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| Product | Description | |
|---|---|---|
| p38 MAPK Inhibitor | p38 MAPK inhibitor is a potent inhibitor of p38 MAP kinase with IC50 value of 35 nM. Synonyms: p38 MAP Kinase Inhibitor; p38 Mitogen-activated Protein Kinase Inhibitor; 2-(4-chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1H-pyrazol-3-one. Grades: ≥98%. CAS No. 219138-24-6. Molecular formula: C20H13ClFN3O. Mole weight: 365.8. |  |
| p38 MAPK Inhibitor IV | p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38α/β MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38??, and p38δ, respectively. Synonyms: p38 MAP Kinase Inhibitor IV; p38 Mitogen-activated Protein Kinase Inhibitor IV; 2,2'-sulfonylbis(3,4,6-trichlorophenol); 3,4,6-trichloro-2-(2,3,5-trichloro-6-hydroxyphenyl)sulfonylphenol. Grades: ≥98%. CAS No. 1638-41-1. Molecular formula: C12H4Cl6O4S. Mole weight: 456.9. | |
| (S)-p38 MAPK Inhibitor III | (S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively). Synonyms: (S)-p38 MAP Kinase Inhibitor III; 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamin; (S)-p38 Mitogen-activated Protein Kinase Inhibitor III. Grades: ≥98%. CAS No. 581098-48-8. Molecular formula: C23H21FN4S. Mole weight: 404.5. | |
| Angelicin | Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression ( IC 50 =28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB , and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2 , Bcl-xL , and Mcl-1 , while activating caspase-9 and caspase-3. Uses: Scientific research. Group: Natural products. Alternative Names: Isopsoralen. CAS No. 523-50-2. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-N0763. |  |
| Antibiotic LL Z1640-2 (Antibiotic C292, Antibiotic L 783278) | Antibiotic LL Z1640-2 a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in an animal models. Group: Biochemicals. Alternative Names: Antibiotic C292, Antibiotic L 783278. Grades: Highly Purified. CAS No. 66018-38-0. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| AS1940477 | AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg/kg (ED(50)=0.053 mg/kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this study demonstrated that AS1940477 is a novel and potent p38 MAPK inhibitor and may be useful as a promising anti-inflammatory agent for treating inflammatory disorders. Synonyms: AS1940477; AS-1940477; AS 1940477. CAS No. 928344-12-1. Molecular formula: C24H22FN5O2. Mole weight: 431.47. | |
| BMS582949 | BMS582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 value of 13nM, which plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNFα and IL-1&beta. It is used for the treatment of rheumatoid arthritis. It was developed by Bristol-Myers Squibb and was in clinic phase 2 trials, but now it is terminated. Uses: Bms582949 is used for the treatment of rheumatoid arthritis. Synonyms: 4-[[5-[(Cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide;BMS-582949;PS-540446; BMS 582949; PS 540446; BMS582949; PS540446. Grades: 98%. CAS No. 623152-17-0. Molecular formula: C22H26N6O2. Mole weight: 406.49. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC 50 of 13 nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912806-16-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14305A. | |
| BMS-582949 hydrochloride | BMS-582949 hydrochloride is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13 nM. It displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases including serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. It is a weak inhibitor of CYP3A4, with an IC50 value ranging from 18 to 40 μM based in multiple tests. It does not significantly inhibit cytochrome P450 isozymes 1A2, 2C9, 2C19, and 2D6 in vitro. It exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively. It is currently under Phase II clinical trials for the treatment of inflammatory diseases. Uses: Bms-582949 hydrochloride is used for the treatment of inflammatory diseases. Synonyms: BMS 582949 hydrochloride; BMS582949 hydrochloride; BMS-582949 hydrochloride; 4-((5-((Cyclopropylamino)carbonyl)-2-methylphenyl)amino)-5-methyl-n-propylpyrrolo(2,1-f)(1,2,4)triazine-6-carboxamide. Grades: >98%. CAS No. 912806-16-7. Molecular formula: C22H27ClN6O2. Mole weight: 442.94. | |
| Broussonin E | Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 90902-21-9. Molecular formula: C17H20O4. Mole weight: 288.3. Purity: 0.98. IUPACName: 5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol. Canonical SMILES: COC1=CC(=C(C=C1)CCCC2=CC(=C(C=C2)OC)O)O. Product ID: ACM90902219. Alfa Chemistry ISO 9001:2015 Certified. Categories: Broussonneti. |  |
