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| Product | Description | |
|---|---|---|
| PDE10A Inhibitor, Cpd15 (Phosphodiesterase 10A Inhibitor, (6-chloro-3,8-dimethyl-1H-pyrazolo[3,4-b]quinolin-4-yl)(2-methylpyrimidin-5-yl)methanol) | A cell-permeable pyrazoloquinoline compound that acts as a potent phosphodiesterase 10A inhibitor (Ki≤5nM against human PDE10A), while exhibiting >500-fold selectivity over other human PDEs 1-11 and little activity against CYP3A4 (IC50 >20uM) or a panel of 23 kinases (IC50 >30uM). Reported to be orally available in monkey and rat species and be efficacious in reversing nMDAR antagonist (+)-MK-801-induced hyperactivity in a ratsl (MED = 10mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences. |  Worldwide |
| RO 20-1724, cAMP-specific Phosphodiesterase Inhibitor (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) | Cell-permeable. A potent,selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 29925-17-5. Pack Sizes: 50mg, 250mg. US Biological Life Sciences. | Worldwide |
| 1,1'-Ethylidenebis[L-tryptophan] | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Synonyms: USP Tryptophan Related Compound A; 1,1'-Ethylidenebis-(L-tryptophan); EBT. Grade: > 95%. CAS No. 132685-02-0. Molecular formula: C24H26N4O4. Mole weight: 434.50. |  |
| 1-(4-Chloro-6,7-dimethoxyphthalazin-1-yl)piperidin-4-yl Ethylcarbamate | 1-(4-Chloro-6,7-dimethoxyphthalazin-1-yl)piperidin-4-yl Ethylcarbamate is a metabolite of Carbazeran (C175790), a phosphodiesterase inhibitor drug that exhibits chronictropic and inotropic effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 1586753-74-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C18H23ClN4O4. US Biological Life Sciences. | Worldwide |
| 1-Cyclohexyl-5-(1,4-dibromobutyl)-1H-tetrazole | 1-Cyclohexyl-5-(1,4-dibromobutyl)-1H-tetrazole is an intermediate in the synthesis of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H18Br2N4. US Biological Life Sciences. | Worldwide |
| 1-Cyclohexyl-5-(4-chlorobutyl)amino-1H-tetrazole | 1-Cyclohexyl-5-(4-chlorobutyl)amino-1H-tetrazole is an impurity of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and an inhibitor of adenosine uptake and has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H20ClN5, Molecular Weight: 257.76. US Biological Life Sciences. | Worldwide |
| 1-Decarboxyl-1-(bromoacetyl) Norneovardenafil | 1-Decarboxy-1-(bromoacetyl) Norneovardenafil is an intermediate in the preparation of the phosphodiesterase inhibitor Norneovardenafil (N824500). Group: Biochemicals. Alternative Names: 2-[5-(Bromoacetyl)-2-ethoxyphenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one. Grades: Highly Purified. CAS No. 358388-58-6. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| (1S)-1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine | (1S)-1-(3-Ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethylamine is an Apremilast (A729700) intermediate. Apremilast, an oral phosphodiesterase 4 inhibitor is used in the treatment of psoriatic arthritis. Group: Biochemicals. Grades: Highly Purified. CAS No. 608141-42-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C12H19NO4S. US Biological Life Sciences. | Worldwide |
| (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide | (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide is a byproduct formed in the preparation of Tadalafil (T004500); a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 951661-85-1. Pack Sizes: 250mg, 2.5g. Molecular Formula: C20H19N3O3, Molecular Weight: 349.38. US Biological Life Sciences. | Worldwide |
