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| Product | Description | |
|---|---|---|
| P11 | P11 is a potent antagonist of the integrin αvβ3-vitronectin interaction with IC50 value of 25.72 nM. Synonyms: H-His-Ser-Asp-Val-His-Lys-NH2; L-histidyl-L-seryl-L-alpha-aspartyl-L-valyl-L-histidyl-L-lysinamide; HSDVHK-NH2. Grades: >98%. CAS No. 848644-86-0. Molecular formula: C30H48N12O9. Mole weight: 720.78. |  |
| P11 | P11 is a selective inhibitor of platelet-activating factor acetylhydrolases ( PAFAHs ) 1b2 and 1b3 that impairs cancer cell survival. P11 exhibits IC 50 values of ~40 and 900 nM for PAFAH1b2 and 1b3, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 942285-55-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-111053. |  |
| P110 TFA | P110 TFA is a dynamin-related protein 1 (Drp1) inhibitor that inhibits Drp1 GTPase activity. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Asp-Leu-Leu-Pro-Arg-Gly-Ser-NH2.TFA; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-glycyl-glycyl-L-alpha-aspartyl-L-leucyl-L-leucyl-L-prolyl-L-arginyl-glycyl-L-serinamide trifluoroacetic acid; Dynamic-related protein 1 (Drp-1)-specific inhibitor P110 trifluoroacetate; P 110 (peptide) trifluoroacetate; P 110 TFA; P-110 TFA. Grades: ≥95%. Molecular formula: C102H180F3N45O27. Mole weight: 2525.80. | |
| P11 (His-Ser-Asp-Val-His-Lys-NH2, Potent antagonist of alphavbeta3-vitronectin Interaction, Antiangiogenic) | Potent antagonist of the integrin avb3-vitronectin interaction (IC50 = 25.72nm). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic. Group: Biochemicals. Grades: Highly Purified. CAS No. 848644-86-0. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Cytochalasin J (Kodocytochalasin 2, Paspalin P11, Deacetylcytochalasin H, 17-Deoxo-zygosporin D) | Cytochalasin J is one of a family of potent mycotoxins produced by a range of fungi. All members of the class exhibit profound effects on cytoskeletal proteins which give rise to pronounced morphogenic activity in animals and plants. Cytochalasin J is the deacetyl analogue of cytochalasin H and exhibits similar, though less potent, antibacterial, antifungal, nematocidal and antitumor activities. Group: Biochemicals. Alternative Names: Kodocytochalasin 2, Paspalin P11, Deacetylcytochalasin H, 17-Deoxo-zygosporin D. Grades: Highly Purified. CAS No. 56144-22-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Integrin alpha-v-beta3 Antagonist, P11 (HSDVHK, HSDVHK-NH2) | A cell-permeable, hexapeptide containing a novel integrin-binding motif, SDV (a Type I PDZ-binding motif) that is shown to compete with vitronectin for the RGD-binding site of integrin avb3 (IC50=1.74pg/ml), in a chip-based assay. It is rapidly internalized into HUVECs, but not in NIH 3T3 cells, at a culture temperature of 37°C, a process which is mediated by caveolin and clathrin. At 10u/ml, this compound is shown to significantly inhibit the phosphorylation of ERK1/2 and MEK in HUVECs. Furthermore, it suppresses bFGF-induced proliferation of HUVECs, dose-dependently, and displays up-regulation of p53 and induction of apoptosis via activation of caspases-3, -8 and -9 at 50ug/ml. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Integrin ?v?3 Antagonist, P11 | The Integrin ?v?3 Antagonist, P11 controls the biological activity of Integrin ?v?3. Group: Fluorescence/luminescence spectroscopy. |  |
| Monoclonal Anti-Mitochondrial p110 antibody produced in mouse | clone 2G2, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| NMS-P118 | NMS-P118 is a highly selective Poly(ADP-ribose) Polymerase 1 (PARP-1) inhibitor with excellent ADME, pharmacokinetic profiles and high efficacy in vivo originated by Nerviano Medical Sciences. It was found to be less myelotoxic in vitro than olaparib which is a dual PARP-1/-2 inhibitor. It was in preclinical trials for Breast cancer, but no development had been published yet. Uses: Breast cancer. Synonyms: NMS-P118; NMS-P 118; NMS P118. 2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide. Grades: 98%. CAS No. 1262417-51-5. Molecular formula: C20H24F3N3O2. Mole weight: 395.42. | |
