Peroxidase Suppliers USA
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Product | Description | |
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Peroxidase Quick inquiry Where to buy Suppliers range | Peroxidase. Uses: Used for research and manufacturing. Group: Food Ingredients. Alternative Names: Peroxidase froM horseradish(EIA Grade,Purified);84 kDa myeloperoxidase;89 kDa myeloperoxidase;ANTI-MYELOPEROXIDASE(N-TERMINAL) antibody produced in rabbit;Myeloperoxidase light chain;Apoperoxidase;Peroxidase isoenzymes Type XI: Apoenzyme from horseradish;ANTI-MYELOPEROXIDASE (CENTER) antibody produced in rabbit. CAS No. 9003-99-0. Product ID: CDF4-0034. | |
Custom Protein Conjugation, Horseradish Peroxidase (HRP) Quick inquiry Where to buy Suppliers range | Custom Protein Conjugation, Horseradish Peroxidase (HRP). Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
GLUTATHIONE PEROXIDASE Quick inquiry Where to buy Suppliers range | Synonyms: GLUTATHIONE: HYDROGEN-PEROXIDE OXIDOREDUCTASE; GLUTATHIONE PEROXIDASE; GSH-PX; EC 1.11.1.9; glutathione peroxidase F. bov. erythro-cytes; Glutathione Peroxidase from bovine erythrocytes; Peroxidase, glutathione; GLUTATHIONE PEROXIDASE F. BOV. ERYTHRO-C YTES, ~1. CAS No. 9013-66-5. | |
Horseradish peroxidase Quick inquiry Where to buy Suppliers range | Peroxidase is a heme-containing enzyme, and it can be used to oxidize a wide variety of substrates. Synonyms: HRP; Peroxidase. CAS No. 9003-99-0. Molecular formula: H2O3. | |
10-Acetyl-3,7-dihydroxyphenoxazine Quick inquiry Where to buy Suppliers range | 10-Acetyl-3,7-dihydroxyphenoxazine is a sensitive and stable substrate for horseradish peroxidase (HRP). It reacts with H2O2 to produce the fluorescent compound resorufin that can be used for detection of H2O2. Synonyms: 1-(3,7-Dihydroxy-10H-phenoxazin-10-yl)ethanone; Amplex Red; Ampliflu Red; ADHP. CAS No. 119171-73-2. Molecular formula: C14H11NO4. Mole weight: 257.245. | |
1-Bromonapthalene Quick inquiry Where to buy Suppliers range | 1-Bromonapthalene is used in the preparation of N-aryl imidazoles and diaryl ethers. Also used in the preparations of glutathione peroxidase-like antioxidant activity of diaryl diselenides. Group: Biochemicals. Grades: Highly Purified. CAS No. 90-11-9. Pack Sizes: 5g, 10 g. Molecular Formula: C10H7Br. US Biological Life Sciences. | Worldwide |
(1S,3R)-RSL3 Quick inquiry Where to buy Suppliers range | (1S,3R)-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor with EC50 of 10 μM in cellular assay. It binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis. Synonyms: RSL3; RSL3 (1S,3R-); 1S,3R-RSL3. Grades: 98%. CAS No. 1219810-16-8. Molecular formula: C23H21ClN2O5. Mole weight: 440.9. | |
2,2'-Dimethoxy-5,5'-dinitro-1,1'-biphenyl Quick inquiry Where to buy Suppliers range | 2,2'-Dimethoxy-5,5'-dinitro-1,1'-biphenyl is an p-acetamidopheno (A161220) analog that were used to determine peroxidase activities. Group: Biochemicals. Grades: Highly Purified. CAS No. 81763-59-9. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
2,5-Norbornadiene Quick inquiry Where to buy Suppliers range | 2,5-Norbornadiene shows anti-ethylene effects on plants and inhibits polyphenol oxidase, peroxidase and phenylalanine ammonia lyase activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 121-46-0. Pack Sizes: 5ml, 10ml. Molecular Formula: C7H8, Molecular Weight: 92.14. US Biological Life Sciences. | Worldwide |
3,3',5,5'-Tetramethylbenzidine Quick inquiry Where to buy Suppliers range | TMP is a substrate for horseradish peroxidase (HRP) in immunoassays. Group: Biochemicals. Alternative Names: TMB; Tetramethylbenzidine base. Grades: Highly Purified. CAS No. 54827-17-7. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C16H20N2. US Biological Life Sciences. | Worldwide |