| (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide-d3 | (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide-d3 is the isotope labelled analog of (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-N-methyl-1H-pyrido[3,4-b]indole-3-carboxamide (B203535); a byproduct formed in the preparation of Tadalafil (T004500) which is a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C20H16D3N3O3, Molecular Weight: 352.4. US Biological Life Sciences. | Worldwide |
| 2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-4H-1-benzopyran-4-one | 2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5,7-dihydroxy-3-(phenylmethoxy)-4H-1-benzopyran-4-one is an intermediate in the synthesis of Quercetin Dihydrate (Q509500), which is a lavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Group: Biochemicals. Grades: Highly Purified. CAS No. 498548-17-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C35H24O7. US Biological Life Sciences. | Worldwide |
| 2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5-hydroxy-3-phenylmethoxy-4H-1-benzopyran-4-one 7-O- β-D-Glucuronide | 2-(2,2-Diphenyl-1,3-benzodioxol-5-yl)-5-hydroxy-3-phenylmethoxy-4H-1-benzopyran-4-one 7-O- β-D-Glucuronide is an intermediate in the synthesis of Quercetin Dihydrate (Q509500), which is a lavonoid with anticancer activity. It is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C41H32O13. US Biological Life Sciences. | Worldwide |
| 2-(2,6-Difluoro-4-methoxyphenyl)-2-oxoacetic Acid | 2-(2,6-Difluoro-4-methoxyphenyl)-2-oxoacetic Acid is a derivative of 3,5-Difluoroanisole (D445395), which is used in the preparation of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 antagonists. Also used in the preparation of imidazo[1,5-a]pyrido[3,2-e]pyrazines and imidazo[1,5-a]quinoxalines as orally active phosphodiesterase 10A inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1183701-25-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C9H6F2O4, Molecular Weight: 216.14. US Biological Life Sciences. | Worldwide |
| 2-(4-Chlorobutyl)-5-cyclohexylamino-2H-tetrazole | 2-(4-Chlorobutyl)-5-cyclohexylamino-2H-tetrazole is an impurity of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and an inhibitor of adenosine uptake and has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H20ClN5, Molecular Weight: 257.76. US Biological Life Sciences. | Worldwide |
| 2,4-Dimethyl-5-oxazolecarboxylic Acid | 2,4-Dimethyl-5-oxazolecarboxylic Acid is a useful synthetic intermediate. It is used as a reagent to synthesize human phosphodiesterases (PDE) 5 inhibitor sildenafil analogs as trypanosomal PDE inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 2510-37-4. Pack Sizes: 250mg, 500mg. Molecular Formula: C6H7NO3. US Biological Life Sciences. | Worldwide |
| 2-?(5-?Acetyl-?2-?ethoxyphenyl)?-?5-?methyl-?7-?propyl-imidazo[5,?1-?f]?[1,?2,?4]?triazin-?4(1H)?-?one | 2-?(5-?Acetyl-?2-?ethoxyphenyl)?-?5-?methyl-?7-?propyl-imidazo[5,?1-?f]?[1,?2,?4]?triazin-?4(1H)?-?one is an intermediate in synthesizing 1-Decarboxy-1-(bromoacetyl) Norneovardenafil, which is used in the preparation of the phosphodiesterase inhibitor Norneovardenafil (N824500). Group: Biochemicals. Grades: Highly Purified. CAS No. 358390-43-9. Pack Sizes: 500mg, 1g. Molecular Formula: C19H22N4O3. US Biological Life Sciences. | Worldwide |
| 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide | 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide is a sulfide-like inhibitor of phosphodiesterase 7 (PDE7; IC50 = 2.1 μM). It is selective for PDE7A, producing only 10-11% inhibition of PDE3A, PDE4D, and PDE4B at 10 μM. Synonyms: 2'-(5-chloro-2-nitrophenylthio)-acetanilide; 2'-(2-Nitro-5-chlorophenylthio)acetoanilide. Grade: ≥98%. CAS No. 107522-19-0. Molecular formula: C14H11ClN2O3S. Mole weight: 322.8. | |
