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Phenylephrine. Uses: For analytical and research use. Group: Api standards; european pharmacopoeia (ph. eur.); pharmaceutical toxicology; pharmacopoeial standards. Alternative Names: Phenylephrine, (1R)-1-(3-Hydroxyphenyl)-2-(methylamino)ethanol. CAS No. 59-42-7. IUPAC Name: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol. Molecular formula: C9H13NO2. Mole weight: 167.20. Catalog: APS59427. SMILES: CNC[C@H](O)c1cccc(O)c1. Format: Neat.
Phenylephrine
(R)-(-)-Phenylephrine is a selective α 1 -adrenoceptor agonist primarily used as a decongestant. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-(-)-Phenylephrine; L-Phenylephrine. CAS No. 59-42-7. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B0769.
Phenylephrine bitartrate
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Phenylephrine HCL USP
Phenylephrine HCL USP.
CA, FL & NJ
Phenylephrine hydrochloride
(R)-(-)-Phenylephrine hydrochloride is a selective α 1 -adrenoceptor agonist with pK i s of 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively. Uses: Scientific research. Group: Natural products. Alternative Names: (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride. CAS No. 61-76-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0471.
Phenylephrine Hydrochloride
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standardsapi standardsbritish pharmacopoeiaeuropean pharmacopoeia (ph. eur.)impurity standardspharmaceutical toxicologypharmacopoeial standards. Alternative Names: Etilefrine Hydrochloride Imp. B (EP) as R-Enantiomer Hydrochloride, Benzenemethanol, 3-hydroxy-alpha-[(methylamino)methyl]-, hydrochloride, (R)-, M-Sympatol, Etilefrine Imp. B (EP), Decadron, Lexatol, Benzenemethanol, 3-hydroxy-alpha-[(methylamino)methyl]-, hydrochloride (1:1), (alphaR)-, l-Phenylephrine hydrochloride, Isophrin, Meta-Synephrine hydrochloride, (R)-Phenylephrine hydrochloride, Neo-S.
Phenylephrine Impurity 21
Phenylephrine Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1242184-39-9. Molecular formula: C9H13NO5S. Mole weight: 247.27. Catalog: APB1242184399.
Phenylephrine Related Compound D
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Phenylephrine Related Compound F
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Phenylephrine Related Compound G
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Intermediate in the preparation of α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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N-(2-Succinyl)phenylephrine(mixture of diastereomers)
N-(2-Succinyl)phenylephrine(mixture of diastereomers). Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[(2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl]-N-methylaspartic Acid. Product Category: Heterocyclic Organic Compound. CAS No. 915278-80-7. Molecular formula: C13H17NO6. Mole weight: 283.28. Product ID: ACM915278807. Alfa Chemistry ISO 9001:2015 Certified.
(±)-Phenylephrine-d3 hydrochloride solution
100 ?g/mL in methanol with 5% 1 M HCl (as free base), ampule of 1 mL, certified reference material. Group: Certified reference materials (crms).
(-)-Phenylephrine hydrogentartrate
(-)-Phenylephrine hydrogentartrate. Group: Biochemicals. Grades: Highly Purified. CAS No. 17162-39-9. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C9H13NO2·C4H6O6. US Biological Life Sciences.
Impurity D of Phenylephrine. Group: Biochemicals. Alternative Names: 3-Hydroxy-α - [ [methyl (phenylmethyl) amino] methyl] benzenemethanol. Grades: Highly Purified. CAS No. 1159977-09-9. Pack Sizes: 10mg. US Biological Life Sciences.
rac Benzyl Phenylephrine (Phenylephrine Impurity D). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-Hydroxy-?-[[methyl(phenylmethyl)amino]methyl]benzenemethanol,Phenylephrine Impurity D. CAS No. 1159977-09-9. Pack Sizes: 10MG. IUPAC Name: 3-[2-[benzyl(methyl)amino]-1-hydroxy-ethyl]phenol. Molecular formula: C16H19NO2. Mole weight: 257.33. Catalog: APS1159977099. SMILES: CN(CC(O)c1cccc(O)c1)Cc2ccccc2. Format: Neat. Shipping: Room Temperature.
rac norphenylephrine hydrochloride (phenylephrine impurity A)
rac norphenylephrine hydrochloride (phenylephrine impurity A). Group: Biochemicals. Alternative Names: a- (Aminomethyl) -3-hydroxy Benzene methanol. Grades: Highly Purified. CAS No. 4779-94-6. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C8H12ClNO2. US Biological Life Sciences.
