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| Product | Description | |
|---|---|---|
| 11-oxo-β-amyrin 30-oxidase | A heme-thiolate protein (cytochrome P-450). The enzyme is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin in the plant Glycyrrhiza uralensis (licorice). The enzyme from the plant Medicago truncatula can also hydroxylate β-amyrin. Group: Enzymes. Synonyms: CYP72A; CYP72A154. Enzyme Commission Number: EC 1.14.13.173. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0771; 11-oxo-β-amyrin 30-oxidase; EC 1.14.13.173; CYP72A; CYP72A154. Cat No: EXWM-0771. |  |
| 17α-hydroxyprogesterone deacetylase | A microsomal cytochrome P-450 (heme-thiolate) protein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.14.19), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and 3β-hydroxyandrost-5-en-17-one, leading to sex hormone biosynthesis. The activity of this reaction is dependent on the allosteric interaction of the enzyme with cytochrome b5 without any transfer of electrons from the cytochrome. The enzymes from different organisms differ in their substrate specificity. While the enzyme...son do not accept the former, and the enzyme from guinea pig does not accept the latter. Group: Enzymes. Synonyms: C-17/C-20 lyase; 17α-hydroxyprogesterone acetaldehyde-lyase; CYP17; CYP17A1 (gene name); 17α-hydroxyprogesterone 17,20-lyase. Enzyme Commission Number: EC 1.14.14.32. CAS No. 62213-24-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0930; 17α-hydroxyprogesterone deacetylase; EC 1.14.14.32; 62213-24-5; C-17/C-20 lyase; 17α-hydroxyprogesterone acetaldehyde-lyase; CYP17; CYP17A1 (gene name); 17α-hydroxyprogesterone 17,20-lyase. Cat No: EXWM-0930. | |
| 1,8-cineole 2-endo-monooxygenase | A heme-thiolate protein (P-450) which uses a flavodoxin-like redox partner to reduce the heme iron. Isolated from the bacterium Citrobacter braakii, which can use 1,8-cineole as the sole source of carbon. Group: Enzymes. Synonyms: P450cin; CYP176A; CYP176A1. Enzyme Commission Number: EC 1.14.13.156. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0756; 1,8-cineole 2-endo-monooxygenase; EC 1.14.13.156; P450cin; CYP176A; CYP176A1. Cat No: EXWM-0756. | |
| 1,8-cineole 2-exo-monooxygenase | A heme-thiolate protein (P-450). The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. cf. EC 1.14.13.97 (taurochenodeoxycholate 6-hydroxylase), EC 1.14.13.67 (quinine 3-monooxygenase) and EC 1.14.13.32 (albendazole monooxygenase). Group: Enzymes. Synonyms: CYP3A4. Enzyme Commission Number: EC 1.14.13.157. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0757; 1,8-cineole 2-exo-monooxygenase; EC 1.14.13.157; CYP3A4. Cat No: EXWM-0757. | |
| 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase | A cytochrome P-450 heme-thiolate enzyme. Involved in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria. Group: Enzymes. Synonyms: tylH1 (gene name). Enzyme Commission Number: EC 1.14.13.186. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0785; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase; EC 1.14.13.186; tylH1 (gene name). Cat No: EXWM-0785. | |
| 25/26-hydroxycholesterol 7α-hydroxylase | A P-450 (heme-thiolate) protein. Unlike EC 1.14.14.26, 24-hydroxycholesterol 7α-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: 25-hydroxycholesterol 7α-monooxygenase; CYP7B1; CYP7B1 oxysterol 7α-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7α-hydroxylase; cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating); 25-hydroxycholesterol 7α-hydroxylase. Enzyme Commission Number: EC 1.14.14.29. CAS No. 149316-80-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0926; 25/26-hydroxycholesterol 7α-hydroxylase; EC 1.14.14.29; 149316-80-3; 25-hydroxycholesterol 7α-monooxygenase; CYP7B1; CYP7B1 oxysterol 7α-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7α-hydroxylase; cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating); 25-hydroxycholesterol 7α-hydroxylase. Cat No: EXWM-0926. | |
| 2-hydroxy-1,4-benzoxazin-3-one monooxygenase | The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases. Group: Enzymes. Synonyms: BX5 (gene name); CYP71C3 (gene name). Enzyme Commission Number: EC 1.14.13.140. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0740; 2-hydroxy-1,4-benzoxazin-3-one monooxygenase; EC 1.14.13.140; BX5 (gene name); CYP71C3 (gene name). Cat No: EXWM-0740. | |
| 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase | A heme-thiolate protein (P-450) enzyme involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus. Group: Enzymes. Synonyms: NcsB3. Enzyme Commission Number: EC 1.14.99.49. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1059; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase; EC 1.14.99.49; NcsB3. Cat No: EXWM-1059. | |
| 2-hydroxyisoflavanone synthase | Requires cytochrome P-450. The reaction involves the migration of the 2-phenyl group of the flavanone to the 3-position of the isoflavanone. The 2-hydroxyl group is derived from the oxygen molecule. EC 4.2.1.105, 2-hydroxyisoflavanone dehydratase, acts on the products with loss of water and formation of genistein and daidzein, respectively. Group: Enzymes. Synonyms: CYP93C; IFS; isoflavonoid synthase. Enzyme Commission Number: EC 1.14.13.136. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0735; 2-hydroxyisoflavanone synthase; EC 1.14.13.136; CYP93C; IFS; isoflavonoid synthase. Cat No: EXWM-0735. | |