| CGH 2466 dihydrochloride | CGH 2466 dihydrochloride is an adenosine A1, A2B and A3 receptor antagonist (IC50 = 19, 21, and 80 nM, respectively). It also displays an inhibitory effect on p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 is potentially used for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Uses: Potential treatment of asthma and copd. Synonyms: CGH 2466 dihydrochloride; CGH2466 dihydrochloride; CGH-2466 dihydrochloride; 4-(3,4-Dichlorophenyl)-5-(4-pyridinyl)-2-thiazolamine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1177618-54-0. Molecular formula: C14H9N3SCl2.2HCl. Mole weight: 395.13. | |
| Chloranthalactone B | Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 66395-03-7. Molecular formula: C15H16O3. Mole weight: 244.29. Purity: 0.98. Canonical SMILES: CC1=C2CC3C(=C)C4CC4C3(C5C2(O5)OC1=O)C. Product ID: ACM66395037. Alfa Chemistry ISO 9001:2015 Certified. | |
| CMPD-1 | CMPD-1, also called MK2a Inhibitor, inhibits tubulin polymerisation. It inhibit p38α-mediated MK2a phosphorylation (apparent Ki = 330 nM). Synonyms: CMPD1; CMPD-1; CMPD 1; IN1225; IN-1225; IN 1225; 4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide; MK2a Inhibitor; MAPKAPK2a Inhibitor; CMPD1; CHEMBL235658; 41179-33-3; IN1225; 4-(2' -Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide; Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor; MK2a Inhibitor_x000D_; SCHEMBL169905. CAS No. 41179-33-3. Molecular formula: C22H20FNO2. Mole weight: 349.4. | |
| Cudraflavone B | Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 19275-49-1. Molecular formula: C25H24O6. Mole weight: 420.45. Purity: 0.98. IUPACName: 8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one. Canonical SMILES: CC(=CCC1=C(OC2=CC3=C(C=CC(O3)(C)C)C(=C2C1=O)O)C4=C(C=C(C=C4)O)O)C. Product ID: ACM19275491. Alfa Chemistry ISO 9001:2015 Certified. | |
| Curcumenol | Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC 50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria , with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Curcumenol. CAS No. 19431-84-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-N2259. | |
| DBM 1285 dihydrochloride | DBM 1285 dihydrochloride is a p38 MAPK inhibitor supressing p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. It was shown to attenuate zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Synonyms: DBM 1285 dihydrochloride; DBM1285 dihydrochloride; DBM-1285 dihydrochloride; N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1782532-29-9. Molecular formula: C21H22FN5S.2HCl. Mole weight: 468.42. | |
| Dehydrocorydaline | Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 13-Methylpalmatine. Product Category: Inhibitors. CAS No. 30045-16-0. Mole weight: 366.4. Purity: 95%+. Product ID: ACM30045160. Alfa Chemistry ISO 9001:2015 Certified. | |
| Dehydrocorydaline nitrate | Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Hydrocortisonenitrate. Product Category: Inhibitors. Appearance: Solid. CAS No. 13005-09-9. Molecular formula: C22H24N2O7. Mole weight: 428.4. Purity: 95%+. Canonical SMILES: [O-][N+]([O-])=O.CC1=C(C=CC(OC)=C2OC)C2=C[N+]3=C1C4=CC(OC)=C(OC)C=C4CC3. Product ID: ACM13005099. Alfa Chemistry ISO 9001:2015 Certified. | |
| Dilmapimod | Dilmapimod, also known as SB-681323, is p38 MAPK inhibitor. The treatment with SB-681832 is a safe and effective means of reducing hsCRP in patients undergoing elective PCI. Synonyms: Dilmapimod; SB-681323; SB 681323; SB681323; GW 681323; GW-681323; GW681323. Grades: 98%. CAS No. 444606-18-2. Molecular formula: C23H19F3N4O3. Mole weight: 456.42. | |
| Doramapimod | Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation. Group: Biochemicals. Alternative Names: N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea; BIRB 796BS; Birb 796. Grades: Highly Purified. CAS No. 285983-48-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Doramapimod (1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea, BRRB 796) | Cell-permeable. A potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors, doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Group: Biochemicals. Grades: Highly Purified. CAS No. 285983-48-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ergothioneine | Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt , which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: L-(+)-Ergothioneine. CAS No. 497-30-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1914. | |