Worldwide
rac Norphenylephrine Hydrochloride (Phenylephrine Impurity A)
Impurity A of phenylephrine. A phenylephrine derivative as leukotriene D4 antagonists. Group: Biochemicals. Alternative Names: α - (Aminomethyl) -3-hydroxy Benzene methanol. Grades: Highly Purified. CAS No. 4779-94-6. Pack Sizes: 10mg. US Biological Life Sciences.
(R) -O, O-Bis (tert-butyldimethlsilyl) phenylephrine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences.
Worldwide
(R)-Phenylephrine-[d3]
(R)-Phenylephrine-[d3] is an isotope labelled (R)-Phenylephrine, which is an α1-adrenoceptor agonist. Synonyms: (R)-Phenylephrine-d3. Grade: 95%. CAS No. 88694-06-8. Molecular formula: C9H10D3NO2. Mole weight: 170.22.
(R)-(-)-Phenylephrine-[d3] Hydrochloride
(R)-(-)-Phenylephrine-[d3] Hydrochloride is the labelled salt of Phenylephrine, which is a selective α1-adrenergic receptor agonist of the phenethylamine class. Synonyms: (R)-(-)-Phenylephrine D3 Hydrochloride; (R)-(-)-Phenylephrine-2,4,6-d3 HCl; Phenylephrine D3 hydrochloride; 3-[(1R)-1-hydroxy-2-(methylamino)ethyl](2,4,6-D3)phenol hydrchloride; (αR)-3-Hydroxy-α-[(methylamino)methyl]benzenemethanol-d3 Hydrochloride; (-)-m-Hydroxy-α-[(methylamino)methyl]benzyl Alcohol-d3 Hydrochloride. Grade: >95%. CAS No. 1276197-50-2. Molecular formula: C9H11D3ClNO2. Mole weight: 206.68.
Phenylephrine HCl is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Grade: >98%. CAS No. 61-76-7. Molecular formula: C9H14ClNO2. Mole weight: 203.67.
R-(-)-Phenylephrine hydrochloride solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material. Group: Certified reference materials (crms).
(R)-Phenylephrine-L-tartaramide (>90%)
(R)-Phenylephrine-L-tartaramide (>90%). Uses: For analytical and research use. Group: Impurity standards. Catalog: APS00109. Format: Neat.
(R/S)-Phenylephrine-d3 Glucuronide
A deuterated labelled of Phenylephrine glucuronide which is a metabolite of Phenylephrine, a selective α1-adrenergic receptor agonist of the phenethylamine class. Grade: 95% by HPLC; 98% atom D. Molecular formula: C15H18D3NO8. Mole weight: 346.35.
(R/S)-Phenylephrine-d3 HCl
An impurity of Phenylephrine which is a powerful vasoconstrictor and works by reducing swelling of the blood vessels in the nasal passages. Grade: 95% by HPLC; 98% atom D. Molecular formula: C9H10D3NO2.HCl. Mole weight: 206.68.
(S)-Phenylephrine-d3 Hydrochloride
An impurity of Phenylephrine which is a decongestant that shrinks blood vessels in the nasal passages. Synonyms: (αS)-3-Hydroxy-α-[(methylamino)methyl]benzenemethanol-d3 Hydrochloride (1:1); (+)-m-Hydroxy-α-[(methylamino)methyl]-benzyl Alcohol-d3; (+)-Phenylephrine-d3 Hydrochloride. Grade: > 95%. Molecular formula: C9H10NO2D3·HCl. Mole weight: 206.69.
An impurity of Phenylephrine which is an oral selective α1-adrenergic receptor agonist. Synonyms: 939-38-8; (+)-Phenylephrine hydrochloride; (S)-Phenylephrine Hydrochloride; UNII-95T627AGR395T627AGR3. Grade: > 95%. CAS No. 939-38-8. Molecular formula: C9H13NO2.HCl. Mole weight: 203.67.
(S)-Phenylephrine Hydrochloride
(S)-Phenylephrine Hydrochloride, is an isomer of (R)-Phenylephrine Hydrochloride. It is a selective α1-adrenergic receptor agonist used mainly as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Group: Biochemicals. Alternative Names: (α S) -3-Hydroxy-α -[ (methylamino) methyl]benzenemethanol Hydrochloride (1:1); (+)-m-Hydroxy-α-[(methylamino)methyl]-benzyl Alcohol; (+)-Phenylephrine Hydrochloride. Grades: Highly Purified. CAS No. 939-38-8. Pack Sizes: 250mg, 500mg, 1g. US Biological Life Sciences.
