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| Product | Description | |
|---|---|---|
| PD153035 | PD153035 (SU-5271; AG1517; ZM 252868) is a potent EGFR inhibitor with K i and IC 50 of 6 and 25 pM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU-5271; AG1517; ZM 252868. CAS No. 153436-54-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14346. |  |
| PD153035 HCl | PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. Synonyms: SU5271; SU 5271; AG 1517; AG-1517; SU-5271 (AG1517) HCl; ZM 252868 HCl; ZM-252868 HCl; ZM252868 HCl; PD153035 HCl; PD 153035 HCl; PD-153035 HCl; AG 1517 hydrochloride; AG1517 hydrochloride; AG-1517 hydrochloride. Grades: >98%. CAS No. 183322-45-4. Molecular formula: C16H14BrN3O2.HCl. Mole weight: 396.67. |  |
| PD153035 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PD153035 Hydrochloride | PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with K i and IC 50 of 6 and 25 pM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU-5271 Hydrochloride; AG1517 Hydrochloride; ZM 252868 Hydrochloride. CAS No. 183322-45-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12013. | |
| EBE-A22 | The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines. Uses: Intercalating agents. Synonyms: EBE-A22; EBE A22; EBEA22. Grades: >98%. CAS No. 229476-53-3. Molecular formula: C17H16BrN3O2. Mole weight: 374.23. | |
| PD-153035 | PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). Uses: Antineoplastic agents. Synonyms: AG 1517; AG1517; AG-1517; NSC 669364; NSC669364; NSC-669364; PD 153035; PD153035; SU 5271; SU5271; SU-5271; WHI-P 79. Grades: >98%. CAS No. 153436-54-5. Molecular formula: C16H14BrN3O2. Mole weight: 360.211. | |
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