| 3,9-dihydroxypterocarpan 6a-monooxygenase | Possibly a heme-thiolate protein (P-450). The product of the reaction is the biosynthetic precursor of the phytoalexin glyceollin in soybean. Group: Enzymes. Synonyms: 3,9-dihydroxypterocarpan 6a-hydroxylase; 3,9-dihydroxypterocarpan 6α-monooxygenase (erroneous). Enzyme Commission Number: EC 1.14.13.28. CAS No. 92584-16-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0835; 3,9-dihydroxypterocarpan 6a-monooxygenase; EC 1.14.13.28; 92584-16-2; 3,9-dihydroxypterocarpan 6a-hydroxylase; 3,9-dihydroxypterocarpan 6α-monooxygenase (erroneous). Cat No: EXWM-0835. | |
| 3-Cyano-7-ethoxycoumarin | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage Target: Cytochrome P450 3-Cyano-7-ethoxycoumarin is a fluorescent probe useful in microsomal dealkylase studies. Uses: Scientific research. Group: Fluorescent dye. CAS No. 117620-77-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-D0055. |  |
| 3-hydroxyindolin-2-one monooxygenase | The enzyme is involved in the biosynthesis of protective and allelophatic benzoxazinoids in some plants, most commonly from the family of Poaceae (grasses). It is a member of the cytochrome P-450 dependent monooxygenases. Group: Enzymes. Synonyms: BX4 (gene name); CYP71C1 (gene name). Enzyme Commission Number: EC 1.14.13.139. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0738; 3-hydroxyindolin-2-one monooxygenase; EC 1.14.13.139; BX4 (gene name); CYP71C1 (gene name). Cat No: EXWM-0738. | |
| 4'-methoxyisoflavone 2'-hydroxylase | A heme-thiolate protein (P-450). Acts on isoflavones with a 4'-methoxy group, such as formononetin and biochanin A. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. EC 1.14.13.89, isoflavone 2'-hydroxylase, is less specific and acts on other isoflavones as well as 4'-methoxyisoflavones. Group: Enzymes. Synonyms: isoflavone 2'-monooxygenase (ambiguous); isoflavone 2'-hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.53. CAS No. 110183-49-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0860; 4'-methoxyisoflavone 2'-hydroxylase; EC 1.14.13.53; 110183-49-8; isoflavone 2'-monooxygenase (ambiguous); isoflavone 2'-hydroxylase (ambiguous). Cat No: EXWM-0860. | |
| 5β-cholestane-3α,7α-diol 12α-hydroxylase | A heme-thiolate protein (P-450). This is the key enzyme in the biosynthesis of the bile acid cholic acid (3α,7α,12α-trihydroxy-5β-cholanoic acid). The activity of this enzyme determines the biosynthetic ratio between cholic acid and chenodeoxycholic acid. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent. Group: Enzymes. Synonyms: 5β-cholestane-3α,7α-diol 12α-monooxygenase; sterol 12α-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1. Enzyme Commission Number: EC 1.14.13.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0904; 5β-cholestane-3α,7α-diol 12α-hydroxylase; EC 1.14.13.96; 5β-cholestane-3α,7α-diol 12α-monooxygenase; sterol 12α-hydroxylase (ambiguous); CYP8B1; cytochrome P450 8B1. Cat No: EXWM-0904. | |
| 5-epiaristolochene 1,3-dihydroxylase | A heme-thiolate protein (P-450). Kinetic studies suggest that 1β-hydroxyepiaristolochene is mainly formed first followed by hydroxylation at C-3. However the reverse order via 3α-hydroxyepiaristolochene does occur. Group: Enzymes. Synonyms: 5-epi-aristolochene 1,3-dihydroxylase; EAH. Enzyme Commission Number: EC 1.14.13.119. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0719; 5-epiaristolochene 1,3-dihydroxylase; EC 1.14.13.119; 5-epi-aristolochene 1,3-dihydroxylase; EAH. Cat No: EXWM-0719. | |
| 6,7-Dihydroxy bergamottin | 6,7-Dihydroxy bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 μM). Uses: Cytochrome p-450 enzyme inhibitors. Synonyms: 6,7-DHB; 6,7-dihydroxybergamottin. Grades: ≥98%. CAS No. 145414-76-2. Molecular formula: C21H24O6. Mole weight: 372.4. |  |
| 6-deoxyerythronolide B hydroxylase | A heme-thiolate protein (P-450). Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin. Group: Enzymes. Synonyms: DEB hydroxylase; eryF (gene name); P450(eryF); CYP107A1. Enzyme Commission Number: EC 1.14.13.188. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0787; 6-deoxyerythronolide B hydroxylase; EC 1.14.13.188; DEB hydroxylase; eryF (gene name); P450(eryF); CYP107A1. Cat No: EXWM-0787. | |
| 7α-hydroxycholest-4-en-3-one 12α-hydroxylase | A P-450 heme-thiolate protein. Requires EC 1.6.2.4, NADPH-hemoprotein reductase and cytochrome b5 for maximal activity. This enzyme is important in bile acid biosynthesis, being responsible for the balance between the formation of cholic acid and chenodeoxycholic acid. Group: Enzymes. Synonyms: 7α-hydroxy-4-cholesten-3-one 12α-monooxygenase; CYP12; sterol 12α-hydroxylase (ambiguous); HCO 12α-hydroxylase. Enzyme Commission Number: EC 1.14.18.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0970; 7α-hydroxycholest-4-en-3-one 12α-hydroxylase; EC 1.14.18.8; 7α-hydroxy-4-cholesten-3-one 12α-monooxygenase; CYP12; sterol 12α-hydroxylase (ambiguous); HCO 12α-hydroxylase. Cat No: EXWM-0970. | |
| 7-deoxyloganin 7-hydroxylase | A heme-thiolate protein (P-450). Group: Enzymes. Enzyme Commission Number: EC 1.14.13.74. CAS No. 335305-40-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0881; 7-deoxyloganin 7-hydroxylase; EC 1.14.13.74; 335305-40-3. Cat No: EXWM-0881. | |
| 8-dimethylallylnaringenin 2'-hydroxylase | A membrane-bound cytochrome P-450 heme-thiolate monooxygenase that is associated with the endoplasmic reticulum. This enzyme is specific for sophoraflavanone B as substrate. NADPH cannot be replaced by NADH, FAD or FMN. Along with EC 2.5.1.70 (naringenin 8-dimethylallyltransferase) and EC 2.5.1.71 (leachianone G 2''-dimethylallyltransferase), this enzyme forms part of the sophoraflavanone-G-biosynthesis pathway. Group: Enzymes. Synonyms: 8-DMAN 2'-hydroxylase. Enzyme Commission Number: EC 1.14.13.103. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0702; 8-dimethylallylnaringenin 2'-hydroxylase; EC 1.14.13.103; 8-DMAN 2'-hydroxylase. Cat No: EXWM-0702. | |
| 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase | The enzyme contains heme. The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyse two separate reactions. Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is subsequently isomerized to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P-450 heme thiolate domain. Group: Enzymes. Synonyms: 5,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 8-hydroperoxide isomerase; (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming); PpoA. Enzyme Commission Number: EC 5.4.4.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5546; 9,12-octadecadienoate 8-hydroperoxide 8R-isomerase; EC 5.4.4.5; 5,8-LDS (bifunctional enzyme); 5,8-linoleate diol synthase (bifunctional enzyme); 8-hydroperoxide isomerase; (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming); PpoA. Cat No: EXWM-5546. | |
| 9β-pimara-7,15-diene oxidase | Requires cytochrome P-450. A rice, Oryza sativa, enzyme involved in the phytoalexin momilactone biosynthesis. It also acts similarly on 9β-stemod-13(17)-ene. Group: Enzymes. Synonyms: CYP99A3. Enzyme Commission Number: EC 1.14.13.144. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0744; 9β-pimara-7,15-diene oxidase; EC 1.14.13.144; CYP99A3. Cat No: EXWM-0744. | |
| abieta-7,13-dien-18-ol hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine), and the gene encoding the enzyme has been identified in Pinus taeda (loblolly pine). The recombinant enzyme catalyses the oxidation of multiple diterpene alcohol and aldehydes, including levopimaradienol, isopimara-7,15-dienol, isopimara-7,15-dienal, dehydroabietadienol and dehydroabietadienal. It is not able to oxidize abietadiene. Group: Enzymes. Synonyms: CYP720B1; PtAO; abietadienol hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.109. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0708; abieta-7,13-dien-18-ol hydroxylase; EC 1.14.13.109; CYP720B1; PtAO; abietadienol hydroxylase (ambiguous). Cat No: EXWM-0708. | |
| abieta-7,13-diene hydroxylase | A heme-thiolate protein (P-450). This enzyme catalyses a step in the pathway of abietic acid biosynthesis. The activity has been demonstrated in cell-free stem extracts of Abies grandis (grand fir) and Pinus contorta (lodgepole pine). The enzyme is localized in the microsomal fraction and requires both oxygen and NADPH. Inhibition by carbon monoxide and several substituted N-heterocyclic inhibitors suggests that the enzyme is a cytochrome P-450-dependent monooxygenase. Activity is induced by wounding of the plant tissue. Group: Enzymes. Synonyms: abietadiene hydroxylase (ambiguous). Enzyme Commission Number: EC 1.14.13.108. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0707; abieta-7,13-diene hydroxylase; EC 1.14.13.108; abietadiene hydroxylase (ambiguous). Cat No: EXWM-0707. | |
| (+)-abscisic acid 8'-hydroxylase | A heme-thiolate protein (P-450). Catalyses the first step in the oxidative degradation of abscisic acid and is considered to be the pivotal enzyme in controlling the rate of degradation of this plant hormone. CO inhibits the reaction, but its effects can be reversed by the presence of blue light. The 8'-hydroxyabscisate formed can be converted into (-)-phaseic acid, most probably spontaneously. Other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.13.11.51 (9-cis-epoxycarotenoid dioxygenase). Group: Enzymes. Synonyms: (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase. Enzyme Commission Number: EC 1.14.13.93. CAS No. 153190-37-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0902; (+)-abscisic acid 8'-hydroxylase; EC 1.14.13.93; 153190-37-5; (+)-ABA 8'-hydroxylase; ABA 8'-hydroxylase. Cat No: EXWM-0902. | |
| adrenodoxin-NADP+ reductase | A flavoprotein (FAD). The enzyme, which transfers electrons from NADPH to adrenodoxin molecules, is the first component of the mitochondrial cytochrome P-450 electron transfer systems, and is involved in the biosynthesis of all steroid hormones. Group: Enzymes. Synonyms: adrenodoxin reductase; nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase; AdR; NADPH:adrenal ferredoxin oxidoreductase; NADPH-adrenodoxin reductase. Enzyme Commission Number: EC 1.18.1.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1111; adrenodoxin-NADP+ reductase; EC 1.18.1.6; adrenodoxin reductase; nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase; AdR; NADPH:adrenal ferredoxin oxidoreductase; NADPH-adrenodoxin reductase. Cat No: EXWM-1111. | |
| aflatoxin B synthase | A heme-thiolate (P-450) enzyme. Isolated from the mold Aspergillus parasiticus. Group: Enzymes. Synonyms: ordA (gene name); 8-O-methylsterigmatocystin,NADPH:O2 oxidoreductase (aflatoxin-B forming). Enzyme Commission Number: EC 1.14.13.175. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0773; aflatoxin B synthase; EC 1.14.13.175; ordA (gene name); 8-O-methylsterigmatocystin,NADPH:O2 oxidoreductase (aflatoxin-B forming). Cat No: EXWM-0773. | |
| alkane 1-monooxygenase | Some enzymes in this group are heme-thiolate proteins (P-450). Also hydroxylates fatty acids in the ω-position. Group: Enzymes. Synonyms: alkane 1-hydroxylase; ω-hydroxylase; fatty acid ω-hydroxylase; alkane monooxygenase; 1-hydroxylase; alkane hydroxylase. Enzyme Commission Number: EC 1.14.15.3. CAS No. 9059-16-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0946; alkane 1-monooxygenase; EC 1.14.15.3; 9059-16-9; alkane 1-hydroxylase; ω-hydroxylase; fatty acid ω-hydroxylase; alkane monooxygenase; 1-hydroxylase; alkane hydroxylase. Cat No: EXWM-0946. | |
| α-humulene 10-hydroxylase | Requires cytochrome P-450. The recommended numbering of humulene gives 10-hydroxy-α-humulene as the product rather than 8-hydroxy-α-humulene as used by the reference. See Section F: Natural Product Nomenclature. Group: Enzymes. Synonyms: CYP71BA1. Enzyme Commission Number: EC 1.14.13.150. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0750; α-humulene 10-hydroxylase; EC 1.14.13.150; CYP71BA1. Cat No: EXWM-0750. | |
| amorpha-4,11-diene 12-monooxygenase | A heme-thiolate protein (P-450). Cloned from the plant Artemisia annua (sweet wormwood). Part of the biosynthetic pathway of artemisinin. Group: Enzymes. Synonyms: CYP71AV1. Enzyme Commission Number: EC 1.14.13.158. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0758; amorpha-4,11-diene 12-monooxygenase; EC 1.14.13.158; CYP71AV1. Cat No: EXWM-0758. | |
| angelicin synthase | This P-450 monooxygenase enzyme is involved in the formation of angular furanocoumarins. Attacks its substrate by syn-elimination of hydrogen from C-3'. Group: Enzymes. Synonyms: CYP71AJ4 (gene name). Enzyme Commission Number: EC 1.14.13.115. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0715; angelicin synthase; EC 1.14.13.115; CYP71AJ4 (gene name). Cat No: EXWM-0715. | |
| aromatase | A cytochrome P-450. The enzyme catalyses three sequential hydroxylations of the androgens androst-4-ene-3,17-dione and testosterone, resulting in their aromatization and forming the estrogens estrone and 17β-estradiol, respectively. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: CYP19A1 (gene name); estrogen synthetase (incorrect). Enzyme Commission Number: EC 1.14.14.14. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0911; aromatase; EC 1.14.14.14; CYP19A1 (gene name); estrogen synthetase (incorrect). Cat No: EXWM-0911. | |
| averantin hydroxylase | A heme-thiolate (P-450) monooxygenase isolated from Aspergillus parasiticus. There is no reaction with (1'R)-averantin. Involved in aflatoxin biosynthesis. Group: Enzymes. Synonyms: AVN hydroxylase; avnA (gene name); (1'S)-averantin,NADPH:O2 oxidoreductase (5'-hydroxylating). Enzyme Commission Number: EC 1.14.13.174. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0772; averantin hydroxylase; EC 1.14.13.174; AVN hydroxylase; avnA (gene name); (1'S)-averantin,NADPH:O2 oxidoreductase (5'-hydroxylating). Cat No: EXWM-0772. | |
| berbamunine synthase | A heme-thiolate enzyme (P-450). Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine. Group: Enzymes. Synonyms: (S)-N-methylcoclaurine oxidase (C-O phenol-coupling). Enzyme Commission Number: EC 1.14.21.3. CAS No. 144941-42-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1025; berbamunine synthase; EC 1.14.21.3; 144941-42-4; (S)-N-methylcoclaurine oxidase (C-O phenol-coupling). Cat No: EXWM-1025. | |
| β-amyrin 11-oxidase | Requires cytochrome P-450. Part of the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-β-amyrin to 11α,30-dihydroxy-β-amyrin but this is not thought to be part of glycyrrhizin biosynthesis. Group: Enzymes. Synonyms: CYP88D6. Enzyme Commission Number: EC 1.14.13.134. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0733; β-amyrin 11-oxidase; EC 1.14.13.134; CYP88D6. Cat No: EXWM-0733. | |
| β-amyrin 24-hydroxylase | A heme-thiolate protein (P-450). Group: Enzymes. Synonyms: sophoradiol 24-hydroxylase; CYP93E1. Enzyme Commission Number: EC 1.14.99.43. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1053; β-amyrin 24-hydroxylase; EC 1.14.99.43; sophoradiol 24-hydroxylase; CYP93E1. Cat No: EXWM-1053. | |
| Bifendate | Bifendate is a synthetic intermediate of schisandrin C, a dibenzocyclooctadiene derivative derived from lignans used in traditional medicine and also a anti-HBV drug used in the treatment of chronic hepatitis B. It has been used in some countries as a hepatoprotectant adjuvant in the treatment of liver diseases, such as chronic viral hepatitis or drug-induced hepatic damage. Uses: Cytochrome p-450 enzyme inhibitors. Synonyms: 7,7'-Dimethoxy-[4,4'-Bi-1,3-benzodioxole]-5,5'-dicarboxylic Acid 5,5'-Dimethyl Ester; DDB; Dimethyl 4,4'-Dimethoxy-5,6,5',6'-di(methylenedioxy)biphenyl-2,2'-dicarboxylate; Dimethyl dicarboxylate Biphenyl; α-DDB. Grades: 97.0%~103.0%. CAS No. 73536-69-3. Molecular formula: C20H18O10. Mole weight: 418.36. | |
| C-19 steroid 1α-hydroxylase | The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P-450, and uses ferredoxin as its electron donor. It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione. Group: Enzymes. Synonyms: CYP260A1. Enzyme Commission Number: EC 1.14.15.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0944; C-19 steroid 1α-hydroxylase; EC 1.14.15.19; CYP260A1. Cat No: EXWM-0944. | |
| calcidiol 1-monooxygenase | A P-450 (heme-thiolate) enzyme found in mammals. Group: Enzymes. Synonyms: 25-hydroxycholecalciferol 1-hydroxylase; 25-hydroxycholecalciferol 1-monooxygenase; 1-hydroxylase-25-hydroxyvitamin D3; 25-hydroxy D3-1α-hydroxylase; 25-hydroxycholecalciferol 1α-hydroxylase; 25-hydroxyvitamin D3 1α-hydroxylase. Enzyme Commission Number: EC 1.14.15.18. CAS No. 9081-36-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0943; calcidiol 1-monooxygenase; EC 1.14.15.18; 9081-36-1; 25-hydroxycholecalciferol 1-hydroxylase; 25-hydroxycholecalciferol 1-monooxygenase; 1-hydroxylase-25-hydroxyvitamin D3; 25-hydroxy D3-1α-hydroxylase; 25-hydroxycholecalciferol 1α-hydroxylase; 25-hydroxyvitamin D3 1α-hydroxylase. Cat No: EXWM-0943. | |
| camphor 5-monooxygenase | A heme-thiolate protein (P-450). Also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide. Group: Enzymes. Synonyms: camphor 5-exo-methylene hydroxylase; 2-bornanone 5-exo-hydroxylase; bornanone 5-exo-hydroxylase; camphor 5-exo-hydroxylase; camphor 5-exohydroxylase; camphor hydroxylase; d-camphor monooxygenase; methylene hydroxylase; methylene monooxygenase; D-camphor-exo-hydroxylase; camphor methylene hydroxylase. Enzyme Commission Number: EC 1.14.15.1. CAS No. 9030-82-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0934; camphor 5-monooxygenase; EC 1.14.15.1; 9030-82-4; camphor 5-exo-methylene hydroxylase; 2-bornanone 5-exo-hydroxylase; bornanone 5-exo-hydroxylase; camphor 5-exo-hydroxylase; camphor 5-exohydroxylase; camphor hydroxylase; d-camphor monooxygenase; methylene hydroxylase; methylene monooxygenase; D-camphor-exo-hydroxylase; camphor methylene hydroxylase. Cat No: EXWM-0934. | |
| (+)-camphor 6-endo-hydroxylase | A cytochrome P-450 monooxygenase from the bacterium Rhodococcus sp. NCIMB 9784. Group: Enzymes. Synonyms: P450camr. Enzyme Commission Number: EC 1.14.15.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0935; (+)-camphor 6-endo-hydroxylase; EC 1.14.15.10; P450camr. Cat No: EXWM-0935. | |
| (+)-camphor 6-exo-hydroxylase | A cytochrome P-450 monooxygenase isolated from Salvia officinalis (sage). Involved in the catabolism of camphor in senescent tissue. Group: Enzymes. Synonyms: (+)-camphor 6-hydroxylase. Enzyme Commission Number: EC 1.14.13.161. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0761; (+)-camphor 6-exo-hydroxylase; EC 1.14.13.161; (+)-camphor 6-hydroxylase. Cat No: EXWM-0761. | |
| carotene ε-monooxygenase | A heme-thiolate protein (P-450). Also acts on zeinoxanthin to give lutein. Group: Enzymes. Synonyms: CYP97C1; LUT1. Enzyme Commission Number: EC 1.14.99.45. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1055; carotene ε-monooxygenase; EC 1.14.99.45; CYP97C1; LUT1. Cat No: EXWM-1055. | |
| Cedrol | Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, insecticidal, and anti-fungal activities. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cypress camphor. Product Category: Inhibitors. Appearance: Pale yellow to yellow green solid. CAS No. 77-53-2. Molecular formula: C15H26O. Mole weight: 222.37. Purity: 0.99. IUPACName: (1S,2R,5S,7R,8R)-2,6,6,8-Tetramethyltricyclo[5.3.1.01,5]undecan-8-ol. Canonical SMILES: CC1CCC2C13CCC(C(C3)C2(C)C)(C)O. Density: 0.9479 g/cm³. Product ID: ACM77532. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Cedrol | Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Cedrol; α-Cedrol. CAS No. 77-53-2. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N2071. | |
| cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] | This enzyme, found in several bacterial pathogens, is involved in degradation of the host's cholesterol. It catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol. The products are exclusively in the (25S) configuration. It is a two-component system consisting of a P-450 (heme thiolate) oxygenase (Cyp125) and a ferredoxin reductase (most likely KshB, which is also a part of EC 1.14.13.142, 3-ketosteroid 9α-monooxygenase). The enzyme also accepts cholesterol as a substrate. cf. EC 1.14.13.221, cholest-4-en-3-one 27-monooxygenase. Group: Enzymes. Synonyms: CYP125; CYP125A1; cholest-4-en-3-one 27-monooxygenase (misleading); cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxyl. Enzyme Commission Number: EC 1.14.13.141. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0741; cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]; EC 1.14.13.141; CYP125; CYP125A1; cholest-4-en-3-one 27-monooxygenase (misleading); cholest-4-en-3-one,NADH:oxygen oxidoreductase (26-hydroxylating); cholest-4-en-3-one 26-monooxygenase (ambiguous). Cat No: EXWM-0741. | |
| cholestanetriol 26-monooxygenase | This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-ene-3β,7α-diol, 7α-hydroxycholest-4-en-3-one, and 5β-cholestane-3α,7α-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase. Group: Enzymes. Synonyms: 5β-cholestane-3α,7α,12α-triol 26-hydroxylase; 5β-cholestane-3α,7α,12α-triol hydroxylase; cholestanetriol 26-hydroxylase; sterol 27-hydroxylase; sterol 26-hydroxylase; cholesterol 27-hydroxyla. Enzyme Commission Number: EC 1.14.15.15. CAS No. 52227-77-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0940; cholestanetriol 26-monooxygenase; EC 1.14.15.15; 52227-77-7; 5β-cholestane-3α,7α,12α-triol 26-hydroxylase; 5β-cholestane-3α,7α,12α-triol hydroxylase; cholestanetriol 26-hydroxylase; sterol 27-hydroxylase; sterol 26-hydroxylase; cholesterol 27-hydroxylase; CYP27A; CYP27A1; cytochrome P450 27A1'. Cat No: EXWM-0940. | |
| cholesterol 24-hydroxylase | A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood-brain barrier whereas cholesterol cannot. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Enzyme Commission Number: EC 1.14.14.25. CAS No. 50812-30-1, 213327-78-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0922; cholesterol 24-hydroxylase; EC 1.14.14.25; 50812-30-1, 213327-78-7; cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Cat No: EXWM-0922. | |
| cholesterol 25-hydroxylase | Unlike most other sterol hydroxylases, this enzyme is not a cytochrome P-450. Instead, it uses diiron cofactors to catalyse the hydroxylation of hydrophobic substrates. The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to the enzyme through interactions with clustered histidine or glutamate residues. In cell cultures, this enzyme down-regulates cholesterol synthesis and the processing of sterol regulatory element binding proteins (SREBPs). Group: Enzymes. Synonyms: cholesterol 25-monooxygenase. Enzyme Commission Number: EC 1.14.99.38. CAS No. 60202-07-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1049; cholesterol 25-hydroxylase; EC 1.14.99.38; 60202-07-5; cholesterol 25-monooxygenase. Cat No: EXWM-1049. | |
| cholesterol 7α-monooxygenase | A P-450 heme-thiolate liver protein that catalyses the first step in the biosynthesis of bile acids. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: cholesterol 7α-hydroxylase; CYP7A1 (gene name). Enzyme Commission Number: EC 1.14.14.23. CAS No. 9037-53-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0920; cholesterol 7α-monooxygenase; EC 1.14.14.23; 9037-53-0; cholesterol 7α-hydroxylase; CYP7A1 (gene name). Cat No: EXWM-0920. | |
| cholesterol monooxygenase (side-chain-cleaving) | A heme-thiolate protein (cytochrome P-450). The reaction proceeds in three stages, with two hydroxylations at C-22 and C-20 preceding scission of the side-chain between carbons 20 and 22. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase. Group: Enzymes. Synonyms: cholesterol desmolase; cytochrome P-450scc; C27-side chain cleavage enzyme; cholesterol 20-22-desmolase; cholesterol C20-22 desmolase; cholesterol side-chain cleavage enzyme; cholesterol side-chain-cleaving enzyme; steroid 20-22 desmolase; steroid 20-22-lyase; CYP11A1 (gene name). Enzyme Commission Number: EC 1.14.15.6. CAS No. 37292-81-2, 440354-98-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0949; cholesterol monooxygenase (side-chain-cleaving); EC 1.14.15.6; 37292-81-2, 440354-98-3; cholesterol desmolase; cytochrome P-450scc; C27-side chain cleavage enzyme; cholesterol 20-22-desmolase; cholesterol C20-22 desmolase; cholesterol side-chain cleavage enzyme; cholesterol side-chain-cleaving enzyme; steroid 20-22 desmolase; steroid 20-22-lyase; CYP11A1 (gene name). Cat No: EXWM-0949. | |
| colneleate synthase | A heme-thiolate protein (P-450). It catalyses the selective removal of pro-R hydrogen at C-8 in the biosynthesis of colneleic acid. It forms also (8E)-9-[(1E,3Z,6Z)-nona-1,3,6-trien-1-yloxy]non-8-enoic acid (i.e. colnelenate) from (9S,10E,12Z,15Z)-9-hydroperoxy-10,12,15-octadecatrienoate. The corresponding 13-hydroperoxides are poor substrates. The divinyl ethers colneleate and colnelenate have antimicrobial activity. Group: Enzymes. Synonyms: 9-divinyl ether synthase; 9-DES; CYP74D; CYP74D1; CYP74 cytochrome P-450; DES1; (8E)-9-[(1E,3E)-nona-1,3-dien-1-yloxy]non-8-enoate synthase. Enzyme Commission Number: EC 4.2.1.121. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4962; colneleate synthase; EC 4.2.1.121; 9-divinyl ether synthase; 9-DES; CYP74D; CYP74D1; CYP74 cytochrome P-450; DES1; (8E)-9-[(1E,3E)-nona-1,3-dien-1-yloxy]non-8-enoate synthase. Cat No: EXWM-4962. | |
