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| Product | Description | |
|---|---|---|
| Olaparib | 500mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C24H23FN4O3. CAS No. 763113-22-0. Prepack ID 90027882-500mg. Molecular Weight 434.46. See USA prepack pricing. |  |
| Olaparib | Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC 50 s of 5 and 1 nM for PARP1 and PARP2 , respectively. Olaparib is an autophagy and mitophagy activator [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD2281; KU0059436. CAS No. 763113-22-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g. Product ID: HY-10162. |  |
| Olaparib | Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.PARP1 acts as a critical molecule in the repair of DNA single-strand breaks (SSBs) and plays an important role in maintaining DNA integrity. de Murcia, J., et al. "Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells." Proc. Natl. Acad. Sci. USA 94: 7303-7307 (1997).PARP inhibitors inhibit PARP1 during S-phase and...num drugs." Proc. Natl. Acad. Sci. USA 105: 17079-17084 (2008).Long-term treatment with olaparib caused the development of drug resistance, which was induced by up-regulation of Abcb1a/b genes encoding P-glycoprotein efflux pumps. The resistance to... Group: Biochemicals. Alternative Names: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone; AZD-2281; KU 0059436; KU-59436; 1- (Cyclopropylcarbonyl) -4- [5- [ (3, 4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine. Grades: Highly Purified. CAS No. 763113-22-0. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 434.46. US Biological Life Sciences. |  Worldwide |
| Olaparib-[d8] | Olaparib-[d8] is the labelled analogue of Olaparib, which is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. Synonyms: Olaparib-d8. Grade: 95% by HPLC; 98% atom D. CAS No. 2143107-52-0. Molecular formula: C24H15D8FN4O3. Mole weight: 442.52. |  |
| Olaparib Impurity 4 | Olaparib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1021298-68-9. Molecular formula: C16H10FN3O. Mole weight: 279.27. Catalog: APB1021298689. |  |
| Olaparib Impurity 5 | Olaparib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 16859-59-9. Molecular formula: C8H6O3. Mole weight: 150.13. Catalog: APB16859599. | |
| Olaparib Impurity 66 | Olaparib Impurity 66. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1090982-59-4. Molecular formula: C10H16N2O2. Mole weight: 196.25. Catalog: APB1090982594. | |
| Olaparib (Standard) | Olaparib (Standard) is the analytical standard of Olaparib. This product is intended for research and analytical applications. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD2281 (Standard); KU0059436 (Standard). CAS No. 763113-22-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10162R. | |
| 1-[(Methylsulfonyl)oxy]-1H-benzotriazole | An impurity of Olaparib. Olaparib is a PARP inhibitor used to treat various cancers associated with BRCA mutations, including ovarian, breast, prostate, and pancreatic cancer. Synonyms: Methanesulfonic acid, 1H-benzotriazol-1-yl ester; 1-Methanesulfonyloxy-1,2,3-benzotriazole; 1H-1,2,3-Benzotriazol-1-yl methanesulfonate; Methanesulfonic acid benzotriazol-1-yl ester; Olaparib Impurity 21; 1-Benzotriazolyl mesylate; 1-Methanesulfonyloxy-benzotriazole; 1,2,3-Benzotriazol-1-yl methanesulfonate; 1H-Benzo[d][1,2,3]triazol-1-yl methanesulfonate. Grade: ≥95%. CAS No. 54769-22-1. Molecular formula: C7H7N3O3S. Mole weight: 213.21. | |
| 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid | 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid is an impurity of olaparib, which selectively binds and inhibits PARP, inhibiting PARP-mediated repair of single-strand DNA breaks. Synonyms: 2-fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic acid; 5-[(3,4-Dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoic Acid. CAS No. 763114-26-7. Molecular formula: C16H11FN2O3. Mole weight: 298.27. | |
