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An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: benzoic acid [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-2-oxolanyl]methyl ester; [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate. Grades: 99 %. CAS No. 874638-80-9. Molecular formula: C20H17FO6. Mole weight: 372.34.
(S)-3-((2R,3S,5S)-5-Allyl-3-(benzyloxy)-4-oxotetrahydrofuran-2-yl)propane-1,2-diyl dibenzoate, a chemical compound demonstrating properties for anti-cancer drug development, exhibits pronounced inhibition of cancer cells through modulation of the cell cycle and promotion of apoptosis. Current research explores its potential for treating conditions pertaining to inflammation and oxidative stress. CAS No. 871348-04-8.
S)-(+)-5-Oxotetrahydrofuran-2-carboxylic acid
1g Pack Size. Group: Building Blocks, Chiral Compounds, Organics. Formula: C5H6O4. CAS No. 21461-84-7. Prepack ID 64377162-1g. Molecular Weight 130.1. See USA prepack pricing.
2-(2,5-Dihydro-3-furanyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is derived from 3-Oxotetrahydrofuran (O870480), which is a reagent in the preparation of dihydropteridinone which are orally active Polo-like kinase-2 (Plk-2) inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 212127-80-5. Pack Sizes: 100mg, 1g. Molecular Formula: C10H17BO3, Molecular Weight: 196.05. US Biological Life Sciences.
Worldwide
2,3,5,6-Tetra-O-acetyl-D-galactono-1,4-lactone
2,3,5,6-Tetra-O-acetyl-D-galactono-1,4-lactone, an esteemed lactone derivative of immense repute, finds its widespread application in biomedicine as a precursor for the synthesis of the essential Vitamin C. Furthermore, it has recently captivated the attention of the medical community as a possible anti-cancer agent, which owes to its unique capacity for instigating apoptosis in the denizens of cancerous growths. Synonyms: (R)-1-((2S,3S,4R)-3,4-Diacetoxy-5-oxotetrahydrofuran-2-yl)ethane-1,2-diyl diacetate. CAS No. 210100-08-6. Molecular formula: C14H18O10. Mole weight: 346.29.
2-Acetamido-2-deoxy-D-galactono-1,4-lactone
2-Acetamido-2-deoxy-D-galactono-1,4-lactone is a vital precursor facilitating the synthesis of glycosaminoglycans, instrumental for cell signaling and extracellular matrix formation. Synonyms: 2-Acetamido-2-deoxy-D-galactono-1,4-lactone; 28876-38-2; N-[(3R,4R,5R)-5-[(1R)-1,2-DIHYDROXYETHYL]-4-HYDROXY-2-OXOOXOLAN-3-YL]ACETAMIDE; N-((3R,4R,5R)-5-((R)-1,2-DIHYDROXYETHYL)-4-HYDROXY-2-OXOTETRAHYDROFURAN-3-YL)ACETAMIDE; W-202205; D-Galactonic acid,2-(acetylamino)-2-deoxy-,g-lactone; 2-(Acetylamino)-2-deoxy-D-galactonic Acid gamma-Lactone. CAS No. 28876-38-2. Molecular formula: C8H13NO6. Mole weight: 219.19.
2-Acetamido-2-deoxy-D-mannono-1,4-lactone
2-Acetamido-2-deoxy-D-mannono-1,4-lactone is a renowned biomedical compound, finding invaluable application in combatting bacterial infections. Exerting its prowess through antimicrobial competencies, it astutely hampers the expansion of diverse bacterial strains. The characteristic attribute of this compound lies within its ability to impede bacterial cell wall construction, effectively hijacking pivotal cellular activities. Synonyms: 2-Acetamido-2-deoxy-D-mannono-1,4-lactone; N-((3S,4R,5S)-5-((R)-1,2-DIHYDROXYETHYL)-4-HYDROXY-2-OXOTETRAHYDROFURAN-3-YL)ACETAMIDE; D-Mannonicacid,2-(acetylamino)-2-deoxy-,g-lactone. CAS No. 28876-37-1. Molecular formula: C8H13NO6. Mole weight: 219.19.
Bretazenil (Ro16-6028) is an imidazopyrrolobenzodiazepine anxiolytic drug that is derived from the benzodiazepine family and was invented in 1988. It is most closely related in structure to the benzodiazepine antagonist flumazenil, although its effects are somewhat different. It is classed as a high-potency benzodiazepine due to its high-affinity binding to benzodiazepine binding sites where it acts as a partial agonist. Its profile as a partial agonist and preclinical trial data suggests that it may have a reduced adverse effect profile. In particular, bretazenil has been proposed to cause a less strong development of tolerance and withdrawal syndrome. Bretazenil differs from traditional 1,4-benzodiazepines by being a partial agonist and because it binds to α1, α2, α3, α4, α5, and α6 subunit-containing GABAA receptor benzodiazepine receptor complexes. 1,4-benzodiazepines bind only to α1, α2, α3 and α5 GABAA benzodiazepine receptor complexes. Group: Salt. Alternative Names: ((2R,3R)-3-(Benzoyloxy)-4,4-difluoro-5-oxotetrahydrofuran-2-yl)methyl benzoate; 2-Deoxyl-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate; 2-Deoxy-2,2-Difluoro-d-Erythro-Pentofuranos-1-Ulose-3,5-Dibenzoate; [(2R,3R)-3-benzoyloxy-4,4-difluoro-5-oxooxolan-2-yl]methyl benzoate; 2-Deoxy-2,2-difluoro-D-erythro-pentonic acid &gamm
Baricitinib Impurity 8
Baricitinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-((3-(4-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazol-1-yl)-5-oxotetrahydrofuran-3-yl)methyl)ethanesulfonamide. Molecular Formula: C16H18N6O4S. Mole Weight: 390.42. Catalog: APB03632.