1,2,3,4-Tetrahydro-2-methyl-4,8-isoquinolinediol Hydrochloride is an product formed during the decomposition of Phenylephrine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 100mg. Molecular Formula: C10H14ClNO2. US Biological Life Sciences.
Product formed during the decomposition of Phenylephrine. Synonyms: 1,2,3,4-Tetrahydro-2-methyl-4,6-isoquinolinediol. Grade: > 95%. CAS No. 23824-24-0. Molecular formula: C10H13NO2. Mole weight: 179.22.
An impurity of Phenylephrine. Phenylephrine is a selective alpha-1 adrenergic receptor agonist used primarily as a decongestant to relieve nasal and sinus congestion caused by colds, allergies, or sinusitis. Synonyms: Phenylephrine Isoquinolinone Analog; Phenylephrine Isoquinolinone; 1-(3-Hydroxybenzoyl)-2-methyl-6(2H)-isoquinolinone. Grade: ≥95%. CAS No. 2990371-07-6. Molecular formula: C17H13NO3. Mole weight: 279.29.
1-(3-Hydroxybenzyl)-2-methylisoquinolin-6(2H)-one
1-(3-Hydroxybenzyl)-2-methylisoquinolin-6(2H)-one is an impurity of Phenylephrine (P320640), an α-Adrenergic agonist. Mydriatic; decongestant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C17H13NO3, Molecular Weight: 279.29. US Biological Life Sciences.
1-[5-(Hydroxymethyl)-2-furyl]-2-methyl-1,2,3,4-tetrahydroisochinolin-4,8-diol is a degradation product of phenylephrine during the synthesis of the anti-cold medicine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1312706-19-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C15H17NO4. US Biological Life Sciences.
1-[5-(Hydroxymethyl)-2-furyl]-2-methyl-1,2,3,4-tetrahydroisochinolin-4,8-diol is a degradation product of phenylephrine during the synthesis of the anti-cold medicine. Group: Biochemicals. Grades: Highly Purified. CAS No. 1312706-18-5. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H17NO4. US Biological Life Sciences.
Worldwide
2,2-Dimethyl-5-oxo-1,3-dioxolane-4-acetic Acid
2,2-Dimethyl-5-oxo-1,3-dioxolane-4-acetic Acid is a reagent used to synthesize degradation products of Phenylephrine (P320635 Hydrochloride salt) in over-the-counter products. Group: Biochemicals. Grades: Highly Purified. CAS No. 114458-03-6. Pack Sizes: 2.5g, 25g. Molecular Formula: C7H10O5, Molecular Weight: 174.15. US Biological Life Sciences.
2,2-Dimethyl-5-oxo-1,3-dioxolane-4-acetic Acid Phenylmethyl Ester is an potential degradation product of phenylephrine in over the counter products. Group: Biochemicals. Grades: Highly Purified. CAS No. 1049703-02-7. Pack Sizes: 50mg, 500mg. Molecular Formula: C14H16O5. US Biological Life Sciences.
Worldwide
2, 2'- (Methylazanediyl) bis (1- (3-hydroxyphenyl) ethanone) Hydrochloride
2, 2'- (Methylazanediyl) bis (1- (3-hydroxyphenyl) ethanone) Hydrochloride is an impurity formed in the synthesis of Phenylephrine (P320635), a selective α1-adrenergic receptor agonist used as a decongestant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 100mg. Molecular Formula: C17H18ClNO4. US Biological Life Sciences.
Intermediate in the preparation of an analogue of α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences.
Intermediate in the preparation of an analogue of α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Intermediate in the preparation of α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Intermediate in the preparation of 6-Bromo Phenylephrine an analogue of the α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
2-Chloro-5-hydroxybenzaldehyde
2-Chloro-5-hydroxybenzaldehyde is used as a reagent in the synthesis of p38 inhibitors which are used for the treatment of chronic obstructive pulmonary disease. It is also used in the preparation of halogenated analogs of L-meta-tyrosine which is a biodegradable herbicide. 2-Chloro-5-hydroxybenzaldehyde may also be used as a starting material in the synthesis of chlorinated phenylephrine. Group: Biochemicals. Grades: Highly Purified. CAS No. 7310-94-3. Pack Sizes: 250mg, 500mg. Molecular Formula: C7H5ClO2, Molecular Weight: 156.57. US Biological Life Sciences.
