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| Product | Description | |
|---|---|---|
| oligomycin | oligomycin. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1404-19-9. Molecular Formula: C135H220O33. Mole Weight: 2371.17. Catalog: APB1404199. |  |
| Oligomycin | Oligomycin, a mixture of A, B, and C Oligomycin isomers, has been found to be a macrolide compound and could exhibit effect in restraining mitochondrial ATP-synthase. It is isolated from Streptomyces diastatochromogenes. Uses: Used as a tool in cytochemistry. Synonyms: RK3325000; Oligomycin A. CAS No. 1404-19-9. Molecular formula: C45H74O11. Mole weight: 791.06. |  |
| Oligomycin | Oligomycin, an antifungal antibiotic, is an inhibitor of H + -ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 1404-19-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N6782. |  |
| Oligomycin | Oligomycin. Group: Biochemicals. Grades: Highly Purified. CAS No. 1404-19-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C45H74O11. US Biological Life Sciences. |  Worldwide |
| Oligomycin A | Oligomycin A is the dominant analogue of a class macrocyclic lactones isolated from selected strains of Streptomyces sp. Oligomycin A is a inhibitor of mitochondrial F1F0-ATPase. Induces apoptosis in a variety of cell types. Makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin exibits a broad biological profile including antifungal, antitumor and nematocidal activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 579-13-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Oligomycin A | Oligomycin A (MCH 32), created by Streptomyces , acts as a mitochondrial F 0 F 1 -ATPase inhibitor, with a K i of 1 μM; Oligomycin A shows anti-fungal activity. Uses: Scientific research. Group: Natural products. Alternative Names: MCH 32. CAS No. 579-13-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-16589. | |
| Oligomycin b | Heterocyclic Organic Compound. Alternative Names: OLIGOMYCIN B;OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES;Oligomycin A, 28-oxo-;Oligomycin B fromStreptomyces diastatochromogenes;28-Oxooligomycin A. CAS No. 11050-94-5. Molecular formula: C45H72O12. Mole weight: 805.05. Appearance: White solid. Purity: >95%. Catalog: ACM11050945. |  |
| Oligomycin B | A minor component of the oligomycin complex isolated from selected strains of streptomyces; an inhibitor of mitochondrial F1F0-atpas; used as an eukaryotic ATP synthase inhibitor, induces apoptosis. Synonyms: BRN 5705502. Grades: >95% by HPLC. CAS No. 11050-94-5. Molecular formula: C45H72O12. Mole weight: 805.04. | |
| Oligomycin B | Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces sp., is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 11050-94-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Oligomycin B | Oligomycin B is an antibiotic isolated from marine Streptomyces , used as an eukaryotic ATP synthase inhibitor, induces apoptosis [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 11050-94-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6784. | |
| Oligomycin c | Heterocyclic Organic Compound. Alternative Names: OLIGOMYCIN C;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Oligomycin A, 12-deoxy-;12-Deoxyoligomycin A;Oligmycin C. CAS No. 11052-72-5. Molecular formula: C45H74O10. Mole weight: 775.06. Appearance: White solid. Purity: >95%. Catalog: ACM11052725. | |
| Oligomycin C | A minor component of the oligomycin complex isolated from selected strains of streptomyces; an inhibitor of mitochondrial F1F0-atpas; used as an eukaryotic ATP synthase inhibitor, induces apoptosis. Synonyms: 12-Deoxyoligomycin A. Grades: >95% by HPLC. CAS No. 11052-72-5. Molecular formula: C45H74O10. Mole weight: 775.06. | |
| Oligomycin C (12-Deoxy-oligomycin A) | Oligomycin C, a minor component of the oligomycin complex isolated from Streptomyces sp., is a inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death and also leads to a switch in the death mode from apoptosis to necrosis. Group: Biochemicals. Alternative Names: 12-Deoxy-oligomycin A. Grades: Highly Purified. CAS No. 11052-72-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Oligomycin D | Oligomycin D is a macrolide compound produced by Streptomyces, which can inhibit mitochondrial F1FO-ATPase. Synonyms: Rutamycin; 26-demethyloligomycin A; A 272; RR 32705; Rutamycin A. Grades: >95% by HPLC. CAS No. 1404-59-7. Molecular formula: C44H72O11. Mole weight: 777.03. | |