| Oligopeptide P11-4 acetate | Synonyms: Ac-Gln-Gln-Arg-Phe-Glu-Trp-Glu-Phe-Glu-Gln-Gln-NH2.CH3CO2H; N-acetyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-phenylalanyl-L-alpha-glutamyl-L-tryptophyl-L-alpha-glutamyl-L-phenylalanyl-L-alpha-glutamyl-L-glutaminyl-L-glutaminamide acetic acid; N2-Acetyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-α-glutamyl-L-phenylalanyl-L-α-glutamyl-L-glutaminyl-L-glutamamide acetate; Curodont acetate; P11-4 acetate; Peptide P11-4 acetate. Grades: ≥95%. Molecular formula: C74H102N20O24. Mole weight: 1655.75. | |
| PAFAH1b2/3-IN-P11 | P11 is an inhibitor of platelet-activating factor acetylhydrolase (PAF-AH) 1b2 and 1b3. At 10 μM, it has been shown to impair Neuro2a and PC3 tumor cell survival. Synonyms: (2S,6S)-6-(4-Tert-butylphenyl)-2-(4-methylphenyl)-1-(4-methylphenyl)sulfonyl-3,6-dihydro-2H-pyridine-5-carboxylic acid. Grades: ≥98%. CAS No. 942285-55-4. Molecular formula: C30H33NO4S. Mole weight: 503.7. | |
| Phosphoinositide 3 Kinase, p110 gamma (His) p101 (GST), Recombinant, Human (PI3K) | PI3K is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3K -/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8alpha-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3K. Distinct regions within the p101 regulatory subunit primary stucture are responsible for interaction with PI3K and Gbg. The PI3K binding site is confined to the N-terminus, whereas binding to Gbg is mediated by the C-terminus of p101. The PI3K catalytic subunit carries a N-terminal His6 affinity Tag, whereas the p101 adaptor subunit carries a N-terminal GST Tag. The molecular weight for p110g chain is 126.3kD (without Tag) and the p101 chain 101kD (without Tag). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: custom. US Biological Life Sciences. | Worldwide |
| Phosphoinositide 3-kinase p110? human | ?95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PI3 kinase [p110a(E545K)/p85a] Active human | recombinant, expressed in baculovirus infected insect cells, ?55% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PI3 kinase [p110a(H1047R)/p85a] Active human | recombinant, expressed in baculovirus infected insect cells, ?60% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PI3 kinase (p110a/p85a) Active human | recombinant, expressed in baculovirus infected insect cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PI3 kinase (p110d/p85a) Active human | recombinant, expressed in baculovirus infected insect cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| PI 3-K Inhibitor XVIII (p110 beta-G beta gamma Interaction Inhibitor peptide, Cell-permeable, Myr-N-KAAEIASSDSANVSSRGGKKFL PV-NH2) | An N-myristoylated cell-permeable PI 3-K p110 beta-derived G beta-gamma-binding peptide (aa514-537 in p110 beta C2-helical linker region) that prevents G beta-gamma-, but not RTK-, mediated p100 beta activation both in cell-free assays (1uM) and in cultures (30uM in p110 beta/p85/Akt/G beta-gamma-transfected HEK 293E cells) without affecting basal p100 beta activity, p110 beta-Rab5 interaction, nor G beta-gamma-dependent activation of adenylyl cyclase or p101-p110-gamma dimer. The ATP-competitive p110 beta inhibitior TGX-221 can be used in conjunction for studying G beta-gamma dependency of p110 beta-mediated cellular functions. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PI3K (p110-?/p55-?), active, His tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PI3K (p110-?/p85-?), active, His tagged from mouse and human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| PI3K (p110-?