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Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase , with an IC 50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 4611-5-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6781.
Ophiobolin A
Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi. It is resistant to gram-positive bacteria, mycobacteria and fungi. Synonyms: Cochliobolin; NSC 114340; Spiro(dicyclopenta(a,d)cyclooctene-3(2H),2'(3'H)-furan)-6-carboxaldehyde, 1,3a,4,4',5',6a,7,8,9a,10,10a-dodecahydro-9-hydroxy-3',9,10a-trimethyl-5'-(2-methyl-1-propenyl)-7-oxo-, (2'S,3'S,3aR,5'R,6aS,9R,9aS,10aR)-. Grades: >95% by HPLC. CAS No. 4611-5-6. Molecular formula: C25H36O4. Mole weight: 400.55.
Ophiobolin A (Cochliobolin A, Ophiobalin, NSC 114340)
Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase. Herbicidal mycotoxin. Phytotoxic, antifungal, antibacterial and nematocidal compound. Anticancer compound. Shown to induce paraptosis-like cell death. Shown to inhibit P-glycoprotein-mediated transport. Group: Biochemicals. Grades: Highly Purified. CAS No. 4611-5-6. Pack Sizes: 100ug, 1mg. US Biological Life Sciences.
Worldwide
Ophiobolin A (Cochliobolin A, Ophiobolin, Ophiobalin)
Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi. Ophiobolin A acts as an inhibitor of calmodulin action in calcium regulation. In-house testing at Microbial Screening Technologies has shown that ophiobolin A possesses a broad biological profile with antibacterial, antifungal, antitumor and nematocidal activiites. Group: Biochemicals. Alternative Names: Cochliobolin A, Ophiobolin, Ophiobalin. Grades: Highly Purified. CAS No. 4611-5-6. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Ophiobolin B
A minor member of a class of phytotoxic metabolites produced by bipolaris and other genera of plant pathogenic fungi; acts by inhibiting calmodulin action in calcium regulation. Synonyms: Zizanin B; 3,14-Dihydroxy-5-oxoophiobola-7,19-dien-25-al. Grades: >95% by HPLC. CAS No. 5601-74-1. Molecular formula: C25H38O4. Mole weight: 402.57.
Ophiobolin B (Cochliobolin B, Zizanin B, Ophiobolsin A)
Ophiobolin B is a minor member of a class of phytotoxic metabolites produced by Bipolaris & other genera of plant pathogenic fungi. Ophiobolin B acts as an inhibitor of calmodulin action in calcium regulation. In-house testing has revealed that ophiobolin B possesses a broad biological profile exhibiting antibacterial, antitumor and nematocidal activities. Group: Biochemicals. Alternative Names: Cochliobolin B, Zizanin B, Ophiobolsin A. Grades: Highly Purified. CAS No. 5601-74-1. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Ophiobolin C
A member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus bipolaris; inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells. Synonyms: Zizanin A. Grades: >98% by HPLC. CAS No. 19022-51-6. Molecular formula: C25H38O3. Mole weight: 386.57.
Ophiobolin C (Zizzanin A)
Ophiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris. Ophiobolin C is an inhibitor of human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 viral entry into cells. Blockade of this binding was considered by scientists at Merck as a potentially new mode of action for the treatment of HIV-1 infection. Group: Biochemicals. Grades: Highly Purified. CAS No. 19022-51-6. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
ophiobolin F synthase
Isolated from the fungus Aspergillus clavatus. The product is a sesterterpenoid (C25 terpenoid). Group: Enzymes. Enzyme Commission Number: EC 4.2.3.145. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5159; ophiobolin F synthase; EC 4.2.3.145. Cat No: EXWM-5159.
3-Anhydroophiobolin A (14,17-Epoxy-5-oxo-3,7,18-ophiobolatrien-21-al)
3-Anhydroophiobolin A is the dehydrated analogue of ophiobolin A and is a major member of the ophiobolin complex of phytotoxic metabolites produced by many species of the genus Bipolaris. Like all ophiobolins, 3- anhydroophiobolin A possesses a broad biological profile with antibacterial, antifungal, antitumor, herbicidal and nematocidal activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 6026-65-9. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
6-epi-Ophiobolin C
Synonyms: epi-6-Ophiobolin C. CAS No. 178152-19-7. Molecular formula: C25H38O3. Mole weight: 386.57.
Anhydroepiophiobolin A
Anhydroepiophiobolin A is a dehydrated analogue of ophiobolin epimerised at the C6 position. Anhydroepiophiobolin A is the major terminal degradation product of ophiobolin A and is co-produced with other ophiobolins in many Bipolaris species. Prior to 1984, references to "anhydroophiobolin" almost certainly refer to anhydroepiophiobolin A as the epimerisation at C6 was not well recognised. Under controlled degradation conditions both anhydroepiophiobolin A and anhydroophiobolin A are observed, but the latter is a minor component readily epimerised to anhydroepiophiobolin A. Like all ophiobolins, anhydroepiophiobolin A possesses a broad biological profile with antibacterial, antifungal, antitumor, herbicidal and nematocidal activities. Group: Aldehydes. Alternative Names: 3-Anhydro-6-Epiophiobolin A. CAS No. 90411-20-4. Molecular formula: C25H34O3. Mole weight: 382.53. Appearance: white solid. Purity: 0.98. Catalog: ACM90411204.
Anhydroepiophiobolin A
Anhydroepiophiobolin A is an ophiobolin with a broad biological profile. It has antibacterial, antifungal, antitumour, herbicidal and nematocidal activities. It is the major terminal degradation product of ophiobolin A and is co-produced with other ophiobolins in many bipolaris species. Synonyms: (6α,18R)-14,18-epoxy-5-oxo-ophiobola-3,7,19-trien-25-al; (2'S, 3'S, 3aR, 5'R, 6aR, 9aS, 10aR)-2, 3a, 4, 4', 5', 6a, 7, 9a, 10, 10a-decahydro-3', 9, 10a-trimethyl-5'-(2-methyl-1-propen-1-yl)-7-oxospiro[dicyclopenta[a, d]cyclooctene-3(1H), 2'(3'H)-furan]-6-carboxaldehyde; 3-Anhydro-6-epi-ophiobolin A; [3S-[3α(3'R*, 5'S*), 3aα, 6aα, 9aβ, 10aβ]]-1, 3a, 4, 4', 5', 6a, 7, 9a, 10, 10a-decahydro-3', 9, 10a-trimethyl-5'-(2-methyl-1-propenyl)-7-oxospiro[dicyclopenta[a, d]cyclooctene-3(2H), 2'(3'H)-furan]-6-carboxaldehyde. Grades: >98% by HPLC. CAS No. 90411-20-4. Molecular formula: C25H34O3. Mole weight: 382.54.
Anhydroophiobolin A
3-Anhydroophiobolin A is the dehydrated analogue of ophiobolin A and is a major member of the ophiobolin complex of phytotoxic metabolites produced by many species of the genus Bipolaris. Like all ophiobolins, 3-anhydroophiobolin A possesses a broad biological profile with antibacterial, antifungal, antitumor, herbicidal and nematocidal activities. Group: Pheromone ingredients. CAS No. 6026-65-9. Molecular formula: C25H34O3. Mole weight: 382.5. Appearance: white solid. Purity: 0.95. Catalog: ACM6026659.
Anhydroophiobolin A
It is the dehydrated analogue of ophiobolin A and a major member of the ophiobolin complex of phytotoxic metabolites produced by many species of the genus bipolaris. It possesses a broad biological profile with antibacterial, antifungal, antitumour, herbicidal and nematocidal activities. Synonyms: 14,17-Epoxy-5-oxo-3,7,18-ophiobolatrien-21-al; Anhydroophiobolin; (18R)-5-Oxo-14,18-epoxy-3,4-didehydroophiobola-7,19-diene-25-al; (2'S, 3'S, 3aR, 5'R, 6aS, 9aS, 10aR)-2, 3a, 4, 4', 5', 6a, 7, 9a, 10, 10a-Decahydro-3', 9, 10a-trimethyl-5'-(2-methyl-1-propen-1-yl)-7-oxospiro[dicyclopenta[a, d]cyclooctene-3(1H), 2'(3'H)-furan]-6-carboxaldehyde; [3S-[3α(3'R*, 5'S*), 3aα, 6aβ, 9aβ, 10aβ]]-1, 3a, 4, 4', 5', 6a, 7, 9a, 10, 10a-Decahydro-3', 9, 10a-trimethyl-5'-(2-methyl-1-propenyl)-7-oxo-spiro[dicyclopenta[a, d]cyclooctene-3(2H), 2'(3'H)-furan]-6-carboxaldehyde; 3-Anhydro-cochliobolin; 3-Anhydroophiobolin A. Grades: >95% by HPLC. CAS No. 6026-65-9. Molecular formula: C25H34O3. Mole weight: 382.54.
Cephalonic acid
It is produced by the strain of Cephalosporium caerulens. It has weak anti-staphylococcus aureus activity. Synonyms: Ophiobolin D; 8-Hydroxy-5-oxoophiobola-3,6,19-trien-25-oic acid; Dicyclopenta(a,d)cyclooctene-4-carboxylic acid, 7-((1S)-1,5-dimethyl-4-hexenyl)-3,5,6,6a,7,8,9,9a,10,10a-decahydro-5-hydroxy-1,9a-dimethyl-3-oxo-, (6aS,7R,9aR,10aR)-. CAS No. 18456-04-7. Molecular formula: C25H36O4. Mole weight: 400.55.
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