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| Product | Description | |
|---|---|---|
| Piericidin a | Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PIERICIDIN A. Product Category: Inhibitors. Appearance: Liquid. CAS No. 2738-64-9. Molecular formula: C25H37NO4. Mole weight: 415.57. Purity: >95%. IUPACName: 2-[(2E,5E,7E,9R,10R,11E)-10-hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one. Canonical SMILES: COC1=C(C(C)=C(N=C1OC)C/C=C(C/C=C/C(C)=C/[C@@H](C)[C@H](/C(C)=C/C)O)\C)O. Density: 1.05 g/cm³. Product ID: ACM2738649. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Piericidin A | Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity. Synonyms: Shaoguanmycin B. Grades: >95.0%. CAS No. 2738-64-9. Molecular formula: C25H37NO4. Mole weight: 415.57. |  |
| Piericidin A from microbial source | >95% (HPLC), DMSO solution. Group: Fluorescence/luminescence spectroscopy. |  |
| Piericidin A (Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D, Piericidin A1) | Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces sp. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface. Group: Biochemicals. Alternative Names: Shaoguanmycin B, Antibiotic MT 1882-I, Antibiotic SN 198E, Antibiotic IT 143D, Piericidin A1. Grades: Highly Purified. CAS No. 2738-64-9. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Glucopiericidin A | Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts. Synonyms: 10'-O-beta-D-Glucopyranosylpiercidin A1; Antibiotic MT 1882-II; 2-[(2E,5E,7E)-10-[(2R,3R,4S,5S,6R,9R,10R)-2-[(E)-but-2-en-2-yl]-3,4,5-trihydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]oxy-3-methyldeca-2,5,7-trienyl]-5,6-dimethoxy-3-methyl-1H-pyridin-4-one. Grades: ≥95%. CAS No. 108073-65-0. Molecular formula: C31H47NO9. Mole weight: 577.71. | |
| Glucopiericidin B | It is produced by the strain of Streptomyces pactum S48727. Its antibacterial activity was stronger than Piericidin A1, and its inhibitory effect on antibody formation was also stronger than Piericidin A1. Synonyms: D-Glucopyranoside, 2-(10-hydroxy-3,7,9,11-tetramethyl-2,5,7,11,tridecatetraenyl)-5,6-dimethoxy-3-methyl-4-pyridinyl-, (R-(R*,R*(all E)))-. Grades: 95%. CAS No. 108073-61-6. Molecular formula: C31H47NO6. Mole weight: 577.71. | |
| Piericidin B | It is produced by the strain of Str. mobaraensis 16-24. It has anti-fungal, gram-positive bacteria and insect effects, but also has weak anti-gram-negative bacteria effect. Synonyms: Piericidin B1; (-)-Piericidin B1; 4-Pyridinol, 2,3-dimethoxy-6-(10-methoxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraenyl)-5-methyl-, (S-(R*,R*-(all-E)))-; 4-Pyridinol, 2,3-dimethoxy-6-[(2E,5E,7E,9R,10R,11E)-10-methoxy-3,7,9,11-tetramethyl-2,5,7,11-tridecatetraen-1-yl]-5-methyl-. CAS No. 16891-54-6. Molecular formula: C26H39NO4. Mole weight: 429.59. | |
| Piericidin C2 | Piericidin C2 is exclusively produced by the strain of actinomycetes, especially members of the genus Streptomyces. Synonyms: Piericidin C2; 58947-81-2; 4-Pyridinol, 2-(10-(2,3-dimethyloxiranyl)-10-hydroxy-3,5,7,9-tetramethyl-2,5,7-decatrienyl)-5,6-dimethoxy-3-methyl-. CAS No. 58947-81-2. Molecular formula: C26H39NO5. Mole weight: 445.59. | |
| Piericidin C3 | Piericidin C3 is exclusively produced by the strain of actinomycetes, especially members of the genus Streptomyces. Synonyms: Piericidin C3; Piericidin C; 58947-84-5; 4-Pyridinol, 2-(10-hydroxy-3,7,9-trimethyl-10-(2-methyl-3-(1-methylethyl)oxiranyl)-2,5,7-decatrienyl)-5,6-dimethoxy-3-methyl-. CAS No. 58947-84-5. Molecular formula: C27H41NO5. Mole weight: 459.62. | |
| Piericidin C4 | Piericidin C4 is exclusively produced by the strain of actinomycetes, especially members of the genus Streptomyces. Synonyms: 4-(1,3-dioxoisoindol-2-yl)-N-[2-(pyrrolidine-1-carbonyl)phenyl]butanamide; Piericidin E. CAS No. 58947-80-1. Molecular formula: C28H43NO5. Mole weight: 473.64. | |
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