| 3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid | 3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid is an impurity of olaparib, which selectively binds and inhibits PARP, inhibiting PARP-mediated repair of single-strand DNA breaks. Synonyms: 3-[(4-Oxo-3,4-dihydro-1-phthalazinyl)methyl]benzoic acid. CAS No. 420846-72-6. Molecular formula: C16H12N2O3. Mole weight: 280.28. | |
| 3-hydroxyisobenzofuran-1(3H)-one | 3-hydroxyisobenzofuran-1(3H)-one is an impurity of olaparib, which selectively binds and inhibits PARP, inhibiting PARP-mediated repair of single-strand DNA breaks. Synonyms: 3-hydroxyisobenzofuran-1(3H)-one; 16859-59-9; o-Phthalaldehydic acid; hydroxyphthalide; CHEBI:495639; MFCD00956142; 3-Hydroxyphthalide; 1(3H)-isobenzofuranone, 3-hydroxy-; 3-hydroxy-3H-2-benzofuran-1-one; SCHEMBL228037; CHEMBL234051; SCHEMBL18705376; AMY7661; JKNKNWJNCOJPLI-UHFFFAOYSA-N; 3-hydroxy-3H-isobenzofuran-1-one; 3-Hydroxybenzo[c]furan-1(3H)-one; 3-hydroxy-2-benzofuran-1(3H)-one; AKOS022504694; DS-19761; SY270554; 3-hydroxy-1,3-dihydro-2-benzofuran-1-one; CS-0143440; FT-0771570; H1754; D71106; Q27105161. CAS No. 16859-59-9. Molecular formula: C8H6O3. Mole weight: 150.13. | |
| 4-(3-(4-butyrylpiperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one | 4-(3-(4-butyrylpiperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one is an impurity of olaparib, which selectively binds and inhibits PARP, inhibiting PARP-mediated repair of single-strand DNA breaks. Synonyms: 4-{3-[(4-Butyryl-1-piperazinyl)carbonyl]-4-fluorobenzyl}-1(2H)-phthalazinone. CAS No. 2250243-17-3. Molecular formula: C24H25FN4O3. Mole weight: 436.48. | |
| 4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one | 4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one is an impurity of olaparib, which selectively binds and inhibits PARP, inhibiting PARP-mediated repair of single-strand DNA breaks. Synonyms: 4-(3-{[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl}benzyl)-1(2H)-phthalazinone; 1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-benzoyl]piperazine. CAS No. 763113-06-0. Molecular formula: C24H24N4O3. Mole weight: 416.47. | |
| 4-(4-fluoro-3-(4-(2-fluoro-4-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one | 4-(4-fluoro-3-(4-(2-fluoro-4-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one is an impurity of olaparib, which selectively binds and inhibits PARP, inhibiting PARP-mediated repair of single-strand DNA breaks. Synonyms: 4,4'-{1,4-Piperazinediylbis[carbonyl(4-fluoro-3,1-phenylene)methylene]}di(1(2H)-phthalazinone). CAS No. 2250242-62-5. Molecular formula: C36H28F2N6O4. Mole weight: 646.64. | |
| BSJ-4-116 | BSJ-4-116 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. BSJ-4-116 downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation). BSJ-4-116 exhibits potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor Olaparib (HY-10162)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2519823-34-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139039. | |
| KSQ-4279 | KSQ-4279 is a USP1 and PARP inhibitor. KSQ-4279 showed anti-proliferative effects in a subset of cell lines, often characterized by the presence of homologous recombination deficiencies (HRD), including mutations in BRCA1/2. The combination of KSQ-4279 with olaparib was able to induce strong and durable regressions across a number of ovarian and TNBC PDX models. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KSQ-4279; KSQ 4279; KSQ4279. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2446480-97-1. Molecular formula: C27H25F3N8O. Mole weight: 534.55. Purity: >98%. IUPACName: 1H-Pyrazolo[3,4-d]pyrimidine, 6-(4-cyclopropyl-6-methoxy-5-pyrimidinyl)-1-[[4-[1-(1-methylethyl)-4-(trifluoromethyl)-1H-imidazol-2-yl]phenyl]methyl]-. Canonical SMILES: FC(C1=CN(C(C)C)C(C2=CC=C(CN3N=CC4=CN=C(C5=C(OC)N=CN=C5C6CC6)N=C43)C=C2)=N1)(F)F. Product ID: ACM2446480971. Alfa Chemistry ISO 9001:2015 Certified. |  |
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