/p85-?), active, His tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| VEGF Inhibitor, CBO-P11 | The VEGF Inhibitor, CBO-P11 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| 1,1-Dimethoxy-N,N-dimethylmethanamine | 1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes. Group: Biochemicals. Alternative Names: 1,1-Dimethoxy-trimethylamine; (Dimethoxymethyl) dimethylamine; (Dimethylamino) dimethoxymethane; (Dimethylamino) formaldehyde Dimethyl Acetal; 1,1-Dimethoxy-N,N-dimethylmethanamine; 1, 1-Dimethoxytri methyl amine; DMF Dimethyl Acetal; DMFDMA; Dimethoxy (dimethylamino) methane; Dimethoxy-N,N-dimethylmethanamine; Dimethoxy-N,N-dimethylmethylamine; Dimethyl Dimethylformamide Acetal; Dimethylformamide Dimethyl Acetal; Methyl-8; N, N-Dimethyl-1, 1-bis (methyloxy) methanamine; N,N-Dimethylformamide Dimethyl Acetal; N-(Dimethoxymethyl)-N,N-dimethylamine; N- (Dimethoxymethyl) dimethylamine; α , α -Dimethoxytri methyl amine. Grades: Highly Purified. CAS No. 4637-24-5. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 2,3,4,5,6-Pentafluorotoluene | 2,3,4,5,6-Pentafluorotoluene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Pentafluorotoluene, Benzene, pentafluoromethyl-, Methylpentafluorobenzene, Methyl pentafluorobenzene, Pentafluoromethylbenzene, 2,3,4,5,6-Pentafluorotoluene, 103977_ALDRICH, Toluene, 2,3,4,5,6-pentafluoro-, NSC88285, CID69869, EINECS 212-233-7, NSC 88285, 2,3,4,5,6-PENTAFLUORO-TOLUENE, P116, TL8005298, Toluene, 2,3,4,5,6-pentafluoro- (8CI), Benzene, 1,2,3,4,5-pentafluoro-6-methyl-, 771-56-2. Product Category: Aryl. Appearance: Colorless Liquid. CAS No. 771-56-2. Molecular formula: C7H3F5. Mole weight: 182.09. Purity: 0.96. IUPACName: 1,2,3,4,5-pentafluoro-6-methylbenzene. Canonical SMILES: CC1=C(C(=C(C(=C1F)F)F)F)F. Density: 1.44. ECNumber: 212-233-7. Product ID: ACM771562. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 3-Aminoisonicotinic Acid Methyl Ester | 3-Aminoisonicotinic Acid Methyl Ester is a useful synthetic intermediate. It is used in the synthesis of morpholinophenyl quinazolines and related derivatives as PI3 kinase p110α inhibitors. It is also used to synthesize aryl tetrahydropyridine inhibitors of farnesyltransferase as antitumor agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 55279-30-6. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H8N2O2, Molecular Weight: 152.15. US Biological Life Sciences. | Worldwide |
| A66 | A66 is a highly specific and selective p110α inhibitor with an IC 50 of 32 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1166227-08-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13261. | |
| A66 | Inhibition of p110α alone by A66 treatment is sufficient to block insulin signalling to Akt/PKB in certain cell lines that harbor H1047R mutations in PIK3CA and have high levels of p110α and class-Ia PI3K activity. Synonyms: A66; A-66; A 66. Grades: >98%. CAS No. 1166227-08-2. Molecular formula: C17H23N5O2S2. Mole weight: 393.53. | |
| Acalisib | Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. Synonyms: GS-9820; GS9820; GS 9820; CAL-120; CAL 120; CAL120; Acalisib; UNII-OVW60IDW1D. CAS No. 870281-34-8. Molecular formula: C21H16FN7O. Mole weight: 401.405. | |
| Alpelisib | Alpelisib (BYL-719) is a potent, selective, and orally active PI3Kα inhibitor. Alpelisib (BYL-719) shows efficacy in targeting PIK3CA-mutated cancer. Alpelisib (BYL-719) also inhibits p110α /p110γ /p110δ /p110β with IC 50 s of 5/250/290/1200 nM, respectively. Antineoplastic activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BYL-719. CAS No. 1217486-61-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15244. | |
| Alpelisib, Free Base, 99+% | Alpelisib, also known as BYL719, is a potent and selective phosphatidylinositol-3 kinase [alpha] inhibitor. It inhibited P110[alpha], p110[beta], p110[delta], and p110[gamma] with IC50 values of 5 nM, 1.2 µM, 0.29 µM and 0.25 µM, respectively, in biochemical assays. It inhibited the Akt phosphorylation with IC50 values of 74 nM in Rat1-myr-p110[alpha] cells, 2.2 µM in Rat1-myr-p110[beta] cells, and 1.2 µM in Rat1-myr-p110[delta] cells. Furet P., et al. "Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation." Bioorg. Med. Chem. Lett. 23: 3741-3748 (2013). Group: Biochemicals. Alternative Names: BYL-719; NVP-BYL719; (S)-Pyrrolidine-1,2-dicarboxylic Acid 2-Amide 1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-pyridin-4-yl]thiazol-2-yl]amide; (2S) -N1- [4- methyl -5- [2- (2, 2, 2-tri fluoro -1, 1-di methyl ethyl ) -4-pyridinyl ] -2-thiazoly l ] -1, 2-pyrrolidinedicarboxami de . Grades: Highly Purified. CAS No. 1217486-61-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C19H22F3N5O2S, Molecular Weight: 441.47. US Biological Life Sciences. | Worldwide |
