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| Product | Description | |
|---|---|---|
| peroxiredoxin | Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see mechanism). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydr...se thioredoxin as an electron donor. The 1-Cys Prxs conserve only the peroxidatic cysteine, so that its oxidized form is directly reduced to cysteine by the reductant molecule. Group: Enzymes. Synonyms: thioredoxin peroxidase; tryparedoxin peroxidase; alkyl hydroperoxide reductase C22; AhpC; TrxPx; TXNPx; Prx; PRDX. Enzyme Commission Number: EC 1.11.1.15. CAS No. 207137-51-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0496; peroxiredoxin; EC 1.11.1.15; 207137-51-7; thioredoxin peroxidase; tryparedoxin peroxidase; alkyl hydroperoxide reductase C22; AhpC; TrxPx; TXNPx; Prx; PRDX. Cat No: EXWM-0496. |  |
| Peroxiredoxin 1 human | ?85% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Peroxiredoxin-5, mitochondrial (163-172) | Peroxiredoxin-5, mitochondrial (163-172) is a truncated fragment of Peroxiredoxin-5, mitochondrial. Peroxiredoxin-5 interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. Synonyms: Peroxisomal Antioxidant Enzyme (163-172); Thioredoxin Peroxidase PMP20 (163-172); Antioxidant Enzyme B166 (163-172). |  |
| Peroxiredoxin I Active human | recombinant, expressed in baculovirus infected insect cells, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Peroxiredoxin II Active human | recombinant, expressed in baculovirus infected insect cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Peroxiredoxin I (K197Q) human | recombinant, expressed in baculovirus infected insect cells, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Peroxiredoxin I (K197R) human | recombinant, expressed in baculovirus infected insect cells, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Peroxiredoxin 2 antibody produced in goat | affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Peroxiredoxin 2 (C-terminal) antibody produced in rabbit | ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Peroxiredoxin 3 antibody produced in rabbit | IgG fraction of antiserum, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Peroxiredoxin 6 (C-terminal) antibody produced in rabbit | ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Peroxiredoxin 6 (N-terminal) antibody produced in rabbit | ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| (+)-cis,trans-Abscisic acid | The natural isomer of the abscission-accelerating plant hormone. (+)-Abscisic acid is a plant hormone and growth regulator involved in several physiological mechanisms including seed dormancy, leaf abscission, stomatal movement, and plant stress responses such as drought. Abscisic acid has been used in a study to learn about expression analysis of four peroxiredoxin genes from Tamarix hispida. Group: Biochemicals. Alternative Names: S-ABA, (2-cis, 4-trans,1S)-5-(1-Hydroxy-2,6,6-trimethyl) -4-oxo-2-cyclohexen-1-yl-3-methyl-2,4-pentadienoic Acid, Dormin; (S-(Z,E)])-5-(1-Hydroxy-2,6,6-trimethyl)-4-oxo-2-cyclohexen-1-yl-3- methyl-2,4-pentadienoic acid; (+)-(S)-Abscisic acid; (+)-(cis,trans)-Abscisic acid. Grades: Reagent Grade. CAS No. 21293-29-8. Pack Sizes: 250mg, 1g, 5g. Molecular Formula: C15H20O4. US Biological Life Sciences. |  Worldwide |
| Conoidin A | Peroxiredoxins are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells. Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine on the enzyme. It has been shown to inhibit peroxiredoxin II (IC50 = 23 μM) in the parasite T. gondii and peroxiredoxin I in the hookworm A. ceylanicum. Synonyms: 2,3-Bis(bromomethyl)quinoxaline 1,4-dioxide. Grades: ≥98%. CAS No. 18080-67-6. Molecular formula: C10H8Br2N2O2. Mole weight: 348. | |
| glutathione amide-dependent peroxidase | This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress. The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase). Group: Enzymes. Enzyme Commission Number: EC 1.11.1.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0498; glutathione amide-dependent peroxidase; EC 1.11.1.17. Cat No: EXWM-0498. | |
| Oxiconazole nitrate | Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti- fungal agent which can inhibit the growth of Candida , Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 13-8996. CAS No. 64211-46-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1324. |  |
| PTACH | PTACH is a SAHA-based novel inhibitor of histone deacetylase (HDAC). It exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1.1 to 9.1 μM. It shows strong activity in cancer cell growth inhibition assay. It inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer. It could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. It upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. It exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA. Uses: Ptach exerts potent growth inhibition against various human cancer cells. it could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction. Synonyms: NCH-51; NCH 51; NCH51. PTACH;Cpd 51;S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)heptyl) 2-methylpropanethioate;S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate;2-Methylpropanethioicacid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester. Grades: >98%. CAS No. 848354-66-5. Molecular formula: C20H26N2O2S2. Mole weight: 390.56. | |
| sulfiredoxin | In the course of the reaction of EC 1.11.1.15, peroxiredoxin, its cysteine residue is alternately oxidized to the sulfenic acid, S-hydroxycysteine, and reduced back to cysteine. Occasionally the S-hydroxycysteine residue is further oxidized to the sulfinic acid S-hydroxy-S-oxocysteine, thereby inactivating the enzyme. The reductase provides a mechanism for regenerating the active form of peroxiredoxin, i.e. the peroxiredoxin-(S-hydroxycysteine) form. Apparently the reductase first catalyses the phosphorylation of the -S(O)-OH group by ATP to give -S(O)-O-P, which is attached to the peroxiredoxin by a cysteine residue, forming an -S(O)-S- link between the two enzymes. Attack by a thiol splits this bond, leaving the peroxiredoxin as the sulfenic acid and the reductase as the thiol. Group: Enzymes. Synonyms: Srx1; sulphiredoxin; peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase. Enzyme Commission Number: EC 1.8.98.2. CAS No. 710319-61-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1683; sulfiredoxin; EC 1.8.98.2; 710319-61-2; Srx1; sulphiredoxin; peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase. Cat No: EXWM-1683. | |
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