3',3'''-Bi-p-acetanisidide Quick inquiry Where to buy Suppliers range | 3',3'''-Bi-p-acetanisidide is an p-acetamidopheno (A161220) analog that were used to determine peroxidase activities. Group: Biochemicals. Alternative Names: N,N'-(6,6'-Dimethoxy[1,1'-biphenyl]-3,3'-diyl)bisacetamide. Grades: Highly Purified. CAS No. 23080-65-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
3,3'-Bi-p-anisidine Quick inquiry Where to buy Suppliers range | 3,3'-Bi-p-anisidine is an p-acetamidopheno (A161220) analog that were used to determine peroxidase activities. Group: Biochemicals. Alternative Names: 6,6'-Dimethoxy-[1,1'-biphenyl]-3,3'-diamine. Grades: Highly Purified. CAS No. 23131-04-6. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
3,3'-Diaminobenzidine Tetrahydrochloride Hydrate Quick inquiry Where to buy Suppliers range | Peroxidase substrate used in immunocytochemistry staining. Group: Biochemicals. Grades: Highly Purified. CAS No. 868272-85-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C12H14N4·4HCI·xH2O, Molecular Weight: 360.11 (anhydrous). US Biological Life Sciences. | Worldwide |
3',5-Dimethoxy-2,4'-dinitro-1,1'-biphenyl Quick inquiry Where to buy Suppliers range | 3',5-Dimethoxy-2,4'-dinitro-1,1'-biphenyl is an p-acetamidopheno (A161220) analog that were used to determine peroxidase activities. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
3-Amino-9-ethylcarbazole Quick inquiry Where to buy Suppliers range | 3-Amino-9-ethylcarbazole, an indispensable chemical entity within the realms of the biomedical sector, occupies a position of prominence. It finds extensive application as a substrate in the realm of enzymatic identification of horseradish peroxidase (HRP) functionality. The compound in question assumes a pivotal stance in a myriad of biochemical examinations, namely immunohistochemistry and immunoblotting, thereby facilitating the identification and analytical evaluation of HRP-tagged proteins implicated in ailments such as cancer and infectious diseases. Synonyms: 3-Amino-N-ethylcarbazole. Grades: 95%. CAS No. 132-32-1. Molecular formula: C14H14N2. Mole weight: 210.27. | |
ABTS (2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonate, Diammonium Salt) Quick inquiry Where to buy Suppliers range | ABTS acts a substrate for HRP (horseradish peroxidase) conjugate during enzyme-linked immunosorbent assay (ELISA). It is the most sensitive, and stable substrate when compared to three other substrates namely, 5-aminosalicylic acid (5AS), O-phenylenediamine (OPD), O-tolidine (OT). It also produces the best visual results, where it gives a bluish-green color. ELISA using ABTS is a highly sensitive, specific and reproducible technique. Group: Biochemicals. Alternative Names: AzBTS-(NH4)2; 2, 2'- (1, 2-Hydrazinediylidene) bis[3-ethyl-2, 3-dihydro-6-benzothiazolesulfonic Acid Ammonium Salt (1:2); 2,2'-Azinobis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Diammonium Salt; 3-Ethyl -2-oxo-6-Benzothiazolinesulfoni c Acid Azine Diammonium Salt; 2,2'-Azino-bis-(3-ethyl-benzthiazoline-6-sulfonate) Diammonium Salt; 2,2'-Azino-bis-(3-ethylbenzothazoline-6-sulfonate); 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt; ABTS Diammonium Salt; Diammonium 2, 2'-Azinobis (3-ethyl -6-benzothiazolinesulfona te) . Grades: Highly Purified. CAS No. 30931-67-0. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C18H24N6O6S4, Molecular Weight: 548.68. US Biological Life Sciences. | Worldwide |