| Indole-5-carboxamide | SD-169 is an ATP-competitive and orally bioactive inhibitor of p38α MAP kinase (IC50 = 3.2 nM) with 38 fold selectivity over p38β MAP kinase (IC50 = 122 nM). SD-169 decreases p38 MAP kinase expression in T cells, lowers blood glucose and reduces the risk of diabetes. It has no inhibitory effect against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2. Synonyms: SD-169; SD169; 5-(Aminocarbonyl)-1H-indole; 5-Carbamoylindole. Grades: 99 %. CAS No. 1670-87-7. Molecular formula: C9H8N2O. Mole weight: 160.17. | |
| L-2286 | L-2286 is a novel PARP inhibitor. L-2286 exerted significant protective effect against ischemia-reperfusion-induced myocardial injury in both experimental models. More importantly, L-2286 facilitated the ischemia-reperfusion-induced activation of Akt, extracellular signal-regulated kinase, and p38-MAPK in both isolated hearts and in vivo cardiac injury. Synonyms: L 2286; L2286; 2-(2-piperidin-1-ylethylsulfanyl)-1H-quinazolin-4-one. Grades: 98%. CAS No. 684276-17-3. Molecular formula: C15H19N3OS. Mole weight: 289.40. | |
| Losmapimod | Losmapimod (GSK-AHAB) is a selective, potent, and orally active p38 MAPK inhibitor with pK i s of 8.1 and 7.6 for p38α and p38β, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-AHAB; GW856553X; SB856553. CAS No. 585543-15-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10402. | |
| Losmapimod | Losmapimod is a promising new agent against cardiovascular diseases. This drug works by inhibiting p38 MAP kinases, which play an important role in the development of atherosclerosis and heart failure caused by ischemic conditions. Losmapimod did not cause an improvement in exercise tolerance or lung function, despite being well-tolerated in this COPD population. The p38 MAPK inhibitor losmapimod (GW856553) attenuates the pro-inflammatory response in humans by reducing PIC production. Synonyms: Losmapimod; GW856553; GW-856553; GW 856553 GSK-AHAB; GW856553X; 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide. Grades: 98%. CAS No. 585543-15-3. Molecular formula: C22H26FN3O2. Mole weight: 383.467. | |
| LY2228820 | LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively). Synonyms: Ralimetinib; LY2228820; LY 2228820; LY-2228820. Grades: >98%. CAS No. 862505-00-8. Molecular formula: C24H29FN6. Mole weight: 420.53. | |
| LY2228820 dimesylate | LY2228820 dimesylate is the salt form of LY2228820, a tri-substituted imidazole derivative and p38α and β MAPK inhibitor. LY2228820 inhibits tumor growth in various cancer models. Synonyms: Ralimetinib Mesylate; Ralimetinib dimesylate; 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine mesylate. Grades: >98%. CAS No. 862507-23-1. Molecular formula: C26H37FN6O6S2. Mole weight: 612.74. | |
| Madecassoside | Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB [5][6] , exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity [10]. Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases. Uses: Scientific research. Group: Natural products. Alternative Names: Asiaticoside A. CAS No. 34540-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-N0568. | |
| MAPK Inhibitor Library | A unique collection of 367 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include ERK, JNK, MEK, p38, MAPK, Raf, RSK, MNK, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1400. Categories: MAPK Inhibitor Libraries. |  |
| ML3403 | ML 3403 is a potent and selective p38 mitogen-activated protein kinase (MAPK) inhibitor. MAPK is a key mediator in cytokine-induced signaling events and plays an integral role in disease states including oncogenesis, autoimmune diseases, and inflammatory processes. Therefore, MAPK inhibitors such as ML 3403 provides an attractive strategy for therapeutic intervention. Synonyms: ML 3403; ML-3403; p38 MAP Kinase Inhibitor III; 4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine. Grades: 98%. CAS No. 549505-65-9. Molecular formula: C23H21FN4S. Mole weight: 404.51. | |
| MnTBAP chloride | Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK. Group: Biochemicals. Alternative Names: Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride. Grades: Highly Purified. CAS No. 55266-18-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C48H28MnN4O8Cl. US Biological Life Sciences. | Worldwide |
| MTBT | MTBT is an anticancer agent and p38 activator with antiproliferative and apoptosis-inducing ( apoptosis ) activities. MTBT increases the phosphorylation of histone H3 serine in cancer cells, thereby arresting the cell cycle in the M phase. SB203580 (HY-10256), a specific inhibitor of p38 MAPK, abolished MTBT-induced cell cycle arrest [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1110905-26-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-118034. | |
