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Oroticacid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Oroticacid is a marker for measurement in routine newborn screening for urea cycle disorders. Oroticacid can induce hepatic steatosis and hepatomegaly in rats [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Carboxyuracil; Vitamin B13. CAS No. 65-86-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-N0157.
Oroticacid
Oroticacid is a heterocyclic compound and an acid. It is manufactured in the body via a mitochondrial enzyme, dihydroorotate dehydrogenase, or a cytoplasmic enzyme of pyrimidine synthesis pathway. Synonyms: UK-20349; UK 20349; UK20349. Grades: >98%. CAS No. 65-86-1. Molecular formula: C5H4N2O4. Mole weight: 156.1.
Oroticacid-13C,15N2 monohydrate
Labeled oroticacid monohydrate. Sometimes used as a mineral carrier in some dietary supplements. Build up of oroticacid may be an indication of a metabolic disorder such as urea cycle disorder. Group: 13c labeled compounds. Alternative Names: 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic Acid-13C,15N2 Monohydrate. CAS No. 1346602-15-0. Molecular formula: C413CH415N2O4 H2O. Mole weight: 177.09. Catalog: ACM1346602150.
Oroticacid potassium (Vitamin B13 potassium) is a precursor of pyrimidine bases and is involved in the synthesis of DNA and RNA. Oroticacid potassium stimulates the growth of animals, plants and microorganisms, participates in carbohydrate metabolism, and is necessary for the growth and life activities of organisms. Oroticacid potassium is a measurement indicator in routine newborn screening for urea cycle abnormalities. Oroticacid potassium can cause hepatic steatosis and hepatomegaly in rats [1] [2] [3] [4]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 6-Carboxyuracil potassium; Vitamin B13 potassium. CAS No. 24598-73-0. Pack Sizes: 5 g; 10 g. Product ID: HY-N0157C.
Oroticacid potassium salt
Oroticacid potassium salt. Group: Biochemicals. Alternative Names: 6-Carboxy-2,4-dihydroxypyrimidine; Uracil-6-carboxylic acid. Grades: Highly Purified. CAS No. 24598-73-0. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C5H3N2O4K. US Biological Life Sciences.
Worldwide
Oroticacid zinc
Oroticacid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Oroticacid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Oroticacid (zinc) can induce hepatic steatosis and hepatomegaly in rats [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 6-Carboxyuracil zinc; Vitamin B13 zinc. CAS No. 68399-76-8. Pack Sizes: 100 mg; 500 mg. Product ID: HY-N0157A.
5-FluorooroticAcid Monohydrate (FOA, 5-FOA)
Useful in the identification and selection of the strains of Saccharomyces cerevisiae that contain the mutant ura3- gene. 5-FOA is toxic to yeast cells that can synthesize the enzyme orotidine-5-phosphate decarboxylase and are therefore unable to grow on 5-FOA-containing media. Group: Biochemicals. Alternative Names: FOA; 5-FOA; 5-Fluoroorotate; 5-FLUORO-4-PYRIMIDINECARBOXYLIC ACID; 5-FLUORO-1,2,3,6-TETRAHYDRO-2,6-DIOXO-(9CI); 1,2,3,6-TETRAHYDRO-2,6-DIOXO-5-FLUORO-4- PYRIMIDINECARBOXYLIC ACID; 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid; 5-Fluorouracil-4-carboxylic acid. Grades: Molecular Biology Grade. CAS No. 207291-81-4,220141-70-8,703-95-7. Pack Sizes: 500mg, 1g, 10g, 25g, 50g, 100g. US Biological Life Sciences.
Worldwide
DL-DihydooroticAcid
DL-DihydooroticAcid. Group: Biochemicals. Alternative Names: HydrooroticAcid; (±)-DihydrooroticAcid; 4,5-DihydrooroticAcid; 5,6-DihydrooroticAcid; 5,6-Dihydrouracil-6-carboxylic Acid; 6-Hydrouracilcarboxylic Acid; DL-4,5-DihydrooroticAcid; Dihydro-DL-oroticAcid; DihydrooroticAcid. Grades: Highly Purified. CAS No. 155-54-4. Pack Sizes: 250mg. Molecular Formula: C5H6N2O4, Molecular Weight: 158.11. US Biological Life Sciences.