An active quorum sensing modulator first recognised in burkholderia pseudomallei. It is detected in hundreds of bacterial species. Synonyms: C10-HSL; N-Decanoyl-L-homoserine lactone; N-[(3S)-2-Oxotetrahydrofuran-3-yl]decanamide. Grades: >99% by HPLC. CAS No. 177315-87-6. Molecular formula: C14H25NO3. Mole weight: 255.35.
(±)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone
(±)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone is a volatile organic compound used in the silylation of alcohols. Group: Biochemicals. Alternative Names: α,γ-Dihydroxy- β, β-dimethylbutyric Acid γ-Lactone; (RS)-Pantolactone; (±)-2-Hydroxy-3,3-dimethyl-γ-butyrolactone; (±)-Pantolactone; (±)-Pantoyl lactone; 2,4-Dihydroxy-3,3-dimethylbutanoic acid γ-lactone; 2,4-Dihydroxy-3,3-dimethylbutyric Acid γ-Lactone; 2-Hydroxy-3,3-dimethyl-γ-butyrolactone; 2-Hydroxy-3,3-dimethylbutan-4-olide; 3-Hydroxy-4,4-dimethyl-2-oxotetrahydrofuran; 3-Hydroxy-4,4-dimethyl-2-tetrahydrofuranone; 3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one; 3-Hydroxydihydro-4,4-dimethyl-2(3H)-furanone; DL-Pantoic acid γ-lactone; DL-Pantolactone; DL-Pantoyl lactone; Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone; NSC 135788; NSC 5926; dl-Pantoyl lactone; α-Hydroxy- β, β-dimethyl-γ-butyrolactone; α-Oxy- β, β-dimethyl-γ-butyrolactone. Grades: Highly Purified. CAS No. 79-50-5. Pack Sizes: 50g. US Biological Life Sciences.
Worldwide
Gemcitabine Impurity 1
Gemcitabine Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((2R,3R)-3-(benzoyloxy)-4,4-difluoro-5-oxotetrahydrofuran-2-yl)methyl benzoate. CAS No. 122111-01-7. Molecular Formula: C19H14F2O6. Mole Weight: 376.31. Catalog: APB122111017.
N-Butanoyl-L-homoserine lactone
N-Butanoyl-L-homoserine lactone is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm. Synonyms: N-[(3s)-2-Oxotetrahydrofuran-3-Yl]butanamide; (S)-N-(2-Oxotetrahydrofuran-3-yl)butyramide. Grades: >98.0%. CAS No. 67605-85-0. Molecular formula: C8H13NO3. Mole weight: 171.19.
N-cis-Tetradec-9Z-enoyl-L-homoserine lactone
N-cis-Tetradec-9Z-enoyl-L-homoserine lactone. Group: Biochemicals. Alternative Names: (S,Z)-N-(2-Oxotetrahydrofuran-3-yl)tetradec-9-enamide. Grades: Highly Purified. Pack Sizes: 5mg, 10mg, 25mg, 50mg. US Biological Life Sciences.
Worldwide
Nivocasan
Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models. Synonyms: GS 9450; GS9450; GS-9450; LB 84451;LB-84451; LB84451; (R)-N-((2S,3S)-2-(Fluoromethyl)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-5-isopropyl-3-(isoquinolin-1-yl)-4,5-dihydroisoxazole-5-carboxamide. Grades: 98%. CAS No. 908253-63-4. Molecular formula: C21H22FN3O5. Mole weight: 415.42.
(rac-Enterolactone)-O-glucuronide (Mixture of Diastereomers)
(rac-Enterolactone)-O-glucuronide is the oxidative metabolite of rac Enterolactone, a metabolite of sesame lignans (sesamin, sesamolin). Inhibits colonic cancer cell growth by inducing cell cycle arrest and apoptosis. Possible relationship between exposure and reduced risk of breast cancer. Synonyms: 3-[[Tetrahydro-4-[(3-hydroxyphenyl)methyl]-2-oxo-3-furanyl]methyl]phenyl-β-D-glucopyranosiduronic Acid; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(3-((4-(3-hydroxybenzyl)-2-oxotetrahydrofuran-3-yl)methyl)phenoxy)tetrahydro-2H-pyran-2-carboxylic Acid. CAS No. 768385-57-5. Molecular formula: C24H26O10. Mole weight: 474.46.