| MW-150 | MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a K i of 101 nM. MW-150 inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MW01-18-150SRM. CAS No. 1628502-91-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120111. | |
| Neochlorogenic Acid | Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (1R,3R,4S,5R)-5-[(E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]oxy-1,3,4-trihydroxycyclohexane-1-carboxylic acid. Product Category: Inhibitors. Appearance: White to off-white solid. CAS No. 906-33-2. Molecular formula: C16H18O9. Mole weight: 354.31. Purity: 0.98. IUPACName: (1R,3R,4S,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid. Canonical SMILES: C1[C@H]([C@@H]([C@@H](C[C@]1(C(=O)O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O. Density: 1.65±0.1 g/ml. Product ID: ACM906332. Alfa Chemistry ISO 9001:2015 Certified. | |
| p38 MAPK-IN-1 | p38 MAPK-IN-1, a naphthyridine N-oxide, is a novel potent and selective inhibitor of p38 MAPK and it was found to have proper balance between potency and pharmacokinetics and excellent action in a chronic model of arthritis for further study in some sorts. Uses: P38 mapk-in-1 is a novel potent and selective inhibitor of p38 mapk and could be useful in studying some sorts of inflammatory conditions. Synonyms: p38alpha-IN-4; p38alpha IN 4; p38alphaIN4; p38alpha inhibitor 4; p38alpha-inhibitor-4; p38 MAP Kinase Inhibitor XI; P38 MAPK-IN-1; CHEMBL1916344; SCHEMBL2077831; BDBM50357886; HY-12839; HY 12839; HY12839. Grades: 95%. CAS No. 1006378-90-0. Molecular formula: C21H15F2N2O. Mole weight: 349.35. | |
| p38 MAPK-IN-4 | p38 MAPK-IN-4 (compound 6) is a p38 MAPK inhibitor with an 50 of 35 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 219138-24-6. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-112466. | |
| p38 MAP Kinase Inhibitor IV | p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC 50 s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1638-41-1. Pack Sizes: 5 mg. Product ID: HY-112401. | |
| Pexmetinib | Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. It has potential antineoplastic, anti-inflammatory, and antiangiogenic activities. It inhibits other kinases including vascular endothelial growth factor receptor (VEGFR2) and Src tyrosine kinases. Synonyms: 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea; Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[[5-fluoro-2-[[1-(2-hydroxyethyl)-1H-indazol-5-yl]oxy]phenyl]methyl]-; N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[[5-fluoro-2-[[1-(2-hydroxyethyl)-1H-indazol-5-yl]oxy]phenyl]methyl]urea; ARRY 614; ARRY-614; ARRY614; N-(3-tert-Butyl-1-p-tolyl-1H-pyrazol-5-yl)-N'-[5-fluoro-2-[1-(2-hydroxyethyl)-1H-indazol-5-yloxy]benzyl]urea. Grades: 98%. CAS No. 945614-12-0. Molecular formula: C31H33FN6O3. Mole weight: 556.63. | |
| Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate) | Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Group: Biochemicals. Alternative Names: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate. Grades: Highly Purified. CAS No. 16561-29-8. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C36H56O8, Molecular Weight: 616.83. US Biological Life Sciences. | Worldwide |
| Prodigiosin (NSC 47147, BRN 4526727) | Red-pigmented antibiotic. Antimalarial. Immunosuppressive. Apoptosis inducer. Cytotoxic. Induces phosphorylation of p38-MAPK. Antimetastatic. Tumor invasion inhibitor. Induces p21WAF1/CIP1 expression. Anticancer compound. gp91(phox) and iNOS expression inhibitor. mTORC1 and mTORC2 complexe inhibitor. Down-regulates SKP2 to induce p27(KIP1) stabilization. Source:Isolated from γ-proteobacterium strain MS-02-063. Group: Biochemicals. Alternative Names: NSC 47147, BRN 4526727. Grades: Highly Purified. CAS No. 82-89-3. Pack Sizes: 250ug, 1mg. Molecular Formula: C20H25N3O, Molecular Weight: 323.4. US Biological Life Sciences. | Worldwide |
| R-268712 | R-268712 is a potent and selective inhibitor of TGF-β type I receptor/ALK5 with an IC50 of 2.5 nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK). It suppresses development of renal fibrosis in a unilateral ureteral obstruction model. It also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Synonyms: R-268712; R 268712; R268712. Grades: >98 %. CAS No. 879487-87-3. Molecular formula: C20H18FN5O. Mole weight: 363.39. | |