Amthamine dihydrobromide Quick inquiry Where to buy Suppliers range | Amthamine dihydrobromide is the dihydrobromide salt of amthamine, which is a highly selective histamine H2 receptor agonist. It is a weak antagonist at H3 and has no activity at H1 receptors. It decreases myogenic tone and induces vasodilation of cerebral arteries in vitro. It can be used in the suppression of the release of serotonin and H2 receptor-mediated eosinophil peroxidase (EPO). It has been used to study the effect of mast cells on T regulatory cell function. Synonyms: 5-(2-Aminoethyl)-4-methylthiazol-2-amine Dihydrobromide; A 4730 Dihydrobromide; 2-Amino-4-methyl-5-thiazoleethanamine dihydrobromide; 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide. Grades: ≥99% by HPLC. CAS No. 142457-00-9. Molecular formula: C6H13N3SBr2. Mole weight: 319.06. | |
Avarol Quick inquiry Where to buy Suppliers range | Antibacterial against selected Gram-positive strains, antifungal. Anticancer compound. Antileukemic. Antimitotic agent. Antiviral compound. Inhibits HIV activity. Anti-inflammatory. Synovial phospholipase A2, cyclooxygenase and lipoxygenase inhibitor. Modulator of superoxide dismutase and glutathione peroxidase. Platelet aggregation inhibitor. Anti-psoriatic, mediated by inhibition of TNF-alpha generation and NF-kappaB activation. Group: Biochemicals. Alternative Names: NSC 306951. Grades: Highly Purified. CAS No. 55303-98-5. Pack Sizes: 1mg. Molecular Formula: C21H30O2. US Biological Life Sciences. | Worldwide |
Carbimazole Quick inquiry Where to buy Suppliers range | Carbimazole is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4. Synonyms: Carbimazole. Grades: >98%. CAS No. 22232-54-8. Molecular formula: C7H10N2O2S. Mole weight: 186.23. | |
CATALASE Quick inquiry Where to buy Suppliers range | CATALASE. Uses: Used for research and manufacturing. Group: Food Ingredients. Alternative Names: equilase;Catalase-Agarose;H2O2 oxidoreductase;Catalase from A. niger, lyophil.;Catalase from bovine liver, lyophil.;Catalase-peroxidase;CATALASE FROM BOVINE LIVERCA.65000 U/MG PROTEIN SUSPENSION;CATALASE FROM ASPERGILLUSNIGER CA.2000 U/MG LYOPH.SALT-FREE. CAS No. 9001-5-2. Pack Sizes: 1 kg. Product ID: CDF4-0037. | |
Cuprolinic Blue Quick inquiry Where to buy Suppliers range | Cuprolinic blue (quinolinic phthalocyanine) is suitable for use in counterstaining of enteric neurons for peroxidase immunocytochemistry. Also, microwave staining of enteric neurons using cuprolinic blue (Quinolinic phthalocyanin) combined with enzyme histochemistry and peroxidase immunohistochemistry. Group: Biochemicals. Alternative Names: (SP-4-1)-[1, 8, 15, 22-tetramethyl-29H, 31H-tetrapyrido[2, 3-b:2, 3-g:2, 3-l:2, 3-q]porphyraziniumato(2-)-κN29, κN30, κN31, κN32]copper(4+) Methyl Sulfate (1:4); [1, 8, 15, 22-tetramethyltetrapyrido [2, 3-b: 2, 3-g: 2, 3-l: 2, 3-q]porphyraziniumato (2-) ]copper (4+) Ion Tetrakis(methyl sulfate); 29H,31H-Tetrapyrido[2,3-b:2,3-g:2,3-l:2,3-q]porphyrazine, copper(4+) Deriv.; Cuproline Blue; Quinolinic phthalocyanine. Grades: Highly Purified. CAS No. 41276-95-3. Pack Sizes: 2.5mg. Molecular Formula: C??H??CuN??O??S?, Molecular Weight: 1084.55. US Biological Life Sciences. | Worldwide |
Ebselen Quick inquiry Where to buy Suppliers range | Ebselen, also known as SPI-1005, is an organoselenium compound with potential anti-oxidant, anti-inflammatory and cytoprotective activity. Upon oral administration of SPI-1005, this agent mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation. Synonyms: SPI-1005; SPI1005; SPI 1005; Ebselen; PZ 51; PZ51; PZ-51; DR3305; DR 3305; DR-3305. Grades: >98%. CAS No. 60940-34-3. Molecular formula: C13H9NOSe. Mole weight: 274.192. | |