2-Hydroxy-4-[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]methylamino]-4-oxobutanoic acid is an impurity of Phenylephrine, which is a selective α1-adrenergic receptor agonist used as a nasal decongestant and cardiotonic agent. Synonyms: Phenylephrine Related Compound; (2RS)-Hydroxy-4[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]methylamino]-4-oxo-butanoic Acid; Butanoic acid, 2-hydroxy-4-[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]methylamino]-4-oxo-; Phenylephrine Impurity 19 (Mixture of Diastereomers); 2-hydroxy-4-(((R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl)(methyl)amino)-4-oxobutanoic acid. Grade: ≥95%. CAS No. 1217525-08-0. Molecular formula: C13H17NO6. Mole weight: 283.28.
3-Hydroxy-α-[(methylamino)methyl]-(R)-benzenemethanol 1-Acetate Hydrochloride is an impurity in the synthesis of (R)-Phenylephrine (P320640), an α-Adrenergic agonist. Mydriatic; decongestant. Group: Biochemicals. Grades: Highly Purified. CAS No. 58952-79-7. Pack Sizes: 10mg, 100mg. Molecular Formula: C13H18ClNO4, Molecular Weight: 287.74. US Biological Life Sciences.
3-Hydroxy-4-[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]methylamino]-4-oxobutanoic acid is an impurity of Phenylephrine, which is a selective α1-adrenergic receptor agonist used as a nasal decongestant and cardiotonic agent. Synonyms: Butanoic acid, 3-hydroxy-4-[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]methylamino]-4-oxo-; 3-hydroxy-4-(((R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl)(methyl)amino)-4-oxobutanoic acid; Phenylephrine Related Compound; Phenylephrine Impurity 31 (Mixture of Diastereomers); N-Methyl-N-[(βR)-β,3-dihydroxyphenethyl]-3-hydroxysuccinamidic acid. Grade: ≥95%. CAS No. 830346-80-0. Molecular formula: C13H17NO6. Mole weight: 283.28.
3-Hydroxymandelic Acid, a metabolite of Phenylephrine , Phenylephrine is a α-receptor agonist. Uses: Scientific research. Group: Natural products. CAS No. 17119-15-2. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W015326.
3-Methyl-5-phenyl-2-oxazolidinone β-D-Glucuronide Triacetate (Mixture of Diastereoisomers)
3-Methyl-5-phenyl-2-oxazolidinone β-D-Glucuronide Triacetate (Mixture of Diastereoisomers) is an intermediate in the synthesis of Phenylephrine β-D-Glucuronide, a metabolite of Phenylephrine, an α-Adrenergic agonist. Synonyms: (2S,3S,4S,5R,6S)-2-(Methoxycarbonyl)-6-(3-(3-methyl-2-oxooxazolidin-5-yl)phenoxy)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C23H27NO12. Mole weight: 509.46.
Intermediate in the preparation of α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. CAS No. 1415393-66-6. Pack Sizes: 50mg. US Biological Life Sciences.
Intermediate in the preparation of 6-Bromo Phenylephrine an analogue of the α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences.
Intermediate in the preparation of α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Intermediate in the preparation of α-adrenergic agonist, Phenylephrine (P320640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
5,6-Epoxyeicosatrienoic acid
5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 ( IC 50 =0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5,6-EET; (±)5,6-EpETrE. CAS No. 87173-80-6. Pack Sizes: 25 μg (312.04 μM * 250 μL in Ethanol); 50 μg (312.04 μM * 500 μL in Ethanol); 100 μg (312.04 μM * 1 mL in Ethanol). Product ID: HY-132184.
ABT-866
ABT-866 is a novel alpha-adrenoceptor agent that demonstrates intrinsic activity at the α1A-adrenoceptor subtype present in the rabbit urethra (pD2=6.22, with 80% of the phenylephrine response). Synonyms: N-[3-(1H-imidazol-5-ylmethyl)phenyl]ethanesulfonamide; ABT-866; ABT 866; ABT866; A 286666; A286666; A-286666. Grade: >98%. CAS No. 258526-74-8. Molecular formula: C12H15N3O2S. Mole weight: 265.33.
Adrenochrome
An impurity of Phenylephrine which selectively binds to alpha receptors which cause blood vessels to constrict. Synonyms: Adrenochrome. Grade: > 95%. CAS No. 54-06-8. Molecular formula: C9H9NO3. Mole weight: 179.18.