| RO3201195 | RO3201195 (compound 1) is an inhibitor of p38 MAPK. RO3201195 inhibits WS cell proliferation with IC 50 value of 190 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 249937-52-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-118612. | |
| RO3201195 | RO3201195 is an orally bioavailable and highly selective inhibitor of p38 MAPK which was selected for advancement into Phase I clinical trials. Synonyms: RO-3201195; RO 3201195; (5-Amino-1-(4-fluoro-phenyl)-1H-pyrazol-4-yl)-(3-(2,3-dihydroxy-propoxy)-phenyl)-methanone. CAS No. 249937-52-8. Molecular formula: C19H18FN3O4. Mole weight: 371.36. | |
| Sauchinone | Sauchinone, coming from the herbs of Saururus chinensis(Lour.) Baill, is a useful adjunctive treatment for bacterial infection. Sauchinone inhibited oxidative stress, as assessed by stainings of 4-hydroxynonenal and nitrotyrosine: these events may have a role in its inhibitory effects on HSCs activation. Sauchinone attenuated CCl4-induced liver fibrosis and TGF-β1-induced HSCs activation, which might be, at least in part, mediated by suppressing autophagy and oxidative stress in HSCs. Sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 MAPK signaling via upregulation of oxidative defense enzymes. Uses: Anti-inflammatory/antibacterial. Synonyms: (5aR,7R,8S,8aR,14aS,14bR)-5a,6,7,8,8a,14b-Hexahydro-7,8-dimethyl-5H-Benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one; (5aα, 7α, 8β, 8aβ, 14aS*, 14bβ)-5a, 6, 7, 8, 8a, 14b-Hexahydro-7, 8-dimethyl-5H-benzo[kl]bis[1, 3]dioxolo[4, 5-b:4', 5'-g]xanthen-5-one. Grades: >98%. CAS No. 177931-17-8. Molecular formula: C20H20O6. Mole weight: 356.36. | |
| SB 202190 hydrochloride | SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, effective against p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. It inhibits p38 MAP kinases, resulting in blockade of tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production in monocytes. Synonyms: SB 202190 HCl; 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol hydrochloride. Grades: ≥98%. CAS No. 350228-36-3. Molecular formula: C20H14FN3O·HCl. Mole weight: 367.8. | |
| SB-203580 | SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM. Uses: Enzyme inhibitors. Synonyms: SB203580; SB203580; SB 203580. Grades: >98%. CAS No. 152121-47-6. Molecular formula: C21H16FN3OS. Mole weight: 377.437. | |
| SB 706504 | SB 706504 is a p38 MAPK inhibitor. SB 706504 inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs), and it also suppresses LPS-induced protein expression of IL-6, IL-10, TNFα and γ-inducible protein 10 in COPD MDMs. Synonyms: SB 706504; SB706504; SB-706504; N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine; 1-cyano-2-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine. Grades: ≥98% by HPLC. CAS No. 911110-38-8. Molecular formula: C24H19F3N8O. Mole weight: 492.46. | |
| SD-282 | SD-282 is an ATP-competitive inhibitor of p38 kinase. SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation. SD-282 may have potential therapeutic value of p38alpha MAPK inhibitors in the treatment of aberrant pain sensitivity produced by diabetes. Synonyms: SD282; SD 282; SCIO-282; SCIO 282; SCIO282; rac-Talmapimod. CAS No. 309915-13-7. Molecular formula: C27H30ClFN4O3. Mole weight: 513.00. | |
| Sesamolin | Sesaminol, isolated from Sesamum indicum, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesaminol potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-[(1S,3aβ,4β,6aβ)-4-(1,3-Benzodioxole-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole. Product Category: Inhibitors. Appearance: White powder. CAS No. 526-07-8. Molecular formula: C20H18O7. Mole weight: 370.36. Purity: 0.98. IUPACName: 5-[[(3S,3aR,6R,6aR)-3-(1,3-benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]oxy]-1,3-benzodioxole. Canonical SMILES: C1C2C(COC2OC3=CC4=C(C=C3)OCO4)C(O1)C5=CC6=C(C=C5)OCO6. Density: 1.418 g/ml. Product ID: ACM526078-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| SIS3 HCl | SIS3 is a potent and specific inhibitor of Smad3 via inhibiting the effects of TGF-β1. SIS3 inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation with no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. It inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts. Synonyms: (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride. Grades: >98%. CAS No. 521984-48-5. Molecular formula: C28H27N3O3.HCl. Mole weight: 489.99. | |
| Skepinone-L | Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM. Grades: >98%. CAS No. 1221485-83-1. Molecular formula: C24H21F2NO4. Mole weight: 425.42. | |