Ebselen Quick inquiry Where to buy Suppliers range | Glutathione peroxidase mimetic. Peroxynitrite scavenger. Anti-inflammatory Antioxidant. Protein kinase C (PKC), NADPH, lipoxygenase, COX, NOS, H+-ATPase and NADPH oxidase inhibitor. Antifungal. Group: Biochemicals. Grades: Highly Purified. CAS No. 60940-34-3. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C13H9NOSe. US Biological Life Sciences. | Worldwide |
Elamipretide TFA Quick inquiry Where to buy Suppliers range | Elamipretide TFA (MTP-131 TFA; RX-31 TFA; SS-31 TFA) is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide. Uses: Peptide Inhibitors. CAS No. 1606994-55-1. Product ID: R1338. | |
Elamipretide triacetate Quick inquiry Where to buy Suppliers range | Elamipretide triacetate is an aromatic-cationic tetrapeptide that targets the mitochondrial intima and is an inhibitor of cardiolipin peroxidase. It easily penetrates cell membranes and has been used in therapeutic trials investigating Leber's Hereditary Optic Neuropathy. Synonyms: L-Phenylalaninamide, D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-, acetate (1:3); SS-31 triacetate; H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2.3CH3CO2H; D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide acetic acid; D-Arg-2',6'-Dmt-Lys-Phe-NH2 triacetate. Grades: ≥95%. CAS No. 1849610-71-4. Molecular formula: C32H49N9O5.3C2H4O2. Mole weight: 819.95. | |
Ellipticine (NSC 71795) Quick inquiry Where to buy Suppliers range | Ellipticine is an alkaloid isolated from Apocyanaceae plants that exhibits antitumor activities by intercalating into DNA and/or inhibiting DNA topoisomerase II. It forms covalent adducts in DNA after being enzymatically activated with cytochrome P450 isoforms (e.g., CYP3A4, CYP1A1, or CYP1A2) or by peroxidases in target tissues. Ellipticine has been shown to inhibit the proliferation of human breast adenocarcinoma MCF-7 cells, leukemia HL-60 and CCRF-CEM cells, neuroblastoma IMR-32, UKF-NB-3, and UKF-NB-4 cells, and U87MG glioblastoma cells with IC50 values ranging from 0.27-4.7uM. Group: Biochemicals. Alternative Names: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole, NSC 71795. Grades: Highly Purified. CAS No. 519-23-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H14N2, Molecular Weight: 246.3. US Biological Life Sciences. | Worldwide |
Guaiac gum Quick inquiry Where to buy Suppliers range | Gum guaiac is a tree resin and crude source of 2,5-di-(4-hydroxy-3-methoxyphenyl)-3,4-dimethylfuran (α-guaiaconic acid).[3] The phenolic α-guaiaconic acid acts as a colorimetric peroxidase substrate.[1][2][4] When reacted with an organic or inorganic oxidizing agent, the α-guaiaconic acid is oxidized to a blue-colored quinone. The guaiac reaction has been used to detect trace amounts of heme from hemoglobin in the presence of peroxide. The Nobles test can be performed using 67% (w/v) gum guaiac diluted in 96% ethanol to analyze the level of extracellular oxidase production [5]. Group: Biochemicals. Grades: Highly Purified. CAS No. 9000-29-7. Pack Sizes: 25g, 50g, 100g, 250g, 500g. US Biological Life Sciences. | Worldwide |
GXpep-3 Quick inquiry Where to buy Suppliers range | GXpep-3 is a novel polypeptide inhibitor of phospholipid hydroperoxidase glutathione peroxidase (GPX4). Currently GPX4 is found to be a target which selectively induces iron-dependent cell death (ferroptosis) in cancer cells that express mutant Ras. GXpep-3 is promisingly developed to be a antitumor drug. Uses: Antitumor. Synonyms: GXpep 3; GXpep3. | |
