Ornithine Tran Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Eflornithine Quick inquiry Where to buy Suppliers range | Eflornithine is a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. Synonyms: Ornithine, 2-(difluoromethyl)-; 2-(Difluoromethyl)ornithine; 2-(Difluoromethyl)-DL-ornithine; DL-2-(Difluoromethyl)ornithine; DL-α-(Difluoromethyl)ornithine; DFMO; DFMO (growth regulator); Difluromethylornithine; Elfornithine; MDL 71782; MDL 71782A; Ornidyl; RFI 71782; RMI 71782; α,δ-Diamino-α-(difluoromethyl)valeric acid; α-(Difluoromethyl)-DL-ornithine; α-(Difluoromethyl)ornithine. Grades: ≥95%. CAS No. 70052-12-9. Molecular formula: C6H12F2N2O2. Mole weight: 182.17. | |
FR 901379 Quick inquiry Where to buy Suppliers range | FR 901379 is an impurity of Micafungin, a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species. FR901379 is an echinocandin-like antifungal lipopeptide with inhibitory activity against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg/ml). FR 901379 has a protective effect against C. albicans infection in mice (ED50 = 1.1 mg/kg). It also reduces the number of lung cysts and trophozoites in a mouse model of Plasmodium carinii infection. Synonyms: 1-[(4R,5R)-4,5-Dihydroxy-N2-(1-oxohexadecyl)-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0; (2α,3β,4β)-(4R,5R)-4,5-Dihydroxy-N2-(1-oxohexadecyl)-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonyl-3-hydroxy-L-glutaminyl-3-hydroxy-4-methyl-L-Proline Cyclic (6?1)-Peptide; 1H-Dipyrrolo[2, 1-c:2', 1'-l][1, 4, 7, 10, 13, 16]hexaazacycloheneicosine Cyclic Peptide Deriv. Grades: ≥90%. CAS No. 144371-88-0. Molecular formula: C51H82N8O21S. Mole weight: 1175.30. | |
H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH Quick inquiry Where to buy Suppliers range | H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH, either alone or in combination with therapeutic agents or large biopolymers, has been shown to easily cross a variety of biofilms (e.g. lipid bilayers and epithelial tissue). The importance of the guanidinium group in transport is supported by the observation that short oligomers of arginine enter cells far more rapidly than the corresponding oligomers of either lysine, histidine, ornithine or citrulline. Synonyms: Heptaarginine; L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginine; H(-Arg)7-OH; L-Arginine, L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-; Hepta-L-arginine. Grades: ≥95% by HPLC. CAS No. 165893-48-1. Molecular formula: C42H86N28O8. Mole weight: 1111.32. | |
N-Acetyl-L-Glutamic acid Quick inquiry Where to buy Suppliers range | N-Acety-L-Glutamic acid is a biologically active compound that is found in the cells. It is a product of the urea cycle and has been shown to inhibit the activity of enzymes such as ester hydrochloride synthetase, which catalyzes the conversion of arginine and citrulline to ornithine and carbamoyl phosphate. N-Acetylglutamic acid also plays an important role in cellular physiology, such as transcriptional regulation and protein synthesis. Deficiency can lead to glutamate accumulation and neurological disorders such as epilepsy. The biochemical properties of N-acetylglutamic acid are still not well known, but it has been shown to react with ammonia to form glutamine. Uses: Used for research and manufacturing. Group: Amino Acid Series. CAS No. 1188-37-0. Product ID: PAP-0020. | |
R-Chlorpheniramine Maleate Quick inquiry Where to buy Suppliers range | An impurity of Chlorpheniramine which inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM. Synonyms: (γR)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine (2Z)-2-Butenedioate; 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine Maleate; (-)-Chlorpheniramine Maleate; L-Chlorpheniramine Maleate. Grades: > 95%. CAS No. 23095-76-3. Molecular formula: C16H19ClN2.C4H4O4. Mole weight: 390.86. | |
Staurosporin Quick inquiry Where to buy Suppliers range | Staurosporine is an alkaloid isolated from the culture broth of Streptomyces staurospores and is a super-potent, cell permeable PKC inhibitor (IC50=0.7); at higher concentrations Staurosporine inhibits other protein kinases: CDK2/cyclin A (IC50=7uM) and CDK4/cyclin D (IC50=3-10uM). At a concentration of 50-100nM it is a functional neurotrophins agonist promoting neurite outgrowth in neuroblastoma, pheochromocytoma and brain primary neuronal cultures. Staurosporine inhibits a variety of kinases including PKA, PKG, MLCK, CaMK, tyrosine kinases, and phosphorylase kinase. This compound displays selectivity toward the PKC isoforms, inhibiting PKCα, PKC β, PKCγ, PKCδ, and PKCε, but not PKC?, and induces PKC translocation. Staurosporine also inhibits topoisomerase II directly by interaction with the ATP binding site, augments PMA-induced ornithine decarboxylase, and activates a bcl-2-regulated apoptosis pathway. Source:Streptomyces staurosporeus. Group: Biochemicals. Alternative Names: Antibiotic AM2282; Antibiotic 230; CCRIS 3272. Grades: Highly Purified. CAS No. 62996-74-1. Pack Sizes: 100ug, 1mg, 5mg, 10mg. Molecular Formula: C28H26N4O3, Molecular Weight: 466.53. US Biological Life Sciences. | Worldwide |
Talotrexin ammonium Quick inquiry Where to buy Suppliers range | Talotrexin ammonium is the ammonium salt of an antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance. Synonyms: PT-523; PT 523; PT523; NSC 712783; NSC712783; NSC-712783; N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine. CAS No. 648420-92-2. Molecular formula: C28H34N10O6. Mole weight: 590.60. | |
tetra-Boc-spermine-5-carboxylic acid Quick inquiry Where to buy Suppliers range | tetra-Boc-spermine-5-carboxylic acid is a spermidine derivative used in nucleic acid transfer reactions, and in the synthesis of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery. Synonyms: Boc4-Sper-COOH; N-α,δ-Bis-Boc-N-a,d-bis(3-Boc-aminopropyl)-L-ornithine; (10S)?-2,?2,?21,?21-tetramethyl-4,?19-dioxo-3,?20-Dioxa-5,?9,?14,?18-tetraazadocosane-9,?10,?14-tricarboxylic acid 9,?14-bis(1,?1-dimethylethyl) ester; (S)-2,2,21,21-tetramethyl-4,19-dioxo-3,20-Dioxa-5,9,14,18-tetraazadocosane-9,10,14-tricarboxylic acid 9,14-bis(1,1-dimethylethyl) ester; Tetra-BOC-ACP; (2S) -2, 5-bis [ (2-methylpropan-2-yl) oxycarbonyl- [3- [ (2-methylpropan-2-yl) oxycarbonylamino] propyl] amino] pentanoic acid; Tetra BOC ACP. Grades: ≥ 97% (HPLC). CAS No. 119798-08-2. Molecular formula: C31H58N4O10. Mole weight: 646.82. |