| 2- (Acetylamino) -6-[[[ (1S) -1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethyl]amino]carbonyl]-benzoic Acid | 2- (Acetylamino) -6-[[[ (1S) -1- (3-ethoxy-4-methoxyphenyl) -2- (methylsulfonyl) ethyl]amino]carbonyl]-benzoic Acid is an impurity of Apremilast (A729700), which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1809170-71-5. Pack Sizes: 10mg, 100mg. Molecular Formula: C22H26N2O8S. US Biological Life Sciences. | Worldwide |
| 2-Amino-4-methyl-1-propyl-1H-pyrrole-3-carbonitrile | 2-Amino-4-methyl-1-propyl-1H-pyrrole-3-carbonitrile is an impurity of Yonkenafil, a novel phosphodiesterase 5 (PDE5) inhibitor that has a potential therapeutic effect on Alzheimer's disease. Synonyms: 1H-Pyrrole-3-carbonitrile, 2-amino-4-methyl-1-propyl-. Grade: ≥95%. CAS No. 804519-27-5. Molecular formula: C9H13N3. Mole weight: 163.22. | |
| 2-Amino-5,6-dichloro-3,4-dihydroquinazoline | 2-Amino-5,6-dichloro-3,4-dihydroquinazoline is a metabolite of Anagrelide (A637300), a phosphodiesterase inhibitor with antiplatelet activity. Used as an antithrombocythemic. Group: Biochemicals. Grades: Highly Purified. CAS No. 444904-63-6. Pack Sizes: 100mg, 1g. Molecular Formula: C8H7Cl2N3. US Biological Life Sciences. | Worldwide |
| 2-Amino-5,6-dichloro-3(4H)-quinazolineacetic Acid Methyl Ester Monohydrobromide | 2-Amino-5,6-dichloro-3(4H)-quinazolineacetic Acid Methyl Ester is an impurity of Anagrelide (A637300, HCl salt) which is a phosphodiesterase inhibitor with antiplatelet activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 70380-52-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C11H12BrCl2N3O2, Molecular Weight: 369.04. US Biological Life Sciences. | Worldwide |
| 2-Chloro-3,4-dimethoxybenzoic Acid | 2-Chloro-3,4-dimethoxybenzoic Acid is an intermediate used in the synthesis of T. brucei phosphodiesterases B1 and B2 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 52009-53-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C9H9ClO4, Molecular Weight: 216.62. US Biological Life Sciences. | Worldwide |
| 2-(Dedimethyldeamino)deethyl Denaverine | A derivative of Denaverine. Denaverine is a phosphodiesterase inhibitor primarily used to treat smooth muscle spasms in the gastrointestinal and urogenital tracts. Synonyms: 2,2-Diphenyl-2-(2-ethylbutoxy)acetic acid; Denaverine Impurity 1; Denaverine Impurity 4; (2-Ethylbutoxy)diphenylacetic acid; α-(2-Ethylbutoxy)-α-phenylbenzeneacetic acid. Grade: ≥95%. CAS No. 2594-45-8. Molecular formula: C20H24O3. Mole weight: 312.41. | |
| 2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl)]-benzaldehyde | 2-Ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl)]-benzaldehyde is an intermediate in the synthesis of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 332374-42-2. Pack Sizes: 50mg, 500mg. Molecular Formula: C14H20N2O4S, Molecular Weight: 312.38. US Biological Life Sciences. | Worldwide |
| 2-Hydroxyethyl Nortadalafil | 2-Hydroxyethyl Nortadalafil is a derivative of Tadalafil, a compound used for the treatment of erectile dysfunction. Also a phosphodiesterase 5 inhibitor. Group: Biochemicals. Alternative Names: (6R, 12aR)-rel-6-(1, 3-Benzodioxol-5-yl)-2, 3, 6, 7, 12, 12a-hexahydro-2-(2-hydroxyethyl)-pyrazino[1', 2':1, 6]pyrido[3, 4-b]indole-1, 4-dione. Grades: Highly Purified. CAS No. 385769-94-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C??H??N?O?, Molecular Weight: 419.43. US Biological Life Sciences. | Worldwide |