Worldwide
L-Dihydrooroticacid
L-Dihydrooroticacid is an important intermediate in the metabolism of oroticacid and a substrate of dihydroorotate dehydrogenase ( DHODH ). L-Dihydrooroticacid can reversibly hydrolyze to yield the acyclic L-ureidosuccinic acid by dihydrowhey enzyme [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 5988-19-2. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W015495.
Methyl Orotate
Methyl Orotate. Group: Biochemicals. Alternative Names: OroticAcid Methyl Ester; 6-Carbomethoxyuracil; Methyl 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate; Methyl Orotate; NSC 42009. Grades: Highly Purified. CAS No. 6153-44-2. Pack Sizes: 5g. Molecular Formula: C6H6N2O4, Molecular Weight: 170.12. US Biological Life Sciences.
Orotate phosphoribosyltransferase (OPRTase) or Oroticacid phosphoribosyltransferase is an enzyme involved in pyrimidine biosynthesis. It catalyzes the formation of orotidine 5'-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate. In yeast and bacteria, orotate phosphoribosyltransferase is an independent enzyme with a unique gene coding for the protein, whereas in mammals and other multicellular organisms, the catalytic function is carried out by a domain of the bifunctional enzyme UMP synthase. Applications: This is the preferred enzyme for assaying orotidine 5?-monophosphate and for the production of omp analogs from the corresponding orot...ty: ~25 units/mg protein (modified Warburg-Christian). Storage: -20°C. Form: Lyophilized powder containing approx. 50% buffer salts. Source: Brewer's bottom yeast. orotidylic acid phosphorylase; orotidine-5'-phosphate pyrophosphorylase; OPRTase; orotate phosphoribosyl pyrophosphate transferase; oroticacid phosphoribosyltransferase; orotidine 5'-monophosphate pyrophosphorylase; orotidine monophosphate pyrophosphorylase; orotidine phosphoribosyltransferase; orotidylate phosphoribosyltransferase; orotidylate pyrophosphorylase; orotidylic acid pyrophosphorylase; orotidylic phosphorylase; orotidylic pyrophosphorylase; EC 2.4.2.10; 9030-25-5. Cat No: NATE-0498.
The enzyme from higher eukaryotes also catalyses the reaction listed as EC 4.1.1.23, orotidine-5'-phosphate decarboxylase. Group: Enzymes. Synonyms: orotidylic acid phosphorylase; orotidine-5'-phosphate pyrophosphorylase; OPRTase; orotate phosphoribosyl pyrophosphate transferase; oroticacid phosphoribosyltransferase; orotidine 5'-monophosphate pyrophosphorylase; orotidine monophosphate pyrophosphorylase; orotidine phosphoribosyltransferase; orotidylate phosphoribosyltransferase; orotidylate pyrophosphorylase; orotidylic acid pyrophosphorylase; orotidylic phosphorylase; orotidylic pyrophosphorylase. Enzyme Commission Number: EC 2.4.2.10. CAS No. 9030-25-5. OPRTase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2639; orotate phosphoribosyltransferase; EC 2.4.2.10; 9030-25-5; orotidylic acid phosphorylase; orotidine-5'-phosphate pyrophosphorylase; OPRTase; orotate phosphoribosyl pyrophosphate transferase; oroticacid phosphoribosyltransferase; orotidine 5'-monophosphate pyrophosphorylase; orotidine monophosphate pyrophosphorylase; orotidine phosphoribosyltransferase; orotidylate phosphoribosyltransferase; orotidylate pyrophosphorylase; orotidylic acid pyrophosphorylase; orotidylic phosphorylase; orotidylic pyrophosphorylase. Cat No: EXWM-2639.
