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| Product | Description | |
|---|---|---|
| Osimertinib | Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-9291; Mereletinib. CAS No. 1421373-65-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15772. |  |
| Osimertinib-[d6] | Osimertinib-[d6], is an isotope labelled derivative of Osimertinib. Osimertinib is an epidermal growth factor receptor tyrosine kinase inhibitor drug used to treat non-small-cell lung carcinomas. Synonyms: Osimertinib D6. Grade: 95% by CP; 98% atom D. CAS No. 1638281-44-3. Molecular formula: C28H27D6N7O2. Mole weight: 505.66. |  |
| Osimertinib mesylate | Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-9291 mesylate; Mereletinib mesylate. CAS No. 1421373-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15772A. | |
| Osimertinib (Standard) | Osimertinib (Standard) is the analytical standard of Osimertinib. This product is intended for research and analytical applications. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1421373-65-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15772R. | |
| (2R,3R,4S,5R)-2-(4-Aminothieno[3,4-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | (2R,3R,4S,5R)-2-(4-Aminothieno[3,4-D]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is a biomedical compound, assuming a pivotal role as an intermediate within Osimertinib's synthesis process. Notably, Osimertinib manifests itself as a therapeutic intervention for Non-small cell lung cancer inflicted with distinct EGFR mutations. Synonyms: 7-(b-D-Ribofuranosyl)thieno[3,4-d]pyrimidine-4-amine. Grade: 98%. CAS No. 152615-84-4. Molecular formula: C11H13N3O4S. Mole weight: 283.30. | |
| 3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole | 3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole is an impurity from the synthesis of Osimertinib (A808075), a selective EGFR inhibitor (epidermal growth factor receptor) used in the treatments of nonsmall-cell lung cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10ClN3, Molecular Weight: 243.69. US Biological Life Sciences. |  Worldwide |
| AZ7550 | AZ7550, an active metabolite of AZD9291, inhibits IGF1R activity with an IC50 of 1.6 μM in a cell-free assay. Synonyms: Osimertinib metabolite M3; 2-Propenamide, N-(4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)-; N-(4-Methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)-2-propenamide; N-(4-Methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}-2-{methyl[2-(methylamino)ethyl]amino}phenyl)acrylamide. Grade: ≥95%. CAS No. 1421373-99-0. Molecular formula: C27H31N7O2. Mole weight: 485.58. | |
| AZD-9291 | AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). Uses: For research used only. Synonyms: Mereletinib; AZD9291; AZD 9291; Osimertinib. Grade: 98%. CAS No. 1421373-65-0. Molecular formula: C28H33N7O2. Mole weight: 499.61. | |
| Becotatug | Becotatug (JMT-101) is an IgG1 antibody targeting EGFR that can also be conjugated to Afatinib (HY-10261) and Osimertinib (HY-15772) as a synthetic ADC [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JMT-101. CAS No. 2648260-93-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990049. | |
| HJM-561 | HJM-561 is a selective and effective orally active EGFR PROTAC degrader. HJM-561 is able to overcome the triple EGFR mutations that are resistant to Osimertinib (HY-15772). HJM-561 exhibits potent degradation of EGFR Del19/T790M/C797S (DC50: 9.2 nM) and L858R/T790M/C797S (DC50: 5.8 nM), and has anti-tumor activity (pink: EGFR ligand (HY-12857); blue: CRBN ligand (HY-A0003); black: linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2570251-68-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156698. | |
| Tamnorzatinib | Tamnorzatinib (ONO-7475) is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. Tamnorzatinib sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. Tamnorzatinib combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC). Uses: Scientific research. Group: Signaling pathways. Alternative Names: ONO-7475. CAS No. 1646839-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114358. | |
| Vociprotafib | Vociprotafib (RMC-4630) is an orally active, selective and potent phosphatase SHP2 inhibitor, which blocks activation of the RAS-RAF-MEK-ERK signaling pathway with antitumor activity. Vociprotafib accelerates the time to, and increases the magnitude of, tumor regressions in Osimertinib (HY-15772)-sensitive EGFR-mutant tumors of mice[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RMC-4630; SHP2-IN-7. CAS No. 2172652-48-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141523. | |
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