Hydroxyurea Quick inquiry Where to buy Suppliers range | Hydroxyurea is used as an inhibitor of DNA synthesis. As an anti-neoplastic, hydroxyurea inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. Group: Biochemicals. Alternative Names: Carbamohydroxamic acid; N-Carbamoyl hydroxylamine; N-Hydroxyurea; Biosupressin; Carbamohydroxamic Acid; Carbamoyl Oxime; Cytodrox; Droxia; HU; Hidrix; Hydrea; Hydreia; Hydroxycarbamide; Hydroxycarbamine; N- (Aminocarbonyl) hydroxylamine; Hydroxylurea; Hydura; Hydurea; Litaler; Litalir; N-Carbamoyl hydroxylamine; NCI C04831; NSC 32065; Oxyurea; SK 22591; SQ 1089. Grades: Molecular Biology Grade. CAS No. 127-07-1. Pack Sizes: 10g, 25g, 100g, 250g, 500g. Molecular Formula: CH4N2O2, Molecular Weight: 76.06. US Biological Life Sciences. | Worldwide |
Hydroxy Urea-13C,15N2 Quick inquiry Where to buy Suppliers range | Labeled Hydroxyurea. An anti-neoplastic - inhibits ribonucleoside reductase and DNA replication. A potential therapy for sickle cell anemia which involves the nitrosylation of sickle cell hemoglobin. Horseradish peroxidase catalyzes nitric oxide formation from hydroxyurea in the presence of hydrogen peroxide. Group: Biochemicals. Alternative Names: N-Hydroxyurea-13C,15N2; Biosupressin-13C,15N2; Carbamohydroxamic Acid-13C,15N2; Carbamoyl Oxime-13C,15N2; Cytodrox-13C,15N2; Droxia-13C,15N2; Hydrea-13C,15N2; Hydreia-13C,15N2; Hydroxycarbamide-13C,15N2; Hydroxycarbamine-13C,15N2; N- (Aminocarbonyl) hydroxylamine-13C, 15N2; Hydroxylurea-13C,15N2; Hydura-13C,15N2; Litaler-13C,15N2; N-Carbamoylhydroxylamine-13C,15N2; NSC 32065-13C,15N2; Oxyurea-13C,15N2; SK 22591-13C,15N2; SQ 1089-13C,15N2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Hypaphorine Quick inquiry Where to buy Suppliers range | Hypaphorine is an indole-3-acetic acid antagonist which specifically competes with indole-3-acetic acid in binding to the indole-3-acetic acid-binding site in plant peroxidases. Synonyms: Lenticin; Tryptophan betaine; Glyyunnanenine. Grades: >98%. CAS No. 487-58-1. Molecular formula: C14H18N2O2. Mole weight: 246.3. | |
L-Selenomethionine Quick inquiry Where to buy Suppliers range | L-Selenomethionine is the predominant food form of selenium with antioxidant activity. L-Selenomethionine has been shown to increase the activity of glutathione peroxidase in endothelial cells. It may be chemoprotective against certain cancers. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Selenomethionine; L-(+)-Selenomethionine; Selenium-L-methionine; L-Selenomethioninum; Seleno-L-methionine; H-Mse-OH; (2S)-2-amino-4-methylselanylbutanoic acid. Grades: 95%. CAS No. 3211-76-5. Molecular formula: C5H11NO2Se. Mole weight: 196.12. | |
Lycopene Quick inquiry Where to buy Suppliers range | Lycopene, in the concentration used, is not toxic and also its health benefits in adipose tissue may play a role against obesity-related complications. Lycopene in tomato puree has decreased indicating an indirect effect on lycopene stability caused by high concentration of hydrogen peroxide and the activation of peroxidase enzymes leading to the reduction of ascorbic acid and its regenerative action towards lycopene. Besides, Lycopene protected β-carotene against isomerization during reactions with singlet oxygen and radicals. These findings can explain the pattern of carotenoid isomers analyzed in fruits and vegetables, where lycopene containing samples showed higher (all-E)/(9Z)-β-carotene ratios, and also in in vivo samples such as human blood plasma. Lycopene can be used as pigment in food processing, and is also used as raw material of antioxidant health food. Uses: Ingredient of health care products. Synonyms: ψ,ψ-Carotene; all-trans-Lycopene; Lyco Vit; Lycopene 7; Lycored; NSC 407322; Redivivo; trans-Lycopene; (all-E)-2,6,10,14,19,23,27,31-Octamethyl-2,6,8,10,12,14,16,18,20,22,24,26,30-dotriacontatridecaene. Grades: 96%. CAS No. 502-65-8. Molecular formula: C40H56. Mole weight: 536.87. | |