| costunolide synthase | A heme-thiolate protein (P-450). The enzyme hydroxylates carbon C-6 of germacra-1(10),4,11(13)-trien-12-oate to give 6α-hydroxygermacra-1(10),4,11(13)-trien-12-oate, which probably spontaneously cyclises to form the lactone ring. Group: Enzymes. Enzyme Commission Number: EC 1.14.13.120. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0721; costunolide synthase; EC 1.14.13.120. Cat No: EXWM-0721. | |
| Cytochrome P450 Reductase from Human, Recombinant | Cytochrome P450 reductase is a membrane bound enzyme required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. The cytochrome P450 enzyme system is mainly involved in the detoxification of xenobiotics in the liver. It also participates in the activation of procarcinogens and the metabolism of endogeneous substrates such as steroids. Applications: Human cytochrome p450 reductase has been used in a study to assess the biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat. human cytochrome p450 reductase has also been u...AD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase. Enzyme Commission Number: EC 1.6.2.4. CAS No. 9023-3-4. Purity: >90% (SDS-PAGE). CPR. Mole weight: 76.5 kDa. Activity: >30 U/mg. Storage: Store at -70°C. Form: Supplied in a solution containing 10 mM potassium phosphate, pH 7.4, 0.1 mM EDTA, 0.5 mM DTT, 20% (v/v) glycerol. Source: Baculovirus infected insect cells. Species: Human. EC 1.6.2.4; NADPH:ferrihemoprotein oxidoreductase; NADPH:hemoprotein oxidoreductase; NADPH:P450 oxidoreductase; P450 reductase; CPR; 9039-06-9; FAD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase. Cat No: NATE-1586. | |
| dammarenediol 12-hydroxylase | A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of ginsenosides. Isolated from ginseng (Panax ginseng). Group: Enzymes. Synonyms: protopanaxadiol synthase; CYP716A47; dammarenediol-II,NADPH:O2 oxidoreductase (12β-hydroxylating). Enzyme Commission Number: EC 1.14.13.183. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0782; dammarenediol 12-hydroxylase; EC 1.14.13.183; protopanaxadiol synthase; CYP716A47; dammarenediol-II,NADPH:O2 oxidoreductase (12β-hydroxylating). Cat No: EXWM-0782. | |
| deoxysarpagine hydroxylase | A heme-thiolate protein (P-450). Group: Enzymes. Synonyms: DOSH. Enzyme Commission Number: EC 1.14.13.91. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0900; deoxysarpagine hydroxylase; EC 1.14.13.91; DOSH. Cat No: EXWM-0900. | |
| dichloroarcyriaflavin A synthase | The conversion of dichlorochromopyrrolate to dichloroarcyriaflavin A is a complex process that involves two enzyme components. RebP is an NAD-dependent cytochrome P-450 oxygenase that performs an aryl-aryl bond formation yielding the six-ring indolocarbazole scaffold. Along with RebC, a flavin-dependent hydroxylase, it also catalyses the oxidative decarboxylation of both carboxyl groups. The presence of RebC ensures that the only product is the rebeccamycin aglycone dichloroarcyriaflavin A. The enzymes are similar, but not identical, to StaP and StaC, which are involved in the synthesis of staurosporine. Group: Enzymes. Enzyme Commission Number: EC 1.13.12.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0609; dichloroarcyriaflavin A synthase; EC 1.13.12.17. Cat No: EXWM-0609. | |
| dihydrochelirubine 12-monooxygenase | A heme-thiolate protein (P-450). Group: Enzymes. Synonyms: dihydrochelirubine 12-hydroxylase. Enzyme Commission Number: EC 1.14.13.57. CAS No. 158736-41-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0864; dihydrochelirubine 12-monooxygenase; EC 1.14.13.57; 158736-41-5; dihydrochelirubine 12-hydroxylase. Cat No: EXWM-0864. | |
| dihydromonacolin L hydroxylase | A heme-thiolate protein (cytochrome P-450). The dehydration of 3α-hydroxy-3,5-dihydromonacolin L acid is believed to be spontaneous. The enzyme from fungi also catalyses the reaction of EC 1.14.13.198, monacolin L hydroxylase. Group: Enzymes. Synonyms: LovA (ambiguous). Enzyme Commission Number: EC 1.14.13.197. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0797; dihydromonacolin L hydroxylase; EC 1.14.13.197; LovA (ambiguous). Cat No: EXWM-0797. | |
| dihydrosanguinarine 10-monooxygenase | A heme-thiolate protein (P-450) involved in benzophenanthridine alkaloid synthesis in higher plants. Group: Enzymes. Synonyms: dihydrosanguinarine 10-hydroxylase. Enzyme Commission Number: EC 1.14.13.56. CAS No. 144388-41-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0863; dihydrosanguinarine 10-monooxygenase; EC 1.14.13.56; 144388-41-0; dihydrosanguinarine 10-hydroxylase. Cat No: EXWM-0863. | |
| ecdysone 20-monooxygenase | An enzyme from insect fat body or malpighian tubules involving a heme-thiolate protein (P-450). NADPH can act as ultimate hydrogen donor. Group: Enzymes. Synonyms: α-ecdysone C-20 hydroxylase; ecdysone 20-hydroxylase. Enzyme Commission Number: EC 1.14.99.22. CAS No. 55071-97-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1040; ecdysone 20-monooxygenase; EC 1.14.99.22; 55071-97-1; α-ecdysone C-20 hydroxylase; ecdysone 20-hydroxylase. Cat No: EXWM-1040. | |