| AMA-37 | AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC 50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 404009-46-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100706. | |
| AS 252424 bispotassium salt | AS 252424 bispotassium salt is the potassium salt form of AS 252424, which is a potent and selective PI3K p110γ inhibitor. Synonyms: AS 252424 bispotassium salt; AS252424 bispotassium salt; AS-252424 bispotassium salt; dipotassium (5Z)-5-[[5-(4-fluoro-2-oxidophenyl)furan-2-yl]methylidene]-4-oxo-1,3-thiazol-2-olate. Grades: 99%. Molecular formula: C14H6FNO4S.K2. Mole weight: 381.46. | |
| BEZ235 Tosylate | BEZ235 tosylate is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Synonyms: NVP-BEZ235; BEZ 235 Tosylate; BEZ-235 Tosylate. Grades: >98%. CAS No. 1028385-32-1. Molecular formula: C37H31N5O4S. Mole weight: 641.74. | |
| BKM120 | BKM120, also called as buparlisib or NVP-BKM120, activity in a range of preclinical cancer models, specifically inhibits class I PI3K isoforms, which blocks p110α (IC50 = 52 nM), p110β (IC50 = 166 nM), p110δ (IC50 = 116 nM) and p110γ (IC50 = 262 nM). BKM120 displays little sensitive to Class III and Class IV PI3K's or PI4K. Synonyms: 5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; BKM120; buparlisib; NVP-BKM120; 944396-07-0; BKM 120; BKM-120; UNII-0ZM2Z182GD; 1202777-78-3; 944396-07-0; NVP-BKM120; Buparlisib; 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; NVP-BKM-120; BKM120; BKM 120; BKM-120; UNII-0ZM2Z182GD; 1202777-78-3; CHEMBL2017974; CHEBI:71954; 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; 5-[2,6-Di(Morpholin-4-Yl)pyrimidin-4-Yl]-4-(Trifluoromethyl)pyridin-2-Amine; C18H21F3N6O2; BKM120, BKM-120|; 2-Pyridinamine,5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-; 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-Pyridinamine. CAS No. 944396-07-0. Molecular formula: C18H21F3N6O2. Mole weight: 410.39. | |
| Buparlisib | Buparlisib (BKM120; NVP-BKM120) is a pan-class I PI3K inhibitor, with IC 50 s of 52, 166, 116 and 262 nM for p110α , p110β , p110δ and p110γ , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BKM120; NVP-BKM120. CAS No. 944396-07-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-70063. | |
| Buparlisib Hydrochloride | Buparlisib Hydrochloride (BKM120 Hydrochloride) is a pan-class I PI3K inhibitor, with IC 50 of 52 nM/166 nM/116 nM/262 nM for p110α / p110β / p110δ / p110γ , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BKM120 Hydrochloride; NVP-BKM120 Hydrochloride. CAS No. 1312445-63-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15180. | |
| CAL-101 | CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor. Group: Biochemicals. Alternative Names: 5-Fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-4(3H)-quinazolinone. Grades: Highly Purified. CAS No. 870281-82-6. Pack Sizes: 10mg, 50mg, 100mg, 200mg. Molecular Formula: C22H18FN7O, Molecular Weight: 415.42. US Biological Life Sciences. | Worldwide |
| CNX-1351 | CNX-1351 is a selective covalent Inhibitor of PI3K&alpha. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20-400 times less potent against β, γ, and &delta. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3K&alpha. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110&alpha. Synonyms: CNX-1351; CNX 1351; CNX1351. Grades: 0.98. CAS No. 1276105-89-5. Molecular formula: C30H35N7O3S. Mole weight: 573.716. | |
| CTCE-9908 | CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1030384-98-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1103. | |
