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| Product | Description | |
|---|---|---|
| Pikromycin | Antibiotic. 14-Membered macrolide. Active against Gram-positive bacteria including mycobacteria. Prolyl endopeptidase (PREP) inhibitor.CAS Number:19721-56-3. Group: Biochemicals. Alternative Names: (3R, 5R, 6S, 7S, 9R, 11E, 13S, 14R)-14-Ethyl-13-hydroxy-3, 5, 7, 9, 13-pentamethyl-6-[[3, 4, 6-trideoxy-3-(dimethylamino)- β -D-xylo-hexopyranosyl] oxy] oxacyclotetradec-11-ene-2, 4, 10-trione; Oxacyclotetradecane, picromycin deriv.; Albomycetin; Amaromycin; Antibiotic B 62169A; Pikromycin; [3R-(3R*, 5R*, 6S*, 7S*, 9R*, 11E, 13S*, 14R*)]-14-Ethyl-13-hydroxy-3, 5, 7, 9, 13-pentamethyl-6-[[3, 4, 6-trideoxy-3-(dimethylamino)- β -D-xylo-hexopyranosyl] oxy] oxacyclotetradec-11-ene-2, 4, 10-trione. Grades: Highly Purified. CAS No. 19721-56-3. Pack Sizes: 1mg, 5mg. Molecular Formula: C28H47NO8 , Molecular Weight: 525.7. US Biological Life Sciences. |  Worldwide |
| Pikromycin | Pikromycin is a macrolide antibiotic that is biosynthesised by Streptomyces venezuelae. It is an inhibitor of Prolyl endopeptidase (PREP) and has an inhibitory effect on E. coli, S. aureus, B. subtilis and mycobacteria. Synonyms: (3R,5R,6S,7S,9R,11E,13S,14R)-14-Ethyl-13-hydroxy-3,5,7,9,13-pentamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradec-11-ene-2,4,10-trione; Albomycetin; Amaromycin; Antibiotic B 62169A; [3R-(3R*,5R*,6S*,7S*,9R*,11E,13S*,14R*)]-14-Ethyl-13-hydroxy-3,5,7,9,13-pentamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradec-11-ene-2,4,10-trione; Picromycin. Grades: ≥95% by HPLC. CAS No. 19721-56-3. Molecular formula: C28H47NO8. Mole weight: 525.67. |  |
| pikromycin synthase | A heme-thiolate protein (cytochrome P-450). Involved in the biosynthesis of a number of bacterial macrolide antibiotics containing a desosamine glycoside unit. With narbomycin it hydroxylates at either C-12 to give pikromycin or C-14 to give neopikromycin or both positions to give narvopikromycin. With 10-deoxymethymycin it hydroxylates at either C-10 to give methymycin or C-12 to give neomethymycin or both positions to give novamethymycin. Group: Enzymes. Synonyms: PikC; CYP107L1. Enzyme Commission Number: EC 1.14.13.185. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0784; pikromycin synthase; EC 1.14.13.185; PikC; CYP107L1. Cat No: EXWM-0784. |  |
| 10-deoxymethynolide desosaminyltransferase | DesVII is the glycosyltransferase responsible for the attachment of dTDP-D-desosamine to 10-deoxymethynolide or narbonolide during the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in the bacterium Streptomyces venezuelae. Activity requires an additional protein partner, DesVIII. Group: Enzymes. Synonyms: glycosyltransferase DesVII; DesVII. Enzyme Commission Number: EC 2.4.1.277. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2509; 10-deoxymethynolide desosaminyltransferase; EC 2.4.1.277; glycosyltransferase DesVII; DesVII. Cat No: EXWM-2509. | |
| 10-deoxymethynolide synthase | The product, 10-deoxymethynolide, contains a 12-membered ring and is an intermediate in the biosynthesis of methymycin in the bacterium Streptomyces venezuelae. The enzyme also produces narbonolide (see EC 2.3.1.240, narbonolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis. Group: Enzymes. Synonyms: pikromycin PKS. Enzyme Commission Number: EC 2.3.1.239. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2187; 10-deoxymethynolide synthase; EC 2.3.1.239; pikromycin PKS. Cat No: EXWM-2187. | |
| narbonolide synthase | The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae. The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239, 10-deoxymethynolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis. Group: Enzymes. Synonyms: pikromycin PKS. Enzyme Commission Number: EC 2.3.1.240. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2189; narbonolide synthase; EC 2.3.1.240; pikromycin PKS. Cat No: EXWM-2189. | |
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