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| Product | Description | |
|---|---|---|
| PI(3,5)P2 | PI(3,5)P2. Group: Others. Purity: >99%. Mole weight: 1239.023. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; PI(3,5)P2; 1-Oleoyl-2-{6-[4-(Dipyrrometheneboron difluoride)butanoyl]amino}hexanoyl-sn-glycero-3-phosphoinositol-3,5-bisphosphate (ammonium salt). Cat No: FLBZ-137. |  |
| 18:1-6:0 Biotin PI(3,5)P2 | 18:1-6:0 Biotin PI(3,5)P2. Group: Others. Purity: >99%. Mole weight: 1149.165. Stability: 1 Year. Storage: -20° C. Avanti Polar Lipids; lipid products; natural lipids; natural; synthetic lipid; synthetic; modified lipids; headgroup modified lipids; fatty acid modified lipids; singnal transduction; cell pathways; 18:1-6:0 Biotin PI(3,5)P2; 1-Oleoyl-2-[6-biotinyl(aminohexanoyl)]-sn-glycero-3-phosphoinositol-3,5-bisphosphate (ammonium salt). Cat No: NSMZ-112. | |
| 18:1-6:0 Biotin PI(3,5)P2 Triammonium salt | 18:1-6:0 Biotin PI(3,5)P2 Triammonium salt is a meticulously formulated synthetic compound crucial for delving into the intricate mechanisms of phosphatidylinositol metabolism and intracellular signal transduction pathways. Its widespread application in diverse research areas such as cancer, diabetes, and neurodegenerative disorders underscores its indispensable role in advancing scientific understanding. Synonyms: 1-oleoyl-2-[6-biotinyl(aminohexanoyl)]-sn-glycero-3-phosphoinositol-3,5-bisphosphate (ammonium salt); D-myo-Inositol, 3,5-bis(dihydrogen phosphate) 1-[(2R)-2-[[6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxohexyl]oxy]-3-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]propyl hydrogen phosphate], ammonium salt (1:3). Grade: >99%. CAS No. 2260670-01-5. Molecular formula: C43H87N6O21P3S. Mole weight: 1149.16. |  |
| GloPIPs Biotin-PI(3,5)P2 | GloPIPs Biotin-PI(3,5)P2 is labelled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labelled PIPs has been changed to a more stable amide from an ester. PI(3,5)P2 is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease). Grade: >95%. Molecular formula: C31H52N4Na5O20P3S. Mole weight: 1040.69. | |
| 1,3-Benzodioxole-5-sulfonyl Chloride | 1,3-Benzodioxole-5-sulfonyl Chloride is a reagent that is used in the preparation of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryloxazolidinone-5-carboxamides as novel P2 ligands. Group: Biochemicals. Grades: Highly Purified. CAS No. 115010-10-1. Pack Sizes: 1g, 10g. Molecular Formula: C7H5ClO4S, Molecular Weight: 220.63. US Biological Life Sciences. |  Worldwide |
| 1-[(5-Methylisoxazol-3-yl)methyl]piperazine | 1-[(5-Methylisoxazol-3-yl)methyl]piperazine is a P2Y12 inhibitor. Synonyms: 1-[(5-methyl-1,2-oxazol-3-yl)methyl]piperazine. CAS No. 173850-51-6. Molecular formula: C9H15N3O. Mole weight: 181.23. | |
| 18:1-6:0 Biotin PI(4,5)P2 | 18:1-6:0 Biotin PI(4,5)P2. Group: Others. Purity: >99%. Mole weight: 1149.165. Stability: 1 Year. Storage: -20°C. Avanti Polar Lipids; lipid products; natural lipids; natural; synthetic lipid; synthetic; modified lipids; headgroup modified lipids; fatty acid modified lipids; singnal transduction; cell pathways; 18:1-6:0 Biotin PI(4,5)P2; 1-Oleoyl-2-[6-biotinyl(aminohexanoyl)]-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt). Cat No: NSMZ-113. | |
| 18:1-6:0 Biotin PI(4,5)P2 Triammonium salt | Biotin PI(4,5)P2 Triammonium salt 18:1-6:0 is an essential lipid compound crucial in the field of biomedicine, pioneering research on intricate cell signal transduction mechanisms pertaining to prevalent disease states such as diabetes and cancer. Furthermore, it serves as a pivotal substrate facilitating enzymatic reactions governing lipid metabolism and cellular communication pathways. Synonyms: 1-oleoyl-2-[6-biotinyl(aminohexanoyl)]-sn-glycero-3-phosphoinositol-4,5-bisphosphate (ammonium salt). Grade: >99%. CAS No. 2260670-03-7. Molecular formula: C43H87N6O21P3S. Mole weight: 1149.16. | |
| 18:1 PI(4,5)P2 | 18:1 PI(4,5)P2 (1,2-Dioleoyl-sn-glycero-3-phospho-(1-myo-inositol-4,5-bisphosphate) (ammonium)) is a kind of biochemical reagent. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,2-Dioleoyl-sn-glycero-3-phospho-1-myo-inositol-4,5-bisphosphate (ammonium). CAS No. 799268-56-7. Pack Sizes: 50 μg; 100 μg. Product ID: HY-157703. |  |
