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| Product | Description | |
|---|---|---|
| Oleandrin | Cardiotonic; diuretic. Group: Biochemicals. Alternative Names: (3 β,5 β,16 β)-16-(Acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide; Neriolin; Corrigen; Folinerin. Grades: Highly Purified. CAS No. 465-16-7. Pack Sizes: 1mg, 5mg, 10mg. US Biological Life Sciences. |  Worldwide |
| Oleandrin | Oleandrin, also known as PBI-05204, is a lipid soluble cardiac glycoside with potential antineoplastic activity. Upon administration, oleandrin specifically binds to and inhibits the alpha3 subunit of the Na/K-ATPase pump in human cancer cells. This may inhibit the phosphorylation of Akt, upregulate MAPK, inhibit NF-kb activation and inhibit FGF-2 export and may downregulate mTOR thereby inhibiting p70S6K and S6 protein expression. All of this may lead to an induction of apoptosis. As cancer cells with relatively higher expression of the alpha3 subunit and with limited expression of the alpha1 subunit more sensitive to oleandrin, one may predict the tumor response to treatment with lipid-soluble cardiac glycosides such as oleandrin based on the tumors Na/K-ATPase pump protein subunit expression. Overexpression of the alpha3 subunit in tumor cells correlates with tumor proliferation. Uses: Anti-proliferative. Synonyms: (3b,5b,16b)-16-(Acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide; Neriolin; Corrigen. Grade: >98%. CAS No. 465-16-7. Molecular formula: C32H48O9. Mole weight: 576.72. |  |
| Oleandrin | Oleandrin (PBI-05204) inhibits the Na + , K + -ATPase activity with an IC 50 of 620 nM. Uses: Scientific research. Group: Natural products. Alternative Names: PBI-05204. CAS No. 465-16-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13719. |  |
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