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| Product | Description | |
|---|---|---|
| Olomoucine | Olomoucine. Group: Biochemicals. Grades: Purified. CAS No. 101622-51-9. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
| Olomoucine | Olomoucine is a CDK inhibitor that competes for the ATP binding site of the kinase. Olomoucine was shown to reversibly arrest differentiated Petunia cells induced to divide at G1 phase and cycling Arabidopsis cells in late G1 and G2. Uses: Enzyme inhibitors. Synonyms: N2-[(2-Hydroxyethyl)-N6-benzyladenine; 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine; NSC 666096; 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine; 2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol; 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine. Grades: ≥98%. CAS No. 101622-51-9. Molecular formula: C15H18N6O. Mole weight: 298.35. |  |
| Olomoucine (N2-[(2-Hydroxyethyl)-N6-benzyladenine) | A purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest. Group: Biochemicals. Alternative Names: N2-[(2-Hydroxyethyl)-N6-benzyladenine. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Iso-olomoucine | Iso-olomoucine is an inactive stereoisomer of olomoucine, a cyclin-dependent kinase (CDK) inhibitor. Olomoucine competitively inhibits the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. Iso-olomoucine can be a negative control compound of olomoucine. Synonyms: 6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine; 2-[[6-(benzylamino)-7-methylpurin-2-yl]amino]ethanol. Grades: ≥98%. CAS No. 101622-50-8. Molecular formula: C15H18N6O. Mole weight: 298.3. | |
| 2-(2-Hydroxyethylamino)-6-benzylamino-7-methylpurine | Heterocyclic Organic Compound. Alternative Names: 2-(2-Hydroxyethylamino)-6-benzylamino-7-methylpurine;Iso-Olomoucine. CAS No. 101622-50-8. Molecular formula: C15H18N6O. Mole weight: 298.34. Appearance: White solid. Purity: 0.96. IUPACName: 2-[[6-(benzylamino)-7-methylpurin-2-yl]amino]ethanol. Canonical SMILES: CN1C=NC2=C1C (=NC (=N2)NCCO)NCC3=CC=CC=C3. Density: 1.36g/cm³. Catalog: ACM101622508. |  |
| 2-Chloro-9-methyl-6-(benzylamino)purine | 2-Chloro-9-methyl-6-(benzylamino)purine is an intermediate in the synthesis of Olomoucine (O567000), a purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest. Group: Biochemicals. Grades: Highly Purified. CAS No. 101622-53-1. Pack Sizes: 25mg, 250mg. Molecular Formula: C13H12ClN5. US Biological Life Sciences. | Worldwide |
| 2-Chloro-9-methyl-6-(benzylamino)purine-d3 | 2-Chloro-9-methyl-6-(benzylamino)purine-d3 is an isotope labelled intermediate in the synthesis of Olomoucine (O567000), a purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C13H9D3ClN5. US Biological Life Sciences. | Worldwide |
| 2-Chloro-N-(phenylmethyl)-1H-purin-6-amine | 2-Chloro-N-(phenylmethyl)-1H-purin-6-amine is an intermediate in the synthesis of Olomoucine (O567000), a purine derivative which inhibits cyclin-dependent kinases and induces G1 arrest. Group: Biochemicals. Grades: Highly Purified. CAS No. 39639-47-9. Pack Sizes: 100mg, 1g. Molecular Formula: C12H10ClN5. US Biological Life Sciences. | Worldwide |
| 6-(2-Hydroxybenzylamino)-2-(3-hydroxypropylamino)-9-isopropylpurine | An analogue of Olomoucine that acts as a potent inhibitor of Cdk 1 (IC50=100nm) and Cdk2 (IC50=80nm). Also displays antiproliferative and proapoptotic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Bohemine | Bohemine, structurally similar to Olomoucine and Roscovitine, is a 2,6,9-trisubstituted purine derivative that inhibits cyclin-dependent kinases (CDKs) and exhibits anticancer activity. Synonyms: 3-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]propan-1-ol; 6-benzylamino-2-(3-hydroxypropylamino)-9-isopropylpurine; bohemine. Grades: ≥97%. CAS No. 189232-42-6. Molecular formula: C18H24N6O. Mole weight: 340.42. | |
| Ibulocydine | Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibulocydine rapidly blocked phosphorylation of the carboxyl-terminal domain (CTD) of the large subunit of RNA polymerase II, a process mediated by Cdk7/9. Anti-apoptotic gene products such as Mcl-1, survivin, and X-linked IAP (XIAP) are crucial for the survival of many cell types, including HCC. Following the inhibition of RNA polymerase II phosphorylation, ibulocydine caused rapid down-regulation of Mcl-1, survivin, and XIAP, thus inducing apoptosis. Furthermore, ibulocydine effectively induced apoptosis in HCC xenografts with no toxic side effects. These results suggest that ibulocydine is a strong candidate anti-cancer drug for the treatment of HCC. Synonyms: Ibulocydine. Grades: 98%. CAS No. 1314096-68-8. Molecular formula: C16H20BrN5O6. Mole weight: 458.26. | |
| (R)-Roscovitine | Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450nM), CDK2 (IC50 = 700nM) and CDK5/p35 (IC50 = 160nM). Inhibits M phase promoting factor (MPF) kinase activity. Arrests human fibroblasts in G1 phase. Antitumor compound. Activates the mitogen-activated protein kinase pathway. Targets both the p53 and NF-kappaB pathways. Has effects on calcium channel gating. Prevents DNA damage-induced cyclin A1 upregulation. Apoptosis inducer. As CYC202 in phase I clinical trials. Group: Biochemicals. Alternative Names: (2R)-2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; (R)-2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; CYC 202; (R)-Roscovitine; R-Roscovitine; Roscovitin; Seliciclib. Grades: Highly Purified. CAS No. 186692-46-6. Pack Sizes: 1mg, 5mg, 50mg. Molecular Formula: C??H??N?O. US Biological Life Sciences. | Worldwide |
| Butyrolactone I | It is one of a family of three butyrolactones isolated from aspergillus fumigatus. It exhibits antitumor activity and inhibits the cell cycle at the G1/S and G2/M transitions. It is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Synonyms: Olomoucin; 4'-O-Demethylversicolactone D; (2R)-2,5-Dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-2-furancarboxylic Acid Methyl Ester; (+)-3''-Dimethylallyl-butyrolactone II. Grades: >95% by HPLC. CAS No. 87414-49-1. Molecular formula: C24H24O7. Mole weight: 424.44. | |
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