Synonyms: Histone Deacetylase 3 Inhibitor; (E) -3-Phenyl-N-[[4- (propylaminocarbamoyl) phenyl]methyl]prop-2-enamide. Grades: ≥98%. CAS No. 2044701-99-5. Molecular formula: C20H23N3O2. Mole weight: 337.4.
LY 156735
This active molecular is high affinity nonselective melatonin receptors MT1 and MT2 agonist which is under development for the treatment of insomnia and other sleep disorders. Its agonist action on MT1 and MT2 receptors in the suprachiasmatic nucleus in the brain enables its action as a chronobiotic. The action of LY 156735 on MT1 and MT2 receptors promots sleeping because melatonin's effects at these same receptors is linked with maintenance of normal-sleep wake cycle. The EC50 value of LY 156735 is 0.0479nM, compared to 0.063nM for melatonin. In May 2004, LY 156735 had received orphan drug status for the treatment of circadian sleep disorders in totally blind individuals in the US. In Nov 2005, data which was presented at the 18th Annual Congress of the European College of Neuropsychopharmacology had been added to the adverse events and Anxiety disorders therapeutic trials sections. Uses: The treatment of insomnia and other sleep disorders. Synonyms: LY 156735; LY156735; LY-156735; TIK-301; TIK 301; TIK301; N-[(2R)-2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide. Grades: 98%. CAS No. 118702-11-7. Molecular formula: C14H17ClN2O2. Mole weight: 280.75.
Propylthiouracil
Propylthiouracil is a thyroperoxidase and 5'-deiodinase inhibitor. It is a thiouracil-derived drug used to treat hyperthyroidism (including Graves' disease) by decreasing the amount of thyroid hormone produced by the thyroid gland. Besides, propylthiouracil inhibits the enzyme thyroperoxidase, which normally acts in thyroid hormone synthesis by oxidizing the anion iodide (I-) to iodine (I0), facilitating iodine's addition to tyrosine residues on the hormone precursor thyroglobulin. But propylthiouracil does not inhibit the action of the sodium-dependent iodide transporter located on follicular cells' basolateral membranes. Uses: Antimetabolites, antithyroid agents. Synonyms: 6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU. Grades: >98%. CAS No. 51-52-5. Molecular formula: C7H10N2OS. Mole weight: 170.23.
Tungsten oxide nanoparticle ink
Solid content: 2.5 wt% crystalline WO3 in 2-propanol and propylene glycol. Uses: The wo3-x nanoparticle ink is for inkjet printing for the use as hole transport layer in printed electronics. the wo3-x nanoparticle ink is universally applicable in normal and inverted architecture solar cells. Group: 3d printing materials organic solar cell (opv) materials printed electronic materials. Alternative Names: Avantama P-10-Jet,Nanograde P-10-Jet,W03 nanoparticle ink,WO3 ink,WO3 nanoparticle dispersion. Pack Sizes: 5 mL in poly bottle.
WEHI-539
WEHI-539, a selective BCL-XL inhibitor that can be function as a single-agent inducer of apoptosis while sparing normal cells, it leads to MOMP and apoptosis due to displacing bound activator BH3s or monomeric BAX and BAK from BCL-XL to induce the homo-ol. Synonyms: 4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-; 5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid; WEHI 539; WEHI539; 5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazineylidene)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid. Grades: ≥95%. CAS No. 1431866-33-9. Molecular formula: C31H29N5O3S2. Mole weight: 583.73.
WEHI-539 hydrochloride
WEHI-539 is a selective BCL-XL inhibitor that can function as a single-agent inducer of apoptosis while sparing normal cells. WEHI-539 provokes BAK-mediated apoptosis in BCL-XL-dependent cells. Synonyms: 4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-, hydrochloride (1:1); 5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazineylidene)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid hydrochloride; WEHI-539 HCl; 5-{3-[4-(Aminomethyl)phenoxy]propyl}-2-[8-(1,3-benzothiazol-2-ylhydrazono)-5,6,7,8-tetrahydro-2-naphthalenyl]-1,3-thiazole-4-carboxylic acid hydrochloride (1:1); WEHI539 hydrochloride; WEHI 539 hydrochloride. Grades: ≥95%. CAS No. 2070018-33-4. Molecular formula: C31H29N5O3S2.HCl. Mole weight: 620.18.
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.