| Oligomycin E | It is a minor metabolite from the oligomycin complex produced by several species of streptomyces. It exhibits weak antibacterial activity and is considerably weaker as an antifungal agent. Synonyms: (1R, 2'S, 4E, 5'S, 6S, 6'S, 7R, 8S, 10R, 11R, 12S, 14R, 15S, 16R, 18E, 20E, 22R, 25S, 28R, 29R)-22-ethyl-5', 6'-dihydro-7, 11, 14, 15, 28-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5', 6, 8, 10, 12, 14, 16, 28, 29-nonamethyl-spiro[2, 26-dioxabicyclo[23.3.1]nonacosa-4, 18, 20-triene-27, 2'-[2H]pyran]-3, 3', 9, 13(4'H)-tetrone; 26-hydroxy-28-oxo-Oligomycin A; [1R-[1R*, 4E, 5'S*, 6S*, 6'S*(R*), 7R*, 8S*, 10R*, 11R*, 12S*, 14R*, 15S*, 16R*, 18E, 20E, 22R*, 25S*, 27S*, 28R*, 29R*]]-22-Ethyl-5', 6'-dihydro-7, 11, 14, 15, 28-pentahydroxy-6'-(2-hydroxypropyl)-5', 6, 8, 10, 12, 14, 16, 28, 29-nonamethyl-spiro[2, 26-dioxabicyclo[23.3.1]nonacosa-4, 18, 20-triene-27, 2'-[2H]pyran]-3, 3', 9, 13(4'H)-tetrone. Grades: >95% by HPLC. CAS No. 110231-34-0. Molecular formula: C45H72O13. Mole weight: 821.05. | |
| Oligomycin E | Miscellaneous. Alternative Names: 26-Hydroxy-28-Oxooligomycin A. CAS No. 110231-34-0. Molecular formula: C45H72O13. Mole weight: 821.04. Canonical SMILES: CCC\1CCC2C (C (C (C3 (O2)C (=O)CC (C (O3)CC (C)O)C) (C)O)OC (=O)/C=C/C (C (C (C (=O)C (C (C (C (=O)C (C (C (C/C=C\C=C1)C)O) (C)O)C)O)C)C)O)C)C. Catalog: ACM110231340. | |
| 21-Hydroxyoligomycin A | It is an anticancer antibiotic first isolated from S. cyaneogriseus ssp. noncyanogenus (LL-F28249). It has more selective action against mammalian tumour cell lines than Oligomycin A, exhibiting only weak antifungal and nematocidal activity. Synonyms: Nemadectin omega; LL-F28249 omega; (1R, 2'S, 4E, 5'S, 6S, 6'S, 7R, 8S, 10R, 11R, 12S, 14R, 15S, 16R, 18E, 20E, 22R, 25S, 28S, 29R)-22-Ethyl-3', 4', 5', 6'-tetrahydro-7, 11, 14, 15, 23-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5', 6, 8, 10, 12, 14, 16, 28, 29-nonamethylspiro[2, 26-dioxabicyclo[23.3.1]nonacosa-4, 18, 20-triene-27, 2'-[2H]pyran]-3, 9, 13-trione. Grades: >95% by HPLC. CAS No. 102042-09-1. Molecular formula: C45H74O12. Mole weight: 807.06. | |
| 21-hydroxyoligomycin A (Nemadectin omega, Antibiotic LL-F28249 omega) | 21-Hydroxyoligomycin A is a rare member of the oligomycin class isolated as a co-metabolite of nemadectin, hence its original naming as nemadectin omega. Only limited literature references to this metabolite are available. However, in-house testing suggests that 21-hydroxyoligomycin has a more selective action against mammalian tumor cell lines than oligomycin A, exhibiting only weak antifungal and nematocidal activity. Group: Biochemicals. Alternative Names: Nemadectin omega, Antibiotic LL-F28249 omega. Grades: Highly Purified. CAS No. 102042-09-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Mitochondrial Fusion Promoter, M1 ( (E) -4-Chloro-2- (1- (2- (2, 4, 6-trichlorophenyl) hydrazono) ethyl) phenol) | A cell-permeable phenylhydrazone that restores mitochondrial tubular network formation in MEF lacking either of the two outer mitochondrial membrane (OMM) mitofusins (EC50=5.3 and 4.42 mM, respectively, in Mfn1 or Mfn2 knockout MEF cells) or in MPP+-treated SH-SY5Y cells (5uM 24h), but not in MEF lacking both Mfn1/2 or the inner mitochondrial membrane (IMM) fusion mediator Opa1 (optic atrophy1). M1 (5uM 24h) is reported to boost the downregulated ATP5A & ATP5B protein level in Mfn1 or Mfn2 knockout MEF to the wild-type MEF level and ATPase inhibitor oligomycin at 5uM is shown to completely offset the mitochondrial fusion effect by 5uM M1 in Mfn1 knockout MEF. Comparing to mdivi-1, M1 exerts its effect via promoting fusion rather than inhibiting fission or division. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| PP2A Activating Ligand, ITH12246 | A cell-permeable, relatively non-toxic, 1,8-naphthyridine derived compound that blocks the inhibitory effect of protein phosphatase inhibitors, such as okadaic acid, on protein phosphatase 2A (PP2A). Exhibits blood-brain barrier permeability. Protects neurons against beta-amyloid peptides (Ab1-42) toxicity and okadaic acid-induced tau hyperphosphorylation. Also protects against rotenone and oligomycin A induced neurotoxicity in SH-SY5Y neuroblastoma cells (at ~300nM). Prevents the development of glutamate-induced neuronal lesions in rat hippocampal slices by up-regulating PP2A (~3uM). Shown to reverse the scopolamine-induced memory loss in mice (~10mg/kg i.p) and significantly reduces the infarct volume in an animal model of stroke (~2.5mg/kg). Also acts as an inhibitor of acetylcholinesterase activity in Electrophorus electricus (IC50 = 60nM) and human erythrocytes (IC50 = 780nM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?·HCl. US Biological Life Sciences. | Worldwide |
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