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| Product | Description | |
|---|---|---|
| Osimertinib | Cas No. 1421373-65-0. |  |
| Osimertinib | Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-9291; Mereletinib. CAS No. 1421373-65-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15772. |  |
| Osimertinib mesylate | Osimertinib mesylate (AZD9291 mesylate) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD-9291 mesylate; Mereletinib mesylate. CAS No. 1421373-66-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15772A. | |
| Osimertinib Mesylate | Osimertinib Mesylate. CAS No. 1421373-66-1. Product ID: 8-05082. Molecular formula: C29H37N7O5S. Mole weight: 595.1. Properties: (AZD9291) oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug. MFCD No. MFCD28137994. |  |
| Osimertinib (Standard) | Osimertinib (Standard) is the analytical standard of Osimertinib. This product is intended for research and analytical applications. Osimertinib (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC 50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1421373-65-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15772R. | |
| (2R,3R,4S,5R)-2-(4-Aminothieno[3,4-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | (2R,3R,4S,5R)-2-(4-Aminothieno[3,4-D]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is a biomedical compound, assuming a pivotal role as an intermediate within Osimertinib's synthesis process. Notably, Osimertinib manifests itself as a therapeutic intervention for Non-small cell lung cancer inflicted with distinct EGFR mutations. Synonyms: 7-(b-D-Ribofuranosyl)thieno[3,4-d]pyrimidine-4-amine. Grades: 98%. CAS No. 152615-84-4. Molecular formula: C11H13N3O4S. Mole weight: 283.30. | |
| 3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole | 3-(4-Chloropyrimidin-2-yl)-1-methyl-1H-indole is an impurity from the synthesis of Osimertinib (A808075), a selective EGFR inhibitor (epidermal growth factor receptor) used in the treatments of nonsmall-cell lung cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 250mg. Molecular Formula: C13H10ClN3, Molecular Weight: 243.69. US Biological Life Sciences. |  Worldwide |
| Becotatug | Becotatug (JMT-101) is an IgG1 antibody targeting EGFR that can also be conjugated to Afatinib (HY-10261) and Osimertinib (HY-15772) as a synthetic ADC [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JMT-101. CAS No. 2648260-93-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990049. | |
| Tamnorzatinib | Tamnorzatinib (ONO-7475) is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. Tamnorzatinib sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. Tamnorzatinib combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC). Uses: Scientific research. Group: Signaling pathways. Alternative Names: ONO-7475. CAS No. 1646839-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114358. | |
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