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| Product | Description | |
|---|---|---|
| Panobinostat | Panobinostat. Group: Biochemicals. Alternative Names: (2E) -N-Hydroxy-3- [4- [ [ [2- (2-methyl-1H-indol-3-yl) ethyl] amino] methyl] phenyl] -2-propenamide. Grades: Highly Purified. CAS No. 404950-80-7. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C21H23N3O2. US Biological Life Sciences. |  Worldwide |
| Panobinostat | Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. Uses: Antineoplastic agents. Synonyms: LBH589; LBH 589; LBH-589; NVP-LBH589; NVP-LBH 589; Panobinostat; trade name Farydak. Grades: >98%. CAS No. 404950-80-7. Molecular formula: C21H23N3O2. Mole weight: 349.434. |  |
| Panobinostat | Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities [1] [2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells [4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LBH589; NVP-LBH589. CAS No. 404950-80-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10224. |  |
| Panobinostat Carboxylic Acid Methyl Ester Hydrochloride | Intermediate in the preparation of Panobinostat. Group: Biochemicals. Alternative Names: (2E) -3- [4- [ [ [2- (2-Methyl-1H-indol-3-yl) ethyl] amino] methyl] phenyl] -2-propenoic Acid Methyl Ester, Hydrochloride. Grades: Highly Purified. CAS No. 441741-66-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Panobinostat lactate | Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LBH589 lactate; NVP-LBH589 lactate. CAS No. 960055-56-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10224A. | |
| Panobinostat (LBH-589, LBH589, LBN-589, NVP-LBH589) | Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumor cell proliferation in vitro. The IC50 values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12nm, respectively. And to A2780 proliferation, IC50 value is 4.6±1.8nm. Group: Biochemicals. Grades: Highly Purified. CAS No. 404950-80-7. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Cytochrome P450 Reductase from Human, Recombinant | Cytochrome P450 reductase is a membrane bound enzyme required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. The cytochrome P450 enzyme system is mainly involved in the detoxification of xenobiotics in the liver. It also participates in the activation of procarcinogens and the metabolism of endogeneous substrates such as steroids. Applications: Human cytochrome p450 reductase has been used in a study to assess the biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat. human cytochrome p450 reductase has also been u...AD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase. Enzyme Commission Number: EC 1.6.2.4. CAS No. 9023-3-4. Purity: >90% (SDS-PAGE). CPR. Mole weight: 76.5 kDa. Activity: >30 U/mg. Storage: Store at -70°C. Form: Supplied in a solution containing 10 mM potassium phosphate, pH 7.4, 0.1 mM EDTA, 0.5 mM DTT, 20% (v/v) glycerol. Source: Baculovirus infected insect cells. Species: Human. EC 1.6.2.4; NADPH:ferrihemoprotein oxidoreductase; NADPH:hemoprotein oxidoreductase; NADPH:P450 oxidoreductase; P450 reductase; CPR; 9039-06-9; FAD-cytochrome c reductase; NADPH-dependent cytochrome c reductase; NADPH:P-450 reductase. Cat No: NATE-1586. |  |
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