| SU 3327 | SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM) with selectivity over p38 MAPK and Akt. SU 3327 inhibits the interaction between JNK and JIP (IC50 = 239 nM). Synonyms: SU 3327; SU3327; SU-3327; 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine. Grades: ≥99% by HPLC. CAS No. 40045-50-9. Molecular formula: C5H3N5O2S3. Mole weight: 261.3. | |
| TA-02 | TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC 50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1784751-19-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100115. | |
| TA-02 | TA-02 is a p38 MAPK inhibitor (IC50 = 20 nM). Synonyms: TA-02, TA 02, TA02; SCHEMBL17002317; EX-A933; EX A933; EXA933; MolPort-039-101-302; 4-[2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine. Grades: ≥98%. CAS No. 1784751-19-4. Molecular formula: C20H13F2N3. Mole weight: 333.342. | |
| TAK-715 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Synonyms: TAK715, TA 715, TAK715. Grades: 0.99. CAS No. 303162-79-0. Molecular formula: C24H21N3OS. Mole weight: 399.512. | |
| Talmapimod | Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC 50 of 9 nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCIO-469. CAS No. 309913-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10406. | |
| Talmapimod hydrochloride | Talmapimod, also known as SCIO-469, is an orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis. p38 MAPK is a serine/threonine protein kinase involved in a MAPK signaling cascade that controls cellular responses to various environmental stresses, cytokines, and endotoxins. Synonyms: SCIO 469 hydrochloride; SCIO469 hydrochloride; SCIO-469 hydrochloride. Grades: >98%. CAS No. 309913-83-5. Molecular formula: C27H30ClFN4O3. Mole weight: 513.01. | |
| TL4-12 | TL4-12 is a potent MAP4K2 (GCK) inhibitor with IC50 value of 37 nM, suppressing IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro. Synonyms: 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide. Grades: ≥98% by HPLC. CAS No. 1620820-12-3. Molecular formula: C25H27F3N6O2. Mole weight: 500.53. | |
| UM-164 | UM-164 is an inhibitor of Src and p38 MAPK kinases with Kds values of 2.7, 2.2, and 5.5 nM for c-Src, p38α, and p38β, respectively. It inhibits cell growth in a panel of triple-negative breast cancer (TNBC) cell lines (IC50s = 6.1-260 nM) and in a patient-derived TNBC cell line (IC50 = 320 nM). Uses: Protein kinase inhibitors. Synonyms: DAS-DFGO-II; 2-[[6-[4- (2-hydroxyethyl) piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-N-[2-methyl-5-[[3- (trifluoromethyl) benzoyl]amino]phenyl]-1, 3-thiazole-5-carboxamide. Grades: ≥98%. CAS No. 903564-48-7. Molecular formula: C30H31F3N8O3S. Mole weight: 640.68. | |
| UPC-K-005 | UPC-K-005 is a novel small-molecule inhibitor of a new allosteric site in p38α (IC50 = 13 mcM), which is the binding site for MAPK-activated protein kinase 2 (MK2). Researchers found that UPC-K-005 inhibits both the p38α peptide substrate and ATF2 protein substrate in a dose-response manner, which indicated that they are more universal inhibitors. Uses: Inhibitor of a new allosteric site in p38&alpha. Synonyms: UPC-K-005; 896842-60-7; SCHEMBL17903201; AKOS005505861. Molecular formula: C21H25N7OS. Mole weight: 423.5. | |
| Verrucarin A | Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria , is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53 [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Muconomycin A. CAS No. 3148-9-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107426. | |
| VX-702 | VX-702 is a highly selective inhibitor of p38α MAPK, 14-fold higher potency against the p38α versus p38&beta. Synonyms: VX-702; VX 702; VX702. Grades: >98%. CAS No. 745833-23-2. Molecular formula: C19H12F4N4O2. Mole weight: 404.3. | |
| KLF5 Inhibitor, CID 5951923 (2- ( (1, 1-Dioxidotetra hydrothiophen-3-yl, methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate) | A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50=1.6uM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182. Group: Biochemicals. Grades: Highly Purified. CAS No. 749872-43-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| p38 MAPK-IN-2 | An inhibitor of p38 kinase. Synonyms: Ethanone, 1-[4-[5-(4-chloro-2-fluorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-; 1-[4-[3-(4-chloro-2-fluorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone. CAS No. 635725-16-5. Molecular formula: C20H19ClFN5O2. Mole weight: 415.85. | |
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