MJ33 lithium salt Quick inquiry Where to buy Suppliers range | MJ33 is a selective and reversible inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6. Prdx6 is a bifunctional enzyme with both non-selenium glutathione peroxidase (Gpx) and PLA2 activities. Synonyms: 1-Hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol, Li. Grades: ≥95%. CAS No. 1007476-63-2. Molecular formula: C22H43F3LiO6P. Mole weight: 498.5. | |
MTP-131; RX-31; SS-31 Elamipretide Quick inquiry Where to buy Suppliers range | Elamipretide is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide under the development of Stealth BioTherapeutics. It can Improve left Ventricular and Mitochondrial Function. Elamipretide can alleviate mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. It can prevent both iHTM and GTM(3) cells from sustained oxidative stress induced by H(2)O(2). Phase II clinical trials for the treatment of Chronic heart failure and Mitochondrial myopathies are ongoing. Uses: Peptide Inhibitors. CAS No. 736992-21-5. Product ID: R1809. | |
Myeloperoxidase Inhibitor-II (4-(5-Fluoro-1H-indol-3-yl)butanamide, MPO Inhibitor II) Quick inquiry Where to buy Suppliers range | A 5-fluorotryptamine derivative that inhibits myeloperoxidase/MPO activity (IC50 = 18nM) via direct affinity interaction with enzyme active site heme pyrrole ring D, while exhibiting much reduced affinity toward serotonin reuptake transporter/SERT (Ki = 631nM). Kinetic studies reveal that the inhibitor acts as a good one-electron donor for the intermediate Compound I "Fe(IV)=O.Por +", facilitating the formation of Compound II (Fe(IV)-OH.Por) and thereby preventing the reduction of Compound I directly to the resting state "Fe(IV).Por" via the "halogenation cycle", while, on the other hand, behaves as a poor electron donor for Compound II, thereby preventing the completion of the "peroxidase cycle" by stalling the further reduction of Compound II to the resting state. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??FN?O, Primary Target: Myeloperoxidase. US Biological Life Sciences. | Worldwide |
NOX Inhibitor VII, Thr101 (NADPH Oxidase Inhibitor VII, 6-Fluoro-2-o-tolylbenzo [d]isothiazol-3 (2H) -one, 6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3(2H)-one) Quick inquiry Where to buy Suppliers range | A cell-permeable, selenium-to-sulfur substituted Ebselen derivative that exhibits similar NOX2 inhibitory activity as Ebselen by blocking p22phox c-terminal PRD (proline-rich domain) and p47phoxbis-SH3 interaction. Although less potent than Ebselen in cell-free p22phox PRD-p47phoxbis-SH3 binding (IC50 = 4 vs. 0.3uM) and NOX2 activity (IC50 = 4 vs. 0.6uM) assays, Thr101 is more potent and NOX2-selective than Ebselen in cell-based assays (Thr101 IC50 /Ebselen IC50 = 0.3/0.5, 3/0.15, 8/no inhibition, 8/0.7uM, respectively, against NOX2, NOX1, NOX4, and NOX5) and exhibits no glutathione peroxidase activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??FNOS, Primary Target: Blocks p22phox c-terminal PRD (proline-rich domain) and p47phox bis-SH3 interaction. US Biological Life Sciences. | Worldwide |
Oxalyl Chloride Quick inquiry Where to buy Suppliers range | Oxalyl Chloride is used in the preparation of cardiolipin analogs which induce peroxidase activity by Cytochrome C. It is also used in the preparation of fluorescent indicators for cytosolic calcium. Group: Biochemicals. Alternative Names: Ethanedioyl Dichloride; Oxalic Acid Chloride; Oxalic Acid Dichloride; Oxalic Dichloride; Oxaloyl Chloride; Oxaloyl Dichloride; Oxalyl Dichloride. Grades: Highly Purified. CAS No. 79-37-8. Pack Sizes: 50g. US Biological Life Sciences. | Worldwide |
