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Product | Description | |
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Okadaic acid Quick inquiry Where to buy Suppliers range | Okadaic acid. CAS No. 78111-17-8. Categories: Okadaic Acid. | |
Okadaic Acid Quick inquiry Where to buy Suppliers range | Okadaic Acid, a marine toxin, polyether derivative produced by dinoflagellates, is a potent, cell-permeable, specific inhibitor of PP-1 and PP-2 serine/threonine-speci?c protein phosphatases in a variety of cell types. Group: Biochemicals. Alternative Names: 9, 10-Deepithio-9, 10-dide hydroacanthifolicin, halochondrine A. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Okadaic Acid Quick inquiry Where to buy Suppliers range | Okadaic acid is a protein phosphatase (PP) inhibitor derived from the marine. Group: Marine Chemicals. Alternative Names: 35-Demethyldinophysistoxin 1. Grades: 95%+. CAS No. 78111-17-8. Product ID: ACM78111178. Molecular formula: C44H68O13. Mole weight: 805. IUPAC Name: (2R)-3-[(2S,6R,8S,11R)-2-[(E,2R)-4-[(2S,2'R,4R,4aS,6R,8aR)-4-Hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methylpropanoic acid. Density: 1.0795 g/cm³. SMILES: CC1CCC2 (CCCCO2)OC1C (C)CC (C3C (=C)C (C4C (O3)CCC5 (O4)CCC (O5)C=CC (C)C6CC (=CC7 (O6)C (CCC (O7)CC (C) (C (=O)O)O)O)C)O)O. | |
Okadaic Acid Quick inquiry Where to buy Suppliers range | Okadaic Acid. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Alternative Names: Okadaic acid. CAS No. 78111-17-8. Pack Sizes: 1MG. IUPAC Name: (2R)-3-[(2S,6R,8S,11R)-2-[(E,2R)-4-[(2S,2'R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methylpropanoic acid. Molecular formula: C44H68O13. Mole weight: 805.00. Catalog: APS78111178. SMILES: C[C@@H] (C[C@H] (O)[C@H]1O[C@@H]2CC[C@@]3 (CC[C@@H] (O3)\C=C\[C@@H] (C)[C@@H]4CC (=C[C@@]5 (O[C@H] (C[C@@] (C) (O)C (=O)O)CC[C@H]5O)O4)C)O[C@H]2[C@H] (O)C1=C)[C@H]6O[C@@]7 (CCCCO7)CC[C@H]6C. Format: Neat. Shipping: Room Temperature. | |
Okadaic Acid Quick inquiry Where to buy Suppliers range | Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1, both isoforms of PP2A and PP3. It is a very weak inhibitor of PP2B and does not inhibit PP2C or other phosphatases. Synonyms: AA8227800; 9,10-Deepithio-9,10-didehydroacanthifolicin. Grades: 95% by HPLC. CAS No. 78111-17-8. Molecular formula: C44H68O13. Mole weight: 805.00. | |
Okadaic acid, Ammonium Salt (Halochondrine A, Ammonium, OA) Quick inquiry Where to buy Suppliers range | An ammonium salt form of the protein phosphatase inhibitor Okadaic acid with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Okadaic acid ammonium salt (High Purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50= >1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Salt form generated in aqueous ammonium hydroxide-methanol solution. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155716-06-6. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H67O13. NH4, Molecular Weight: 822. US Biological Life Sciences. | Worldwide |
Okadaic acid from Prorocentrum concavum Quick inquiry Where to buy Suppliers range | 92-100% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 78111-17-8. Pack Sizes: 25μG, 0.1MG. Mole weight: 805.00. Catalog: AP78111178. Assay: 92-100% (HPLC). | |
Okadaic acid (High Purity) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
Okadaic acid potassium salt Quick inquiry Where to buy Suppliers range | Okadaic acid potassium salt, originally derived from marine dinoflagellates, Prorocentrium sp., is a potent, cell permeable inhibitor of serine/threonine protein phosphatases. It inhibits protein phosphatase 1 (IC50 = 3-15 nM) and protein phosphatase 2A (IC50 = 0.1-1 nM). Synonyms: 35-Demethyl-DTX 1 Potassium Salt. CAS No. 209266-79-5. Molecular formula: C44H68O13K. Mole weight: 844.10. | |
Okadaic acid potassium salt (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) (High Purity) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0.2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1uM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Okadaic acid, Potassium Salt (Halochondrine A, Potassium, OA) Quick inquiry Where to buy Suppliers range | Potassium salt form of the protein phosphatase inhibitor Okadaic acid with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 155751-72-7. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Okadaic Acid, Prorocentrum sp. (OA) Quick inquiry Where to buy Suppliers range | An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50=10-15nM) and protein phosphatase 2A (IC50=0.1nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. Group: Biochemicals. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
