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| Product | Description | |
|---|---|---|
| Obeticholic acid | Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC 50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid. CAS No. 459789-99-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12222. |  |
| Obeticholic Acid | Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. It reduced liver fat and reverted cholestasis in a rat model. Synonyms: 6-ECDCA; 6-Ethylchenodeoxycholic acid; Obeticholic acid; INT 747; INT-747; INT747; 6-ECDCA; Ocaliva; (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid. Grades: >98%. CAS No. 459789-99-2. Molecular formula: C26H44O4. Mole weight: 420.634. |  |
| Obeticholic Acid Impurity 10 | Obeticholic Acid Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1537866-49-1. Molecular formula: C26H46O3. Mole weight: 406.65. Catalog: APB1537866491. |  |
| Obeticholic Acid Impurity 16 | Obeticholic Acid Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10452-65-0. Molecular formula: C27H42O5. Mole weight: 446.63. Catalog: APB10452650. | |
| Obeticholic Acid Impurity 25 | Obeticholic Acid Impurity 25. Uses: For analytical and research use. Group: Impurity standards. CAS No. 15073-97-9. Molecular formula: C25H40O5. Mole weight: 420.59. Catalog: APB15073979. | |
| Obeticholic Acid Impurity 26 | Obeticholic Acid Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1516887-34-5. Molecular formula: C26H40O4. Mole weight: 416.6. Catalog: APB1516887345. | |
| Obeticholic Acid Intermediate 2 | Obeticholic Acid Intermediate 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10538-59-7. Molecular formula: C25H40O4. Mole weight: 404.59. Catalog: APB10538597. | |
| Obeticholic Acid Intermediate 3 | Obeticholic Acid Intermediate 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1516887-33-4. Molecular formula: C26H40O4. Mole weight: 416.6. Catalog: APB1516887334. | |
| Obeticholic Acid Intermediate 5 | Obeticholic Acid Intermediate 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1516887-35-6. Molecular formula: C26H44O4. Mole weight: 420.63. Catalog: APB1516887356. | |
| Tauro-obeticholic acid | Tauro-obeticholic acid is an active metabolite of obeticholic acid, a farnesoid X receptor (FXR) agonist. Synonyms: Obeticholic acid taurine conjugate; Tauro 6-ethylchenodeoxycholic acid. Grades: ≥95%. CAS No. 863239-61-6. Molecular formula: C28H49NO6S. Mole weight: 527.76. | |
| EP-024297 | EP-024297 is a novel agonist of farnesoid X receptor (FXR). Study in Chinese hamster ovary cells showed that it is 20000-fold more potent than obeticholic acid (OCA). EP-024297 is selective for FXR over TGR5. It promisingly becomes a new treatment of NASH. Uses: The potential treatment of nash. Synonyms: EP-024297; EP 024297; EP024297. | |
| (R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,Z)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid | (R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,Z)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a] phenanthren-17-yl)pentanoic acid is an impurity of obeticholic acid, which is used in the treatment of primary biliary cholangitis and various liver diseases. Synonyms: (E)-3-hydroxy-6-ethylidene-7-keto-5-cholan-24-oic acid. CAS No. 1516887-34-5. Molecular formula: C26H40O4. Mole weight: 416.60. | |
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