AdTx1
AdTx1 is a high affinity, selective and non-competitive α1A adrenoceptor antagonist with Ki value of 0.35 nM. It is a 65 amino-acid peptide originally isolated from the venom of the green mamba. It is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. It displays no significant activity against a range of other GPCRs. It antagonizes effects of phenylephrine on intra-urethral pressure in rats and on isolated rabbit prostate muscle in vitro. It is used as a potent relaxant of smooth muscles. Synonyms: ρ-Da1a. Grade: >98%. Molecular formula: C310H481N87O100S8. Mole weight: 7283.22.
ARC 239
ARC239 dihydrochloride is a potent and selective α2 B adrenoceptor antagonist. It is used as an α-adrenoceptor blocking drug. It competitively antagonizes pressor responses to adrenaline and inhibits pressor responses to noradrenaline, tyramine, phenylephrine and dimethylphenylpiperazinium. Uses: Arc239 dihydrochloride is used as an α-adrenoceptor blocking drug. Synonyms: ARC239 dihydrochloride; ARC 239 dihydrochloride; ARC-239 dihydrochloride; 2-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride; AR-C239 Dihydrochloride. Grade: 98%. CAS No. 67339-62-2. Molecular formula: C24H29N3O3. Mole weight: 407.5.
BIX NHE1 inhibitor
BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC50 = 31 nM). It attenuates ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo, attenuates phenylephrine-induced cardiomyocyte hypertrophy in vitro. Synonyms: BI-9627; BI 9627; BI9627; 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride. Grade: ≥98% by HPLC. CAS No. 1204329-34-9. Molecular formula: C16H19F3N4O2.HCl. Mole weight: 392.8.
Ethyl cinnamate
Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga , exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC 50 values of 0.30 mM and 0.38 mM in rat aorta [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 103-36-6. Pack Sizes: 10 mM * 1 mL; 100 g. Product ID: HY-Y0121.
Fmoc-His(3-Me)-OH
Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC 50 s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca 2+ ] i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 252049-16-4. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-W111226.
HA1077 (Fasudil Dihydrochloride)
A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK).HA1077 is an inhibitor of ROK/ROCK II (IC50 1.9uM), PRK2 (IC50 4uM), MSK1 (IC50 5uM), Rsk2 (IC50 15uM), PKA, p70 S6 Kinase, CaM Kinase (Ki 1.8nM) and MLCK (Ki 20nM). HA1077 is a calcium antagonist and has antivasospastic properties. Inhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK. Group: Biochemicals. Alternative Names: Fasudil Dihydrochloride; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine 2HCl; 1-(5-Isoquinolinesulfonyl) homopiperazine 2HCl). Grades: Highly Purified. CAS No. 103745-39-7. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C14H17N3O2S 2HCl, Molecular Weight: 364.29. US Biological Life Sciences.
Worldwide
Mesaconitine
Mesaconitine is the main active component of genus aconitum plants.IC50 value:Target:in vitro: In HUVECs, 30 microM mesaconitine increased the [Ca(2+)](I) level in the presence of extracellular CaCl(2) and NaCl, and the response was inhibited by KBR7943. Mesaconitine increased intracellular Na(+) concentration level in HUVECs. The [Ca(2+)](I) response by mesaconitine was inhibited by 100 microM D-tubocurarine. Mesaconitine at 30 microM inhibited 3 microM phenylephrine-induced contraction in the endothelium-intact, but not endothelium-denuded, aortic rings. MA promoted the alpha-MT-induced decrease in NE levels in hippocampus, medulla oblongata plus pons and spinal cord. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (1-alpha,3-alpha,6-alpha,14-alpha,15-alpha,16-beta)-8-acetate14-benzoat;13,14,15-pentol,1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-aconitane-8;MESACONITINE;Aconitane-3,8,13,14,15-pentol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)- ;MESACONITINE, 98% (PRIMARY STANDARD);Mesaaconitine;1α,6α,16β-Trimethoxy-4-methoxymethyl-20-. Product Category: Inhibitors. Appearance: Solid. CAS No. 2752-64-9. Molecular formula: C33H45NO11. Mole weight: 631.71. Purity: 0.9883. Canonical SMILES: CO[C@@H]1C2([C@@](C[C@@]3(O)[C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]4([H])[C@](OC(C)=O)([C@@H](O)[C@@H]3OC
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