| 2-Hydroxyethyl Nortadalafil | One analogue of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Synonyms: (6R,12aR)-rel-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-(2-hydroxyethyl)-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione. Grade: > 95%. CAS No. 385769-94-8. Molecular formula: C23H21N3O5. Mole weight: 419.44. | |
| 2-Hydroxyethyl Nortadalafil-d4 | 2-Hydroxyethyl Nortadalafil-d4 is the isotope labelled analog of 2-Hydroxyethyl Nortadalafil (H942245); a derivative of Tadalafil (T004500) which is a compound used for the treatment of erectile dysfunction. Also a phosphodiesterase 5 inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C23H17D4N3O5, Molecular Weight: 423.45. US Biological Life Sciences. | Worldwide |
| 2-Hydroxypropylnortadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Synonyms: (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-(2-hydroxypropyl)-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione. Grade: > 95%. CAS No. 1353020-85-5. Molecular formula: C24H23N3O5. Mole weight: 433.47. | |
| 2-Methyl-4-hydroxypyridine | 2-Methyl-4-hydroxypyridine is used in the synthesis of novel indolizine compounds as inhibitors of phosphodiesterase IV. Also used in the preparation of 2-substituted imidazole ring compoiunds for treatment againast human African trypanosomiasis. Group: Biochemicals. Alternative Names: 2-Methylpyridin-4-ol; 4-Hydroxy-2-methylpyridine; 2-Methyl-4-pyridinol. Grades: Highly Purified. CAS No. 18615-86-6. Pack Sizes: 1g. Molecular Formula: C?H?NO, Molecular Weight: 109.13. US Biological Life Sciences. | Worldwide |
| (2S,3S,4S,5R,6S)-6-(5-((R)-1-(4-Acetamido-1,3-dioxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid | (2S,3S,4S,5R,6S)-6-(5-((R)-1-(4-Acetamido-1,3-dioxoisoindolin-2-yl)-2-(methylsulfonyl)ethyl)-2-ethoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid is a related compound of Apremilast (A729700), which is an oral phosphodiesterase 4 inhibitor used in the treatment of psoriatic arthritis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C27H30N2O13S, Molecular Weight: 622.6. US Biological Life Sciences. | Worldwide |
| 2-Triethylmethyl Tadalafil | 2-Triethylmethyl Tadalafil is derived from Tadalafil (T004500), which is used for the treatment of erectile dysfunction and is also a phosphodiesterase 5 inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C27H29N3O4, Molecular Weight: 459.54. US Biological Life Sciences. | Worldwide |
| 3-(3,4-Dimethoxyphenyl)-1-methylpiperidine-2,4-dione | 3-(3,4-Dimethoxyphenyl)-1-methylpiperidine-2,4-dione is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 100mg. Molecular Formula: C14H17NO4. US Biological Life Sciences. | Worldwide |
| 3, 4-Bis (difluoromethoxy) benzaldehyde | 3, 4-Bis (difluoromethoxy) benzaldehyde is an impurity of the antiasthmatic drug Roflumilast. 3, 4-Bis (difluoromethoxy) benzaldehyde is used in the preparation of diphenylethylene compounds as PDE4 (phosphodiesterase-4) inhibitors for treatment of cancer, CNS disorders, and inflammatory disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 127842-54-0. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 3,4-Dehydro Cilostazol-[d11] | 3,4-Dehydro Cilostazol-[d11] is a labelled metabolite of Cilostazol. Cilostazol is a phosphodiesterase inhibitor used to treat intermittent claudication of patients with peripheral vascular disease. Synonyms: 3,4-Dehydro Cilostazol D11; 6-[4-(1-Cyclohexyl-d11-1H-tetrazol-5-yl)butoxy]-2(1H)-quinolinone; OPC 13015-d11. Grade: ≥97% by HPLC; ≥99% atom D. CAS No. 1073608-13-5. Molecular formula: C20H14D11N5O2. Mole weight: 378.51. | |
| 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-N-[2-(methylamino)ethyl]-Benzenesulfonamide | 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxy-N-[2-(methylamino)ethyl]-Benzenesulfonamide is a Sildenafil derivative. Sildenafil is an orally active type 5 cGMP phosphodiesterase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 466684-88-8. Pack Sizes: 25mg, 100mg. Molecular Formula: C20H28N6O4S, Molecular Weight: 448.54. US Biological Life Sciences. | Worldwide |
| 3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonyl Chloride | 3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonyl Chloride is an intermediate used in the synthesis of O-Desethyl-O-propyl Methisosildenafil (D289495), which is an analogue of the selective type of 5cGMP phosphodiesterase inhibitor, Sildenafil (S435000). Group: Biochemicals. Grades: Highly Purified. CAS No. 139756-24-4. Pack Sizes: 10mg, 25mg. Molecular Formula: C18H21ClN4O4S, Molecular Weight: 424.9. US Biological Life Sciences. | Worldwide |
| 3-acetamidophthalic acid | Apremilast Impurity 18 is an impurity of Apremilast, which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis. Synonyms: 3-(Acetylamino)phthalic acid; 3-(Acetylamino)-1,2-benzenedicarboxylic Acid; 1,2-Benzenedicarboxylic acid, 3-(acetylamino)-. CAS No. 15371-06-9. Molecular formula: C10H9NO5. Mole weight: 223.18. | |
| 3-Acetamidophthalic Acid | 3-Acetamidophthalic Acid is an impurity of Apremilast (A729700); an oral phosphodiesterase 4 inhibitor used in the treatment of psoriatic arthritis. Apremilast EP Impurity B. Group: Biochemicals. Grades: Highly Purified. CAS No. 15371-06-9. Pack Sizes: 5mg, 25mg. Molecular Formula: C10H9NO5. US Biological Life Sciences. | Worldwide |
| 3-(Acetylamino)-1,2-benzenedicarboxylic Acid Methyl Ester | 3-(Acetylamino)-1,2-benzenedicarboxylic Acid Methyl Ester α S) -3-Ethoxy-4-methoxy-α -[ (methylsulfonyl) methyl]-N-[ (1S) -1-phenylethyl]-benzenemethanamine which is an impurity of Apremilast (A729700), which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis. Group: Biochemicals. Grades: Highly Purified. CAS No. 144841-10-1. Pack Sizes: 5mg, 10mg. Molecular Formula: C11H11NO5. US Biological Life Sciences. | Worldwide |
| 3-Acetylaminophthalic Anhydride | 3-Acetylaminophthalic Anhydride is used in the synthesis of Apremilast, a potent phosphodiesterase 4 and tumor necrosis Factor-α inhibitor used in the treatment of psoriatic arthritis. Also a reagent in the preparation of Tillivalline. Apremilast Impurity 2. Group: Biochemicals. Grades: Highly Purified. CAS No. 6296-53-3. Pack Sizes: 1g, 10g. Molecular Formula: C10H7NO4, Molecular Weight: 205.17. US Biological Life Sciences. | Worldwide |
| 3-Amino-2,4-dibromopyridine | 3-Amino-2,4-dibromopyridine is a versatile reactant used in the synthesis of novel indolizine 2-oxoacetamides that are inhibitors of phosphodiesterase IV and tumor necrosis factor-α production in human peripheral blood mononuclear cell. Group: Biochemicals. Grades: Highly Purified. CAS No. 102249-45-6. Pack Sizes: 50mg, 250mg. Molecular Formula: C5H4Br2N2, Molecular Weight: 251.91. US Biological Life Sciences. | Worldwide |
| 3-(But-3-en-1-yloxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | An impurity of Roflumilast. Roflumilast is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: Roflumilast Impurity 6. CAS No. 2368178-29-2. Molecular formula: C17H14Cl2F2N2O3. Mole weight: 403.20. | |
| 3-(Cyclopropylmethoxy)-3-hydroxybenzoic Acid Methyl Ester | 3-(Cyclopropylmethoxy)-3-hydroxybenzoic Acid Methyl Ester is an intermediate in the synthesis of Roflumilast (R639700), an selective phosphodiesterase 4(PDE4) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 848574-60-7. Pack Sizes: 100mg, 1g. Molecular Formula: C12H14O4. US Biological Life Sciences. | Worldwide |
| 3- (Cyclopropylmethoxy) -4- (methoxymethoxy) benzoic Acid | 3- (Cyclopropylmethoxy) -4- (methoxymethoxy) benzoic Acid is an impurity formed in the synthesis of Roflumilast (R639700), an selective phosphodiesterase 4(PDE4) inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 250mg. Molecular Formula: C13H16O5. US Biological Life Sciences. | Worldwide |
| 3'-Desethoxy Drotaverine Hydrochloride | An impurity of Drotaverine. Drotaverine is an antispasmodic drug, which acts as a phosphodiesterase 4 inhibitor. Synonyms: 5-((6,7-Diethoxy-3,4-dihydroisoquinolin-1-yl)methyl)-2-ethoxyphenol hydrochloride; Phenol, 5-[(6,7-diethoxy-3,4-dihydro-1-isoquinolinyl)methyl]-2-ethoxy-, hydrochloride (1:1). CAS No. 85475-87-2. Molecular formula: C22H28ClNO4. Mole weight: 405.92. | |
| 3-Isobutyl-1-methylxanthine (IBMX) | A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50=2-50uM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-a expression in adipocyte precursor cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 28822-58-4. Pack Sizes: 250mg, 1g. US Biological Life Sciences. | Worldwide |
| 3-O-Methylquercetin | 3-O-Methylquercetin is an inhibitor of cAMP and CGMP-phosphodiesterase ( PDE ) with IC 50 at 13.8 μM and 14.3 μM, respectively. 3-O-Methylquercetin is an inhibitor of β-secretase with an IC 50 of 6.5 μM. 3-O-Methylquercetin has a neuroprotective effect against neuronal death caused by oxidative damage. 3-O-Methylquercetin has strong antiviral activity against poliovirus, coxsackie virus and human rhinovirus. 3-O-Methylquercetin has anti-inflammatory and trachea-relaxing effects and can be used in the study of inflammatory diseases and asthma [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 1486-70-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1860. |  |
| 3- (S) - hydroxypyrrolidinyl avanafil | 3- (S) - hydroxypyrrolidinyl avanafil is a metabolite of Avanafil (A794670), a phosphodiesterase (PDE5) inhibitor, used to treat erectile dysfunction. Group: Biochemicals. Grades: Highly Purified. CAS No. 330785-58-5. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C23H26ClN7O4, Molecular Weight: 499.95. US Biological Life Sciences. | Worldwide |
| 4-Amino-1-tert-butyl-3-(3-ethyl)pyrazolo[3,4-d]pyrimidine | A phosphodiesterase inhibitor for treating cardiovascular diseases such as congestive heart failure and hypertension. Group: Biochemicals. Alternative Names: 1-(1,1-Dimethylethyl)-3-ethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grades: Highly Purified. CAS No. 1246816-12-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-Amino-3-chloropyridine | A derivative of Fampridine. Fampridine is a potent convulsant. Uses: 4-amino-3-chloropyridine is a chlorinated heteroarylamine. 4-amino-3-chloropyridine is used in the preparation of inhibitor of phosphodiesterase type 4 (pde4) as antiasthmatic agents as well as other pyridine based pharmaceutical agents. Synonyms: 3-chloro-4-pyridinamine; 3-chloropyridin-4-amine. Grade: > 95 %. CAS No. 19798-77-7. Molecular formula: C5H5ClN2. Mole weight: 128.56. | |
| 4-(Chloromethyl)-1,3-dimethyl-1H-pyrazole-5-carboxylic Acid Methyl Ester | 4-(Chloromethyl)-1,?3-dimethyl-1H-pyrazole-5-carboxylic Acid Methyl Ester is an intermediate of Clenbuterol and is used as a reagent in the synthesis of pyrazolopyridine derivatives as inhibitors of phosphodiesterase-4 (PDE-IV) and production of tumor necrosis factor-α (TNF-α). Synonyms: 1H-Pyrazole-5-carboxylic acid, 4-(chloromethyl)-1,3-dimethyl-, methyl ester; Methyl 4-(chloromethyl)-1,3-dimethyl-1H-pyrazole-5-carboxylate. Grade: ≥95%. CAS No. 1001415-64-0. Molecular formula: C8H11ClN2O2. Mole weight: 202.64. | |