| 1-phosphatidylinositol-4-phosphate 5-kinase | This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known. Group: Enzymes. Synonyms: diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase. Enzyme Commission Number: EC 2.7.1.68. CAS No. 104645-76-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3099; 1-phosphatidylinositol-4-phosphate 5-kinase; EC 2.7.1.68; 104645-76-3; diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase. Cat No: EXWM-3099. | |
| 2',3'-O-(N-Methylanthraniloyl)-adenosine-5'-diphosphate triethylammonium salt | 2',3'-O-(N-Methylanthraniloyl)-adenosine-5'-diphosphate triethylammonium salt is an accomplished antagonist of P2Y1, assuming a pivotal role in research of cardiovascular perspicacity. Synonyms: MANT-ADP. Molecular formula: C18H22N6O11P2. Mole weight: 560.35. | |
| 2-(Methylamino)pyridine-4-boronic acid pinacol ester | 2-(Methylamino)pyridine-4-boronic acid pinacol ester. Synonyms: 1350913-08-4; N-METHYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-AMINE; 2-(METHYLAMINO)PYRIDINE-4-BORONIC ACID PINACOL ESTER; SCHEMBL12070204; XHSDOOFCOGZVOT-UHFFFAOYSA-N; N-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine; MFCD11878218; MB10890; AS-72878; CS-0183543; EN300-153085; P20205. CAS No. 1350913-08-4. Molecular formula: C12H21BN2O3. Mole weight: 252.12. | |
| 3-Bromo-6-methylpyridazine | 3-Bromo-6-methylpyridazine is used as a reagent in the synthesis of piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans. 3-Bromo-6-methylpyridazine is also used in the preparation of cyclohexyl fluoropyrimidinyl benzamides as CNS penetrable P2X7 receptor antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 65202-58-6. Pack Sizes: 250mg, 500mg. Molecular Formula: C5H5BrN2. US Biological Life Sciences. | Worldwide |
| A 438079 | A potent, competitive, and selective antagonist of P2X7 purinergic receptor (pIC50 = 6.5nM and 6.9nM for rat and human P2X7 receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10uM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC50 = 100 and 300nM at rat and human P2X7 receptors, respectively. Developed by Abbott. Group: Biochemicals. Alternative Names: 3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine Hydrochloride; P2X7 Purinergic Receptor Antagonist; A 438079; A438079; A-438079. Grades: Highly Purified. CAS No. 899507-36-9. Pack Sizes: 10mg. Molecular Formula: C??H?Cl?N? HCl, Molecular Weight: DMSO. US Biological Life Sciences. | Worldwide |
| A-438079 HCl | A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. Synonyms: A-438079 HCl; A 438079 HCl; A438079 HCl. Grade: 98%. CAS No. 899431-18-6. Molecular formula: C13H10Cl3N5. Mole weight: 342.61. | |
| A 438079 hydrochloride | A 438079 hydrochloride is a competitive P2X7 receptor antagonist with pIC50 value of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. It protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, but not by inflammasome activation. It partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. Synonyms: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride; A-438079 HCl; A-438079 hydrochloride; A438079 hydrochloride; A 438079 hydrochloride. Grade: >98 %. CAS No. 899507-36-9. Molecular formula: C13H10Cl3N5. Mole weight: 342.61. | |
| A 438079 hydrochloride | Competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). Devoid of activity at other P2 receptors (IC50 >> 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo. Inhibits methamphetamine-induced microglial migration and phagocytosis in vitro. Group: Biochemicals. Alternative Names: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride; 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine Monohydrochloride; A 438079. Grades: Highly Purified. CAS No. 899431-18-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C??H??Cl?N?, Molecular Weight: 342.61. US Biological Life Sciences. | Worldwide |
| AF 353 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. Synonyms: AF353; AF-353; 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-; Ro 4; 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyrimidinediamine. Grade: >98%. CAS No. 865305-30-2. Molecular formula: C14H17IN4O2. Mole weight: 400.21. | |