Okadaic Acid, Sodium salt (Halochondrine A) Quick inquiry Where to buy Suppliers range | Okadaic Acid, a marine toxin, polyether derivative produced by dinoflagellates, is a potent, cell-permeable, specific inhibitor of PP-1 and PP-2 serine/threonine-speci?c protein phosphatases in a variety of cell types. Salt form of okadaic acid, with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Alternative Names: 9, 10-Deepithio-9, 10-dide hydroacanthifolicin, Halochondrine A. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 100ug, 300ug. US Biological Life Sciences. | Worldwide |
Okadaic acid sodium salt (high purity) (Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin) Quick inquiry Where to buy Suppliers range | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
Okadaic acid, Sodium Salt (OA, Halochondrine A, Sodium Salt) Quick inquiry Where to buy Suppliers range | Sodium salt form of the protein phosphatase inhibitor Okadaic acid with somewhat greater stability than the free acid when stored in organic solvents. Group: Biochemicals. Grades: Highly Purified. CAS No. 209266-80-8. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
Okadaic Acid (sodium salt) solution in methanol Quick inquiry Where to buy Suppliers range | Okadaic Acid (sodium salt) solution in methanol. Uses: For analytical and research use. Group: Nutritional Composition Compounds. CAS No. 209266-80-8. Molecular formula: C44H67O13.Na. Mole weight: 826.98. Catalog: APS209266808. SMILES: [Na+]. C[C@@H] (C[C@H] (O)[C@H]1O[C@@H]2CC[C@@]3 (CC[C@@H] (O3)\C=C\[C@@H] (C)[C@@H]4CC (=C[C@@]5 (O[C@H] (C[C@@] (C) (O)C (=O)[O-])CC[C@H]5O)O4)C)O[C@H]2[C@H] (O)C1=C)C6O[C@@]7 (CCCCO7)CC[C@H]6C. Shipping: Dry ice. | |
Okadaic acid solution in methanol Quick inquiry Where to buy Suppliers range | Okadaic acid solution in methanol. Uses: For analytical and research use. Group: Mycotoxins; Environmental Food Contaminants; Mycotoxins. Catalog: APS010722. Format: Single Solution. Shipping: Room Temperature. | |
Mussel tissue-Okadaic acid and Dinophysistoxin-1 Quick inquiry Where to buy Suppliers range | Mussel tissue-Okadaic acid and Dinophysistoxin-1. Uses: For analytical and research use. Group: Mycotoxins; Environmental Food Contaminants; Mycotoxins. Catalog: APS010098. Format: Single Solution. Shipping: Dry ice. | |
CALYCULIN A Quick inquiry Where to buy Suppliers range | Calyculin A is a effective inhibitor of the catalytic subunit of type-2A phosphatase as well as the type-1 phosphatase. IC50: 0.5 to 1 nM and 2 nM,respectively. It has lower IC50 value than okadaic acid which is a active blocker of phosphatase mentioned a. Uses: Calyculin a is a effective inhibitor of the catalytic subunit of type-2a phosphatase as well as the type-1 phosphatase. Synonyms: CALYCULIN A;CALYCULIN A, DISCODERMIA CALYX;calyculin A from discodermia calyx;CALYCULIN A FROM DISCODERMIA CALYX, 10 U G;N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam;L-Ribonamide. Grades: >98 %. CAS No. 101932-71-2. Molecular formula: C50H81N4O15P. Mole weight: 1009.17. | |
Microcystin-LR Quick inquiry Where to buy Suppliers range | Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2 The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose. Uses: Enzyme inhibitors. Synonyms: Microcystin LR; Microcystin; Microcystin-a; MicrocystinLR; Cyanoginosin-LR; Toxin T 17; cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]; 5-L-Arginine-microcystin LA; cyclo(Ala-Leu-MAsp-Arg-Adda-isoGlu-Mdha). Grades: >95%. CAS No. 101043-37-2. Molecular formula: C49H74N10O12. Mole weight: 995.17. | |
PP2A Activating Ligand, ITH12246 Quick inquiry Where to buy Suppliers range | A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against beta-amyloid peptides (Ab1-42) toxicity and okadaic acid-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ~300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (~3uM). Shown to reverse the scopolamine-induced memory loss in mice (~10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (~2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60nM) and human erythrocytes (IC50 = 780nM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·HCl. US Biological Life Sciences. | Worldwide |
Z-Ile-Glu(O-t-butyl)-Ala-Leucinal Quick inquiry Where to buy Suppliers range | PSI is a drug that blocks the action of proteasomes, protein complexes that degrade unneeded and damaged proteins. It causes dopaminergic cell death in vitro and prevents activation of NF-κB in response to TNF-α and okadaic acid by inhibiting IκB-α degradation. Uses: Cysteine proteinase inhibitors. Synonyms: Proteasome Inhibitor I; PSI peptide; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-1-formyl-3-methylbutyl]-, 1,1-dimethylethyl ester. Grades: ≥ 90 % by HPLC. CAS No. 158442-41-2. Molecular formula: C32H50N4O8. Mole weight: 618.76. |