| D-Lysine homopolymer hydrobromide | D-Lysine homopolymer hydrobromide. Group: Polyamino acids. Alternative Names: Poly-D-lysine hydrobromide, Poly-DL-lysine hydrobromide, P0296_SIGMA, P0899_SIGMA, P1024_SIGMA, P1149_SIGMA, P4408_SIGMA, P6403_SIGMA, P6407_SIGMA, P7280_SIGMA, P7405_SIGMA, P7886_SIGMA, NSC169847, AKOS015834116, MCULE-8132017980, NSC-169847, 27964-99-4, 73565-55-6. CAS No. 27964-99-4. Product ID: (2R)-2,6-diaminohexanoic acid. Molecular formula: 146.19g/mol. Mole weight: C6H14N2O2. C(CCN)CC(C(=O)O)N. InChI=1S/C6H14N2O2/c7-4-2-1-3-5 (8)6 (9)10/h5H, 1-4, 7-8H2, (H, 9, 10)/t5-/m1/s1. KDXKERNSBIXSRK-RXMQYKEDSA-N. 96%. |  |
| DNA-PK Inhibitor IV | DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK). It also inhibits the phosphatidylinositol 3-kinase (PI3K) isoforms p110β, p110δ, and p110γ but not p110α or class II PI3Ks, PI4Kβ, ATM, ATR, mTOR, CK2, or GRK2. Synonyms: 2-hydroxy-4-(4-morpholinyl)-benzaldehyde. Grades: ≥98%. CAS No. 70362-07-1. Molecular formula: C11H13NO3. Mole weight: 207.23. | |
| Duvelisib | Duvelisib (IPI-145) is a selectivite p100δ inhibitor with IC 50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IPI-145; INK1197. CAS No. 1201438-56-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17044. | |
| Epitalon | Epitalon is an anti-aging agent and a telomerase activator. Epitalon has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon can be used for cancer, old age and Retinitis Pigmentosa [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Epithalon; Epithalamin. CAS No. 307297-39-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1149. | |
| FC131 TFA | FC131 TFA is a CXCR4 antagonist, inhibits [ 125 I]-SDF-1 binding to CXCR4, with an IC 50 of 4.5 nM. Anti- HIV activity [1]. Uses: Scientific research. Group: Peptides. CAS No. 842166-42-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1104A. | |
| Galanin (1-30), human | Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors , with K i s of both 1 nM. Uses: Scientific research. Group: Peptides. Alternative Names: Glanin. CAS No. 119418-04-1. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P1127. | |
| Galanin (2-11) (AR-M 1896) | AR-M 1896 has been found to be a galanin GAL2 receptor agonist and could be used as an antiepileptogenic agent. Synonyms: WTLNSAGYLL-CONH2; 367518-31-8; Galanin (2-11) porcine, rat; AR-M1896; CHEMBL578710; Galanin-2-11-NH.2.; AR-M 1896; Gal(2-11)amide; Galanin(2-11)porcine,rat; HY-P1129; BDBM50307252; AKOS024457247; CS-0028038; Galanin (2-11) porcine, rat, >=97% (HPLC), lyophilized powder. Grades: ≥97% by HPLC. CAS No. 367518-31-8. Molecular formula: C54H81N13O14. Mole weight: 1136.3. | |
| Galanin (swine) | Galanin (swine), a neuropeptide, consists of 29 amino acids and contains a C-terminal amidated glycine. Galanin (swine) inhibits basal and stimulated insulin secretion both in vivo and in vitro under a variety of experimental conditions. Galanin (swine) is a galanin receptor agonist with pK i s of 9.63, 9.49, 9.02, 8.98, 8.01 and 8.14 at human GAL1, rat GAL1, human GAL2, rat GAL2, human GAL3 and rat GAL3 respectively [1]. Uses: Scientific research. Group: Peptides. CAS No. 88813-36-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1128. | |
| GDC0941 | GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K that inhibits p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM. Synonyms: 4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine; GDC-0941; GDC 0941; GDC0941; RG7321; RG-7321; RG 7321; GNE0941; GNE-0941; GNE 0941; Pictrelisib; Pictilisib. CAS No. 957054-30-7. Molecular formula: C23H27N7O3S2. Mole weight: 513.635. | |
| GDC-0941 dimethanesulfonate | GDC-0941 dimethanesulfonate is a potent inhibitor of PI3Kα/δ with modest selectivity against p110β and p110&gamma. It is a novel selective class I phosphatidylinositol-3-kinase (PI3K) inhibitor. It is designed to bind the ATP-binding pocket of PI3K and to prevent formation of phosphatidylinositol-3, 4, 5-triphosphate (PIP3), a second messenger that transmits PI3K downstream signals. It causes growth inhibition in a variety of cancer cell lines, including A2780, MDA-MB-361, PC3, and U87MG. It also inhibits the growth of trastuzumab-sensitive and -resistant HER2-amplied cancer cells which harbor p110( mutations or PTEN loss. It also reduces tumor volume in different xenograft models. Synonyms: GDC-0941 dimethanesulfonate; GDC 0941 dimethanesulfonate; GDC0941 dimethanesulfonate; Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt). Grades: >98%. CAS No. 957054-33-0. Molecular formula: C25H35N7O9S4. Mole weight: 705.85. | |