| 4-(Cyclopropylmethoxy)-3-(difluoromethoxy)benzaldehyde | An impurity of Roflumilast. Roflumilast is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: 4-Cyclopropylmethoxy-3-difluoromethoxy-benzaldehyde. CAS No. 162401-78-7. Molecular formula: C12H12F2O3. Mole weight: 242.22. | |
| 4-Hydroxycarbazeran | 4-Hydroxycarbazeran is a metabolite of Carbazeran , a phosphodiesterase inhibitor drug that exhibits chronictropic and inotropic effects. Group: Biochemicals. Alternative Names: 1-(3,4-Dihydro-6,7-dimethoxy-4-oxo-1-phthalazinyl)-4-piperidinyl Ester Ethylcarbamic Acid. Grades: Highly Purified. CAS No. 96724-43-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 4-Methoxy-1-naphthalenepropanoic Acid Ethyl Ester | Intermediate in the preparation of disubstituted tetrahydrofurans as inhibitors of serotonin re-uptake and inhibitors of phosphodiesterase 4 enzyme activity. Group: Biochemicals. Alternative Names: Ethyl 3-(4-methoxy-1-naphthyl)propanoate. Grades: Highly Purified. CAS No. 861354-99-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 6-(((1,3-Dioxolan-2-yl)methyl)amino)-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione | 6-(((1,3-Dioxolan-2-yl)methyl)amino)-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione is an intermediate in the synthesis of Doxofylline, which is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: 6-[(1,3-Dioxolan-2-ylmethyl)amino]-1,3-dimethyl-5-nitro-2,4(1H,3H)-pyrimidinedione; 2,4(1H,3H)-Pyrimidinedione, 6-[(1,3-dioxolan-2-ylmethyl)amino]-1,3-dimethyl-5-nitro-. Grade: 98%. Molecular formula: C10H14N4O6. Mole weight: 286.24. | |
| 6-(((1,3-Dioxolan-2-yl)methyl)amino)-5-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione | 6-(((1,3-Dioxolan-2-yl)methyl)amino)-5-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione is an intermediate in the synthesis of Doxofylline, which is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. Synonyms: 6-[(1,3-Dioxolan-2-ylmethyl)amino]-5-amino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione. Grade: 98%. Molecular formula: C10H16N4O4. Mole weight: 256.26. | |
| 6R,12S-Tadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Synonyms: Tadalafil EP Impurity A; (6R,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; (6R-cis)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a- hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione. Grade: > 95%. CAS No. 171596-27-3. Molecular formula: C22H19N3O4. Mole weight: 389.41. | |
| 6S,12R-Tadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Synonyms: Tadalafil EP Impurity C; (6S ,12ar)-Tadalafil; (6S,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; (6S-cis)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione. Grade: > 95%. CAS No. 171596-28-4. Molecular formula: C22H19N3O4. Mole weight: 389.41. | |
| 6S,12S-Tadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Synonyms: ent-Tadalafil; Tadalafil USP Impurity B; (6S,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; L-Tadalafil; L-Tildenafil. Grade: > 95%. CAS No. 629652-72-8. Molecular formula: C22H19N3O4. Mole weight: 389.41. | |
| 8-CPT-cAMP | 8-CPT-cAMP is an activator of cAMP- and cGMP-dependent protein kinase and of Epac. It has an improved membrane permeability, phosphodiesterase stability and selectivity for site B of cAK type II. Uses: Enzyme inhibitors. Synonyms: 8- (4- Chlorophenylthio)adenosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 99% by HPLC. CAS No. 93882-12-3. Molecular formula: C16H14ClN5O6PS · Na. Mole weight: 493.8. | |
| 8-Methoxymethyl-3-isobutyl-1-methylxanthine - CAS 78033-08-6 | A cell-permeable selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase (PDE I; IC?? = 4 μM). Group: Fluorescence/luminescence spectroscopy. |  |
