Nt 2 Suppliers USA
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Product | Description | |
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NT-2 Quick inquiry Where to buy Suppliers range | NT-2 is a toxin produced by Fusarium sporotrichioides M-1. Molecular formula: C19H26O8. Mole weight: 382.4. | |
H-1152 Dihydrochloride Quick inquiry Where to buy Suppliers range | H-1152 Dihydrochloride is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. It inhibits sulprostone-induced contractions in guinea pig aorta (IC50 = 190 nM) and displays proerectile effects in rats. It selectively blocks lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells. Synonyms: (S) - (+) -2-Methyl-1-[ (4-methyl-5-isoquinolynyl) sulfonyl]homopiperazine Dihydrochloride;5-[[(2S)-Hexahydro-2-Methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-Methylisoquinoline dihydrochloride;4-methyl-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline dihydrochloride. Grades: >98 %. CAS No. 871543-07-6. Molecular formula: C16H23Cl2N3O2S. Mole weight: 392.34. | |
Rho Kinase Inhibitor (H-1152, H-1152P, (S) - (+) -2-Methyl-1- [ (4-methyl-5-isoquinolinyl) sulfonyl] homopiperazine, 2HCl, ROCK Inhibitor) Quick inquiry Where to buy Suppliers range | A cell-permeable isoquinolinesulfonamid e compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki=1.6nM). Inhibits other serine/threonine kinases only at higher concentrations (Ki=630nM for PKA, 9.27 uM for PKC, and 10.1uM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC50=2.5uM). Reported to be a more potent and selective inhibitor than Y-27632. Group: Biochemicals. Grades: Highly Purified. CAS No. 872543-07-6. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |