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| Product | Description | |
|---|---|---|
| Palbociclib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Palbociclib | Palbociclib Inhibitor. Uses: Scientific use. Product Category: T1785. CAS No. 571190-30-2. |  |
| Palbociclib | Palbociclib is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. Synonyms: PD 0332991; PD0332991; PD-0332991; Ibrance; 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one; 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one. Grade: 98%. CAS No. 571190-30-2. Molecular formula: C24H29N7O2. Mole weight: 447.53. |  |
| Palbociclib | Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC 50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma [1] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD 0332991. CAS No. 571190-30-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-50767. |  |
| Palbociclib | Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Palbociclib;571190-30-2;PD0332991;Ibrance;PD-0332991;PD 0332991;UNII-G9ZF61LE7G;Palbociclib free base;Palbociclib-d8;6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;PD-332991;571190-30-2 (free base);MFCD11840850;6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE;6-Acetyl-8-cyclopentyl-5-m. Product Category: Inhibitors. CAS No. 571190-30-2. Molecular formula: C24H29N7O2. Mole weight: 447.5g/mol. Purity: 0.9994. IUPACName: 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one. Canonical SMILES: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C. Product ID: ACM571190302. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Palbociclib-[d8] | Palbociclib-[d8] is the labelled analogue of Palbociclib, which is a selective cyclin-dependent kinase (CDK) 4/6 inhibitor to treat ER-positive and HER2-negative breast cancer. Synonyms: Palbociclib D8; 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one-d8. Grade: 95% by HPLC; 95% atom D. CAS No. 1628752-83-9. Molecular formula: C24H21D8N7O2. Mole weight: 455.58. | |
| Palbociclib, Free Base Salt, 99+% | PD 0332991 is a potent selective inhibitor of cyclin dependent kinases CDK4 and CDK6 with in vitro IC50 = 11 nM (CDK4) and 16 nM (CDK6). PD 0332991 induces G1 arrest in retinoblastoma (Rb)-positive tumor cells. Group: Biochemicals. Alternative Names: 6-acetyl-8-cyclopentyl-5-methyl-2- [ [5- (1-piperazinyl) -2-pyridinyl]amino]pyrido [2, 3-d]pyrimidin-7 (8H) -one 2-hydroxy-ethanesulfonic acid (1:1); PD0332991; Palbociclib; isethionate. Grades: Highly Purified. CAS No. 571190-30-2. Pack Sizes: 25mg, 50mg, 100mg. US Biological Life Sciences. |  Worldwide |
| Palbociclib hydrochloride | Palbociclib (PD 0332991) hydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC 50 values of 11 and 16 nM, respectively. Palbociclib hydrochloride has potent anti-proliferative activity and induces cell cycle arrest in cancer cells. Palbociclib hydrochloride can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma [1] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD-0332991 hydrochloride. CAS No. 571189-11-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-50767C. | |
| Palbociclib Impurity 18 | Palbociclib Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1244949-62-9. Molecular formula: C11H14ClN3O. Mole weight: 239.7. Catalog: APB1244949629. | |
| Palbociclib Impurity 2 | Palbociclib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1072-97-5. Molecular formula: C5H5BrN2. Mole weight: 173.01. Catalog: APB1072975. | |
| Palbociclib Impurity 24 | Palbociclib Impurity 24. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1013916-37-4. Molecular formula: C13H14ClN3O. Mole weight: 263.72. Catalog: APB1013916374. | |
| Palbociclib Impurity 36 | Palbociclib Impurity 36. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: tert-butyl 4-(2-aminopyridin-3-yl)piperazine-1-carboxylate. CAS No. 1023594-49-1. Molecular formula: C14H22N4O2. Mole weight: 278.35. Catalog: APB1023594491. | |
| Palbociclib Impurity 6 | Palbociclib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 153747-97-8. Molecular formula: C14H20BrN3O2. Mole weight: 342.23. Catalog: APB153747978. | |
| Palbociclib Impurity 75 | Palbociclib Impurity 75. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,6-dibromo-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one. CAS No. 1415560-29-0. Molecular formula: C13H13Br2N3O. Mole weight: 387.07. Catalog: APB1415560290. | |
| Palbociclib Impurity I | Palbociclib Impurity I. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1016636-76-2. Molecular formula: C13H13BrClN3O. Mole weight: 342.62. Catalog: APB1016636762. | |
| Palbociclib Impurity P | Palbociclib Impurity P. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1082876-26-3. Molecular formula: C9H14N4. Mole weight: 178.24. Catalog: APB1082876263. | |
| Palbociclib isethionate | Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC 50 values of 11 and 16 nM, respectively. Palbociclib isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma [1] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD 0332991 isethionate. CAS No. 827022-33-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0065. | |
| Palbociclib Isethionate | Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Palbociclib Isethionate;827022-33-3;PD0332991 Isethionate;PD 0332991 isethionate;UNII-W1NYL2IRDR;Palbociclib (PD0332991) Isethionate;W1NYL2IRDR;Palbociclib (isethionate);827022-33-3 (isethionate);6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 2-hydroxyethanesulfonate;Palbociclib Isethionate [USAN];PD 0332991-0054;PF-00080665-73;6-acetyl-8-. Product Category: Inhibitors. CAS No. 827022-33-3. Molecular formula: C26H35N7O6S. Mole weight: 573.7g/mol. Purity: 0.9999. IUPACName: 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;2-hydroxyethanesulfonic acid. Canonical SMILES: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O. Product ID: ACM827022333. Alfa Chemistry ISO 9001:2015 Certified. | |
| Palbociclib monohydrochloride | Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib monohydrochloride has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD 0332991 monohydrochloride. CAS No. 827022-32-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50767A. | |
| Palbociclib (Standard) | Palbociclib (Standard) is the analytical standard of Palbociclib. This product is intended for research and analytical applications. Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD 0332991 (Standard). CAS No. 571190-30-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50767R. | |
| 1-Piperazin-N-oxide Palbociclib | 1-Piperazin-N-oxide Palbociclib is a derivative compound of Palbociclib (P139900). Palbociclib (also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C24H29N7O3, Molecular Weight: 463.53. US Biological Life Sciences. | Worldwide |
| 6-Desacetyl-6-Bromo Palbociclib | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: 6-Bromo-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one; Pyrido-[2,3-d]-pyrimidin-7-one 41. CAS No. 851067-56-6. Molecular formula: C22H26BrN7O. Mole weight: 484.402. | |
| 6-Desacetyl-6-Bromo Palbociclib Hydrochloride | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: 6-bromo-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride. CAS No. 850918-83-1. Molecular formula: C22H27ClBrN7O. Mole weight: 520.86. | |
| 6-Desacetyl Palbociclib | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]-; Pyrido-[2,3-d]-pyrimidin-7-one 38. CAS No. 571190-22-2. Molecular formula: C22H27N7O. Mole weight: 405.506. | |
| 6-Desacetyl Palbociclib Hydrochloride | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride. CAS No. 571189-66-7. Molecular formula: C22H28ClN7O. Mole weight: 441.96. | |
| 1-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]ethanone | 1-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]ethanone acts as a reagent for the preparation of Palbociclib, a drug for the treatment of ER-positive and HER-negative breast cancer development. Group: Biochemicals. Grades: Highly Purified. CAS No. 1244949-62-9. Pack Sizes: 50mg, 100mg. Molecular Formula: C11H14ClN3O, Molecular Weight: 239.7. US Biological Life Sciences. | Worldwide |
| 1,4-Bis(4-nitrophenyl)piperazine | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: 1,4-Bis(4-nitrophenyl)piperazine; 16264-05-4; Piperazine, 1,4-bis(4-nitrophenyl)-EINECS 240-371-8UNII-P6TE7B2EYY. CAS No. 16264-05-4. Molecular formula: C16H16N4O4. Mole weight: 328.328. | |
| 1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-1-oxidopyridin-3-yl)piperazine 1-oxide | An impurity of Palbociclib which is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Synonyms: Palbociclib Impurity 25. Grade: >95%. CAS No. 2488840-59-9. Molecular formula: C24H29N7O4. Mole weight: 479.54. | |
| 1-?(6-?Nitro-?3-?pyridinyl)?piperazine | 1-?(6-?Nitro-?3-?pyridinyl)?piperazine is a reagent used in the preparation of highly potent and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependant kinases as anticancer agents. Also is an impurity of Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Group: Biochemicals. Grades: Highly Purified. CAS No. 775288-71-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C9H12N4O2. US Biological Life Sciences. | Worldwide |
| 1-Boc-4-(6-aminopyridin-3-yl)piperazine-d4 | 1-Boc-4-(6-aminopyridin-3-yl)piperazine-d4 is an intermediate in synthesizing Palbociclib-d4 (P139901), an isotope labelled compound of Palbociclib (P139900). Palbociclib (P139900) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Group: Biochemicals. Grades: Highly Purified. CAS No. 1808106-94-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C14H18D4N4O2. US Biological Life Sciences. | Worldwide |
| 2,6-Dibromo-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one | An impurity of Palbociclib which is a drug for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: Pyrido[2,3-d]pyriMidin-7(8H)-one, 2,6-dibroMo-8-cyclopentyl-5-Methyl-; Palbociclib Impurity T. Grade: ≥95%. CAS No. 1415560-29-0. Molecular formula: C13H13Br2N3O. Mole weight: 387.07. | |
| 2-? Chloro-? 8-? cyclopentyl-? 5-? methyl-? 8H-? pyrido [2, ? 3-? d] ? pyrimidin-? 7-? one | 2-? Chloro-? 8-? cyclopentyl-? 5-? methyl-? 8H-? pyrido [2, ? 3-? d] ? pyrimidin-? 7-? one is an impurity of Palbociclib (P139900),(also known as compound number PD-0332991) is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Group: Biochemicals. Grades: Highly Purified. CAS No. 1013916-37-4. Pack Sizes: 250mg, 1g. Molecular Formula: C13H14ClN3O, Molecular Weight: 263.72. US Biological Life Sciences. | Worldwide |
| 5-bromo-4-chloro-N-cyclopentylpyrimidin-2-amine | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: 5-Bromo-4-chloro-N-cyclopentylpyrimidin-2-amine; 1823404-28-9; CS-0011349; D87404; 5-?Bromo-?4-?chloro-?N-?cyclopentylpyrimidin?-?2-?amine. CAS No. 1823404-28-9. Molecular formula: C9H11BrClN3. Mole weight: 276.56. | |
| 6-acetyl-2-amino-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one | An impurity of Palbociclib which is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Synonyms: Palbociclib Impurity 27; Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-acetyl-2-amino-8-cyclopentyl-5-methyl-. CAS No. 571189-64-5. Molecular formula: C15H18N4O2. Mole weight: 286.33. | |
| 6-Acetyl-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidine-2,7(3H,8H)-dione | An impurity of Palbociclib which is a drug for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: Pyrido(2,3-d)pyrimidine-2,7(1H,8H)-dione, 6-acetyl-8-cyclopentyl-5-methyl-; Palbociclib Impurity I. Grade: ≥95%. CAS No. 2172256-78-7. Molecular formula: C15H17N3O3. Mole weight: 287.31. | |
| 6-Bromo-5-(bromomethyl)-2-chloro-8-cyclopentylpyrido[2,3-d]pyrimidin-7(8H)-one | An impurity of Palbociclib which is a drug for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-bromo-5-(bromomethyl)-2-chloro-8-cyclopentyl-; Palbociclib Impurity U. Grade: ≥95%. CAS No. 2324831-15-2. Molecular formula: C13H12Br2ClN3O. Mole weight: 421.52. | |
| 6-Bromo-8-cyclopentyl-2-[[5-(4-Boc-1-piperazinyl)-2-pyridyl]amino]-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one | An impurity of Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. Palbociclib is developed for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-2-pyrido[2,3-d]pyrimidinyl)amino]-3-pyridinyl]-1-piperazinecarboxylic acid tert-butyl ester; tert-butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylate. CAS No. 571188-82-4. Molecular formula: C27H34BrN7O3. Mole weight: 584.51. | |
| 6-Bromo-8-cyclopentyl-5-methylquinazoline-2,7(3H,8H)-dione | An impurity of Palbociclib which is a drug for the treatment of ER-positive and HER2-negative breast cancer. Synonyms: Palbociclib Impurity R. Grade: ≥95%. CAS No. 1922954-32-2. Molecular formula: C13H14BrN3O2. Mole weight: 324.17. | |
| 8-cyclopentyl-5-methyl-2,6-bis((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | An impurity of Palbociclib which is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Synonyms: Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-cyclopentyl-5-methyl-2,6-bis[[5-(1-piperazinyl)-2-pyridinyl]amino]; Palbociclib Impurity G. CAS No. 2458234-37-0. Molecular formula: C31H39N11O. Mole weight: 581.73. | |
| BSJ-03-204 | BSJ-03-204 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-03-204 is a potent and selective Palbociclib-based CDK4/6 dual degrader (PROTAC), with IC50s of 26.9 nM and 10.4 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-03-204 does not induce IKZF1/3 degradation and has anti-cancer activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2349356-09-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136250. | |
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