| AF353 (P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353) | A novel, potent, orally bioavailable antagonist of P2X3/P2X2/3 receptors (pIC50 = 8 in human and rat; pIC50 = 7.3 for human P2X2/3 receptor). Shown to be highly brain penetrant with a brain to plasma ratio of 6. Blocks agonist-evoked intracellular Ca2+ flux and inward currents in nanomolar range (10nM to 1uM) in cell lines recombinantly expressing human P2X3 and P2X2/3 receptors. Exhibits desirable pharmacokinetic properties (t1/2 = 1.63 h and Tmax = 30 min). Group: Biochemicals. Grades: Highly Purified. CAS No. 927887-18-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClIN?O?. US Biological Life Sciences. | Worldwide |
| APY0201 | APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P2 in the presence of in the presence of [33P]ATP with an IC50 of 5.2 nM. APY0201 also inhibits IL-12/IL-23 production. Uses: Scientific research. Group: Signaling pathways. CAS No. 1232221-74-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15982. | |
| Biotin Phosphatidylinositol 3,5-bisphosphate | Biotin Phosphatidylinositol 3,5-bisphosphate is a water-soluble analog of PI(3,5)P2 labelled with biotin at the sn-1 position. PI(3,5)P2 is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease). Synonyms: Biotin PI(3,5)P2. Grade: >95%. Molecular formula: C37H62N4Na5O22P3S. Mole weight: 1154.84. | |
| Biotin Phosphatidylinositol 4,5-bisphosphate | Biotin Phosphatidylinositol 4,5-bisphosphate is a water-soluble analog of PI(4,5)P2 labelled with biotin at the sn-1 position. PI(4,5)P2 has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3. Synonyms: Biotin PI(4,5)P2. Grade: >95%. Molecular formula: C37H62N4Na5O22P3S. Mole weight: 1154.84. | |
| Biotin PI(3,4,5)P3 | Biotin PI(3,4,5)P3 is a water-soluble analog of PI(3,4,5)P2 (PIP3) labelled with biotin at the sn-1 position. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 through phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. Synonyms: Biotin Phosphatidylinositol 3,4,5-trisphosphate. Grade: >95%. Molecular formula: C37H61N4Na7O25P4S. Mole weight: 1278.78. | |
| BMS 299897, gamma-Secretase Inhibitor XXIV (4-(2-((1R)-1-(((4-Chlorophenyl)sulfonyl)-2,5-difluoroanilino)ethyl)-5-fluorophenyl)butanoic Acid, BMS-299897, BMS 299897) | An orally bioavailable sulfonamide compound that acts as a potent, reversible and allosteric y-secretase activity inhibitor with ~15-fold greater selectivity over Notch-1 proteolysis processing (IC50=7.1 and 105.9nM in HEK293-wtAPP) and preferentially inhibits PS1 (presenillin 1)-comprised y-secretase (EC50=8, 108, 286 and 29nM for PS1, Triple PS1-L172M,T281P, L282I, PS2 and Triple PS2-M178L, P287T, I288L), respectively). Shown to reduce the levels of Ab38, Ab40 and Ab42 in Tg2576 mice, Ab40 brain and plasma in APP-YAC mice (ED50=30 and 16mg/kg, p.o.) and Abtotal brain, CSF and plasma in guinea pigs (ED50=30mg/kg, i.p.). Group: Biochemicals. Grades: Highly Purified. CAS No. 290315-45-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CAY10626 | Phosphatidylinositol 3-kinases (PI3K) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3K catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. Synonyms: CAY 10626; CAY-10626. Grade: ≥98%. CAS No. 1202884-94-3. Molecular formula: C31H35F3N8O3. Mole weight: 624.7. | |
| Click PI(4,5)P2-azido | Click PI(4,5)P2-azido. Group: Others. Purity: >99%. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; Click PI(4,5)P2-azido; 1-Oleoyl-2-(6-(6-azidoHexanoyl)aminoHexanoyl)-sn-glycero-3-phosphoinositol-4.5-bisphosphate (ammonium salt). Cat No: FLBZ-248. | |
| Defluoro N,N-Dibenzyl Paroxetine Bromide | An impurity of Paroxetine (P205750). Group: Biochemicals. Alternative Names: trans- (-) -3-[ (1, 3-Benzodioxol-5-yloxy) methyl]-4-phenyl-1, 1-di (phenylmethyl) piperidine. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Elastase, Porcine pancreas | Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EC 3.4.21.36; Pancreatopeptidase E. CAS No. 39445-21-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P2974. | |
| GloPIPs Biotin-PI(3,4,5)P3 | GloPIPs Biotin-PI(3,4,5)P3 is labelled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labelled PIPs has been changed to a more stable amide from an ester. Phosphatidylinositol 3,4,5-trisphosphate, formed from PI(4,5)P2 through phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. Grade: >95%. Molecular formula: C31H51N4Na7O23P4S. Mole weight: 1164.64. | |
| GloPIPs Biotin-PI(3,4)P2 | GloPIPs Biotin-PI(3,4)P2 is labelled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labelled PIPs has been changed to a more stable amide from an ester. PI(3,4)P2 is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions. Grade: >95%. Molecular formula: C31H52N4Na5O20P3S. Mole weight: 1040.69. | |
| GloPIPs Biotin-PI(4,5)P2 | GloPIPs Biotin-PI(4,5)P2 is labelled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labelled PIPs has been changed to a more stable amide from an ester. PI(4,5)P2 has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3. Molecular formula: C35H53BF2N4O19P3. Mole weight: 975.55. | |
| GSK-A1 | GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIII?) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns(4,5)P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2. GSK-A1 has the potential for anti-hepatitis C virus (HCV) research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416334-69-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-125118. | |
| JTE-607 HCl | JTE-607, also known as TO-207, is a cytokine production inhibitor potentially for the treatment of systemic inflammatory response, and induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TO-207; TO 207; TO207; JTE-607; JTE 607; JTE 607; JTE-607 HCl; JTE-607 dihydrochloride. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 188791-09-5. Molecular formula: C25H33Cl4N3O5. Mole weight: 597.36. Purity: >98%. IUPACName: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Canonical SMILES: O=C(OCC)[C@H](CC1=CC=CC=C1)NC(C2=CC(Cl)=C(OCCN3CCN(C)CC3)C(Cl)=C2O)=O.[H]Cl.[H]Cl. Product ID: ACM188791095. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Luteinizing hormone (human) | Luteinizing hormone (human), a heterodimeric glycoprotein hormone produced by the pituitary gland (LH), plays key roles in human reproduction [1]. Uses: Scientific research. Group: Peptides. CAS No. 39341-83-8. Pack Sizes: 10 μg; 50 μg. Product ID: HY-P2293. | |
| NP-1815-PX sodium | NP-1815-PX sodium is a potent and selective P2X4R antagonist. NP-1815-PX sodium has anti-inflammatory activity, and can relieve pain in chronic pain models. NP-1815-PX sodium also inhibits guinea pig tracheal/bronchial smooth muscle (TSM and BSM) contractions [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1239578-80-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150270A. | |
| P2X Antagonist III (Purinergic Receptor P2X Antagonist III, N- ( (4- (4-Phenylpiperazin-1-yl) tetrahydro-2H-pyran-4-yl) methyl) -2- (phenylthio) nicotinamide) | A phenylthio-nicotinamide that acts as a high affinity P2X7 antagonist (pKi = 8.7 and 7.9, respectively, against 30nM A-804598 for rat and human P2X7 binding) and potently inhibits P2X7-dependent cellular Ca2+ mobilization (pIC50 = 8.3, 7.5, and 7.2, respectively, using 1321N1 expressing human, mouse, or rat P2X7; drug added 0.5 h prior to 3 min 0.25 mM BzATP stimulation), while exhibiting much reduced or little potency toward a panel of 50 ion channels, transporters, and receptors. Although not suitable for oral dosing due to high hepatic extraction ratios, effective delivery and brain P2X7 occupancy can be achieved via s.c. dosing in rats (30mg/kg) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | This enzyme hydroylses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4). The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. Group: Enzymes. Synonyms: SHIP1; SHIP2; SHIP; p150Ship. Enzyme Commission Number: EC 3.1.3.86. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3692; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; EC 3.1.3.86; SHIP1; SHIP2; SHIP; p150Ship. Cat No: EXWM-3692. | |
| phosphoinositide phospholipase C | These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four β-isoforms regulated by G-proteins, two γ-forms regulated by tyrosine kinases, four Δ-forms regulated at least in part by calcium and an ε-form, probably regulated by the oncogene ras, have been found. Group: Enzymes. Synonyms: triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Enzyme Commission Number: EC 3.1.4.11. CAS No. 63551-76-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3711; phosphoinositide phospholipase C; EC 3.1.4.11; 63551-76-8; triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase. Cat No: EXWM-3711. | |