Orotidine
Orotidine is a nucleoside metabolized from oroticacid. In humans, orotidine occurs as its 5'-phosphate (orotidylic acid), which is an intermediate in pyrimidine nucleotide biosynthesis (cytidine and uridine) that are found in nucleic acids. Synonyms: 6-Carboxyuridine; 3-Ribofuranosyloroticacid; Uridin-6-carboxylic acid. CAS No. 314-50-1. Molecular formula: C10H12N2O8. Mole weight: 288.21.
orotidine-5'-phosphate decarboxylase
The enzyme from higher eukaryotes is identical with EC 2.4.2.10 orotate phosphoribosyltransferase. Group: Enzymes. Synonyms: orotidine-5'-monophosphate decarboxylase; orotodylate decarboxylase; orotidine phosphate decarboxylase; OMP decarboxylase; orotate monophosphate decarboxylase; orotidine monophosphate decarboxylase; orotidine phosphate decarboxylase; OMP-DC; orotate decarboxylase; orotidine 5'-phosphate decarboxylase; orotidylic decarboxylase; orotidylic acid decarboxylase; orotodylate decarboxylase; ODCase; orotic decarboxylase; orotidine-5'-phosphate carboxy-lyase. Enzyme Commission Number: EC 4.1.1.23. CAS No. 9024-62-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4768; orotidine-5'-phosphate decarboxylase; EC 4.1.1.23; 9024-62-8; orotidine-5'-monophosphate decarboxylase; orotodylate decarboxylase; orotidine phosphate decarboxylase; OMP decarboxylase; orotate monophosphate decarboxylase; orotidine monophosphate decarboxylase; orotidine phosphate decarboxylase; OMP-DC; orotate decarboxylase; orotidine 5'-phosphate decarboxylase; orotidylic decarboxylase; orotidylic acid decarboxylase; orotodylate decarboxylase; ODCase; orotic decarboxylase; orotidine-5'-phosphate carboxy-lyase. Cat No: EXWM-4768.
β-Pyrazofurin Trifluoroacetic Acid Salt
β-Pyrazofurin Trifluoroacetic Acid Salt is a remarkable antineoplastic compound, used for studying a myriad of malignancies encompassing leukemia, lymphoma and solid tumors. In its unparalleled mode of action, this extraordinary product stifles the catalytic endeavors of orotidine 5?-monophosphate decarboxylase, thereby instigating a disruptive cascade culminating in hindered RNA and DNA synthesis within the stricken neoplastic cells. Embodying a beacon of hope, it unveils an array of therapeutic possibilities for those afflicted by these insidious pathologies. Synonyms: 4-Hydroxy-3-β-D-ribofuranosyl-1H-pyrazole-5-carboxamide Trifluoroacetic Acid Salt; Antibiotic A 23813 Trifluoroacetic Acid Salt; NSC 143095 Trifluoroacetic Acid Salt; Pirazofurin Trifluoroacetic Acid Salt; Przf Trifluoroacetic Acid Salt; Pyrazofurin Trifluoroacetic Acid Salt; Pyrazomycin Trifluoroacetic Acid Salt; Pyrozofurin Trifluoroacetic Acid Salt; β-Pyrazomycin Trifluoroacetic Acid Salt. Molecular formula: C11H14F3N3O8. Mole weight: 373.24.
Carboxyamidotriazole orotate
Carboxyamidotriazole orotate (CTO) is the orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: L-651582 Orotate; CAI Orotate; CTO; 4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, compd. with 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide (1:1); 2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid 5-amino-1-[3,5-dichloro-4-(4-chlorobenzoyl)benzyl]-1H-1,2,3-triazole-4-carboxamide (1:1). Grades: ≥90%. CAS No. 187739-60-2. Molecular formula: C22H16Cl3N7O6. Mole weight: 580.76.
Orotidine
Orotidine. Group: Biochemicals. Alternative Names: Uridine-6-carboxylic acid. Grades: Highly Purified. CAS No. 314-50-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C10H12N2O8. US Biological Life Sciences.
Worldwide
Orotidine 5'-monophosphate trisodium salt
Orotidine 5'-monophosphate trisodium salt is a vital biomedical compound aiding in sdtuying pyrimidine metabolic disorders. Its multifaceted role as a precursor in the biosynthesis of crucial nucleotide uridine 5'-triphosphate is an indispensable component for RNA and DNA synthesis. Synonyms: Orotidylic acid; OMP; 3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-2,6-dioxopyrimidine-4-carboxylic acid,sodium; sodium 3- ( (2R, 3R, 4S, 5R) -3, 4-dihydroxy-5- (phosphonatooxymethyl) tetrahydrofuran-2-yl) -2, 6-dioxo-1, 2, 3, 6-tetrahydropyrimidine-4-carboxylate. CAS No. 68244-58-6. Molecular formula: C10H10N2O11PNa3. Mole weight: 434.14.
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