| GDC-0941, Free Base, PI3K Inhibitor | GDC-0941 is a potent inhibitor of p110a and p110d (IC?? = 3nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. "The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer." J. Med. Chem. 51: 5522-5532 (2008).GDC-0941 inhibited the growth of >70% ...I., et al. "Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941." Mol. Cancer Ther. 8: 1725-1738 (2009). Group: Biochemicals. Alternative Names: 2- (1H-indazol-4-yl) -6- ( (4- (methylsulfonyl) piperazin-1-yl) methyl) -4-morpholinothieno[3, 2-d]pyrimidine; 4-[2- (1H-Indazol-4-yl) -6-[[4- (methylsulfonyl) piperazin-1-yl]methyl]thieno[3, 2-d]pyrimidin-4-yl]morpholine; GDC 0941; GDC 941; GNE 0941; Pictilisib; Pictrelisib. Grades: Highly Purified. CAS No. 957054-30-7. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 513.64. US Biological Life Sciences. | Worldwide |
| GLP-1(9-36)amide | GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 161748-29-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1141. | |
| GLP-2(rat) | GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR) [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 195262-56-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1142. | |
| GSK2636771 | GSK2636771 is an orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells. Uses: Antineoplastic agents. Synonyms: GSK2636771; GSK-2636771; GSK 2636771. CAS No. 1372540-25-4. Molecular formula: C22H22F3N3O3. Mole weight: 433.431. | |
| GSK2636771 | GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with a K i of 0.89 nM and an IC 50 of 5.2 nM, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms. Uses: Scientific research. Group: Signaling pathways. CAS No. 1372540-25-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15245. | |
| Hemokinin 1, human | Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 491851-53-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1198. | |
| IC87114, PI3K Inhibitor (2-[6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone) | Cell-permeable. A potent, ATP-competitive and selective inhibitor of PI 3-K isoform p110e (IC?? =60nM). Inhibits p110a and p110b only at higher concentrations (>1uM). IC87114 does not inhibit other PIK-related kinases such as ATM, ATR, DNA-PK, and mTOR even at concentrations up to 100uM. Group: Biochemicals. Grades: Highly Purified. CAS No. 371242-69-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Idelalisib | Idelalisib (CAL-101; GS-1101) is a highly selective and orally bioavailable p110δ inhibitor with an IC 50 of 2.5 nM, showing 40- to 300-fold selectivity for p110δ over other PI3K class I enzymes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CAL-101; GS-1101. CAS No. 870281-82-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13026. | |
| Insulin(cattle) | Insulin cattle is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells. Insulin cattle has often been used as growth supplement in culturing cells. Uses: Scientific research. Group: Peptides. CAS No. 11070-73-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1156. | |
| IPI-3063 | IPI-3063 is a potent and selective phosphoinoside-3-kinase (PI3K) p110δ inhibitor. IPI-3063 was shown to inhibit mouse B cell proliferation, survival, and plasmablast differentiation, and also inhibit human B cell proliferation in vitro. Synonyms: 4-Amino-6-[1-[8-(1-methyl-6-oxopyridin-3-yl)-1-oxo-2-propan-2-ylisoquinolin-3-yl]ethylamino]pyrimidine-5-carbonitrile. CAS No. 1425043-73-7. Molecular formula: C25H25N7O2. Mole weight: 455.51. | |