Oxidation-Reduction Compound Library Quick inquiry Where to buy Suppliers range | A unique collection of 1279 compounds with defined prooxidant or antioxidant activity can be used for HTS and HCS; - Contains hydroperoxides, polyphenolics, metal chelators, thiols, thiol traps, radical scavengers, lazaroids and glutathione modulators as well as small molecule enzyme mimetics for SOD and glutathione peroxidase, and antioxidant natural products, etc. ?- Structurally diversified with potent bioactivity and cell permeable; - Detailed compound information with structure, target, and biological activity description?- NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2900. Categories: Oxidation-Reduction Compounds Libraries. | |
Peroxiredoxin-5, mitochondrial (163-172) Quick inquiry Where to buy Suppliers range | Peroxiredoxin-5, mitochondrial (163-172) is a truncated fragment of Peroxiredoxin-5, mitochondrial. Peroxiredoxin-5 interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. Synonyms: Peroxisomal Antioxidant Enzyme (163-172); Thioredoxin Peroxidase PMP20 (163-172); Antioxidant Enzyme B166 (163-172). | |
PF-1355 Quick inquiry Where to buy Suppliers range | PF-1355 is a selective, mechanism-based inhibitor of myeloperoxidase (MPO) (IC50 = 1.5 μM in LPS-stimulated human whole blood) with excellent selectivity for MPO without disrupting a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. PF-1355 was used to test the hypothesis that MPO activity is a critical mediator of disease activity in immune complex vasculitis mouse models, and to support the confidence in rationale for this mechanism as a therapeutic approach to treat related human condition such as alleviating tissue injury caused by Goodpasture syndrome and pulmonary vasculitis induced by immune complexes. Synonyms: 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide;PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355. CAS No. 1435467-38-1. Molecular formula: C14H15N3O4S. Mole weight: 321.35. | |
Trigonelline Hydrochloride Quick inquiry Where to buy Suppliers range | Trigonelline is a pyridine alkaloid found in various edible seeds and legumes, including coffee. It is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3; nicotinic acid) and, as a product of niacin metabolism, is excreted in urine of mammals.1 Trigonelline has been used to reduce blood glucose levels and to inhibit PPARγ expression in rat models of diabetes.2,3 It is also reported to inhibit the migration of hepatocarcinoma cells and render them more susceptible to apoptosis by reducing Raf/ERK/Nrf2 protein levels and activities of anti-oxidative enzymes further downstream, such as SOD, catalase, and glutathione peroxidase.4,5. Group: Biochemicals. Alternative Names: 1-Methylpyridinium-3-carboxylate hydrochloride; N-Methylnicotinic acid betaine hydrochloride. Grades: Plant Grade. CAS No. 6138-41-6. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C7H8ClNO2, Molecular Weight: 173.6. US Biological Life Sciences. | Worldwide |
Tyramine hydrochloride Quick inquiry Where to buy Suppliers range | A naturally occurring derivative of tyrosine. A catecholamine releasing agent that promotes blood pressure elevation. Uses: Tyramine hydrochloride has been:coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressurelabelled with fluorescence dyes (atto 488 and atto 655) to serve as a substrate for peroxidase in immunofluorescence analysisused in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification. Synonyms: 4-(2-Aminoethyl)phenol hydrochloride; 4-Hydroxyphenethylamine hydrochloride. Grades: 98.0%. CAS No. 60-19-5. Molecular formula: C8H11NO·HCl. Mole weight: 173.64. |