Phosphoribosyltransferase Suppliers USA
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Product | Description | |
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3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridinium Triflate Quick inquiry Where to buy Suppliers range | 3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridinium Triflate is an intermediate in synthesizing β-Nicotinamide Mononucleotide, a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. Synonyms: 3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridinium 1,1,1-Trifluoromethanesulfonate; 3-(Aminocarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-pyridinium Salt with Trifluoromethanesulfonic Acid. CAS No. 774599-53-0. Molecular formula: C17H21N2O8? CF3O3S?. Mole weight: 381.36. | |
β-Nicotinic Acid Mononucleotide Quick inquiry Where to buy Suppliers range | A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH. Synonyms: 3-Carboxy-1-(5-O-phosphono-β-D-ribofuranosyl)pyridinium Inner Salt; 3-Carboxy-1-β-D-ribofuranosylpyridinium Hydroxide 5'-Phosphate Inner Salt; Nicotinate Mononucleotide; Nicotinate Ribonucleotide; Nicotinic Acid Ribonucleotide; Nicotinic Acid Ribotide; Nicotinic Mononucleotide; β-NaMN. Grades: 95%. CAS No. 321-02-8. Molecular formula: C11H14NO9P. Mole weight: 335.2. | |
Boc-(4-aminomethyl) benzoic acid Quick inquiry Where to buy Suppliers range | Boc-(4-aminomethyl) benzoic acid (CAS# 33233-67-9) is the Boc protected form of 4-(Aminomethyl)benzoic Acid (A615230) and is used as a reagent in the synthesis of indoleamide derivatives as EP2 antagonists with high selectivity. 4-(Boc-aminomethyl)benzoic Acid is also used as a reagent in the synthesis of aminopyridine-derived amides as nicotinamide phosphoribosyltransferase inhibitors. Synonyms: Boc-4-Amb-OH; 4-(Boc-aminomethyl)benzoic acid; 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid. Grades: ≥ 98 % (HPLC). CAS No. 33233-67-9. Molecular formula: C13H17NO4. Mole weight: 251.27. | |
FK866 Quick inquiry Where to buy Suppliers range | FK866 is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt) with potential antineoplastic and antiangiogenic activities. FK866 binds to Nampt to suppress the biosynthesis of nicotinamide adenine dinucleotide (NAD+), leading to tumor cell apoptosis. Uses: Potential anticancer agent. Synonyms: Daporinad; (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-pyridin-3-ylprop-2-enamide; APO 866; FK 866; APO866; FK866; APO-866; FK-866. CAS No. 658084-64-1. Molecular formula: C24H29N3O2. Mole weight: 391.515. | |
FK 866 hydrochloride Quick inquiry Where to buy Suppliers range | FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, visfatin, PBEF1) (Ki = 0.3 nM) and inhibits NAD biosynthesis. It induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM)and induces apoptosis in four different neuroblastoma cell lines. FK 866 exhibits antineoplastic and antiangiogenic activities. Synonyms: FK-866 Hydrochloride; FK 866 Hydrochloride; FK866 Hydrochloride; 2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 2727965-45-7. Molecular formula: C24H29N3O2.HCl. Mole weight: 427.97. | |
GPP 78 Quick inquiry Where to buy Suppliers range | GPP 78 is a potent inhibitor of Nicotinamide phosphoribosyltransferase (Nampt) with an IC50 value of 3 nM. Synonyms: CAY10618; NMPRTase Inhibitor; N-[1,1'-biphenyl]-2-yl-4-(3-pyridinyl)-1H-1,2,3-triazole-1-octanamide. Grades: ≥95%. CAS No. 1202580-59-3. Molecular formula: C27H29N5O. Mole weight: 439.6. | |
GPP 78 hydrochloride Quick inquiry Where to buy Suppliers range | GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), which is subsequently converted to NAD+. It was shown to induce autophagy in neuroblastoma cells. Synonyms: GPP 78 hydrochloride; GPP78 hydrochloride; GPP-78 hydrochloride; N-[1,1'-Biphenyl]-2-yl-4-(3-pyridinyl)-1H,1,2,3-triazole-1-octanamide hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C27H29N5O.HCl. Mole weight: 476.01. | |
Nampt-IN-1 Quick inquiry Where to buy Suppliers range | Nampt-IN-1, a pyridyloxyacetyl tetrahydroisoquinoline compound, is a novel inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with the potential to treat cancer. IC50: NCI-H1155 cell= 18 nM, Calu-6 cell= 49 nM, HCC1937 cell= 333 nM, MCF-7 cell= 3. Synonyms: Nampt-IN-1; Nampt-IN 1; Nampt-IN1; LSN3154567; LSN-3154567; LSN 3154567; 2-hydroxy-2-methyl-N-[2-(2-pyridin-3-yloxyacetyl)-3,4-dihydro-1H-isoquinolin-6-yl]propane-1-sulfonamideNampt-IN-1CHEMBL3586462SCHEMBL16634738. CAS No. 1698878-14-6. Molecular formula: C20H25N3O5S. Mole weight: 419.49. |