| ent-kaurene oxidase | Requires cytochrome P-450. Catalyses three sucessive oxidations of the 4-methyl group of ent-kaurene giving kaurenoic acid. Group: Enzymes. Enzyme Commission Number: EC 1.14.13.78. CAS No. 149565-67-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0885; ent-kaurene oxidase; EC 1.14.13.78; 149565-67-3. Cat No: EXWM-0885. | |
| ent-kaurenoic acid oxidase | Requires cytochrome P-450. Catalyses three sucessive oxidations of ent-kaurenoic acid. The second step includes a ring-B contraction giving the gibbane skeleton. In pumpkin (Cucurbita maxima) ent-6α,7α-dihydroxykaur-16-en-19-oate is also formed. Group: Enzymes. Enzyme Commission Number: EC 1.14.13.79. CAS No. 337507-95-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0886; ent-kaurenoic acid oxidase; EC 1.14.13.79; 337507-95-6. Cat No: EXWM-0886. | |
| ent-sandaracopimaradiene 3-hydroxylase | A heme-thiolate protein (cytochrome P-450). Isolated from Oryza sativa (rice). Participates in the pathway for the biosynthesis of oryzalexins, a group of related phytoalexins produced by rice. Group: Enzymes. Synonyms: CYP701A; OsKOL4. Enzyme Commission Number: EC 1.14.13.191. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0791; ent-sandaracopimaradiene 3-hydroxylase; EC 1.14.13.191; CYP701A; OsKOL4. Cat No: EXWM-0791. | |
| farnesoate epoxidase | A heme-thiolate protein (cytochrome P-450). The enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate (cf. EC 1.14.13.202, methyl farnesoate epoxidase). It is involved in the synthesis of juvenile hormone. Group: Enzymes. Synonyms: CYP15C1. Enzyme Commission Number: EC 1.14.13.203. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0805; farnesoate epoxidase; EC 1.14.13.203; CYP15C1. Cat No: EXWM-0805. | |
| fatty-acid peroxygenase | A cytosolic heme-thiolate protein with sequence homology to P-450 monooxygenases. Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function. Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis). Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalysed by the common P-450s. A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated. Oxidizes the peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction. Group: Enzymes. Synonyms: fatty acid hydroxylase (ambiguous); P450 peroxygenase; CYP152A1; P450BS; P450SP&alpha. Enzyme Commission Number: EC 1.11.2.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0515; fatty-acid peroxygenase; EC 1.11.2.4; fatty acid hydroxylase (ambiguous); P450 peroxygenase; CYP152A1; P450BS; P450SP&alpha. Cat No: EXWM-0515. | |
| flavanoid 3',5'-hydroxylase | A heme-thiolate protein (P-450). The 3',5'-dihydroxyflavanone is formed via the 3'-hydroxyflavanone. In Petunia hybrida the enzyme acts on naringenin, eriodictyol, dihydroquercetin (taxifolin) and dihydrokaempferol (aromadendrin). The enzyme catalyses the hydroxylation of 5,7,4'-trihydroxyflavanone (naringenin) at either the 3' position to form eriodictyol or at both the 3' and 5' positions to form 5,7,3',4',5'-pentahydroxyflavanone (dihydrotricetin). The enzyme also catalyses the hydroxylation of 3,5,7,3',4'-pentahydroxyflavanone (taxifolin) at the 5' position, forming ampelopsin. NADH is not a good substitute for NADPH. Group: Enzymes. Synonyms: flavonoid 3',5'-hydroxylase. Enzyme Commission Number: EC 1.14.13.88. CAS No. 94047-23-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0896; flavanoid 3',5'-hydroxylase; EC 1.14.13.88; 94047-23-1; flavonoid 3',5'-hydroxylase. Cat No: EXWM-0896. | |
| fumitremorgin C monooxygenase | A heme-thiolate protein (P-450). Involved in the biosynthetic pathway of the indole alkaloid verruculogen. Group: Enzymes. Synonyms: ftmG (gene name). Enzyme Commission Number: EC 1.14.13.177. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0775; fumitremorgin C monooxygenase; EC 1.14.13.177; ftmG (gene name). Cat No: EXWM-0775. | |
| fumitremorgin C synthase | A heme-thiolate protein (P-450). The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen. Group: Enzymes. Synonyms: ftmE (gene name). Enzyme Commission Number: EC 1.14.21.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1021; fumitremorgin C synthase; EC 1.14.21.10; ftmE (gene name). Cat No: EXWM-1021. | |
| geraniol 8-hydroxylase | Requires cytochrome P-450. Also hydroxylates nerol and citronellol, cf. EC 1.14.13.151 linalool 8-monooxygenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the product rather than 10-hydroxygeraniol as used by references 1-3. See prenol nomenclature Pr-1. The cloned enzyme also catalysed, but less efficiently, the 3'-hydroxylation of naringenin (cf. EC 1.14.13.21, flavonoid 3'-monooxygenase). Group: Enzymes. Synonyms: CYP76B6; G10H; CrG10H; SmG10H. Enzyme Commission Number: EC 1.14.13.152. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0752; geraniol 8-hydroxylase; EC 1.14.13.152; CYP76B6; G10H; CrG10H; SmG10H. Cat No: EXWM-0752. | |
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