| Kisspeptin 234 TFA | Kisspeptin 234 TFA, is a 10 amino acid peptide as well as a kisspeptin receptor (KISS1, GPR54) antagonist. Kisspeptin 234 TFA is an analog of Kisspeptin 10 [1]. Uses: Scientific research. Group: Peptides. CAS No. 1848962-29-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1196A. | |
| LDV-FITC | LDV-FITC, a fluorescent peptide, is a FITC-conjugated LDV peptide (HY-P2267). LDV-FITC binds to the α4β1 integrin with high affinity ( K d : 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn 2+ respectively). LDV-FITC can be used to detect α4β1 integrin affinity [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1207610-07-8. Pack Sizes: 1 mg. Product ID: HY-P1188. | |
| Locustatachykinin I | Locustatachykinin I is a insect tachykinin-related peptide isolated from Locusta migratoria. Locustatachykinin I exhibits sequence homologies with the vertebrate tachykinins. In Lacanobia, Locustatachykinin I is also a substrate for a deamidase [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 126985-97-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1183. | |
| LY 294002, 4?-NH? - CAS 942289-87-4 | A cell-permeable LY 294002 4'-amino derivative with enhanced potency against p110?/?/?/?. Group: Fluorescence/luminescence spectroscopy. | |
| LY294002 hydrochloride | LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC 50 values of 0.5, 0.57, and 0.97 μM for P110α , P110δ and P110β , respectively. LY294002 hydrochloride also inhibits CK2 with an IC 50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934389-88-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10108A. | |
| M1145 | M1145, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a K i of 6.55 nM. M1145 shows more than 90-fold higher affinity for GAL2 over GAL1 (K i =587 nM) and a 76-fold higher affinity over GalR3 (K i =497 nM). M1145 has an additive effect on the signal transduction of galanin [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1172089-00-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1135. | |
| M617 | M617 is a selective galanin receptor 1 (GAL1) agonist, with K i s of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 860790-38-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1131. | |
| M871 | M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is a selective galanin receptor type 2 ( GalR2 ) antagonist. M871 exhibits K i values of 13.1 nM and 420 nM for GalR2 and GalR1 , respectively. M871 can be used for research on GalR2 -related diseases (such as epilepsy, pain) [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide. CAS No. 908844-75-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1130. | |
| MEDICA16 | MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 87272-20-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1123. | |
| mTOR Inhibitor XII, Torin2 (9- (6-aminopyridin-3-yl) -1- (3- (trifluoromethyl) phenyl) benzo[h][1, 6]naphthyridin-2 (1H) -one, DNA-PK Inhibitor VII, PI 3-K Inhibitor XIX, PI 4-K Inhibitor) | A Torin1 structural analog that acts as a cell-permeable, potent, ATP-competitive inhibitor against DNA-PK and mTOR (IC50 = 0.5 and 2.81nM, respectively). Comparing to Torin1, Torin2 displays enhanced inhibitory potency against PI 4-Kbeta (IC50 = 18.3nM) and PI 3-K (IC50 =4.68, 5.67, 8.58, 17.5, 24.5, and 28.1nM, respectively, against P110alpha/P85alpha, P110-gamma, hVPS34, P110delta/P85alpha, C2beta, C2alpha, respectively), while being more effective in inhibiting S6K1 Thr389 phosphorylation in MEF cultures (IC50 = 0.25nM vs 2nM, respectively, for Torin2 and Torin1) in vitro and displaying much improved oral bioavailability in mice (Cmax (ng/mL) /T1/2 (h) = 3968/0.72 and 223/0.79, respectively, for Torin2 and Torin1; 10/mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O, Primary Target: MTOR. US Biological Life Sciences. | Worldwide |
| NVP-BKM120 Hydrochloride | NVP-BKM120 Hcl(BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Synonyms: BKM-120 hydrochloride; BKM120 hydrochloride; BKM 120 hydrochloride. Grades: >98%. CAS No. 1312445-63-8. Molecular formula: C18H22ClF3N6O2. Mole weight: 446.85. | |
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