| 8-pCPT-PET-cGMP | 8-pCPT-PET-cGMP is an activator of cyclic GMP-dependent protein kinase as well as an inhibitor of the retinal type cGMP-gated ion channel, thus it can be used for distinction between kinase and ion channel mediated effects. It effects against mammalian cyclic nucleotide-dependent phosphodiesterases. Compared to 8-Br-PET-cGMP, 8-pCPT-PET-cGMP is much more lipophilic and membrane-permeant. Synonyms: 8- (4- Chlorophenylthio)- β- phenyl- 1, N2- ethenoguanosine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. Molecular formula: C24H18ClN5O7PS · Na. Mole weight: 609.9. | |
| Acetaminotadalafil | One of the impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Synonyms: N-[(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-3,4,6,7,12,12a-hexahydro-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indol-2(1H)-yl]-acetamide. Grade: 90%. CAS No. 1446144-71-3. Molecular formula: C23H20N4O5. Mole weight: 432.44. | |
| Acetaminotadalafil-d3 | One of the labelled impurities of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Grade: 95% by HPLC; 98% atom D. Molecular formula: C23H17N4O5D3. Mole weight: 435.46. | |
| Acetildenafil | It is a designer drug which acts as a phosphodiesterase inhibitor. It is a structural analogue of Sidenafil (Viagra), named for a substitution of an acetyl group for a sulfonyl group. which has been detected in numerous different brands of supposedly herbal aphrodisiac products sold to boost libido and alleviate erectile dysfunction. Group: Biochemicals. Alternative Names: 5-[2-Ethoxy-5-[2- (4-ethyl-1-piperazinyl) acetyl]phenyl]-1, 6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4, 3-d]pyrimidin-7-one; Hongdenafil. Grades: Highly Purified. CAS No. 831217-01-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 466.58. US Biological Life Sciences. | Worldwide |
| Acetildenafil-d8 | It is a designer drug which acts as a phosphodiesterase inhibitor. It is a structural analogue of Sidenafil (Viagra), which has been detected in numerous different brands of supposedly herbal aphrodisiac products sold to boost libido and alleviate erectile dysfunction. Group: Biochemicals. Alternative Names: 5-[2-Ethoxy-5-[2-(4-ethyl-1-piperazinyl-d8)acetyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Acetyl Vardenafil | Acetyl Vardenafil is an analogue of Vardenafil. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Synonyms: 2-[2-Ethoxy-5-[2-(4-ethyl-1-piperazinyl)acetyl]phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one. CAS No. 1261351-28-3. Molecular formula: C25H34N6O3. Mole weight: 466.59. | |
| Aminophylline | Aminophylline is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist. Synonyms: Phyllocontin. Grade: >98%. CAS No. 317-34-0. Molecular formula: C16H24N10O4. Mole weight: 420.43. | |
| Aminotadalafil | Aminotadalafil is an analogue of Tadalafil, which is an inhibitor of phosphodiesterase 5 and could be used in the treatment of erectile dysfunction. Synonyms: (6R,12aR)-2-Amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione; Amino Tadalafil. Grade: > 95%. CAS No. 385769-84-6. Molecular formula: C21H18N4O4. Mole weight: 390.40. | |
| Amrinone | A selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. Cardiotonic. Group: Biochemicals. Alternative Names: 5-Amino-[3,4'-bipyridin]-6(1H)-one; 3-Amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone; 5-Amino-1,6-dihydro-6-oxo-[3,4'-bipyridine]; AWD 08-250; Cartonic; Cordemcura; Inamrinone; Vesistol; Win 40680; Wincoram. Grades: Highly Purified. CAS No. 60719-84-8. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
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