| PI(4,5)P2 | PI(4,5)P2. Group: Others. 1-Oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphoinositol-4.5-bisphosphate (ammonium salt); PI(4,5)P2. Cat No: PHOZ-086. | |
| Piromelatine | Piromelatine (Neu-P11) is a melatonin MT 1 /MT 2 receptor agonist, serotonin 5-HT 1A / 5-HT 1D agonist, and serotonin 5-HT 2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Neu-P11. CAS No. 946846-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105285. | |
| PIT | PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC 50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,2'-Pyridylisatogen tosylate. CAS No. 56583-49-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108662. | |
| Prodigiosin | Prodigiosin is an intensely red pyrrole pigment produced by several bacteria, most notably, Serratia marcescens. Prodigiosin has a broad biological profile with activity against fungi, tumor cell lines and malaria. It was shown to be an immunosuppressant in 2007. The mode of action of prodigiosin has recently received considerable attention as an inducer of apoptosis in human primary cancer cells via caspase activation. Prodigiosin also acts as an inducer of p21WAF1/CIP1 expression via transforming growth factor-B receptor pathway, and of NAG-1activation by acting on glycogen synthase kinase-3B. Group: Biochemicals. Grades: Highly Purified. CAS No. 82-89-3. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| RO-3 | RO-3 is a potent, CNS-penetrant, and orally active P2X 3 and P2X 2/3 antagonist with pIC 50 s of 5.9 and 7.0 for human homomultimeric P2X 3 and heteromultimeric P2X 2/3 receptors, respectively. RO-3 shows selectivity for P2X 3 and P2X 2/3 over all other functional homomultimeric P2X receptors (IC 50 >10 μM at P2X 1,2,4,5,7 ) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1026582-88-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19978. | |
| Ro 51 | Ro 51 is a potent and selective dual antagonist of purinoceptor subtypes P2X3 and P2X2/3. P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions making Ro 51 a potential option in the treatment of pain. Group: Biochemicals. Alternative Names: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2-pyrimidinyl]amino]-1,3-propanediol; RO-51. Grades: Highly Purified. CAS No. 1050670-85-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| SMI-4a | Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth. Group: Biochemicals. Grades: Highly Purified. CAS No. 327033-36-3. Pack Sizes: 5mg. Molecular Formula: C11H6F3NO2S, Method for Determining. US Biological Life Sciences. | Worldwide |
| Stem bromelain | Stem bromelain (EC 3.4.22.32) is a cysteine proteinase, isolated from pineapple ( Ananas comosus ) stem. Stem bromelain is a major bromelain, which exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Stem bromelain has in vivo antitumoral and antileukemic activity, as well as antimetastatic action [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 37189-34-7. Pack Sizes: 5 g; 25 g; 100 g. Product ID: HY-P2970. | |
| TPC2-A1-P | TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 ?M. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2804595-86-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131615. | |
| TRPML Agonist (ML-SA1, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1) | A membrane permeable dihydroquinolinyloxo-isoindolinedione compound that acts as a potent and selective agonist of lysosomal mucolipin transient receptor potential (TRP) channel 1,2,3 (TRPML) in all mammalian cells. Does not appear to affect six other related TRP channels. Shown to rapidly activate whole-endolysosome TRPML-like current and induce lysosomal Ca2+ release (~10uM). Its activating action on whole-endolysosome is comparable to that of PI(3,5)P2 (1uM) with which it shows a synergistic effect. ML-SA1-induced Ca2+ responses are reportedly abolished by glycyl-L-phenylalanine 2-naphthylamide, induces osmotic lysis of lysosomes, and Bafilomycin A1, a V-ATPase inhibitor. Also reduces lactosylceramide and cholesterol accumulation and corrects trafficking defects in Niemann-Pick (NP) disease cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 332382-54-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
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